Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: A potential protective mechanism in plaque stability

Circulation Research

Volumn 83, Issue 3, 1998, Pages 270-278

  Fabunmi, Rosalind P ^b   Sukhova, Galina K ^b   Sugiyama, Seigo ^b   Libby, Peter ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b NONE

Author keywords

Atherosclerosis; Macrophage; Smooth muscle cell; Tissue inhibitor of metalloproteinases

Indexed keywords

MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA;

AORTA; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER;

EID: 0032504755     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.3.270     Document Type: Article

References (32)

1. Davies MJ, Thomas AC. Plaque fissuring: the cause of acute myocardial infarction, sudden ischemic death, and crescendo angina. Br Heart J. 1985;53:363-373.
2. Fuster V, Badimon I, Badimon J, Chesebro J. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 1992;326:242-250.
3. Richardson P, Davies M, Born G. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet. 1989;2:941-944.
4. Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995;91:2844-2850.
5. Henney AM, Wakeley PR, Davies MJ, Foster K, Hembry R, Murphy G. Humphries S. Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci U S A. 1991;88:8154-8158.
6. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94: 2493-2503.
7. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner J. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation. 1995;91: 2125-2131.
8. Nikkari S, Geary R, Hatsukami T, Ferguson M, Forough R, Alpers C, Clowes A. Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy. Am J Pathol. 1996;148:777-783.
9. Halpert I, Sires U, Roby J, Potter-Perigo S, Wight T, Shapiro S, Welgus H, Wickline S, Parks W. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A. 1996;18:9748-9753.
10. Docherty AJP, Lyons A, Smith BJ, Wright EM, Stephens PE, Harris TJR, Murphy G, Reynolds JJ. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature. 1985;318:66-69.
11. Stetler-Stevenson WG, Brown PD, Onisto M, Levy AT, Liotta LA. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. J Biol Chem. 1990;265:13933-13938.
12. Uría JA, Ferrando AA, Velasco G, Freije JMP, López-Otín C. Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family. Cancer Res. 1994;54:2091-2094.
13. Greene J, Wang M, Liu Y, Raymond L, Rosen C, Ye S. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J Biol Chem. 1996;271:30375-30380.
14. Pavloff N, Staskus PW, Kishnani NS, Hawkes SP. A new inhibitor of metalloproteinases from chicken: ChIMP-3, a third member of the TIMP family. J Biol Chem. 1992;267:17321-17326.
15. Apte S, Olsen B, Murphy G. The gene structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. J Biol Chem. 1995;270:14313-14318.
16. Willenbrock F, Murphy G. Structure-function relationships in the tissue inhibitors of metalloproteinases. Am J Respir Crit Care Med. 1994;150: S165-S170.
17. Birkedal-Hansen H, Moore WGI, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med. 1993;4:197-250.
18. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E, Libby P. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res. 1994;75:181-189.
19. Kenagy RD, Nikkari ST, Welgus HG, Clowes AW. Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase and collagenase) in primate arterial smooth muscle cells. J Clin Invest. 1994;93:1987-1993.
20. Fabunmi R, Baker A, Murray E, Booth R, Newby A. Divergent regulation by growth factors and cytokines of 95-kDa and 72-Da gelatinases and tissue inhibitors of metalloproteinases-1, -2 and -3 in rabbit aortic smooth muscle cells. Biochem J. 1996;315:335-342.
21. Gunther S, Alexander RW, Atkinson WJ, Gimbrone MA Jr. Functional angiotensin II receptors in cultured vascular smooth muscle. J Cell Biol. 1982;92:289-298.
22. Libby P, O'Brien K. Culture of quiescent arterial smooth muscle cells in a defined serum-free medium. J Cell Physiol. 1983;115:217-223.
23. Kranzhofer R, Clinton S, Ishii K, Coughlin S, Fenton JPL. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res. 1996;79: 286-294.
24. Welgus H, Campbell E, Cury J, Eisen A, Senior R, Wilhelm S, Goldberg G. Neutral metalloproteinases produced by human mononuclear phagocytes: enzyme profile, regulation, and expression during cellular development. J Clin Invest. 1990;86:1496-1502.
25. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res. 1994;75:539-545.
26. Zempo N, Kenagy RD, Au T, Bendeck M, Clowes MM, Reidy MA, Clowes AW. Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid. J Vasc Surg. 1994;20:209-217.
27. Southgate KM, Fisher M, Banning AP, Thurston VJ, Baker AH, Fabunmi RP, Groves PH, Davies M, Newby AC. Upregulation of basement membrane degrading metalloproteinase secretion after balloon injury of pig carotid arteries. Circ Res. 1996;79:1177-1187.
28. Forough R, Koyama N, Hasenstab D, Lea H, Clowes M, Nikkari S, Clowes A. Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo. Circ Res. 1996;79:812-820.
29. Hasenstab D, Forough R, Clowes A. Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinases-2 increase after arterial injury in rats. Circ Res. 1997;80:490-496.
30. Kaplan M, Aviram M. Oxidized LDL binding to a macrophage-secreted extracellular matrix. Biochem Biophys Res Commun. 1997; 237:271-276.
31. Stary H, Chandler A, Dinsmore R, Fuster V, Glagov S, Insull W, Rosenfeld M, Schwartz C, Wagner W, Wissler R. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92:1355-1374.
32. Seiffert D, Mimuro J, Schleef R, Luskutoff D. Interactions between type I plasminogen activator inhibitor, extracellular matrix and vitronectin. Cell Differ Dev. 1990;32:287-292.