Mechanisms mediating the inhibitory effect of all-trans retinoic acid on primitive hematopoietic stem cells in human long-term bone marrow culture

Stem Cells

Volumn 18, Issue 3, 2000, Pages 214-219

  Sammons, J ^a   Ahmed, N ^a   Khokher, M A ^a   Hassan, H T ^a,b  

^a UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

Adhesion molecules; Cobblestone area forming cell; gp130; Interleukin 11; Interleukin 6; Primitive stem cell; Retinoic acid

Indexed keywords

GLYCOPROTEIN GP 130; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 11; INTERLEUKIN 6; RETINOIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; BONE MARROW CULTURE; CELL ADHESION; CELL PROLIFERATION; COLONY FORMING UNIT GM; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LIGAND BINDING; SIGNAL TRANSDUCTION;

EID: 0034091486     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.18-3-214     Document Type: Article

References (37)

1. Douer D, Koeffler HP. Retinoic acid enhances colony-stimulating factor induced growth of normal human myeloid progenitor cells in vitro. Exp Cell Res 1982;138:193-198.
2. Aglietta M, Piacibello W, Sanavio F et al. Retinoic acid enhances the growth of only one subpopulation of granulomonocytic precursors. Acta Haematol 1984;71:97-99.
3. Nagler A, Riklis I, Kletter Y et al. Effect of 1,25 dihydroxyvitamin D3 and retinoic acid on normal human pluripotent (CFU-mix), erythroid (BFU-E) and myeloid (CFU-C) progenitor cell growth and differentiation patterns. Exp Hematol 1986;14:60-65.
4. Bleiberg I, Fabian I, Kantor S et al. The effect of 13-cis retinoic acid on haematopoiesis in human long-term bone marrow cultures. Leuk Res 1988;12:545-550.
5. Hassan HT. Synergism between differentiation agents: preclinical and clinical studies in myeloid leukaemia. In: Rifkind RA, ed. The Pharmacology of Cell Differentiation. Amesterdam: Elsevier Science Publishers B.V., 1993:277-294.
6. Tallman MS, Andersen JW, Schiffer CA et al. All-trans retinoic acid in acute promyelocytic leukaemia. N Engl J Med 1997;337:1021-1028.
7. Jacobsen SE, Fahlman C, Blomhoff HK et al. All-trans and 9-cis retinoic acid: potent direct inhibitors of primitive murine haematopoietic progenitors in vitro. J Exp Med 1994;179:1665-1670.
8. Smeland EB, Rusten L, Jacobsen SE et al. All-trans retinoic acid directly inhibits G-CSF-induced proliferation of CD34 positive human haematopoietic progenitor cells. Blood 1994;84:2940-2945.
9. Pleomacher R. Cobblestone-area-forming cell assay. In: Freshney RI, Pragnell IB, Freshney MG, eds. Culture of Haemopoietic Cells. New York: Wiley-Liss Inc., 1994:1-21.
10. Blomhoff HK, Smeland EB, Erikstein B et al. Vitamin A is a key regulator for cell growth, cytokine production and differentiation in normal B cells. J Biol Chem 1992;267:23988-23992.
11. Zitnik RJ, Kotloff RM, Latifpour J et al. Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. J Immunol 1994;152:1419-1427.
12. DiSepio D, Malhotra M, Chandraratna RA et al. Retinoic acid receptor-nuclear factor-interleukin 6 antagonism. A novel mechanism of retinoid-dependent inhibition of a keratinocyte hyperproliferative differentiation marker. J Biol Chem 1997;272:25555-25559.
13. Ahmed N, Sammons J, Khokher MA et al. Retinoic acid suppresses interleukin 6 production in normal human osteoblasts. Cytokine 2000;12:289-293.
14. Nagpal S, Cai J, Zheng T et al. Retinoid antagonism of NF-IL-6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma. Mol Cell Biol 1997;17:4159-4168.
15. Sidell N, Taga T, Hirano T et al. Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors. J Immunol 1991;146:3809-3814.
