Itraconazole pulse therapy is effective in dermatophyte onychomycosis of the toenail: A double-blind placebo-controlled study

Journal of Dermatological Treatment

Volumn 11, Issue 1, 2000, Pages 33-37

  Gupta, A K ^a,b,e   Maddin, S ^c   Arlette, J ^d   Giroux, J M ^e   Shear, N H ^a,b  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e NONE

Author keywords

Itraconazole; Onychomycosis; Pulse therapy

Indexed keywords

ITRACONAZOLE; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; CANADA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATOMYCOSIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLU LIKE SYNDROME; FUNGUS CULTURE; HEADACHE; HUMAN; LIVER FUNCTION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MULTICENTER STUDY; NAIL INFECTION; NAUSEA; ONYCHOMYCOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SORE THROAT; UPPER RESPIRATORY TRACT INFECTION;

EID: 0034065689     PISSN: 09546634     EISSN: None     Source Type: Journal    
DOI: 10.1080/09546630050517658     Document Type: Article

References (15)

1. Gupta AK, Sauder DN, Shear NH, Antifungals - an overview. Part I. J Am Acad Dermatol (1994) 30: 377-98.
2. Gupta AK, Sauder DN, Shear NH, Antifungals - an overview. Part II. J Am Acad Dermatol (1994) 30: 911-33.
3. De Doncker P, Decroix J, Pierard GE et al, Antifungal pulse therapy for onychomycosis. Arch Dermatol (1996) 132: 34-41.
4. Cauwenbergh G, Degreef H, Heykants J et al, Pharmacokinetic profile of orally administered itraconazole in human skin. J Am Acad Dermatol (1988) 18: 263-8.
5. Havu V, Brandt H, Heikkilä H et al, A double-blind, randomized study comparing itraconazole pulse therapy with continuous dosing for the treatment of toe-nail onychomycosis. Br J Dermatol (1997) 136: 230-4.
6. Bonifaz A, Carrasco-Gerard E, Saul A, Itraconazole in onychomycosis: intermittent dose schedule. Int J Dermatol (1997) 36: 70-2.
7. Odom R, Daniel R, Aly R, a double-blind, randomized comparison of itraconazole capsules and placebo in the treatment of onychomycosis of the toenail. J Am Acad Dermatol (1996) 35: 110-11.
8. Jones HE, Zaias N, Double-blind, randomized comparison of itraconazole capsules and placebo in onychomycosis of toenail. Int J Dermatol (1996) 35: 589-90.
9. Elewski BE, Scher R, Aly R et al, Double-blind, randomized comparison of itraconazole capsules vs. placebo in the treatment of toenail onychomycosis. Cutis (1997) 59: 217-20.
10. Goodfield MJD, Andrew L, Evans EGV, Short term treatment of dermatophyte onychomycosis with terbinafme. Br Med J (1992) 304: 1151-5.
11. Svejgaard EL, Flemming B, Kragballe K, Oral terbinafine in toenail dermatophytosis. Acta Dermatol Venereol (Stockh) (1997) 77: 66-9.
12. De Doncker P, van Lint J, Dockx P, Roseeuw D, Pulse therapy with one-week itraconazole monthly for three or four months in the treatment of onychomycosis. Cutis (1995) 56: 180-3.
13. Gupta AK, Pharmacoeconomic analysis of oral antifungal therapies used to treat dermatophyte onychomycosis of the toenails. A US analysis. PharmacoEconomics (1998) 13: 243-56.
14. Gupta AK, De Doncker P, Scher RK et al, Itraconazole for the treatment of onychomycosis: an overview. Int J Dermatol (1998) 37: 303-8.
15. De Doncker P, Gupta AK, Marynissen G et al, Itraconazole intermittent pulse therapy is effective and safe in the treatment of onychomycosis and dermatomycoses: an overview. J Am Acad Dermatol (1997) 37: 969-74.