메뉴 건너뛰기




Volumn 182, Issue 2, 2000, Pages 143-150

The antiovulatory potential of progesterone antagonists correlates with a down-regulation of progesterone receptors in the hypothalamus, pituitary and ovaries

Author keywords

Hypothalamus; Immunohistochemistry; Ovary; Pituitary; Progesterone antagonist; Progesterone receptor

Indexed keywords

ANTIGESTAGEN; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTROGEN; LUTEINIZING HORMONE; ONAPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR; SERIC GONADOTROPIN;

EID: 0034063499     PISSN: 09409602     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-9602(00)80073-4     Document Type: Article
Times cited : (7)

References (39)
  • 1
    • 0016280927 scopus 로고
    • The role of sex steroid hormones in modulating the responsiveness of the anterior pituitary gland to luteinizing hormone releasing factor in the female rat
    • Aiyer MS, Fink G (1974) The role of sex steroid hormones in modulating the responsiveness of the anterior pituitary gland to luteinizing hormone releasing factor in the female rat. J Endocrinol 62: 553-572
    • (1974) J Endocrinol , vol.62 , pp. 553-572
    • Aiyer, M.S.1    Fink, G.2
  • 2
    • 0024845569 scopus 로고
    • Steroid hormone receptors in the uterus and ovary of immature rats treated with gonadotropins
    • Arakawa S, Iyo M, Ohkawa R, Kambegawa A, Okinaga S, Arai K (1989) Steroid hormone receptors in the uterus and ovary of immature rats treated with gonadotropins. Endocrinol Japon 36: 219-228
    • (1989) Endocrinol Japon , vol.36 , pp. 219-228
    • Arakawa, S.1    Iyo, M.2    Ohkawa, R.3    Kambegawa, A.4    Okinaga, S.5    Arai, K.6
  • 3
    • 0025870321 scopus 로고
    • Progesterone receptor regulation in uterine cells: Stimulation by estrogen, cyclic adenosine 3′, 5′-monophosphate, and insulin-like growth factor-I and suppression by antiestrogens and protein kinase inhibitors
    • Aronica SM, Katzenellenbogen BS (1991) Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3′, 5′-monophosphate, and insulin-like growth factor-I and suppression by antiestrogens and protein kinase inhibitors. Endocrinology 128: 2045-2052
    • (1991) Endocrinology , vol.128 , pp. 2045-2052
    • Aronica, S.M.1    Katzenellenbogen, B.S.2
  • 4
    • 0006481741 scopus 로고
    • Sex steroid regulation of reproductive neuroendocrine processes
    • Greep RO, Astwood EB (eds) Handbook of Physiology American Physiological Society, Washington D.C.
    • Barraclough CA (1973) Sex steroid regulation of reproductive neuroendocrine processes. In: Greep RO, Astwood EB (eds) Handbook of Physiology. Vol 2 Female reproductive system. American Physiological Society, Washington D.C., pp 29-56
    • (1973) Vol 2 Female Reproductive System , vol.2 , pp. 29-56
    • Barraclough, C.A.1
  • 5
    • 0015969761 scopus 로고
    • New data concerning the role played by progesterone in the control of follicular growth in the rat
    • Copenh.
    • Buffler G, Roser S (1974) New data concerning the role played by progesterone in the control of follicular growth in the rat. Acta Endocrinol (Copenh.) 75: 569-578
    • (1974) Acta Endocrinol , vol.75 , pp. 569-578
    • Buffler, G.1    Roser, S.2
  • 6
    • 0015110556 scopus 로고
    • Biphasic effect of progesterone on the release of gonadotropin in rats
    • Caligaris L, Astrada JJ, Taleisnik S (1971) Biphasic effect of progesterone on the release of gonadotropin in rats. Endocrinology 89: 331-337
    • (1971) Endocrinology , vol.89 , pp. 331-337
    • Caligaris, L.1    Astrada, J.J.2    Taleisnik, S.3
  • 7
    • 0025293539 scopus 로고
    • Progestin regulation of cellular proliferation
    • Clark CL, Sutherland RL (1990) Progestin regulation of cellular proliferation. Endocr Rev 11: 266-301
    • (1990) Endocr Rev , vol.11 , pp. 266-301
    • Clark, C.L.1    Sutherland, R.L.2
  • 8
    • 0022977510 scopus 로고
    • Blockade of the spontaneous midcycle gonadotropin surge in monkeys by RU 486: A progesterone antagonist or agonist?
    • Collins RL, Hodgen GD (1986) Blockade of the spontaneous midcycle gonadotropin surge in monkeys by RU 486: a progesterone antagonist or agonist? J Clin Endocrinol Metab 63: 1270-1276