16. Ogata A, Nishimoto N, Shima Y et al. Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction. Blood 1994;84:3040-3046.
17. Chen YH, Desai P, Shiao RT et al. Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: synergy through modulation of IL-6 autocrine loop at multiple sites. Blood 1996;87:314-323.
18. Levy Y, Labaume S, Colombel M et al. Retinoic acid modulates the in vivo and in vitro growth of Interleukin-6 autocrine human myeloma cell lines via induction of apoptosis. Clin Exp Immunol 1996;104:167-172.
19. Taetle R, Dos Santos B, Akamatsu K et al. Effects of all-trans retinoic acid and antireceptor antibodies on growth and programmed cell death of human myeloma cells. Clin Cancer Res 1996;2:253-259.
20. Smith MR, Xie T, Joshi I et al. Dexamethasone plus retinoids decrease Interleukin-6/Interleukin-6 receptor and induce apoptosis in myeloma cells. Br J Haematol 1998;102:1090-1097.
21. hi stem cells to bone marrow stroma. J Clin Invest 1992;90:358-367.
22. Hassan HT, Biermann B, Zander AR. Maintenance and expansion of erythropoiesis in human long-term bone marrow cultures in presence of erythropoietin plus stem cell factor and interleukin-3 or interleukin-11. Eur Cytokine Netw 1996;7:129-136.
23. Breems DA, van Hennik P, Kusadasi N et al. Individual stem cell quality in leukapheresis products is related to the number of mobilized stem cells. Blood 1996;87:5370-5378.
24. Bellido T, Stahl N, Farruggella TJ et al. Detection of receptors for IL-6, IL-11, LIF, oncostatin M and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J Cell Invest 1996;97:431-437.
25. + cells. J Exp Med 1996;184:1357-1364.
26. Sui X, Tsuji K, Tanaka R et al. gp130 and c-kit signalings synergize for ex vivo expansion of human primitive haemopoietic progenitor cells. Proc Natl Acad Sci USA 1995;92:2859-2863.
27. Sui X, Tsuji K, Tajima S et al. Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34 positive cells. J Exp Med 1996;183:837-845.
28. Nakahata T, Sui X, Tanaka R et al. Role of glycoprotein 130 and c-kit signaling in proliferation and differentiation of human haemopoietic progenitor cells. Cancer Chemother Pharmacol 1996;38(suppl):S64-S68.
29. Ebhira Y, Tsuji K, Lyman SD et al. Synergistic action of Flt3 and gp130 signalings in human hematopoiesis. Blood 1997;90:4363-4368.
30. Kimura T, Sakabe H, Tanimukai S et al. Simultaneous activation of signals through gp130, c-kit and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors. Blood 1997;90:4767-4778.
31. Rappold I, Watt SM, Kusadasi N et al. Gp130-signaling synergises with FL and TPO for the long-term expansion of cord blood progenitors. Leukemia 1999;13:2036-2048.
32. + cells through glycoprotein (gp)130 signaling. Blood 1999;93:2525-2532.
33. Takagi M, Nakamura T, Sawada T et al. Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor alpha, (IL-6R alpha)-, IL-1 1R alpha-, and gp130-low to negative primitive hematopoietic progenitors. Mol Biol Cell 1999;10:3633-3642.
34. Montero-Julian FA, Brailly H, Sautes C et al. Characterisation of soluble gp130 released by melanoma cell lines: a polyvalent antagonist of cytokines from the interleukin 6 family. Clin Cancer Res 1997;3:1443-1451.
35. Muller-Newen G, Kuster A, Hemmann U et al. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. J Immunol 1998;161:6347-6355.
36. Weiss L, Geduldig U. Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow. Blood 1991;78:975-990.
37. - cells and stroma induces the soluble activity that specifically increases primitive haemopoietic cell production. Exp Hematol 1999;27:734-741.