Therapeutic effects of the endothelin receptor antagonist Ro 48-5695 in the TNBS/DNBS rat model of colitis

European Journal of Gastroenterology and Hepatology

Volumn 12, Issue 3, 2000, Pages 257-265

  Padol, Ireneusz ^a   Huang, JiaQing ^a   Hogaboam, Cory M ^a   Hunt, Richard H ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Bosentan; Colitis; Endothelins; Inflammatory bowel disease; Therapy

Indexed keywords

2 PYRIDYLCARBAMIC ACID 2 [[5 (2 METHOXYPHENOXY) 6 [[(4 ISOPROPYLPHENYL)SULFONYL]AMINO] 2 MORPHOLINO 4 PYRIMIDINYL]OXY]ETHYL ESTER; ENDOTHELIN RECEPTOR ANTAGONIST; HAPTEN; MYELOPEROXIDASE; SULFONIC ACID DERIVATIVE; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; DIARRHEA; ENZYME ACTIVITY; FECES ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034077176     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200012030-00001     Document Type: Article

References (59)

1. 1 Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332:411-415.
2. 2 McMillen MA, Huribal M, Cunningham ME, Kumar R, Sumpio BE. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6. Crit Care Med 1995; 23:34-40.
3. 3 Inagaki H, Bishop AE, Escrig C, Wharton J, Allen-Mersh TG, Polak JM. Localization of endothelin-like immunoreactivity and endothelin binding sites in human colon. Gastroenterology 1991; 101:47-54.
4. 4 Saeki Y, Arakawa T, Higuchi K, Uno H, Watanbe T, Tominaga K, et al. Effects of endothelin on serum gastrin level and acid secretion in rats. J Cardiovasc Pharmacol 1995; 26:S123-S125.
5. 5 Blank MA, Fuortes M, Nyren O, Jaffe BM. Effect of endothelin-1 and vasoactive intestinal contractor on blood flow and output of vasoactive intestinal polypeptide in the feline colon. Life Sci 1991; 48:1937-1944.
6. 6 Brown MA, Smith PL. Endothelin: a potent stimulator of intestinal ion secretion in vitro. Regul Pept 1991; 36:1-19.
7. 7 Kiyohara T, Okuno M, Nakanishi T, Shinomura Y, Matsuzawa Y. Effect of endothelin-1 in ion transport in isolated rat colon. Gastroenterology 1993; 104:1328-1336.
8. B agonist (IRL1620). J Pharmacol Exp Ther 1995; 273:1313-1322.
9. 9 Moummi C, Xie Y, Kachur JF, Gaginella TS. Endothelin-1 stimulates contraction and ion transport in the rat colon: different mechanisms of action. J Pharmacol Exp Ther 1992; 262:409-414.
10. 10 Wallace JL, Cirino G, DeNucci G, McKnight W, MacNaughton WK. Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. Am J Physiol 1989; 256:G661-G666.
11. 11 Lazaratos S, Kashimura H, Nakahara A, Fukutomi H, Osuga T, Urushidani T, et al. Gastric ulcer induced by submucosal injection of ET-1: role of potent vasoconstriction and intraluminal acid. Am J Physiol 1993; 265:G491-G498.
12. 12 Masuda E, Kawano S, Nagano K, Tsuji S, Ishigami Y, Tsujii M, et al. Effect of intravascular ethanol on modulation of gastric mucosal integrity: possible role of endothelin-1. Am J Physiol 1992; 262:G785-G790.
13. 13 Michida T, Kawano S, Masuda E, Kobayashi I, Nishimura Y, Tsujii M, et al. Role of endothelin-1 in haemorrhagic shock-induced gastric mucosal injury in rats. Gastroenferology 1994; 106:988-993.
14. 14 Lopez-Belmonte J, Whittle BJR. Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation. Eur J Pharmacol 1995; 278:R7-R9.
15. 15 Kanse SM, Takahashi K, Lam HC, Rees A, Warren JB, Porta M, et al. Cytokine stimulated endothelin release from endothelial cells. Life Sci 1991; 48:1379-1384.
16. 16 Kahaleh MB, Fan P-S. Effect of cytokines on the production of endothelin by endothelial cells. Clin Exp Rheumatol 1997; 15:163-167.
