The antiovulatory effect of the antiprogestin Onapristone could be related to Down-regulation of intraovarian progesterone (receptors)

Journal of Steroid Biochemistry and Molecular Biology

Volumn 62, Issue 1, 1997, Pages 107-118

  Donath, J ^a   Michna, H ^a,b   Nishino, Y ^a  

^a BAYER PHARMA AG   (Germany)

^b DSHS Cologne ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN RECEPTOR; ANTIGESTAGEN; CHORIONIC GONADOTROPIN; ESTROGEN RECEPTOR; ONAPRISTONE; PROGESTERONE RECEPTOR; SERIC GONADOTROPIN; TESTOSTERONE 17BETA DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOLOGY; NONHUMAN; OVARY FOLLICLE DEVELOPMENT; OVULATION; RADIOIMMUNOASSAY; RAT; RECEPTOR DOWN REGULATION; SUBCUTANEOUS DRUG ADMINISTRATION;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ANDROSTENEDIONE; ANIMALS; CHORIONIC GONADOTROPIN; DOWN-REGULATION; ESTRADIOL; FEMALE; GONADOTROPINS, EQUINE; GONANES; GRANULOSA CELLS; HORMONE ANTAGONISTS; KINETICS; OVARY; OVULATION; OVULATION INDUCTION; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; THECA CELLS;

EID: 0030817797     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00012-5     Document Type: Article

References (35)

