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Volumn 22, Issue 5, 1997, Pages 917-922

Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap α phenyl-N-tert-butyl nitrone

Author keywords

Flurothyl; Free radical scavenger; Histopathology; Status epilepticus; Substantia nigra damage

Indexed keywords

FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; SCAVENGER;

EID: 0031038035     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(96)00478-9     Document Type: Article
Times cited : (25)

References (41)
  • 1
    • 0001902703 scopus 로고
    • The pathology of epilepsy
    • W. Blackwood, & J.A.N. Corsellis. London: Arnold
    • Corsellis J. A. N., Meldrum B. S. The pathology of epilepsy. Blackwood W., Corsellis J. A. N. Greenfields neuropathology. 1976;771-795 Arnold, London.
    • (1976) Greenfields Neuropathology , pp. 771-795
    • Corsellis, J.A.N.1    Meldrum, B.S.2
  • 2
    • 0015549391 scopus 로고
    • Prolonged epileptic seizures in primates: Ischemic cell change and its relation to ictal physiological events
    • Meldrum B., Brierly J. Prolonged epileptic seizures in primates: Ischemic cell change and its relation to ictal physiological events. Arch. Neurol. 28:1973;10-17.
    • (1973) Arch. Neurol. , vol.28 , pp. 10-17
    • Meldrum, B.1    Brierly, J.2
  • 3
    • 0020690782 scopus 로고
    • Metabolic factors during prolonged seizures and their relation to nerve cell death
    • Meldrum B. S. Metabolic factors during prolonged seizures and their relation to nerve cell death. Adv. Neurol. 34:1983;261-275.
    • (1983) Adv. Neurol. , vol.34 , pp. 261-275
    • Meldrum, B.S.1
  • 4
    • 0020955862 scopus 로고
    • Epileptic brain damage in rats induced by sustained electrical stimulation of the perforant path 1. Acute electrophysiological and light microscopic studies
    • Sloviter R. Epileptic brain damage in rats induced by sustained electrical stimulation of the perforant path 1. Acute electrophysiological and light microscopic studies. Brain Res. Bull. 10:1983;675-697.
    • (1983) Brain Res. Bull. , vol.10 , pp. 675-697
    • Sloviter, R.1
  • 5
    • 0021838038 scopus 로고
    • Status epilepticus in well-oxygenated rats causes neuronal necrosis
    • Nevander G., Ingvar M., Auer R., Siesjö B. K. Status epilepticus in well-oxygenated rats causes neuronal necrosis. Ann. Neurol. 18:1985;281-290.
    • (1985) Ann. Neurol. , vol.18 , pp. 281-290
    • Nevander, G.1    Ingvar, M.2    Auer, R.3    Siesjö, B.K.4
  • 6
    • 0017139895 scopus 로고
    • Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline
    • Meldrum B. S., Nilsson B. Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline. Brain. 99:1976;523-542.
    • (1976) Brain , vol.99 , pp. 523-542
    • Meldrum, B.S.1    Nilsson, B.2
  • 7
    • 0017249235 scopus 로고
    • Glucose consumption in rat cerebral cortex in normoxia, hypoxia and hypercapnia
    • Borgström L., Norberg K., Siesjö B. K. Glucose consumption in rat cerebral cortex in normoxia, hypoxia and hypercapnia. Acta Physiol. Scand. 96:1976;569-574.
    • (1976) Acta Physiol. Scand. , vol.96 , pp. 569-574
    • Borgström, L.1    Norberg, K.2    Siesjö, B.K.3
  • 8
    • 0020591153 scopus 로고
    • Local blood flow and glucose consumption in the rat brain during sustained bicuculline-induced seizures
    • Ingvar M., Siesjö B. K. Local blood flow and glucose consumption in the rat brain during sustained bicuculline-induced seizures. Acta Neurol. Scand. 68:1983;129-144.
    • (1983) Acta Neurol. Scand. , vol.68 , pp. 129-144
    • Ingvar, M.1    Siesjö, B.K.2
  • 9