17. 17 Hafström I, Ringertz B, Lundberg T, Palmblad J. The effect of endothelin, neuropeptide Y, calcitonin gene-related peptide and substance P on neutrophil functions. Acta Physiol Scand 1993; 148:341 -346.
18. 18 Elferink JGR, de Koster BM. Stimulation and inhibition of neutrophil chemotaxis by endothelin-3. J Cardiovasc Pharmacol 1995; 26(suppl 3):S142-S144.
19. 19 Boros M, Massberg S, Baranyi L, Okada H, Messmer K. Endothelin-1 induces leukocyte adhesion in submucosal venules of the rat small intestine. Gastroenterology 1998; 114:103-114.
20. 20 Ota S, Hirata Y, Sugimoto T, Kohmoto O, Hata Y, Yoshiura K, et al. Endothelin-1 secretion from cultured rabbit gastric epithelial cells. J Cardiovasc Pharmacol 1991; 17(suppl 7):S406-S407.
21. 21 Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, et al. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 1990; 172:1741-1748.
22. 22 Sessa WC, Kaw S, Hecker M, Vane JR. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun 1991; 174:613-618.
23. 23 Murch SH, Braegger CP, Sessa WC, McDonald TT. High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis. Lancet 1992; 339:381-385.
24. 24 Traish AM, Moran M, Saenz de Tejada I. Physiochemical characterization and solubilization of endothelin receptors. Receptor 1991; 1:229-242.
25. 25 Urade Y, Fujitani Y, Oda K, Watakabe T, Umemura I, Takai M, et al. An endothelin B receptor-selective antagonist: TRI 1038[Cys11-Cys15] endothelin-1 (11-21). FEBS Lett 1992; 311:12-16.
26. C receptor) from Xenopus laevis dermal melanophores. J Biol Chem 1993; 268:19126-19133.
27. 27 Lazaratos S, Nakahara A, Goto K, Fukutomi H. Bosentan antagonizes the effects of endothelin-1 on rat gastric blood flow and mucosal integrity. Life Sci 1995; 56:195-200.
28. 28 Hogaboam CM, Muller MJ, Collins SM, Hunt RH. An orally active nonselective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis. Eur J Pharmacol 1996; 309:261-269.
29. 29 Neidhart W, Breu V, Burri K, Clozel M, Hirth G, Klinkhammer U, et al. Discovery of Ro 48-5695: a potent mixed endothelin receptor antagonist optimized from bosentan. Bioorg Med Chem Lett 1997; 7:2223-2228.
30. 30 Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989; 96:795-803.
31. 31 Wallace JL, Le T, Carter L, Appleyard CB, Beck PL. Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid. J Pharmacol Toxicol Methods 1995; 33:237-239.
32. 32 Hawkins JV, Emmel EL, Feuer JJ, Nedelman MA, Harvey CJ, Klein HJ, et al. Protease activity in a hapten-induced model of ulcerative colitis in rats. Dig Dis Sci 1997; 42:1969-1980.
33. 33 Wallace JL, Keenan CM. An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis. Am J Physiol 1990; 258:G527-G534.
34. 34 Clozel M, Breu V, Gray GA, Kalina B, Loffler BM, Burri K, et al. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994; 270:228-235.
35. 35 Benigni A, Remuzzi G. Endothelin antagonists. Lancet 1999; 353:133-138.
36. B receptor antagonist, in portal hypertensive rats. Hepatol 1998; 28:655-659.
37. 37 Padol I, Huang JQ, Hunt RH. Anti-ulcerogenic properties of endothelin receptor antagonists in the rat. Aliment Pharmacol Ther 1999; 13:537-544.
38. B receptors. Br J Pharmacol 1995; 115:227-236.
39. 39 Andersson SE, Hemsén A, Lundberg JM. The effect of endothelin receptor blockade on the development of the Sephadex-induced inflammation in the rat lung. Acta Physiol Scand 1996; 158:189-193.
40. 40 Finsnes F, Skjønsberg OH, Tønnessen T, Naess O, Lyberg T, Christensen G. Endothelin production and effects of endothelin antagonism during experimental airway inflammation. Am J Respir Crit Care Med 1997; 155:1404-1412.
41. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 1994; 89:1203-1208.
42. 42 Smith PL, Lee C-P, Pullen M, Ohlstein EH, Beck G, Eddy EP. et al. Nonpeptide endothelin receptor antagonists: IV. Identification of receptors in rabbit colonic mucosa and smooth muscle and correlation with physiological effects. J Pharmacol Exp Ther 1995; 272:1204-1210.
43. 43 Miura S, Kurose I, Fukumura D, Suematsu M, Sekizuka E, Tashiro H, et al. Ischemic bowel necrosis induced by endothelin-1 : an experimental model in rats. Digestion 1991; 48:163-172.
44. 44 Whittle BJR, Esplugues JV. Induction of rat gastric damage by the endothelium-derived peptide, endothelin. Br J Pharmacol 1988; 95:1011-1013.
45. 45 Lopez-Belmonte J, Whittle BJR. The involvement of endothelial dysfunction, nitric oxide and prostanoids in the rat gastric microcirculatory responses to endothelin-1. Br J Pharmacol 1994; 112:267-271.
46. 46 Masuda E, Kawano S, Nagano K, Tsuji S, Takei Y, Hayashi N, et al. Role of endogenous endothelin in the pathogenesis of ethanol-induced gastric mucosal injury in rats. Am J Physiol 1993; 265:G474-G481.
47. 47 Yanagisawa M. The endothelin system. A new target for therapeutic intervention. Circulation 1994; 89:1320-1322.
48. 48 Hogaboam CM, Jacobson K, Collins SM, Blennerhassett MG. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am J Physiol 1995; 268:G673-G684.
49. 49 Roden M, Plass H, Vierhapper H, Turnheim K. Endothelin-1 stimulates chloride and potassium secretion in rabbit descending colon. Eur J Pharmacol 1992; 421:163-167.
50. 50 Endo T, Uchida Y, Matsumoto H, Suzuki N, Nomura A, Hirata F, et al. Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines. Biochem Biophys Res Commun 1992; 186:1594-1599.
51. 51 Mitaka C, Hirata Y, Ichikawa K, Yokoyama K, Emori T, Kanno K, et al. Effect of TNF-α on hemodynamic changes in circulating endothelium-derived vasoactive factors in dogs. Am J Physiol 1994; 267:H1530-H1536.
52. 52 Namiki A, Hirata Y, Fukazawa M, Ishikawa M, Moroi M, Aikawa J, et al. Granulocyte-colony stimulating factor stimulates immunoreactive endothelin-1 release from cultured bovine endothelial cells. Eur J Pharmacol 1992; 227:339-341.
53. 53 Kurihara H, Yoshizumi M, Sugiyama T, Takaku F, Yanagisawa Y, Masaki T, et al. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun 1989; 159:1435-1440.
54. 54 Yoshizumi M, Kurihara H, Morita T, Yamashita T, Oh-Hashi Y, Sugiyama T, et al. Interleukin-1 increases the production of endothelin-1 by cultured endothelial cells. Biochem Biophys Res Commun 1990; 166:324-330.
55. 55 Sugira M, Inagami T, Kono V. Endotoxin stimulates endothelin release in vivo and in vitro as determined by radioimmunoassay. Biochem Biophys Res Commun 1989; 161:1220-1226.
56. 56 Huribal M, Kumar R, Cunningham ME, Sumpio BE, McMillen MA. Endothelin-stimulated monocyte supernatants enhance neutrophil superoxide production. Shock 1994; 1:184-187.
57. 57 Cunningham ME, Bala RJ, McMillen MA. Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines. Crit Care Med 1997; 25:958-964.
58. 58 Hamilton MI, Dick R, Crawford L, Thompson NP, Pounder RE, Wakefield AJ. Is proximal demarcation of ulcerative colitis determined by the territory of the inferior mesenteric artery? Lancet 1995; 345:688-690.
59. 59 Thompson NP, Wakefield AJ, Pounder RE. Inherited disorders of coagulation appear to protect against inflammatory bowel disease. Gastroenterology 1995; 108:1011-1015.