In vivo skin decontamination of methylene bisphenyl isocyanate (MDI): Soap and water ineffective compared to polypropylene glycol, polyglycol- based cleanser, and corn oil

Toxicological Sciences

Volumn 48, Issue 1, 1999, Pages 1-4

  Wester, Ronald C ^a   Hui, Xiaoying ^a   Landry, Timothy ^b   Maibach, Howard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

Corn oil; MDI; Polyglycol based cleanser; Polypropylene glycol; Rhesus monkey; Skin decontamination; Skin tape stripping; Soap and water wash

Indexed keywords

CORN OIL; GLYCOL; ISOCYANIC ACID DERIVATIVE; MACROGOL; POLYPROPYLENE; SOAP; WATER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LIPOPHILICITY; NONHUMAN; RHESUS MONKEY; SKIN ABSORPTION; SKIN TOXICITY; WASTE MANAGEMENT; WORKPLACE;

ANIMALIA; MACACA MULATTA; ZEA MAYS;

EID: 0032983984     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.toxsci.a034663     Document Type: Article

References (13)

1. Feldmann, R. J., and Maibach, H. I. (1974). Systemic absorption of pesticides through the skin of man. In: Occupational Exposure to Pesticides: Report to the Federal Working Group on Pest Management, from the Task Group on Occupational Exposure to Pesticides. Appendix B, pp. 120-127.
2. Hewitt, P. G., Hotchkiss, P. G., and Caldwell, J. (1995). Decontamination procedures after in vitro topical exposure of human and rat skin to 4,4′-methylenebis [2-chloroaniline] and 4,4′-methylenedianiline. Fundam. Appl. Toxicol. 26, 91-98.
3. Kazen, C., Bloomer, A., Welch, R., Oudbier, A., and Price, H. (1974). Persistence of pesticides on the hands of some occupationally-exposed people. Arch. Environ. Health 29, 315-318.
4. Kintz, P., Tracqui, A., and Morgin, P. (1992). Accidental death caused by the absorption of 2,4-dichlorophenol through the skin. Arch. Toxicol. 66, 298-299.
5. Merrick, M. V., Simpson, J. D., and Liddell, S. (1982). Skin decontamination - a comparison of four methods. Br. J. Radiol. 55, 317-318.
6. Rattray, N. J., Botham, P. H., Hext, P. M., Woodcock, D. R., Fielding, I. Dearman, R. J., and Kimber, I. (1994). Induction of respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate (MDI) in guinea pigs: Influence of route of exposure. Toxicology 88, 15-30.
7. Tanaka, K., Takeoka, A., Nishimura, F., and Hanada, S. (1987). Contact sensitivity induced in mice by methylene bisphenyl diisocyanate. Contact Dermatitis 17, 199-204.
8. Wester, R. C., and Maibach, H. I. (1984). Advances in percutaneous absorption. In Cutaneous Toxicity (Drill, V., and Lazar, P., Eds.), pp. 29-40. Raven Press, New York.
9. Wester R. C., and Maibach, H. I. (1997). Toxicokinetics: Dermal exposure and absorption of toxicants. In Comprehensive Toxicology (Bond, J., Ed.), pp. 99-114. Elsevier Science, New York.
10. Wester, R. C., Maibach, H. I., Bucks, D. A. W., McMaster, J., Mobayen, M., Sarason, R., and Moore, A. (1990). Percutaneous absorption and skin decontamination of PCBs: in vitro studies with human skin and in vivo studies in the rhesus monkey. J. Toxicol. Environ. Health 31: 235-246.
11. Wester, R. C., Maibach, H. I., Melendres, J., Sedik, L., Knaak, J., and Wang, R. (1992b). In vivo and in vitro percutaneous absorption and skin evaporation of isofenphos in man. Fundam. Appl. Toxicol. 19: 521-526.
12. Wester, R. C., Melendres, J., and Maibach, H. I. (1992a). In vivo percutaneous absorption of alachlor in rhesus monkey. J. Toxicol. Environ. Health 36, 1-12.
13. Wester, R. C., Melendres, J., Sarason, R., McMaster, J., and Maibach, H. I. (1991). Glyphosate skin binding, absorption, residual tissue distribution, and skin decontamination. Fund. Appl. Toxicol. 16, 725-732.