Protein wasting in severe illness: Pathogenesis and therapy

Diabetes, Nutrition and Metabolism - Clinical and Experimental

Volumn 13, Issue 1, 2000, Pages 21-24

  Wernerman, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cachexia; Cancer; Catabolism; Proteolysis

Indexed keywords

ALBUMIN; GLUTAMINE; MUSCLE PROTEIN; WATER;

CONFERENCE PAPER; CRITICAL ILLNESS; HUMAN; INTENSIVE CARE; MUSCLE ATROPHY; PARENTERAL NUTRITION; PHYSICAL STRESS; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SKELETAL MUSCLE;

BODY WATER; GLUTAMINE; HUMANS; INTENSIVE CARE UNITS; MUSCLE PROTEINS; MUSCLES; PROTEINS; WASTING SYNDROME;

EID: 0034085322     PISSN: 03943402     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (27)

1. Gamrin L., Essén P., Forsberg A.-M., Hultman E., Wernerman J.: A descriptive study of skeletal metabolism in critically ill patients: Free amino acids, protein, energy-rich phosphates, nucleic acids, fat, water and electrolytes. Crit. Care Med. 24: 575-583, 1996.
2. Gamrin L., Essén P., Andersson K., Hultman E., Nilsson E., Wernerman J.: Longitudinal changes of biochemical parameters in muscle during critical illness. Metabolism 46: 756-762, 1997.
3. Wernerman J., von der Decken A., Vinnars E.: Protein synthesis in skeletal muscle after abdominal surgery: The effect of total parenteral nutrition. JPEN 10: 578-582, 1986.
4. Essén P., McNurlan M.A., Wernerman J., Vinnars E., Garlick P.J.: Uncomplicated surgery but not general anaesthesia, decreases muscle protein synthesis. Am. J. Physiol. 262: E253-E260, 1992.
5. Rennie M.J., Bennegård K., Edén E., Emery P.W., Lundholm K.: Urinary excretion and efflux from the leg of 3-methylhistidine before and after major surgical operation. Metabolism 33: 250-256, 1984.
6. Esssén P., McNurlan M.A., Gamrin L., Garlick P.J., Wernerman J: Tissue protein synthesis rate in critically ill patients. Crit. Care Med. 26: 92-100, 1998.
7. Sjölin J., Stjernström H., Friman G., Larsson J., Wahren J.: Total and net muscle protein breakdown in infection determined by amino acid effluxes. Am. J. Physiol. 258: E856-E863, 1990.
8. 2+ activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients. Proc. Natl. Acad. Sci. (USA) 93: 2714-2718, 1996.
9. Tiao G., Hobler S., Wang J.J., Meyer T.A., Luchette F.A., Fischer J.E., Hasselgren P.O.: Sepsis is associated with increased mRNAa of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J. Clin. Invest. 99: 163-168, 1997.
10. Roth E., Funovics J., Mühlbacker F., Schemper M., Mauritz W., Sporn P., Fritsch A.: Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle. Clin. Nutr. 1: 25-42, 1982.
11. Hammarqvist F., Luo J., Cotgreave I., Andersson K., Wernerman J.: Skeletal muscle glutathione is depleted in critically ill patients. Crit. Care Med. 25: 78-84, 1996.
12. Essén P., Wernerman J., Sonnenfeld T., Thunell S., Vinnars E.: Free amino acids in plasma and muscle during 24 hours post-operatively - a descriptive study. Clin. Physiol. 12: 163-177, 1992.
13. Petersson B., Vinnars E., Waller S.-O., Wernerman J.: Long-term changes in muscle free amino acid levels after elective abdominal surgery. Br. J. Surg. 79: 212-216, 1992.
14. Jepson M.M., Pell J.M., Bates P.C., Millward D.J.: The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochem. J. 235: 329-336, 1986.
15. MacLennan P., Brown R.A., Rennie M.: A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. FEBS Lett. 215: 187-191, 1987.
16. Wernerman J., Hammarqvist F., Vinnars E.: Alpha-ketoglutarate and postoperative muscle catabolism. Lancet 335: 701-703, 1990.
17. Palmer T.E.A., Griffiths R.D., Jones C.: Effect of parenteral 1-glutamine on muscle in the very severely ill. Nutrition 12: 316, 1996.
18. Gamrin L., Andersson K., Essén P., Wernerman J.: Growth hormone treatment increases muscle free glutamine in critically ill patients. Clin. Nutr. 14 (Suppl.): O24, 1995.
19. Gamrin L., Essén P., Garlick P.J., McNurlan M., Wernerman J.: Growth hormone increases skeletal muscle protein synthesis rate in critically ill patients. Clin. Nutr. 18 (Suppl.): 10, 1999.
20. Fleck A., Hawker F., Wallace P.I., Raines G., Trotter J., Ledingham I.M., Calman K.C.: Increased vascular permeability: a major cause of hypoalbuminemia in disease and injury. Lancet 1: 781-784, 1985.
21. Barle H., Essén P., Wernerman J.: Studies of Protein and Amino Acid Metabolism in the Human Liver. In: Vincent J.L. (Ed.), Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag, Berlin 1999, pp. 75-91.
22. 13C]leucine. Kidney Int. 41: 132-138, 1992.
23. Barle H., Nyberg B., Essén P., McNurlan M.A., Garlick P.J., Hogersson J., Wernerman J.: Growth hormone stimulates albumin synthesis in man. Intensive Care Med. 24: S13, 1998.
24. Barle H., Gamrin L., Essén P., McNurlan M., Wernerman J., Garlick P.: Growth hormone does not affect albumin synthesis in the critically ill. Clin. Nutr. 17 (Suppl. 1): 67, 1998.
25. Takala J., Ruokonen E., Webster N., Nielsen M., Zandstra D., Vundenlinckx G., Hinds C.: Increased mortality associated with growth hormone treatment in critically ill adults. N. Engl. J. Med. 341: 785-792, 1999.
26. Mjaaland M., Unneberg K., Hotvedt R., Revhaug A.: Nitrogen retention caused by growth hormone in patients undergoing gastrointestinal surgery with epidural analgesia and parenteral nutrition. Eur. J. Surg. 157: 21-27, 1991.
27. Griffiths R.D., Jones C., Palmer T.E.A.: A six-month outcome of critically ill patients given glutamine supplemented parenteral nutrition. Nutrition 13: 295-302, 1997.