Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2059-2064

  Dubuffet, Thierry ^a   Newman Tancredi, Adrian ^a   Cussac, Didier ^a   Audinot, Valerie ^a   Loutz, Annie ^a   Millan, Mark J ^a   Lavielle, Gilbert ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPYRAN DERIVATIVE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; PYRROLE DERIVATIVE; S 33084; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; RECEPTOR AFFINITY; STEREOCHEMISTRY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BENZOPYRANS; CHO CELLS; CRICETINAE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; IODINE RADIOISOTOPES; PYRROLES; PYRROLIDINES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP; SULPIRIDE; TETRAHYDRONAPHTHALENES; TRANSFECTION;

EID: 0033584162     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00312-1     Document Type: Article

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17. 8 was prepared from the corresponding 8-methoxy derivative (EP 0095 666, Abbott).
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24. 2: C, 71.37; H, 6.20; Cl, 7.26; N, 8.61. Found: C, 71,32; H, 6.21; Cl, 7.39; N, 8.57.