In vivo percutaneous absorption of boric acid, borax, and disodium octaborate tetrahydrate in humans compared to in vitro absorption in human skin from infinite and finite doses

Toxicological Sciences

Volumn 45, Issue 1, 1998, Pages 42-51

  Wester, Ronald C ^a   Hui, Xiaoying ^a   Hartway, Tracy ^a   Maibach, Howard I ^a   Bell, Kathleen ^a   Schell, Michael J ^b   Northington, D Jack ^c   Strong, Philip ^d   Culver, B Dwight ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^c West Coast Analytical Service   (United States)

^d Rio Tinto Group   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORATE SODIUM; BORIC ACID;

ADULT; ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; COMPARATIVE STUDY; DIFFUSION; DOSE RESPONSE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; ISOTOPE LABELING; NORMAL HUMAN; RISK ASSESSMENT; SKIN ABSORPTION;

EID: 0031751562     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2490     Document Type: Article

References (32)

1. Abou-Shakra, F. R., Havercroft, J. M., and Ward, N. I. (1989). Lithium and boron in biological tissues and fluids. Trace Elem. Med. 6, 142-146.
2. Anderson, D. L., Cunningham, W. C., and Lindstrom, T. R. (1994). Concentrations and intakes of H, B, S, K, Na, and NaC1 in Foods. J. Food Compos. Anal. 7, 59-82.
3. Beys, K. H. (1983). Final report of the expert panel on cosmetic ingredient review. J. Am. Coll. Toxicol. 2(7), 87-125.
4. Bronaugh, R. L., Stewart, R. F., and Storm, J. E. (1989). Extent of cutaneous metabolism during percutaneous absorption of exenobiotics. Toxicol. Appl. Pharmacol. 99, 534-543.
5. Draize, J. H., and Kelley, E. A. (1959). The urinary excretion of boric acid preparations following oral administration and topical applications to intact and damaged skin of rabbits. Toxicol. Appl. Pharmacol. 1, 267-276.
6. Freimuth, H. D., and Fisher, R. S. (1958). The effect of pH and the presence of other elements in solution on the absorption of boron. J. Invest. Dermatol. 30, 83-84.
7. Friis-Hansen, B., Aggerbeck, B., and Jansen, J. A. (1982). Unaffected blood boron levels in newborn infants treated with a boric acid ointment. Food Chem. Toxicol. 20, 451-454.
8. Hoaglin, D. C., Mosteller, F., and Tukey, J. W. (1983). Understanding Robust and Exploratory Data Analysis. Wiley, New York.
9. Hunt, C. D., Herbel, J. L., and Nielsen, F. H. (1997). Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: Boron, calcium and magnesium absorption and retention and blood mineral concentrations. Am. J. Clin. Nutr. 65, 803-813.
10. Hurst, L. N., Brown, D. H., and Murray, K. A. (1984). Prolonged life and improved quality for stored skin grafts. Plast. Reconstr. Surg. 73, 105-109.
11. Imbus, H. R., Cholak, J., Miller, L. H., and Sterling, T. (1963). Boron, cadmium, chromium and nickel in blood and urine. Arch. Environ. Health 6, 112-121.
12. Jansen, J. A., Anderson, J., and Schou, J. S. (1984). Boric acid single dose pharmacokinetics after intravenous administration to man. Arch. Toxicol. 55, 64-67.
13. Johnstone, D. E., Bascila, N., and Glaser, J. (1955). A study on boric acid absorption in infants from the use of baby powders. J. Pediatr. 46, 160-167.
14. Kahlenberg, L., and Barwasser. (1928). On time of absorption and excretion of boric acid in man. J. Biol. Chem. 79, 405-408.
15. Kahlenberg, L. (1924). On the passage of boric acid through the skin by osmosis. J. Biol. Chem. 62, 149.
