Microregional heterogeneity of non-protein thiols in cervical carcinomas assessed by combined use of HPLC and fluorescence image analysis

Clinical Cancer Research

Volumn 6, Issue 5, 2000, Pages 1826-1832

  Vukovic, Vojislav ^a   Nicklee, Trudey ^a   Hedley, David W ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

THIOL DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; FEMALE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RADIOSENSITIVITY; UTERINE CERVIX CARCINOMA;

ADENOCARCINOMA; CARCINOMA, SQUAMOUS CELL; CERVIX UTERI; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; FEMALE; GLUTATHIONE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; UTERINE CERVICAL NEOPLASMS;

EID: 0034075992     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Meister, A., and Anderson, M. E. Glutathione, Annu. Rev. Biochem., 52: 711-760, 1983.
2. Biaglow, J. E., Varnes, M. E., Clark, E. P., and Epp, E. R. The role of thiols in cellular response to radiation and drugs. Radiat. Res., 95: 437-455, 1983.
3. Ozols, R. F., Louie, K. G., Plowman, J., Behrens, B. C., Fine, R. L., Dykes, D., and Hamilton, T. C. Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochem. Pharmacol., 36: 147-153, 1987.
4. Kigawa, J., Minagawa, Y., Cheng, X., and Terakawa, N. Gammaglutamyl cysteine synthetase up-regulates glutathione and multidrug resistance-associated protein in patients with chemoresistant epithelial ovarian cancer. Clin. Cancer Res., 4: 1737-1741, 1998.
5. Marbeuf-Gueye, C., Broxterman, H. J., Dubru, F., Priebe, W., and Garnier-Suillerot, A. Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells. Mol. Pharmacol., 53: 141-147, 1998.
6. Higashi, T., Furukawa, M., Hikita, K., Naruse, A., Tateishi, N., and Sakamoto, Y. Re-evaluation of protein bound glutathione in rat liver. J. Biochem. (Tokyo), 98: 1661-1667, 1985.
7. Ketterer, B. Protective role of glutathione transferases in mutagenesis and carcinogenesis. Mutat. Res., 202: 343-361, 1988.
8. Holmgren, A. Thioredoxin and glutaredoxin systems. J. Biol. Chem., 264: 13963-13966, 1989.
9. Nakamura, H., Nakamura, K., and Yodoi, J. Redox regulation of cellular activation. Annu. Rev. Immunol., 15: 351-369, 1997.
10. Fahey, R. C., Prise, K. M., Stratford, M. R. L., Watfa, R. R., and Michael, B. D. Rates for repair of pBR 322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength. Int. J. Radiat. Biol., 59: 901-917, 1991.
11. Bump, E. A., Cerce, B. A., Al-Sarraf, R., Pierce, S. M., and Koch, C. J. Radioprotection of DNA in isolated nuclei by naturally occurring thiols at intermediate oxygen tension. Radiat. Res., 132: 94-104, 1992.
12. Aguilera, J. A., Newton, G. L., Fahey, R. C., and Ward, J. F. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiat. Res., 130: 194-204, 1992.
13. Koch, C. J., and Evans, S. M. Cysteine concentrations in rodent tumors: unexpectedly high values may cause therapy resistance. Int. J. Cancer, 67: 661-667, 1996.
14. Guichard, M., Lespinasse, F., Estelin, R., Gerbaulet, A., Haie, C., Lartigau, E., Malaise, E. P., Micheau, C., Prade, M., and Richard, J. M. Glutathione and cysteine levels in human tumour biopsies. Br. J. Radiol., 63: 557-561, 1990.
15. Ghazal-Aswad, S., Hogarth, L., Hall, A. G., George, M., Sinha, D. P., Lind, M., Calvert, A. H., Sunter, J. P., and Newell, D. R. The relationship between tumour glutathione concentration, glutathione S-transferase isoenzyme expression and response to single agent carboplatin in epithelial ovarian cancer patients. Br. J. Cancer, 74: 468-473, 1996.
