Chromophore-assisted laser inactivation (CALI) to validate drug targets and pharmacogenomic markers

Drug Development Research

Volumn 49, Issue 1, 2000, Pages 65-73

  Ilag, Leodevico L ^a   Ng, Jocelyn H ^a   Jay, Daniel G ^b  

^a Xerion Pharmaceuticals AG   (Germany)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibodies; CALI; Functional genomics; Pharmacogenomics; Proteomics; Target validation

Indexed keywords

DRUG;

ARTICLE; CHROMATOPHORE; DRUG RESEARCH; DRUG TARGETING; GENE TECHNOLOGY; KNOCKOUT GENE; LASER; PROTEIN EXPRESSION; PROTEIN TARGETING; VALIDATION PROCESS;

EID: 0034066990     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(200001)49:1<65::AID-DDR10>3.0.CO;2-T     Document Type: Article

References (60)

1. Beerman AE, Jay DG. 1994. Chromophore-assisted laser inactivation of cellular proteins. Methods Cell Biol 44:716-732.
2. Blackstock WP, Weir MP. 1999. Proteomics: quantitative and physical mapping of cellular proteins. TIBTECH 17:121-127.
3. Buchstaller A, Jay DG. 1999. Micro-scale chromophore-assisted laser inactivation of nerve growth cone proteins. Microsc Res Tech (in press).
4. Castelo LA, Jay DG. 1999. Radixin is involved in lamellipodial stability during nerve growth cone motility. Mol Biol Cell 10:1511-1520.
5. Chang HY, Takei K, Sydor AM, Born T, Rusnack F, Jay DG. 1995. Asymmetric retraction of growth cone filopodia follows focal inactivation of calcineurin. Nature 376:686-690.
6. Cleveland DW, Hwo SY, Kirschner MW. 1977. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol 116:227-247.
7. Collet MS, Erikson RL. 1978. Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci USA 75:2021-2064.
8. Diamond P, Mallavarapu A, Schnipper J, Booth J, Park L, O'Connor TP, Jay DG. 1993. Fasciclin I and II have distinct roles in the development of grasshopper pioneer neurons. Neuron 11:409-421.
9. Drews J. 1996. Genomic sciences and the medicine of tomorrow. Nat Biotechnol 14:1516-1518.
10. Famulok M, Mayer G. 1999. Aptamers as tools in molecular biology and immunology. Curr Top Microbiol Immunol 243:123-136.
11. Feigenbaum JJ, Choubal MD, Crumrine DS, Kanofsky JR, Payza K. 1996a. Receptor inactivation by dye-neuropeptide conjugates. 3. Comparative binding of dye-neuropeptide conjugates to FMR-Famide receptors of Helix aspersa and Loligo pealei. Peptides 17:1279-1284.
12. Feigenbaum JJ, Choubal MD, Crumrine DS, Kanofsky JR. 1996b. Receptor inactivation by dye-neuropeptide conjugates. 2. Characterization of the quantum yield of singlet oxygen generated by irradiation of dye-neuropeptide conjugates. Peptides 17:1213-1217.
13. Feigenbaum JJ, Choubal MD, Payza K, Kanofsky JR, Crumrine DS. 1996c. Receptor inactivation by dye-neuropeptide conjugates. 1. The synthesis of Cys-containing dye-neuropeptide conjugates. Peptides 17:991-994.
14. Gallop MA, Barrett RW, Dower WJ, Fodor SPW, Gordon EM. 1994. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 37:1233-1251.
15. Giese KP, Martini R, Lemke G, Soriano P, Schachner M. 1992. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules and degeneration of myelin and axons. Cell 71:565-576.
16. Gordon EM, Barret RW, Dower WJ, Fodor SPW, Gallop MA. 1994. Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. J Med Chem 37:1385-1401.
17. Grant GN, Karl KA, Kiebler MA, Kandel ER. 1995. Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev 9:1909-1921.
18. Grate D, Wilson C. 1999. Laser-mediated, site-specific inactivation of RNA transcripts. Proc Natl Acad Sci USA 96:6131-6136.
19. Greningloh G, Rehm EJ, Goodman CS. 1991. Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Cell 67:45-57.
20. Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T, Hirokawa N. 1994. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369:488-491.
21. Harrelson AL, Goodman CS. 1988. Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily. Science 242:700-708.
22. Hellstrom KE, Hellstrom I. 1991. In: Devita VT, Helman S, Rosenberg SA, editors. Biological therapy of cancer: principles and practices. Philadelphia: Lipincott. p 35-52.
23. Henry MD, Agosti CG, Solomon F. 1995. Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains. J Cell Biol 129:1007-1022.
24. Hodgson J. 1999. Analysts, firms pour cold water on SNP Consortium. Nat Biotechnol 17:526.
25. Jay DG. 1988. Selective destruction of protein function by chromophore-assisted laser inactivation. Proc Natl Acad Sci USA 85:5454-5458.
26. Jay DG, Keshishian H. 1990. Laser inactivation of fasciclin I disrupts axon adhesion of grasshopper pioneers neurons. Nature 348:548-550.
27. Jay DG, Sakurai T. 1999. Chromophore-assisted laser inactivation (CALI) to elucidate the cellular mechanisms of cancer. ROCO (in press).
28. Klausner RD, Lippincott-Schwartz J, Bonifacino JS. 1990. The T cell antigen receptor: insights into organelle biology. Annu Rev Cell Biol 6:403-431.
29. Kohler G, Milstein C. 1976. Derivation of specific antibody-producing tissue culture and tumor cell lines by cell fusion. Eur J Immunol 6:1012-1020.
