Determinants of plasma homocyst(e)ine in patients with nephrotic syndrome

Journal of Molecular Medicine

Volumn 78, Issue 3, 2000, Pages 147-154

  Joven, Jorge ^a   Arcelús, Rosa ^b   Camps, Jordi ^a   Ordóñez Llanos, Jordi ^b,c   Vilella, Elisabet ^a   González Sastre, Francesc ^b,c   Blanco Vaca, Francisco ^b  

^a HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Albuminuria; Hyperhomocyst(e)inemia; Proteinuria; Renal failure

Indexed keywords

HOMOCYSTEINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CARDIOVASCULAR RISK; DISEASE SEVERITY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY FAILURE; KIDNEY TUBULE FUNCTION; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; PROTEINURIA;

EID: 0034078237     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090000093     Document Type: Article

References (40)

1. 1. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274:1049-1057
2. 2. Refsum H, Ueland PM, Nygard O, Vollset SE (1998) Homocysteine and cardiovascular disease. Annu Rev Med 49:31-61
3. 3. Goyette P, Summer JS, Milos R, Duncan AMV, Rosenblatt DS, Matthews RG, Rozen R (1994) Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 7:195-200
4. 4. Garrow TA (1996) Purification, kinetics properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J Biol Chem 271:22831-22838
5. 5. Bostom AG, Shemin D, Lapane KL, Miller JW, Sutherland P, Nadeau M, Seyoum E, Hartman W, Prior R, Wilson PWF, Selhub J (1995) Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a case-control study. Atherosclerosis 114:93-103
6. 6. Chauveau P, Chadefaux B, Coudé M, Aupetit J, Hannedouche T, Kamoun P, Jungers P (1993) Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients. Kidney Int 43 [Suppl 41]:S72-S77
7. 7. Bostom AG, Shemin D, Verhoef P, Nadeau MR, Jacques PF, Selhub J, Dworkin L, Rosenberg IH (1997) Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study. Arterioscler Thromb Vasc Biol 17:2554-2558
8. 8. Moustapha A, Naso A, Nahlawi M, Gupta A, Arheart KL, Jacobsen DW, Robinson K, Dennis VW (1998) Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 97:138-141
9. 9. Mallick NP, Short CD (1981) The nephrotic syndrome and ischaemic heart disease. Nephron 27:54-57
10. 10. Joven J, Simó JM, Vilella E, Camps J, Espinel E, Villabona C (1995) Accumulation of atherogenic remnants and lipoprotein (a) in the nephrotic syndrome: relation to remission of proteinuria. Clin Chem 41:908-913
11. 11. Chico A, Pérez A, Córdoba A, Arcelús R, Carreras G, de Leiva A, González-Sastre F, Blanco-Vaca F (1998) Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus. A new link between diabetic nephropathy and cardiovascular disease? Diabetologia 41:684-693
12. 12. Hofman MA, Kohl B, Zumbach MS, Borcea V, Bierhaus A, Henkels M, Amiral J, Schmidt AM, Fiehn W, Ziegler R, Wahl P, Nawroth PP (1998) Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care 21:841-848
13. 13. Hoogeveen EK, Kostense PJ, Jager A, Heine RJ, Jakobs C, Bouter LM, Donker Ab JM, Stehouwer CDA (1998) Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn study. Kidney Int 54:203-209
14. 14. Joven J, Espinel E, Simó JM, Vilella E, Camps J, Oliver A (1996) The influence of hypoalbuminemia in the generation of nephrotic hyperlipidemia. Atherosclerosis 126:243-252
15. 15. Simó J, Bertran N, Juanpere M, Camps J, Joven J (1998) Evaluatión preliminar del analizador automático Monarch 2000. Quim Clin 8:329-335
16. 16. Cameron JS, Blanford G (1966) The simple assessment of selectivity in heavy proteinuria. Lancet 2:242-247
17. 17. Córdoba-Porras A, Sánchez-Quesada JL, González-Sastre F, Ordóñez-Llanos J, Blanco-Vaca F (1996) Susceptibility of plasma low- and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinemia. J Mol Med 74:771-776
18. 18. Hyland K, Bottiglieri T (1992) Measurement of total plasma and cerebrospinal fluid homocysteine by fluorescence following high-performance liquid chromatography and precolumn derivatization with ortho-phthaldehyde. J Chromatogr 579:55-62