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1270-1276
    • Collins, R.L.1    Hodgen, G.D.2
  • 10
    • 0023029540 scopus 로고
    • Effect of the antiprogestin RU 486 on progesterone production by cultured human granulosa cells: Inhibition of the ovarian 3β-hydroxysteroid dehydrogenase
    • DiMattina M, Albertson B, Seyler DE, Loriaux DL, Falk RJ (1986) Effect of the antiprogestin RU 486 on progesterone production by cultured human granulosa cells: inhibition of the ovarian 3β-hydroxysteroid dehydrogenase. Contraception 34: 199-206
    • (1986) Contraception , vol.34 , pp. 199-206
    • Dimattina, M.1    Albertson, B.2    Seyler, D.E.3    Loriaux, D.L.4    Falk, R.J.5
  • 11
    • 0030817797 scopus 로고    scopus 로고
    • The antiovulatory effect of the antiprogestin Onapristone could be relaled to down-regulation of intraovarian progesterone (receptors)
    • Donath J, Michna H, Nishino Y (1997) The antiovulatory effect of the antiprogestin Onapristone could be relaled to down-regulation of intraovarian progesterone (receptors). J Steroid Biochem Molec Biol 62: 107-118
    • (1997) J Steroid Biochem Molec Biol , vol.62 , pp. 107-118
    • Donath, J.1    Michna, H.2    Nishino, Y.3
  • 12
    • 0342639772 scopus 로고
    • Comparative pharmacological studies on new progesterone antagonists in cyclic pregnant animals and their therapeutic perspectives
    • Elger W, Beier S, Puri CP, Follow K, Chwalisz K, Fähnrich M, Hasan SH, Neef G (1989) Comparative pharmacological studies on new progesterone antagonists in cyclic pregnant animals and their therapeutic perspectives. Nichidoku-Iho 33: 171-186
    • (1989) Nichidoku-Iho , vol.33 , pp. 171-186
    • Elger, W.1    Beier, S.2    Puri, C.P.3    Follow, K.4    Chwalisz, K.5    Fähnrich, M.6    Hasan, S.H.7    Neef, G.8
  • 13
    • 0002185096 scopus 로고
    • The mammalian female reproductive cycle and its controlling mechanisms
    • Young WD (ed) Williams and Wilkens, Baltimore
    • Everett JW (1961) The mammalian female reproductive cycle and its controlling mechanisms. In: Young WD (ed) Sex and internal secretions. Williams and Wilkens, Baltimore, pp 497-555
    • (1961) Sex and Internal Secretions , pp. 497-555
    • Everett, J.W.1
  • 14
    • 0023677025 scopus 로고
    • Oestrogen and progesterone interactions in the control of gonadotrophin and prolactin secretion
    • Fink G (1988) Oestrogen and progesterone interactions in the control of gonadotrophin and prolactin secretion. J Steroid Biochem 30: 169-178
    • (1988) J Steroid Biochem , vol.30 , pp. 169-178
    • Fink, G.1
  • 15
    • 0025137881 scopus 로고
    • Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary
    • Fox SR, Harlan R, Shivers B, Pfaff DW (1990) Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Neuroendocrinology 51: 276-283
    • (1990) Neuroendocrinology , vol.51 , pp. 276-283
    • Fox, S.R.1    Harlan, R.2    Shivers, B.3    Pfaff, D.W.4
  • 16
    • 0019351699 scopus 로고
    • The sites of action of ovarian steroids in the regulation of LH secretion
    • Goodman RL, Knobil E (1981) The sites of action of ovarian steroids in the regulation of LH secretion. Neuroendocrinology 32: 57-63
    • (1981) Neuroendocrinology , vol.32 , pp. 57-63
    • Goodman, R.L.1    Knobil, E.2
  • 17
    • 0022639025 scopus 로고
    • Androgen receptors in brain and pituitary of female rats: Cyclic changes and comparison with the male
    • Handa RJ, Reid DL, Resko JA (1986) Androgen receptors in brain and pituitary of female rats: cyclic changes and comparison with the male. Biol Reprod 34: 293-303
    • (1986) Biol Reprod , vol.34 , pp. 293-303
    • Handa, R.J.1    Reid, D.L.2    Resko, J.A.3
  • 18
    • 0019411769 scopus 로고
    • Relative distribution of estrogen and progesterone receptors among the epithelial, adipose, and connective tissue components of the normal mammary gland
    • Haslam SZ, Shyalama G (1981) Relative distribution of estrogen and progesterone receptors among the epithelial, adipose, and connective tissue components of the normal mammary gland. Endocrinology 108: 825-830
