Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor α (IL-6Rα)-, IL-11Rα-, and gp130-low to -negative primitive hematopoietic progenitors

Molecular Biology of the Cell

Volumn 10, Issue 11, 1999, Pages 3633-3642

  Takagi, Mineo ^a   Nakamura, Takanori ^a   Sawada, Toshie ^a   Kaneko, Azusa ^a   Nozaki Ukai, Manabu ^a   Nakahata, Tatsutoshi ^a   Yokota, Takashi ^a   Heike, Toshio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11 RECEPTOR; INTERLEUKIN 6 RECEPTOR; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL SUSPENSION; COLONY FORMATION; CONTROLLED STUDY; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0032694047     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.11.3633     Document Type: Article

References (28)

1. Deberry, C., Mou, S., and Linnekin, D. (1997). Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. 327, 73-80.
2. Escary, J.L., Perreau, J., Dumenil, D., Ezine, S., and Brulet, P. (1993). Leukemia inhibitory factor is necessary for maintenance of hematopoietic stem cells and thymocyte stimulation. Nature 363, 361-364.
3. Hirano, T. (1998). Interleukin 6 and its receptor: ten years later. Int. Rev. Immunol. 16, 249-284.
4. Hirota, H., Kiyama, H., Kishimoto, T., and Taga, T. (1996). Accelerated nerve regeneration in mice by up-regulated expression of interleukin (IL) 6 and IL-6 receptor after trauma [see comments]. J. Exp. Med. 183, 2627-2634.
5. Hogan, B., Beddington, R., Costantini, F., and Lacy, E. (1994). Manipulating the Mouse Embryo, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
6. Holyoake, T.L., Freshney, M.G., McNair, L., Parker, A.N., McKay, P.J., Steward, W.P., Fitzsimons, E., Graham, G.J., and Pragnell, I.B. (1996). Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow. Blood 87, 4589-4595.
7. Iscove, N.N., and Melchers, F. (1978). Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes. J. Exp. Med. 147, 923-933.
8. Kirby, S.L., Cook, D.N., Walton, W., and Smithies, O. (1996). Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. Proc. Natl. Acad. Sci. USA 93, 9402-9407.
9. Kishimoto, T., Akira, S., Narazaki, M., and Taga, T. (1995). Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254.
10. Kodama, H., Nose, M., Niida, S., and Nishikawa, S. (1994). Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells. Exp. Hematol. 22, 979-984.
11. Koike, K., Nakahata, T., Takagi, M., Kobayashi, T., Ishiguro, A., Tsuji, K., Naganuma, K., Okano, A., Akiyama, Y., and Akabane, T. (1988). Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture. J. Exp. Med. 168, 879-890.
12. Koshimizu, U., Taga, T., Watanabe, M., Saito, M., Shirayoshi, Y., Kishimoto, T., and Nakatsuji, N. (1996). Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells. Development 122, 1235-1242.
13. Muto, A., Watanabe, S., Miyajima, A., Yokota, T., and Arai, K. (1995). High affinity chimeric human granulocyte-macrophage colony-stimulating factor receptor carrying the cytoplasmic domain of the beta subunit but not the alpha subunit transduces growth promoting signals in Ba/F3 cells. Biochem. Biophys. Res. Commun. 208, 368-375.
14. Nakahata, T., Gross, A.J., and Ogawa, M. (1982). A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture. J. Cell. Physiol. 113, 455-458.
15. Nakahata, T., and Ogawa, M. (1982). Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies. Proc. Natl. Acad. Sci. USA 79, 3843-3847.
16. Nakamura, T., Arai, T., Takagi, M., Sawada, T., Matsuda, T., Yokota, T., and Heike, T. (1998). A selective switch-on system for self-renewal of embryonic stem cells using chimeric cytokine receptors. Biochem. Biophys. Res. Commun. 248, 22-27.
17. Nishijima, I., Nakahata, T., Hirabayashi, Y., Inoue, T., Kurata, H., Miyajima, A., Hayashi, N., Iwakura, Y., Arai, K., and Yokota, T. (1995). A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF. Mol. Biol. Cell 6, 497-508.
18. Okumura, N., Tsuji, K., Ebihara, Y., Tanaka, I., Sawai, N., Koike, K., Komiyama, A., and Nakahata, T. (1996). Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells. Blood 87, 4100-4108.
19. Osawa, M., Hanada, K., Hamada, H., and Nakauchi, H. (1996). Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242-245.
20. Peters, M., Schirmacher, P., Goldschmitt, J., Odenthal, M., Peschel, C., Fattori, E., Ciliberto, G., Dienes, H.P., Meyer zum Buschenfelde, K.H., and Rose-John, S. (1997). Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice. J. Exp. Med. 185, 755-766.
21. Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., and Kishimoto, T. (1992). Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. USA 89, 232-235.
22. Sui, X., et al. (1995). gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells. Proc. Natl. Acad. Sci. USA 92, 2859-2863.
23. Tajima, S., et al. (1996). Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J. Exp. Med. 184, 1357-1364.
24. Takagi, M., Hara, T., Ichihara, M., Takatsu, K., and Miyajima, A. (1995). Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. J. Exp. Med. 181, 889-899.
25. Tang, B., Mano, H., Yi, T., and Ihle, J.N. (1994). Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol. Cell. Biol. 14, 8432-8437.
26. Weiler, S.R., Mou, S., DeBerry, C.S., Keller, J.R., Ruscetti, F.W., Ferris, D.K., Longo, D.L., and Linnekin, D. (1996). JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor. Blood 87, 3688-3693.
27. Yonemura, Y., Ku, H., Lyman, S.D., and Ogawa, M. (1997). In vitro expansion of hematopoietic progenitors and maintenance of stem cells: comparison between FLT3/FLK-2 ligand and KIT ligand. Blood 89, 1915-1921.
28. Yoshida, K., et al. (1996). Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 93, 407-411.