19. 19. Berlyne GM, Mallick NP (1969) Ischemic heart disease as a complication of nephrotic syndrome. Lancet II:399-400
20. 20. Wass V, Cameron JS (1981) Cardiovascular disease and the nephrotic syndrome: the other side of the coin. Nephron 27: 58-61
21. 21. Llach F, Arieff AI, Massry SG (1975) Renal vein thrombosis and nephrotic syndrome: a prospective study of 36 adult patients. Ann Intern Med 83:8-14
22. 22. Farrell RJ, Collins R, Goggins M, Forkin C, Gaffney E, Keogh JAB, Weir DG (1995) Nephrotic syndrome, renal vein thrombosis, and folate deficiency in a young man: is there a relationship to homocysteine metabolism?. Nephrol Dial Transplant 10:2130-2132
23. 23. Hultberg B, Andersson A, Arnadottir M (1995) Reduced, free and total homocysteine and other thiol compounds in plasma from patients with renal failure. Nephron 70:62-67
24. 24. Alfthan G, Aro A, Gey KF (1997) Plasma homocysteine and cardiovascular disease mortality. Lancet 349:397 (letter)
25. 25. Harpel PC, Chang VT, Borth W (1992) Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein (a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism. Proc Natl Acad Sci USA 89:10193-10197
26. 26. Stampfer MJ, Malinow MR (1995) Can lowering homocysteine levels reduce cardiovascular risk? N Engl J Med 332: 328-329
27. 27. Joven J, Villabona C, Vilella E (1993) The pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus. Nephron 64:565-569
28. 28. Lussier-Cacan S, Xhignesse M, Piolot A, Selhub J, Davignon J, Genest J Jr (1996) Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 64:587-593
29. 29. Cohen PE, Lemann J (1991) The role of the laboratory in the evaluation of kidney function. Clin Chem 37:785-796
30. 30. Guder WG, Hofmann W (1992) Markers for the diagnosis and monitoring of renal tubular lesions. Clin Nephrol 38 [Suppl 1]:S3-S7
31. 31. Lanfredini M, Fiorina P, Peca MG, Veronelli A, Mello A, Astorri E, Dall'Aglio P, Craveri A (1998) Fasting and post-methionine load homocyst(e)ine values are correlated with microalbuminuria and could contribute to worsening vascular damage in non-insulin-dependent diabetes mellitus patients. Metabolism 47:915-921
32. 32. Cronin CC, McPartlin JM, Barry DG, Ferris JB, Scott JM, Weir DG (1998) Plasma homocysteine concentrations in patients with type 1 diabetes. Diabetes Care 21:1843-1847
33. 33. Smulders YM, Rakic M, Slaats EH, Treskes M, Sijbrands EJG, Odekerken DAM, Stehouwer CDA, Silverbush J (1999) Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care 22:125-132
34. 34. Wollesen F, Brattström L, Refsum H, Ueland PM, Berglund L, Berne C (1999) Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Kidney Int 55:1028-1035
35. 35. Stehouwer CDA, Gall M-A, Hougaard P, Jakobs C, Parving H-H (1999) Plasma homocysteine concentration predicts mortality in non-insulin-dependent diabetes mellitus with and without albuminuria. Kidney Int 55:308-314
36. 36. Smulders YM, Brouwer CB, Silverbusch J (1999) Is plasma homocysteine related to albumin excretion rate in patients with diabetes mellitus?. Diabetologia 42:382
37. 37. Chico A, Pérez A, Córdoba A, Arcelús R, Carreras G, de Leiva A, González-Sastre F, Blanco-Vaca F (1999) Response. Diabetologia 42:383
38. 38. Holm J, Hemmingsen L, Nielsen NV (1993) Low-molecular-mass proteinuria as a marker of proximal renal tubular dysfunction in normo- and microalbuminuric non-insulin-dependent diabetic subjects. Clin Chem 39:517-519
39. 39. Lever M, Sizeland PCB, Bason LM, Haymer CM, Robson RA, Chambers ST (1994) Abnormal glycine betaine content of the blood and urine of diabetic and renal patients. Clin Chim Acta 230:69-79
40. 40. Laryea MD, Steinhagen F, Pawliczek S, Wendel U (1998) Simple method for the routine determination of betaine and N,N-dimethylglycine in blood and urine. Clin Chem 44:1937-1941