    • (1981) Endocrinology , vol.108 , pp. 825-830
    • Haslam, S.Z.1    Shyalama, G.2
  • 19
    • 0019993591 scopus 로고
    • The effects of an antiprogesterone steroid in women: Interruption of the menstrual cycle and of early pregnancy
    • Herrmann W, Wyss R, Riondel A, Philibert D, Teusch G, Sakiz E, Baulieu EE (1982) The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy. C R Acad Sci Paris 294: 933-938
    • (1982) C R Acad Sci Paris , vol.294 , pp. 933-938
    • Herrmann, W.1    Wyss, R.2    Riondel, A.3    Philibert, D.4    Teusch, G.5    Sakiz, E.6    Baulieu, E.E.7
  • 20
    • 0000435593 scopus 로고
    • Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle
    • Baulieu EE, Segal SJ (eds) Plenum Press, New York
    • Herrmann W, Schindler AM, Wyss R, Bischof P (1985) Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle. In: Baulieu EE, Segal SJ (eds) The antiprogestin steroid RU 486 and human fertility control. Plenum Press, New York, pp 179-198
    • (1985) The Antiprogestin Steroid RU 486 and Human Fertility Control , pp. 179-198
    • Herrmann, W.1    Schindler, A.M.2    Wyss, R.3    Bischof, P.4
  • 21
    • 0018138071 scopus 로고
    • Estrogen control of progesterone receptor in human breast cancer: Correlation with nuclear processing of estrogen receptors
    • Horwitz KB, McGuire WL (1978) Estrogen control of progesterone receptor in human breast cancer: correlation with nuclear processing of estrogen receptors. J Biol Chem 253: 2223-2228
    • (1978) J Biol Chem , vol.253 , pp. 2223-2228
    • Horwitz, K.B.1    McGuire, W.L.2
  • 22
    • 0026636999 scopus 로고
    • The molecular biology of RU 486. Is there a role for antiprogestins in the treatment of breast cancer?
    • Horwitz KB (1992) The molecular biology of RU 486. Is there a role for antiprogestins in the treatment of breast cancer? Endoer Rev 13: 146-163
    • (1992) Endoer Rev , vol.13 , pp. 146-163
    • Horwitz, K.B.1
  • 23
    • 0021276851 scopus 로고
    • Opoid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat
    • Kalra SP, Kalra PS (1984) Opoid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology 38: 418-426
    • (1984) Neuroendocrinology , vol.38 , pp. 418-426
    • Kalra, S.P.1    Kalra, P.S.2
  • 24
    • 0017708304 scopus 로고
    • Specific progesterone receptors in the hypothalamus and anterior hypophysis of the rat
    • Kato J, Onouchi T (1977) Specific progesterone receptors in the hypothalamus and anterior hypophysis of the rat. Endocrinology 101: 920-928
    • (1977) Endocrinology , vol.101 , pp. 920-928
    • Kato, J.1    Onouchi, T.2
  • 25
    • 0018139920 scopus 로고
    • Hypothalamic and hypophysial progesterone receptors: Estrogen-priming effect, differential localization, 5α-dihydroprogesterone binding, and nuclear receptors
    • Kato J, Onouchi T, Okinaga S (1978) Hypothalamic and hypophysial progesterone receptors: estrogen-priming effect, differential localization, 5α-dihydroprogesterone binding, and nuclear receptors. J Steroid Biochem 9: 419-427
    • (1978) J Steroid Biochem , vol.9 , pp. 419-427
    • Kato, J.1    Onouchi, T.2    Okinaga, S.3
  • 26
    • 0025058496 scopus 로고
    • Multi-hormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: Interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen
    • Katzenellenbogen B, Norman M (1990) Multi-hormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. Endocrinology 126: 891-898
    • (1990) Endocrinology , vol.126 , pp. 891-898
    • Katzenellenbogen, B.1    Norman, M.2
  • 27
    • 0023571530 scopus 로고
    • Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU 486
    • Liu JH, Morris S, Stuenkel C, Ulman A, Yen SSC (1987) Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU 486. J Clin Endocrinol Metab 65: 1135-1140
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1135-1140
    • Liu, J.H.1    Morris, S.2    Stuenkel, C.3    Ulman, A.4    Yen, S.S.C.5
  • 28
    • 0017336835 scopus 로고
    • Inhibition of ovulation in immature rats by antiprogesterone antiserum
    • Mori T, Suzuki A, Nishimura T, Kambegawa A (1977) Inhibition of ovulation in immature rats by antiprogesterone antiserum. J Endocrinol 73: 185-186
