Understanding percutaneous absorption for occupational health and safety

International Journal of Occupational and Environmental Health

Volumn 6, Issue 2, 2000, Pages 86-92

  Wester, Ronald C ^a,b   Maibach, Howard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Box 0316   (United States)

Author keywords

Chemical toxicity; Percutaneous absorption; Skin; Topical exposures; Toxicity

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2,4 DICHLOROPHENOXYACETIC ACID; 4 DIMETHYLAMINOAZOBENZENE; ACETYLCYSTEINE; BENZOIC ACID DERIVATIVE; CAFFEINE; CHLORPHENOTANE; CORTISONE; HALOPROGIN; LINDANE; MALEIC ACID DIETHYL ESTER; NITROBENZENE; PARATHION; RETINOIC ACID; TESTOSTERONE; TRICLOCARBAN;

ARTICLE; BIOAVAILABILITY; CELL VIABILITY; CONTAMINATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OCCUPATIONAL HEALTH; OCCUPATIONAL SAFETY; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PENETRATION; SKIN TOXICITY; SOLUBILITY; STRATUM CORNEUM;

EID: 0034070989     PISSN: 10773525     EISSN: None     Source Type: Journal    
DOI: 10.1179/oeh.2000.6.2.86     Document Type: Article

References (16)

1. Wester RC, Maibach HI. Toxicokinetics: dermal exposure and absorption of toxicants. In: Bond J (ed). Comprehensive Toxicology. Vol 1, General Principles. Oxford, England: Pergamon Press, Elsevier Science Ltd., 1997:99-114.
2. Wester RC, Maibach HI. In vivo methods for percutaneous absorption measurements. In: Bronaugh R, Maibach H (eds). Percutaneous Absorption. Vol 3. New York: Marcel Dekker, 1999:215-27.
3. Wester RC, Melendres, Hui X, et al. Human in vivo and in vitro hydroquinone topical bioavailability, metabolism and disposition. J Toxicol Environ Health. 1998:A54:101-17.
4. Wester RC, Corley RA, Hui X, Poet TS, Thrall KD. Bioavailability of organic solvents in soil: imput into biologically-based dose-response models for human risk assessment. U.S. Department of Energy, EMSO, 1999.
5. Poet TS, Thrall DK, Corley RA, Hui X, Maibach HI, Wester RC. An innovative method to evaluate the dermal bioavailability of volatile compounds in soil and water from dermal exposures in rats and humans. Toxicol Sci. In press.
6. Wester RC, Mobayen M, Maibach HI. In vivo and in vitro absorption and binding to powdered stratum corneum as method to evaluate skin absorption of environmental chemical contaminants from ground and surface water. J Toxicol Environ Health. 1987;21:367.
7. Wester RC, Christoffel J, Hartway T, Poblete N, Maibach HI, Forsell J. Human cadaver skin viability for in vitro percutaneous absorption: storage and detrimental effects of heat-separation and freezing. Pharmacol Res. 1998;15:82-4.
8. 14C]benzo[a]pyrene from soil. Fundam Appl Toxicol. 1998;125:510-6.
9. 14C] chlordane from soil. Toxicol Environ Health. 1992;35:269-77.
10. Wester RC, Maibach HI, Sedik L, et al. In vitro percutaneous absorption of cadmium from water and soil into human skin. Fundam Appl Toxicol. 1992;19:1-5.
11. Wester RC, Maibach HI, Sedik L, et al. In vivo and in vitro percutaneous absorption and skin decontamination of arsenic from water and soil. Fundam Appl Toxicol. 1993;20:336-40.
12. Wester RC, Maibach HI, Sedik L, et al. Percutaneous absorption of pentachlorophenol from soil. Fundam Appl Toxicol. 1993;20.68-71.
13. Wester RC, Maibach HI, Sedik L, et al. Percutaneous absorption of PCBs from soil: in vivo rhesus monkey, in vitro human skin, and binding to powdered human stratum corneum. J Toxicol Environ Health. 1993;39:375-82.
14. Wester RC, Hui X, Hartway T, et al. In vivo percutaneous absorption of boric acid, borax and disoderm octaborate tetrahydrate in humans compared to in vitro absorption in human skin from infinite and finite doses. Toxicol Sci. 1998,45:42-51.
15. Wester RC, Hui X, Landry T, Maibach HI. In vivo skin decontamination of methylene bisphenyl isocyanate (MDI): soap and water ineffective compared to polypropylene glycol, polyglycol-based cleanser, and corn oil. Toxicol Sci. 1999;48:1-4.
16. Wester RC, Maibach HI. Cutaneous pharmacokinetics: 10 steps to percutaneous absorption. Drug Metab Rev. 1983;14:169-205.