16. Lee, F. Y. F., Vessey, A., Rofstad, E., Siemann, D. W., and Sutherland, R. M. Heterogeneity of glutathione content in human ovarian cancer. Cancer Res., 49: 5244-5248, 1989.
17. Honegger, C. G., Torhorst, J., Langemann, H., Kabiersch, A., and Krenger, W. Quantitative determination of water-soluble scavengers in neoplastic and non-neoplastic human breast tissue. Int. J. Cancer, 41: 690-694, 1988.
18. Langemann, H., Torhorst, J., Kabiersch, A., Krenger, W., and Honegger, C. G. Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue. Int. J. Cancer, 43: 1169-1173, 1989.
19. Cook, J. A., Pass, H. I., Iyoe, S. N., Friedman, N., DeGraff, W., Russo, A., and Mitchell, J. B. Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue. Cancer Res., 51: 4287-4294, 1991.
20. Parise, O., Janot, F., Luboinski, B., Massaad, L., Albin, N., Toussaint, C., Verjus, M. A., Bonnay, M., Gouyette, A., and Chabot, G. G. Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues. Head Neck, 16: 158-164, 1994.
21. Jadhav, G. K. R., Bhanumathi, P., Devi, P. U., Seetharamaiah, T., Viduyasagar, M. S., Rao, K. K., Hospet, C. S., and Solomon, J. G. R. Possible role of glutathione in predicting radiotherapy response of cervix cancer. Int. J. Radiat. Oncol. Biol. Phys., 41: 3-5, 1998.
22. Berger, S. J., Gosky, D., Zborowska, E., Willson, J. K. V., and Berger, N. A. Sensitive enzymatic cycling assay for glutathione: measurements of glutathione content and its modulation by buthionine sulfoximine in vivo and in vitro human colon cancer. Cancer Res., 54: 4077-4083, 1994.
23. Hochwald, S. N., Rose, D. M., Brennan, M. F., and Burt, M. E. Elevation of glutathione and related enzyme activities in high-grade and metastatic extremity soft tissue sarcoma. Ann. Surg. Oncol., 4: 303-309, 1997.
24. Chang, T. C., Chang, M. J. W., and Hsueh, S. Glutathione concentration and distribution in cervical cancers and adjacent normal tissues. Gynecol. Obstet. Investig., 36: 52-55, 1993.
25. Murray, G. I., Burke, M. D., and Ewen, S. W. B. Glutathione localization in benign and malignant breast lesions. Br. J. Cancer, 55: 605-609, 1987.
26. Voehringer, D. W., McConkey, D. J., McDonnell, T. J., Brisbay, S., and Meyn, R. E. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc. Natl. Acad. Sci. USA, 95: 2956-2960, 1998.
27. Moreno-Merlo, F., Nicklee, T., and Hedley, D. W. Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts. Br. J. Cancer, in press, 2000.
28. Fyles, A. W., Milosevic, M., Wong, R., Kavanagh, M. C., Pintilie, M., Sun, A., Chapman, W., Levin, W., Manchul, L., Keane, T. J., and Hill, R. P. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol., 48: 149-156, 1998.
29. Griffith, O. W., Anderson, M. E., and Meister, A. Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J. Biol. Chem., 254: 1205-1210, 1979.
30. Bailey, H. H., Ripple, G., Tutsch, K. D., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Mahvi, D., Schink, J., Pomplun, M., Mulcahy, R. T., and Wilding, G. Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. J. Natl. Cancer Inst., 89: 1789-1796, 1997.
31. Wong, D. Y. K., Hsiao, Y. L., Poon, C. K., Kwan, P. C., Chao, S. Y., Chou, S. T., and Yang, C. S. Glutathione concentration in oral cancer tissues. Cancer Lett., 81: 111-116, 1994.
32. Perry, R. P., Mazetta, J., Levin, M., and Barranco, S. C. Glutathione levels and variability in breast tumors and normal tissue. Cancer (Phila.), 72: 783-787, 1993.
33. El-Sharabasy, M. M. H., El-Dosoky, I., Horria, H., and Khalaf, A. H. Elevation of glutathione. glutathione-reductase and nucleic acids in both normal tissues and tumour of breast cancer patients. Cancer Lett., 72: 11-15, 1993.