    • 0024326852 scopus 로고
    • Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronounced intra- and extracellular acidosis
    • Inamura K., Smith M.-L., Hansen A. J., Siesjö B. K. Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronounced intra- and extracellular acidosis. J. Cereb. Blood Flow Metab. 9:1989;821-829.
    • (1989) J. Cereb. Blood Flow Metab. , vol.9 , pp. 821-829
    • Inamura, K.1    Smith, M.-L.2    Hansen, A.J.3    Siesjö, B.K.4
  • 10
    • 0022870680 scopus 로고
    • Early axonal lesion and preserved microvasculature in epilepsy-induced hypermetabolic necrosis of the substantia nigra
    • Auer R. N., Ingvar M., Nevander G., Olsson Y., Siesjö B. K. Early axonal lesion and preserved microvasculature in epilepsy-induced hypermetabolic necrosis of the substantia nigra. Acta Neuropathol. (Berl.). 71:1986;207-215.
    • (1986) Acta Neuropathol. (Berl.) , vol.71 , pp. 207-215
    • Auer, R.N.1    Ingvar, M.2    Nevander, G.3    Olsson, Y.4    Siesjö, B.K.5
  • 11
    • 0023100875 scopus 로고
    • Metabolic alterations underlying the development of hypermetabolic necrosis in the substantia nigra in status epilepticus
    • Ingvar M., Folbergrová J., Siesjö B. K. Metabolic alterations underlying the development of hypermetabolic necrosis in the substantia nigra in status epilepticus. J. Cereb. Blood Flow Metab. 7:1987;103-108.
    • (1987) J. Cereb. Blood Flow Metab. , vol.7 , pp. 103-108
    • Ingvar, M.1    Folbergrová, J.2    Siesjö, B.K.3
  • 12
    • 0019475506 scopus 로고
    • Topographical and cytological location of iron in rat and monkey brains
    • Francois C., Nguyen-Legros J., Percheron G. Topographical and cytological location of iron in rat and monkey brains. Brain Res. 215:1981;317-322.
    • (1981) Brain Res. , vol.215 , pp. 317-322
    • Francois, C.1    Nguyen-Legros, J.2    Percheron, G.3
  • 13
    • 0019522455 scopus 로고
    • Determination of Cu, Mn, Fe, and Ca in six regions of normal human brain, by atomic absorption spectroscopy
    • Goldberg W. J., Allen N. Determination of Cu, Mn, Fe, and Ca in six regions of normal human brain, by atomic absorption spectroscopy. Clin. Chem. 27:1981;562-564.
    • (1981) Clin. Chem. , vol.27 , pp. 562-564
    • Goldberg, W.J.1    Allen, N.2
  • 14
    • 0024204729 scopus 로고
    • Biological differences between ischemia, hypoglycemia and epilepsy
    • Auer R. N., Siesjö B. K. Biological differences between ischemia, hypoglycemia and epilepsy. Ann. Neurol. 24:1988;699-707.
    • (1988) Ann. Neurol. , vol.24 , pp. 699-707
    • Auer, R.N.1    Siesjö, B.K.2
  • 15
    • 0021144370 scopus 로고
    • Distribution of hypoglycemic brain damage: Relationship to white matter and cerebrospinal fluid pathways
    • Auer R. N., Wieloch T., Olsson Y., Siesjö B. K. Distribution of hypoglycemic brain damage: Relationship to white matter and cerebrospinal fluid pathways. Acta Neuropathol. (Berl.). 64:1984;177-191.
    • (1984) Acta Neuropathol. (Berl.) , vol.64 , pp. 177-191
    • Auer, R.N.1    Wieloch, T.2    Olsson, Y.3    Siesjö, B.K.4
  • 16
    • 0021352225 scopus 로고
    • Irreversible neuronal damage after short periods of status epilepticus
    • Nevander G., Ingvar M., Auer R., Siesjö B. K. Irreversible neuronal damage after short periods of status epilepticus. Acta Physiol. Scand. 120:1984;155-157.
    • (1984) Acta Physiol. Scand. , vol.120 , pp. 155-157
    • Nevander, G.1    Ingvar, M.2    Auer, R.3    Siesjö, B.K.4
  • 17
    • 0028322103 scopus 로고
    • Hyperthermia aggravates and hypothermia ameliorates epileptic brain damage
