Immunological detection of polycystin-1 in human kidney

Histochemistry and Cell Biology

Volumn 113, Issue 4, 2000, Pages 303-311

  Nauta, Jeroen ^a   Goedbloed, Miriam A ^a   Van Den Ouweland, Ans M W ^b   Nellist, Mark ^b   Hoogeveen, André T ^b  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCYSTIN;

ARTICLE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

EID: 0034063587     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180000135     Document Type: Article

References (32)

1. Aguiari GL, Bozza A, Piva R, Vilinia S, Reali E, Maestri I, Magri E, Cavazzinin L, Senno L del (1997) Expression of protein fragments from the human PKD1 gene and production of rabbit polyclonal antibodies to the recombinant proteins. Contrib Nephrol 122:49-52
2. Brasier JL, Henske EP (1997) Loss of polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss of function model for cyst pathogenesis. J Clin Invest 99:194-199
3. Erickson BW, Merrifield RB (1976). In: Neurath H, Hill RL (eds) The proteins, 3rd edn. Academic Press, New York, pp 255-527
4. Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Glucksmann-Kuis AM, Schneider MC, Ericsson M, Reeders ST, Zhou J (1996) Identification and localization of polycystin, the PKD1 gene product. J Clin Invest 98:2674-2682
5. Geng L, Segal Y, Pavlova A, Barros EJ, Lohning C, Lu W, Nigam SK, Frischauf AM, Reeders ST, Zhou J (1997) Distribution and developmentally regulated expression of murine polycystin. Am J Physiol 272:F451-F459
6. Griffin MD, Torres VE, Grande JP, Kumar R (1996) Immunolocalization of polycystin in human tissues and cultured cells. Proc Assoc Am Physicians 108:185-197
7. Griffin MD, O'Sullivan DA, Torres VE, Grande JP, Kanwar YS, Kumar R (1997a) Expression of polycystin in mouse metanephros and extra-metanephric tissues. Kidney Int 52:1196-1205
8. Griffin MD, Torres VE, Grande JP, Kumar R (1997b) Vascular expression of polycystin. J Am Soc Nephrol 8:616-626
9. Hughes J, Ward CJ, Peral B, Aspinwall R, Clark K, San Millán JL, Gamble V, Harris PC (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 10:151-160
10. Hughes J, Ward CJ, Aspinwall R, Butler R, Harris PC (1999) Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hum Mol Genet 8:543-549
11. Ibraghimov-Beskrovnaya O, Dackowski WR, Foggensteiner L, Coleman N, Thiru S, Petry LR, Burn TC, Connors TD, Van Raay T, Bradley J, Qian F, Onuchic LF, Watnick TJ, Piontek K, Hakim RM, Landes GM, Germino GG, Sandford R, Klinger KW (1997) Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein. Proc Natl Acad Sci USA 94: 6397-6402
12. Koptides M, Hadjimichael C, Koupepidou P, Pierides A, Constantinou Deltas C (1999) Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease. Hum Mol Genet 8:509-513
13. Lu W, Fan X, Basora N, Babakhanlou A, Law T, Rifai N, Harris PC, Perez-Atayda AR, Rennke HG, Zhou J (1999) Late onset of renal and hepatic cysts in PKD1-targeted heterozygotes. Nat Genet 21:160-161
14. Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuizen B, Saris JJ, Reynolds DM, Cai Y, Gabow PA, Pierides A, Kimberling WJ, Breuning MH, Constantinou Deltas CD, Peters DJM, Somlo S (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272:1339-1342
15. Ong ACM, Ward CJ, Butler RJ, Biddolph S, Bowker C, Torra R, Pei Y, Harris PC (1999a) Coordinate expression of the autosomal dominant polycystic kidney disease proteins, Polycystin-2 and Polycystin-1, in normal and cystic tissue. Am J Pathol 154:1721-1729
16. Ong ACM, Harris PC, Davies DR, Pritchard L, Rossetti S, Biddolph S, Vaux DJT, Migone N, Ward CJ (1999b) Polycystin-1 expression in PKD1, early onset PKD1 and TSC2/PKD1 cystic tissue: implications for understanding cystogenesis. Kidney Int 56:1324-1333
17. Palsson R, Sharma CP, Kim K, McLaughlin M, Brown D, Arnaout MA (1996) Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med 2:702-711
18. Peters DJ, Spruit L, Klingel R, Prins F, Baelde H, Giordano PC, Bernini LF, Heer E de, Breuning MH, Bruijn JA (1996) Adult, fetal and polycystic kidney expression of polycystin, the polycystic kidney disease-1 gene product. Lab Invest 75:221-230
19. Peters DJM, Wal A van de, Spruit L, Saris JJ, Breuning MH, Bruijn JA, Heer E de (1999) Cellular localisation and tissue distribution of polycystin-1. J Pathol 188:439-446
20. Qian F, Watnick TJ, Onuchic LF, Germino GG (1996) The molecular basis of focal cyst formation in human autosomal polycystic kidney disease type 1. Cell 87:979-987
21. Sandford R, Sgotto B, Aparicio S, Brenner S, Vaudin M, Wilson RK, Chissoe S, Pepin K, Bateman A, Chothia C, Hughes J, Harris (1997) Polycystin: comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Hum Mol Genet 6:1483-1489
22. The European Polycystic Kidney Disease Consortium (1994) The polycystic kidney disease 1 gene encodes a 14-kb transcript and lies within a duplicated region on chromosome 16. Cell 77:881-894
23. The International Polycystic Kidney Disease Consortium (1995) Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. Cell 81:289-298
24. Van Adelsberg J, Chamberlain S, d'Agati V (1997) Polycystin expression is temporally and spatially regulated during renal development. Am J Physiol 272: F602-F609
25. Ward CJ, Turley H, Ong ACM, Comley M, Biddolph S, Chetty R, Ratcliffe PJ, Gatter K, Harris PC (1996) Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. Proc Natl Acad Sci USA 93:1524-1528
26. Watnick TJ, Torres VE, Gandolph MA, Qian F, Onuchic LF, Klinger KW, Landes G, Germino GG (1998) Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease. Mol Cell 2:247-251
27. Welling LW, Grantham JJ (1996) Cystic and developmental diseases of the kidney. In: Brenner BM (ed) The kidney, vol 2. Saunders, Philadelphia, pp 1828-1863
28. Weston BS, Jeffery S, Jeffrey I, Sharaf SFA, Carter N, Saggar-Malik A, Price RG (1997) Polycystin expression during embryonic development of human kidney in adult tissues and ADPKD tissue. Histochem J 29:847-856
29. Willemsen R, Tibbe JJM, Kroos MA, Martin BM, Reuser AJJ, Ginns EI (1995) A biochemical and immunocytochemical study on the targeting of alglucerase. Histochem J 27:639-646
30. Wilson PD (1997) Epithelial cell polarity and disease. Am J Physiol 272:F434-F442
31. Wilson PD, Burrow CR (1999) Cystic diseases of the kidney: role of adhesion molecules in normal and abnormal tubulogenesis. Exp Nephrol 7:114-124
32. Wu G, D'Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S (1998) Somatic inactivation of PKD2 results in polycystic kidney disease. Cell 93:177-188