    • (1977) J Endocrinol , vol.73 , pp. 185-186
    • Mori, T.1    Suzuki, A.2    Nishimura, T.3    Kambegawa, A.4
  • 29
    • 0021610642 scopus 로고
    • New steroids with antiprogestational and antiglucocorticoid activities
    • Neef G, Beier S, Elger W, Henderson D, Wiechert R (1984) New steroids with antiprogestational and antiglucocorticoid activities. Steroids 44: 349-372
    • (1984) Steroids , vol.44 , pp. 349-372
    • Neef, G.1    Beier, S.2    Elger, W.3    Henderson, D.4    Wiechert, R.5
  • 30
    • 0024401395 scopus 로고
    • Acute facilitory action of progesterone on gonadotropin secretion of perifused rat pituitary cells
    • Ortmann O, Wiese H, Knuppen R, Emons G (1989) Acute facilitory action of progesterone on gonadotropin secretion of perifused rat pituitary cells. Acta Endocrinol 121: 426-434
    • (1989) Acta Endocrinol , vol.121 , pp. 426-434
    • Ortmann, O.1    Wiese, H.2    Knuppen, R.3    Emons, G.4
  • 31
    • 0026388995 scopus 로고
    • Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge
    • Park OK, Mayo K (1991) Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Mol Endocrinol 5: 967-978
    • (1991) Mol Endocrinol , vol.5 , pp. 967-978
    • Park, O.K.1    Mayo, K.2
  • 32
    • 0028147407 scopus 로고
    • Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3′, 5′-monophosphate in rat granulosa cells
    • Park OK, Mayo K (1994) Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3′, 5′-monophosphate in rat granulosa cells. Endocrinology 134: 709-718
    • (1994) Endocrinology , vol.134 , pp. 709-718
    • Park, O.K.1    Mayo, K.2
  • 34
    • 0023949844 scopus 로고
    • The role of preovulatory progesterone in the midcycle gonadotrophin surge, ovulation and subsequent luteal phase: Studies with RU 486 in rhesus monkeys
    • Remohi J, Balmaceda JP, Rojas FJ, Asch RH (1988) The role of preovulatory progesterone in the midcycle gonadotrophin surge, ovulation and subsequent luteal phase: studies with RU 486 in rhesus monkeys. Reprod 3: 431-435
    • (1988) Reprod , vol.3 , pp. 431-435
    • Remohi, J.1    Balmaceda, J.P.2    Rojas, F.J.3    Asch, R.H.4
  • 35
    • 0022512375 scopus 로고
    • Immunohistochemical localization of estrogen receptor in rat brain, pituitary and uterus with monoclonal antibodies
    • Sar M, Parikh I (1986) Immunohistochemical localization of estrogen receptor in rat brain, pituitary and uterus with monoclonal antibodies. J Steroid Biochem 24: 497-503
    • (1986) J Steroid Biochem , vol.24 , pp. 497-503
    • Sar, M.1    Parikh, I.2
  • 36
    • 0018736057 scopus 로고
    • Progesterone receptor in rat ovary
    • Schreiber JR, Hsueh AJW (1979) Progesterone receptor in rat ovary. Endocrinology 105: 915-919
    • (1979) Endocrinology , vol.105 , pp. 915-919
    • Schreiber, J.R.1    Hsueh, A.J.W.2
  • 37
    • 0028948212 scopus 로고
    • Disturbance of follicular development and endocrine reactions induced by the antiovulatory effective progesterone antagonist Onapristone
    • Schubert C, Nishino Y, Michna H (1995) Disturbance of follicular development and endocrine reactions induced by the antiovulatory effective progesterone antagonist Onapristone. Ann Anat 177: 139-144
    • (1995) Ann Anat , vol.177 , pp. 139-144
    • Schubert, C.1    Nishino, Y.2    Michna, H.3
  • 38
    • 0030239235 scopus 로고    scopus 로고
    • The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat
    • Schubert C, Donath J, Michna H, Nishino Y (1996) The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat. J Steroid Biochem Molec Biol 59: 75-82
    • (1996) J Steroid Biochem Molec Biol , vol.59 , pp. 75-82
    • Schubert, C.1    Donath, J.2    Michna, H.3    Nishino, Y.4
  • 39
    • 0016169908 scopus 로고
    • Induction of ovulation in hypophysectomized rats by progesterone
    • Takahashi M, Ford J, Yoshinaga K, Greep R (1974) Induction of ovulation in hypophysectomized rats by progesterone. Endocrinology 95: 1322-1326
    • (1974) Endocrinology , vol.95 , pp. 1322-1326
    • Takahashi, M.1    Ford, J.2    Yoshinaga, K.3    Greep, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.