16. Ku, W. W., Chapin, R. R., Moseman, R. F., Brink, R. E., Pierce, K. D., and Adams, K. Y. (1991). Tissue disposition of boron in male Fischer rats. Toxicol. Appl. Pharmacol. 111, 145-151.
17. Lewis, D. R. (1990). Metals. In Occupational Medicine (J. LaDou, Ed.), pp. 302-303. Appleton & Lange, East Norwalk, CT.
18. Little, R., and Rubin, D. (1987). Statistical Analysis with Missing Data. Wiley, New York.
19. Minoia, C., Sabbioni, E., Apostoli, P., Pietra, R., Pozzoli, L., Gallorini, M., Nicolaou, B., Alessio, L., and Capodaglio, E. (1989). Trace element reference values in tissues from inhabitants of the European Community. I. A study of 46 elements in urine, blood, and serum of Italian subjects. Sci. Total Environ. 95, 89-105.
20. Moore, J. A., and an Expert Scientific Committee (1997). An assessment of boric acid and borax using the IEHR Evaluative process for assessing human developmental and reproductive toxicity of agents. Reprod. Toxicol. 7, 305-319.
21. Murray, F. J. (1995). A human health risk assessment of boron (boric acid and borax) in drinking water. Regul. Toxicol. Pharmacol. 22, 221-230.
22. Pfeifer, D. D., Hallman, L. F., and Gersh, I. (1955). Boric acid ointment: A study of possible intoxication in the treatment of burns. J. Am. Med. Assoc. 128, 266-274.
23. Smith, F. G., Wiederin, D. R., Houk, R. S., Egan, C. B., and Serfass, R. E. (1991). Measurement of boron concentration and isotope ratios in biological samples by inductively coupled plasma mass spectrometry and direct injection nebulization. Anal. Chim. Acta 248, 229-234.
24. Stuttgen, G., Siebel, Th., and Aggerbeck, B. (1982). Absorption of boric acid through human skin depending on the type of vehicle. Arch. Dermatol. Res. 272, 21-29.
25. Vignec, A. J., and Ellis, R. (1954). Inabsorbability of boric acid in infant powder. A.M.A. Am. J. Dis. Child. 72-80.
26. Wester, R. C., and Maibach, H. I. (1985). Dermatopharmacokinetics in clinical dermatology. In Percutaneous Absorption (R. Bronaugh and H. Maibach, Eds.), pp. 125-132. Dekker, New York.
27. Wester, R. C., and Maibach, H. I. (1989). Interrelationships in the dose-response of percutaneous absorption. In Percutaneous Absorption (R. Bronaugh and H. Maibach, Eds.), pp. 343-355. Dekker, New York.
28. Wester, R. C., and Maibach, H. I. (1991). Individual and regional variation with in vitro Percutaneous absorption. In In Vitro Percutaneous Absorption (R. Bronaugh and H. Maibach, Eds.), pp. 25-30. CRC Press, Boca Raton, FL.
29. Wester, R. C., Maibach, H. I., Melendres, J., Sedik, L., Knaak, J., and Wang, R. (1992). In vivo and in vitro percutaneous absorption and skin evaporation of isofenphos in man. Fund. Appl. Toxicol. 19, 521-526.
30. Wester, R. C., Sedik, L., Melendres, J., Logan, F., Maibach, H. I., and Russell, I. (1993). Percutaneous absorption of diazinon in humans. Food Chem. Toxicol. 31, 569-572.
31. Wester, R. C., and Maibach, H. I. (1996). Percutaneous absorption of hazardous substances from soil and water. In Dermatotoxicology (F. Marzulli and H. Maibach, Eds.), Fifth ed., pp. 325-335. Taylor & Francis, London.
32. Wester, R. C., Christoffel, J., Hartway, T., Poblete, N., Maibach, H., and Forsell, J. (1998). Human cadaver skin viability for in vitro percutaneous absorption: Storage and detrimental effects of heat-separation and freezing. Pharm. Res. 15, 82-84.