The synthesis, in vitro reactivity, and evidence for formation in humans of 5-phenyl-1,3-oxazinane-2,4-dione, a metabolite of felbamate

Drug Metabolism and Disposition

Volumn 28, Issue 4, 2000, Pages 434-439

  Thompson, Charles D ^a   Miller, Thomas A ^a   Barthen, Mary T ^a   Dieckhaus, Christine M ^a   Sofia, R Duane ^b   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Wallace Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FELBAMATE; OXAZINE DERIVATIVE;

ARTICLE; CATALYSIS; DRUG ACTIVITY; DRUG DECOMPOSITION; DRUG METABOLISM; DRUG SYNTHESIS; DRUG URINE LEVEL; HUMAN; METABOLITE; PRIORITY JOURNAL;

ANTICONVULSANTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPILEPSY; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; OXAZINES; PROPYLENE GLYCOLS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0034071742     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

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2. Kapetanovic I, Torchin C, Thompson C, Miller T, McNeilly P, Macdonald T, Kupferherg H, Perhach J, Sofia R and Strong J (1998) Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro. Drug Metab Dispos 26:1089-1095.
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