30. Lamb R, Ozanne BW, Roy C, McGarry L, Stipp C, Mangeat P, Jay DG. 1997. Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts. Curr Biol 7:682-688.
31. Liao JC, Roider J, Jay DG. 1994. Chromophore-assisted laser inactivation of proteins is mediated by the generation of free radicals. Proc Natl Acad Sci USA 91:2659-2663.
32. Liao JC, Berg L, Jay DG. 1995. Chromophore-assisted laser inactivation of subunits of the T cell receptor in living cells is spatially restricted. Photochem Photobiol 62:923-929.
33. Linden KG, Liao JC, Jay DG. 1992. The spatial specificity of chromophore-assisted laser inactivation of protein function. Biophys J 61:956-962.
34. Liu CA, Lee G, Jay DG. 1999. Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons. Cell Motil Cytoskeleton 43:232-242.
35. Martin M, Andreoli C, Sahuquet A, Montcorrier P, Algrain M, Mangeat P. 1995. Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain. J Cell Biol 128:1081-1093.
36. McFarlane S, Cornel E, Amaya E, Holt CE. 1996. Inhibition of FGF receptor activity in retinal ganglion cell axons causes errors in target recognition. Neuron 17:245-254.
37. Milstein C. 1980. Monoclonal antibodies. Sci Am 243:66-74.
38. Mitchison T, Kirschner M. 1988. Cytoskeleton dynamics and nerve growth. Neuron 1:761-762.
39. Müller BK, Bonhoeffer F. 1995. Molecular inactivation: spatially and temporally defined molecular knockouts. Curr Biol 5:1255-1256.
40. Müller BK, Jay DG, Bouhoffer F. 1996. Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule. Curr Biol 6:1497-1502.
41. Novak K, Titus M. 1992. Dictyostellium cells devoid of two unconventional myosins show defects in growth. Mol Biol Cell 3:3a.
42. Schmucker D, Su A, Beerman A, Jackle H, Jay DG. 1994. Laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. Proc Natl Acad Sci USA 91:2664-2668.
43. Schroeder R, Tautz D, Jay DG. 1996. Chromophore-assisted laser inactivation of even skipped in Drosophila phenocopies genetic loss of function. Dev Genes Evol 206:86-88.
44. Schroeder R, Jay DG, Tautz D. 1999. Elimination of EVE protein by CALI in the short germ band insect Tribolium suggests a conserved pair-rule function for even skipped. Mech Devel 80:191-195.
45. Sheets MD, Amerdorfer P, Finnern R, Sargent P, Lindqvist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD. 1998. Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci USA 95:6157-6162.
46. Shimkets RA, Lowe DG, Tai JT, Sehl P, Jin H, Yang R, Predki PF, Rothberg BE, Murtha MT, Roth ME, Shenoy SG, Windemuth A, Simpson JW; Simons JF, Daley MP, Gold SA, McKenna MP, Hillan K, Went GT, Rothberg JM. 1999. Gene expression analysis by transcript profiling coupled to a gene database query. Nat Biotechnol 8:798-803.
47. Soriano P, Montgomery C, Gesake R, Bradley A. 1991. Targeted disruption of the c-src proto-oncogene leads to osteoporosis in mice. Cell 64:693-702.
48. Stoeckli ET, Sonderegger P, Pollerberg GE, Landmesser LT. 1997. Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons. Neuron 18:209-221.
49. Surrey T, Elowitz MB, Wolf PE, Yang F, Nedelec F, Shokat K, Liebler S. 1998. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proc Natl Acad Sci USA 95:4293-4298.
50. Sydor AM. 1995. The role of cytoskeletal proteins talin and vinculin in neuronal growth cone motility. PhD dissertation, Harvard University.
51. Sydor AM, Su AL, Wang FS, Xu A, Jay DG. 1996. Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone. J Cell Biol 134:1197-1208.
52. Takei K, Shin RM, Inoue T, Kato K, Mikoshiba K. 1998a. Regulation of nerve growth mediated by inositol 1,4,5-triphosphate receptors in growth cones. Science 282:1705-1708.
53. Takei Y, Junlin T, Harada A, Inomata-Terada S, Hirokawa N. 1998b. Abnormal development of nervous system in mice lacking tau and MAP1B. Mol Biol Cell 9:394a.
54. Takei K, Chan TA, Wang FS, Deng H, Rutishauser U, Jay DG. 1999. The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth. J Neurosci 19:9469-9479.
55. Takeuchi K, Sato N, Kasahara H, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita Sh. 1994. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol 125:1371-1384.
56. Wang FS, Jay DG. 1996. Chromophore-assisted laser inactivation (CALI): probing protein function in situ with a high degree of spatial and temporal resolution. Trends Cell Biol 6:442-445.
57. Wang FS, Wolenski JS, Cheney RE, Mooseker MS, Jay DG. 1996. Function of myosin-V in filopodial extension of neuronal growth cones. Science 273:660-663.
58. Williams EJ, Furness J, Walsh FS, Doherty P. 1994. Characterization of the second messenger pathway underlying neurite outgrowth stimulated by FGF. Development 120:1685-1693.
59. Wilm M, Shevchenko A, Houthaeve T, Breit S, Schweigerer L, Fotsis T, Mann M. 1996. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 379:466-469.
60. Zinn K, McAllister L, Goodman CS. 1988. Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila. Cell 53:577-587.