1. Schubert C., Donath J., Michna H. and Nishino Y.: The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat. J. Steroid Biochem. Molec. Biol. 59 (1996) 75-82.
2. Nishino Y., Schubert C. and Hasan S.: Increase in the antiovulatory potency of the antiprogestin ZK 112993 by combination with the antiandrogen flutamide in the rat. Exp. Clin. Endocr. 102 (1994) 111.
3. Elger W., Beier S., Puri C. P., Follow K., Chwalisz K., Fähnrich M., Hasan S. H. and Neef G.: Comparative pharmacological studies on new progesterone-antagonists in cyclic and pregnant animals and their therapeutic perspectives. Nichidoku-Iho 33 (1989) 171-186.
4. Rondell P.: Role of steroid synthesis in the process of ovulation. Biol. Reprod. 10 (1974) 199-215.
5. Takahashi M., Ford J., Yoshinaga K. and Greep R.: Induction of ovulation in hypophysectomized rats by progesterone. Endocrinology 95 (1974) 1322-1326.
6. Rao I. and Mahesh V.: Role of progesterone in the modulation of the preovulatory surge of gonadotropins and ovulation in the pregnant mare's serum gonadotropin-primed immature rat and the adult rat. Biol. Reprod. 35 (1986) 1154-1161.
7. Mori T., Suzyju A., Nishimura T. and Kambegawa A.: Inhibition of ovulation in immature rats by antiprogesterone antiserum. J. Endocr. 73 (1977) 185-186.
8. Snyder B., Beecham G. and Schane H.: Inhibition of ovulation in rats with epostane, an inhibitor of 3β-hydroxysteroid dehydrogenase (41865). Proc. Soc. Exp. Biol. Med. 176 (1984) 238-242.
9. Iwamasa J., Shibata S., Tanaka N., Matsuura K. and Okamura H.: The relationship between ovarian progesterone and proteolytic enzyme activity during ovulation in the gonadotropin-treated immature rat. Biol. Reprod. 46 (1992) 309-313.
10. Iwal T., Fuji S., Nanbu Y., Nonogaki H., Konishi I., Mori T. Okamura H.: Effect of human chorionic gonadotropin on the expression of progesterone receptors and estrogen receptors in rabbit ovarian granulosa cells and the uterus. Endocrinology 129 (1991) 1840-1848.
11. Hild-Petito S., Stouffer R. and Brenner R.: Immunocytochemical localization of estradiol and progesterone receptors in the monkey ovary throughout the menstrual cycle. Endocrinology 123 (1988) 2896-2905.
12. Iwai M., Yasuda K., Fukuoka M., Iwai T., Takakura K., Taii S., Nakanishi S. and Mori T.: Luteinizing hormone induces progesterone receptor gene expression in cultured porcine granulosa cells. Endocrinology 129 (1991) 1621-1627.
13. Lydon J. P., De Mayo F. J., Conneely O. M. and O'Malley B. W.: Reproductive phenotypes of the progesterone receptor null mutant mouse. J. Steroid Biochem. Molec. Biol. 56 (1996) 67-77.
14. Neef G., Beier S., Elger W., Henderson D. and Wiechert R.: New steroids with antiprogestational and antiglucocorticoid activities. Steroids 44 (1984) 349-372.
15. Tsafriri A., Abisogun A. and Reich R.: Steroids and follicular rupture at ovulation. J. Steroid Biochem. 27 (1987) 359-361.
16. Tanaka N., Iwamasa J., Matsuura K. and Okamura H.: Effects of progesterone and anti-progesterone RU 486 on ovarian 3β-hydroxysteroid dehydrogenase activity during ovulation in the gonadotrophin-primed immature rat. J. Reprod. Fertil. 97 (1993) 167-172.
17. Uilenbroek J., Sánchez-Criado J. and Karels B.: Decreased luteinizing hormone-stimulated progesterone secretion by preovulatory follicles isolated from cyclic rats treated with the progesterone antagonist RU 486. Biol. Reprod. 47 (1992) 368-373.
18. Brann D. W. and Mahesh V. B.: Regulation of gonadotropin secretion by steroid hormones. Front. Neuroendocr. 12 (1991) 165-207.
19. Park O.-K. and Mayo K.: Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Molec. Endocrinol. 5 (1991) 967-978.
20. Park O.-K. and Mayo K.: Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3′, 5′-monophosphate in rat granulosa cells. Endocrinology 134 (1994) 709-718.
21. Hsueh A., Adashi E., Jones P. and Welsh T. Jr: Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr. Rev. 5 (1984) 76-127.
22. Saiduddin S. and Zassenhaus H.: Estradiol-17β receptors in the immature rat ovary. Steroids 29 (1977) 197-213.
23. Kim I. and Greenwald G.: Effect of estrogens on follicular development and ovarian and uterine estrogen receptors in the immature rabbit, guinea pig and mouse. Endocr. Japon. 34 (1987) 871-878.
24. Suzuki T., Sasano H., Kimura N., Tamura M., Fukaya T., Yajima A. and Nagura H.: Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes. Human Reprod. 9 (1994) 1589-1595.
25. Schubert C., Michna H. and Nishino Y.: Disturbance of follicular development and endocrine reactions induced by the antiovulatory effective progesterone antagonist Onapristone. Ann. Anat. 177 (1995) 139-146.
26. Sánchez-Criado J., Galiot F., Bellido C., Gonzalez D. and Tébar M.: Hypothalamus-pituitary-ovarian axis in cyclic rats lacking progesterone actions. Biol. Reprod. 48 (1993) 916-925.
27. Richards J.: Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation. Physiol. Rev. 60 (1980) 51-89.
28. 3H-estradiol in target tissues. Endocrinology 85 (1969) 31-37.
29. Payne R., Hellbaum A. and Owens J. Jr: The effect of androgens on the ovaries and uterus of the estrogen-treated hypophysectomized immature rat. Endocrinology 59 (1956) 275-278.
30. Hillier S., Knazek R. and Ross G.: Androgenic stimulation of progesterone production by granulosa cells from preantral ovarian follicles further in vitro studies using replicate cell cultures. Endocrinology 100 (1977) 1539-1549.
31. Erickson G.: An analysis of follicle development and ovum maturation. Semin. Reprod. Endocr. 4 (1986) 233-254.
32. Beyer C., Cruz M., Gay V. and Jaffe R.: Effects of testosterone and dihydrotestosterone on FSH serum concentration and follicular growth in female rats. Endocrinology 95 (1974) 722-727.
33. Kumari G., Datta J., Das R. and Roy S.: Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats. Hormone Res. 9 (1978) 112-120.
34. Mori T., Suzuki A., Nishimura T. and Kambegawa A.: Evidence for androgen participation in induced ovulation in immature rats. Endocrinology 101 (1977) 623-626.
35. Welsh T., Jones P., Ruiz de Galarreta C., Fanjul L. and Hsueh A.: Androgen regulation of progestin biosynthetic enzymes in FSH-treated rat granulosa cells in vitro. Steroids 40 (1982) 691-700.