Skeletal muscle glutathione is depleted in critically ill patients

Critical Care Medicine

Volumn 25, Issue 1, 1997, Pages 78-84

  Hammarqvist, Folke ^a   Luo, Jia Li ^b   Cotgreave, Ian A ^c   Andersson, Kerstin ^b   Wernerman, Jan ^b  

^a ST GÖRAN S HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

amino acids; critical illness; glutamine; glutathione; intensive care; muscle biopsy; oxygen free radicals; redox status; skeletal muscle; thiols

Indexed keywords

GLUTATHIONE;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKELETAL MUSCLE;

EID: 0031030466     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199701000-00016     Document Type: Article

References (39)

1. Shan X, Aw TY, Jones DP: Glutathione-dependent protection against oxidative injury. Pharmacol Ther 1990; 47:61-71
2. Kawabata T, Ogino T, Awai M: Protective effects of glutathione against lipid peroxidation in chronically iron-loaded mice. Biochim Biophys Acta 1989; 1004:89-94
3. Meister A: On the antioxidant effects of ascorbic acid and glutathione. Biochem Pharmacol 1992; 44:1905-1915
4. Takeda K, Shimada Y, Amano M, et al: Plasma lipid peroxides and alpha-tocopherol in critically ill patients. Crit Care Med 1984; 12:957-963
5. Purucker E, Egri L, Hamar H, et al: Differences in glutathione status and lipid peroxidation of red and white muscles: Alterations following ischemia and reperfusion. Res Exp Med 1991; 191:209-217
6. Bulkley GB: The role of oxygen free radicals in human disease processes. Surgery 1983; 94:407-411
7. Sies H: Biochemistry of oxidative stress. Angewandte Chemie Int Ed Engl 1986; 25:1058-1071
8. McCord JM: The superoxide radicals: Its biochemistry and pathophysiology. Surgery 1983; 94:412-414
9. Meakins JL: Etiology of multiple organ failure. J Trauma 1990; 30:S165-S168
10. Reichard SM, Bailey NM, Galvin MJ: Alterations in tissue glutathione levels following traumatic shock. Adv Shock Res 1981; 5:37-45
11. Keller GA, Barke R, Harty JT, et al: Decreased hepatic glutathione levels in septic shock. Arch Surg 1985; 120: 941-945
12. Mârtensson J, Meister A: Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci USA 1989; 86:471-475
13. Corbucci GG, Gasparetto A, Candiani A, et al: Shock-induced damage to mitochondrial function and some cellular antioxidant mechanisms in humans. Circ Shock 1985; 15:15-26
14. Khairallah EA, Bartolone J, Brown P, et al: Does glutathione play a role in regulating intracellular proteolysis? In: Intracellular Protein Catabolism. Khairallah EA, Bond JS, Bird JWC (Eds). New York, Alan R Liss, 1985, pp 373-383
15. Tischler ME, Fagan JM, Allen D: Relationship of the redox state to muscle protein degradation. In: Intracellular Protein Catabolism. Khairallah EA, Bond JS, Bird JWC (Eds). New York, Alan R Liss, 1985, pp 363-372
16. Larsson J, Liljedahl S-O, Schildt B, et al: Metabolic studies in multiple injured patients. Acta Chir Scand 1981; 147:317-324
17. Roth E, Zöch G, Schulz F, et al: Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis. Clin Chem 1985; 31:1305-1309
18. Gore DC, Honeycutt D, Jahoor F, et al: Effect of exogenous growth hormone on whole-body and isolated-limb protein kinetics in burned patients. Arch Surg 1991; 126:38-43
19. Larsson J, Schildt B, Liljedahl S-O, et al: The effect of severe trauma on muscle energy metabolism in man. Acta Chir Scand 1984; 150:611-618
20. Bergström J, Boström H, Fürst P, et al: Preliminary studies of energy-rich phosphagens in muscle from severely ill patients. Crit Care Med 1976; 4:197-204
21. Knaus WA, Draper EA, Wagner DP, et al: Apache II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
22. Bergström J: Muscle electrolytes in man. Scand J Clin Lab Invest 1962; 14(Suppl 168):11-14
23. Luo J-L, Hammarqvist F, Andersson K, et al: Skeletal muscle glutathione after surgical trauma. Ann Surg 1996; 223:420-427
24. Bergström J, Fürst P, Norée L-O, et al: Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 1974; 36:693-697
25. Snedecor GW, Cochran WG: Statistical Methods. Seventh Edition. Ames, IA, 1980, pp 141-143
26. Kobayashi T, Robinson MK, Robinson V, et al: Glutathione depletion alters hepatocellular high-energy phosphate metabolism. J Surg Res 1993; 543: 189-195
27. Stein HJ, Oosthuizen MMJ, Hinder RA, et al: Oxygen free radicals and glutathione in hepatic ischemia/reperfusion injury. J Surg Res 1991; 50:398-402
28. Robinson MK, Rounds JD, Hong RW, et al: Glutathione deficiency increases organ dysfunction after hemorrhagic shock. Surgery 1992; 112:140-149
29. Hong RW, Rounds JD, Helton WS, et al: Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992; 215:114-119
30. Hong RW, Helton WS, Rounds JD, et al: Glutamine-supplemented TPN preserves hepatic glutathione and improves survival following chemotherapy. Surg Forum 1990; 41:9-11
31. Gamrin L, Essén P, Hultman E, et al: A descriptive study of skeletal muscle metabolism in critically ill patients: Free amino acids, energy rich phosphates, protein, nucleic acids, fat, water and electrolytes. Crit Care Med 1996; 24: 575-583
32. Roth E, Funovics J, Mühlbacher F, et al: Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle. Clin Nutr 1982; 1:25-42
33. Welbourne TC: Ammonia production and glutamine incorporation into glutathione in the fractioning rat kidney. Can J Biochem 1979; 57:233-237
34. Dass PB, Bourke E: Interaction of glutathione and glutamine in separated rat renal proximal tubules. Contrib Nephrol 1988; 63:77-85
35. MacLennan PA, Smith K, Weryk B, et al: Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle. FEBS Lett 1988; 237:133-136
36. Askanazi J, Carpentier YA, Michelsen CB, et al: Muscle and plasma amino acids following injury: Influence of intercurrent infection. Ann Surg 1980; 191:78-85
37. Hammarqvist F, Wernerman J, Ali MR, et al: Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle. Br J Surg 1990; 77:214-218
38. Vinnars E, Bergström J, Fürst P: Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann Surg 1975; 182: 665-671
39. Sies H, Akerboom TPM: Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol 1984; 105: 445-451