    • Lundgren J., Smith M.-L., Blennow G., Siesjö B. K. Hyperthermia aggravates and hypothermia ameliorates epileptic brain damage. Exp. Brain Res. 99:1994;43-55.
    • (1994) Exp. Brain Res. , vol.99 , pp. 43-55
    • Lundgren, J.1    Smith, M.-L.2    Blennow, G.3    Siesjö, B.K.4
  • 18
    • 0027229368 scopus 로고
    • Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats
    • Pahlmark K., Folbergrová J., Smith M.-L., Siesjö B. K. Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats. Stroke. 24:1993;731-737.
    • (1993) Stroke , vol.24 , pp. 731-737
    • Pahlmark, K.1    Folbergrová, J.2    Smith, M.-L.3    Siesjö, B.K.4
  • 20
    • 0019842691 scopus 로고
    • Cell damage in the brain: A speculative synthesis
    • Siesjö B. K. Cell damage in the brain: A speculative synthesis. J. Cereb. Blood Flow Metab. 1:1981;155-185.
    • (1981) J. Cereb. Blood Flow Metab. , vol.1 , pp. 155-185
    • Siesjö, B.K.1
  • 21
    • 0021278632 scopus 로고
    • Status epilepticus: The reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus
    • Griffths T., Evans M. C., Meldrum B. S. Status epilepticus: The reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus. Neuroscience. 12:1984;557-567.
    • (1984) Neuroscience , vol.12 , pp. 557-567
    • Griffths, T.1    Evans, M.C.2    Meldrum, B.S.3
  • 22
    • 0022579767 scopus 로고
    • Epileptic brain damage: Pathophysiology and neurochemical pathology
    • Siesjö B. K., Wieloch T. Epileptic brain damage: Pathophysiology and neurochemical pathology. Adv. Neurol. 44:1986;813-847.
    • (1986) Adv. Neurol. , vol.44 , pp. 813-847
    • Siesjö, B.K.1    Wieloch, T.2
  • 23
    • 0023753142 scopus 로고
    • Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
    • Choi D. W. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11:1988;465-469.
    • (1988) Trends Neurosci. , vol.11 , pp. 465-469
    • Choi, D.W.1
  • 24
    • 0028799654 scopus 로고
    • Calcium: Still center-stage in hypoxic-ischemic neuronal death
    • Choi D. W. Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60.
    • (1995) Trends Neurosci. , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 25
    • 0023774654 scopus 로고
    • Mechanisms of ischemic brain damage
    • Siesjö B. K. Mechanisms of ischemic brain damage. Crit. Care Med. 16:1988;954-963.
    • (1988) Crit. Care Med. , vol.16 , pp. 954-963
    • Siesjö, B.K.1
  • 26
    • 0002664633 scopus 로고
    • The role of calcium in cell death
    • D. Price, A. Aguayo, & H. Thoenen. Chichester: John Wiley & Sons Ltd
    • Siesjö B. K. The role of calcium in cell death. Price D., Aguayo A., Thoenen H. Neurodegenerative disorders: Mechanisms and prospects for therapy. 1991;35-59 John Wiley & Sons Ltd, Chichester.
    • (1991) Neurodegenerative Disorders: Mechanisms and Prospects for Therapy , pp. 35-59
    • Siesjö, B.K.1
  • 27
    • 0026647763 scopus 로고
    • Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd R. A., Carney J. M. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:1992;S22-S27.
    • (1992) Ann. Neurol. , vol.32
    • Floyd, R.A.1    Carney, J.M.2
  • 28
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1992;1609-1623.
    • (1992) J. Neurochem. , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 32
    • 0026685810 scopus 로고
    • Effects of dimethylthiourea treatment on ischemic brain damage in hyperglycemic rats
    • Lundgren J., Smith M.-L., Siesjö B. K. Effects of dimethylthiourea treatment on ischemic brain damage in hyperglycemic rats. J. Neurol. Sci. 113:1992;187-197.
    • (1992) J. Neurol. Sci. , vol.113 , pp. 187-197
    • Lundgren, J.1    Smith, M.-L.2    Siesjö, B.K.3
  • 33
    • 0023887866 scopus 로고
    • Oxygen free radical involvement in ischemia and reperfusion injury to brain
    • Cao W., Carney J. M., Duchon A., Floyd R., Chevion M. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88:1988;233-238.
    • (1988) Neurosci. Lett. , vol.88 , pp. 233-238
    • Cao, W.1    Carney, J.M.2    Duchon, A.3    Floyd, R.4    Chevion, M.5
  • 34
    • 0025314685 scopus 로고
    • Role of oxygen free radicals in carcinogenesis and brain ischemia
    • Floyd R. A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4:1990;2587-2597.
    • (1990) FASEB J. , vol.4 , pp. 2587-2597
    • Floyd, R.A.1
  • 35
    • 0025309904 scopus 로고
    • Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain
    • Oliver C., Starke-Reed P., Stadtman E., Liu G., Carney J. M., Floyd R. A. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA. 87:1990;5144-5147.
    • (1990) Proc. Natl. Acad. Sci. USA. , vol.87 , pp. 5144-5147
    • Oliver, C.1    Starke-Reed, P.2    Stadtman, E.3    Liu, G.4    Carney, J.M.5    Floyd, R.A.6
  • 36
    • 0025088070 scopus 로고
    • Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl- α -phenylnitrone (PBN)
    • Phillis J., Clough-Helfman C. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl- α -phenylnitrone (PBN). Neurosci. Lett. 116:1990;315-319.
    • (1990) Neurosci. Lett. , vol.116 , pp. 315-319
    • Phillis, J.1    Clough-Helfman, C.2
  • 37
    • 0028181531 scopus 로고
    • α -Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia
    • Cao X., Phillis J. α -Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res. 644:1994;267-272.
    • (1994) Brain Res. , vol.644 , pp. 267-272
    • Cao, X.1    Phillis, J.2
  • 38
    • 0027937751 scopus 로고
    • Delayed treatment with the spin trap α -phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats
    • Zhao Q., Pahlmark K., Smith M.-L., Siesjö B. K. Delayed treatment with the spin trap α -phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152:1994;349-350.
    • (1994) Acta Physiol. Scand. , vol.152 , pp. 349-350
    • Zhao, Q.1    Pahlmark, K.2    Smith, M.-L.3    Siesjö, B.K.4
  • 39
    • 0029067088 scopus 로고
    • N-tert-butyl- α -phenylnitrone improves recovery of brain energy state in the rats following transient focal ischemia
    • Folbergrová J., Zhao Q., Katsura K., Siesjö B. K. N-tert-butyl- α -phenylnitrone improves recovery of brain energy state in the rats following transient focal ischemia. Proc Natl Acad Sci USA. 92:1995;5057-5061.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5057-5061
    • Folbergrová, J.1    Zhao, Q.2    Katsura, K.3    Siesjö, B.K.4
  • 40
    • 0029872044 scopus 로고    scopus 로고
    • Secondary bioenergetic failure after transient focal ischemia is due to mitochondrial injury
    • Kuroda S., Katsura K., Tsuchidate R., Siesjö B. Secondary bioenergetic failure after transient focal ischemia is due to mitochondrial injury. Acta Physiol. Scand. 156:1996;149-150.
    • (1996) Acta Physiol. Scand. , vol.156 , pp. 149-150
    • Kuroda, S.1    Katsura, K.2    Tsuchidate, R.3    Siesjö, B.4
  • 41
    • 0025932511 scopus 로고
    • Protection against oxidative damage to CNS by α -phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers
    • Carney J. M., Floyd R. A. Protection against oxidative damage to CNS by α -phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3:1991;47-57.
    • (1991) J. Mol. Neurosci. , vol.3 , pp. 47-57
    • Carney, J.M.1    Floyd, R.A.2


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