The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat

Journal of Steroid Biochemistry and Molecular Biology

Volumn 59, Issue 1, 1996, Pages 75-82

  Schubert, C ^a   Donath, J ^b   Michna, H ^c   Nishino, Y ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b BAYER PHARMA AG   (Germany)

^c Dept of Morphology and Tum R ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; ESTRADIOL; LUTEINIZING HORMONE; ONAPRISTONE; PROGESTERONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; DEVELOPMENT; ENDOMETRIUM; FEMALE; HISTOLOGY; LUTEINIZING HORMONE RELEASE; MAMMARY GLAND; MENSTRUAL CYCLE; NONHUMAN; OVULATION INHIBITION; PROGESTERONE RELEASE; RABBIT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANDROSTENES; ANIMALS; DEPRESSION, CHEMICAL; ENDOMETRIUM; ESTRADIOL; ESTRUS; FEMALE; GONANES; HORMONE ANTAGONISTS; LUTEINIZING HORMONE; MAMMARY GLANDS, ANIMAL; OVULATION; OVULATION INDUCTION; PROGESTERONE; RABBITS; RATS; TESTOSTERONE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0030239235     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00090-8     Document Type: Article

References (33)

1. 1. Philibert D., Moguilewsky M., Mary I., Lecaque D., Tournemine C., Secchi J. and Deraedt R.: Pharmacological profile of RU 486 in animals. In The antiprogestin steroid RU 486 and human fertility control (Edited by Baulieu E. E. and Segal S. J.). Plenum Press, New York (1985) pp. 49-68.
2. 2. Rao I. M. and Mahesh V. B.: Role of progesterone in the modulation of the preovulatory surge of gonadotropins and ovulation in the pregnant mare's serum gonadotropin-primed immature rat and adult rat. Biol. Reprod. 26 (1986) 513-520.
3. 3. Elger W., Beier S., Puri C. P., Pollow K., Chwalisz K., Fähnrich M., Hasan S. H. and Neef G.: Comparative pharmacological studies on new progesterone-antagonists in cyclic and pregnant animals and their therapeutic perspectives. Satellite meeting on new aspects of gynaecological endocrinology. Endocr. Nichidoku-iho 33 (1988) 170-186.
4. 4. Michna H., Nishino Y., Schneider M. R., Louton T. and El Etreby M. F.: A bioassay for the evaluation of antiproliferative potencies of progesterone antagonists. J. Steroid Biochem. 38 (1991) 359-365.
5. 5. Philibert D.: RU 38 486: a multificated antihormone in vivo. In Adrenalsteroid antagonisms (Edited by Agrawal M. K.). Walter de Gruyter, Berlin, New York (1984) pp. 77-97.
6. 6. Elger W. A. G.: Effects of prostaglandins and progesterone antagonists on early pregnancy in guinea pigs, in comparison with ovariectomy. In Early pregnancy factors (Edited by Ellendorff F. and Koch E.). Perinatology Press, New York (1987) pp. 47-51.
7. 7. Baulieu E. E. and Ulmann A.: Mini Review: Antiprogesterone activity of RU486 and its contragestive and other applications. Human Reprod. 1(2) (1986) 107-110.
8. 8. van der Schoot P., Bakker G. H. and Klijn J. G. M.: Effects of the progesterone antagonist RU 486 on ovarian activity in the rat. Endocrinology 121 (1987) 1375-1382.
9. 9. Sanchez-Criado J. E., Uilenbroek J.Th.J. and de Jong F. H.: Antiprogesterone RU 486 increases serum immunoreactive inhibin levels and LH:FSH and testosterone:estradiol ratios in cyclic rats. J. Endocr. 134 (1992) 51-57.
10. 10. Schubert C., Nishino Y. and Michna H.: Disturbance of follicular development and endocrine reactions induced by the antiovulatory effective progesterone antagonist Onapristone. Ann. Anat. 177 (1995) 139-146.
11. 11. Erickson G. F.: An analysis of follicle development and ovum maturation. Semin. Reprod. Endocr. 4 (1986) 233-254.
12. 12. Saiduddin S. and Zassenhaus H. P.: Effect of testosterone and progesterone on estradiol receptor in the immature rat ovary. Endocrinology 102 (1978) 1069-1076.
13. 13. Louvet J.-P., Harman S. M. and Ross G. T.: Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone on ovarian weights in estrogen-primed hypophysectomized immature female rats. Endocrinology 96 (1975) 1179-1186.
14. 14. Louvet J.-P., Harman S. M., Schreiber J. R. and Ross G. T.: Evidence for a role of androgens in follicular maturation. Endocrinology 97 (1975) 366-372.
15. 15. Chacravorty A., Mahesh V. B. and Mills T. M.: Inhibition by diethylstilboestrol of proliferative potential of follicles of different sizes in immature rat ovaries. J. Reprod. Fertil. 92 (1991) 323-332.
16. 16. Chacravorty A., Mahesh V. B. and Mills T. M.: Regulation of follicular development by diethylstilboestrol in ovaries of immature rats. J. Reprod. Fertil. 92 (1991) 307-321.
17. 17. Uilenbroek J. Th. J., Sanchez-Criado J. E. and Karel B.: Decreased luteinizing hormone-stimulated progesterone secretion by preovulatory follicles from cyclic rats treated with the progesterone antagonist RU 486. Biol. Reprod. 47 (1992) 368-373.
18. 18. Takahashi M., Ford J. J., Yoshinaga K. and Greep R. O.: Induction of ovulation in hypophysectomized rats by progesterone. Endocrinology 95 (1974) 1322-1326.
19. 19. Snyder B. W., Beecham G. D. and Schane H. P.: Inhibition of ovulation in rats with epostane, an inhibitor of 3β-hydroxysteroid dehydrogenase (41865). Proc. Soc. Exp. Biol. Med. 176 (1984) 238-242.
20. 20. Zalan S.: Antiprogesterone blocks LH peak and ovulation. 1st European Congress on Endocrinology, Copenhagen, Denmark, 21-25 June 1987 [Abstr. 184].
21. 21. Uilenbroek J. Th. J.: Hormone concentrations and ovulatory response in rats treated with antiprogestagens. J. Endocr. 129 (1991) 423-429.
22. 22. Neef G., Beier S., Elger W., Henderson D. and Wiechert R.: New steroids with antiprogestational and antiglucocorticoid activities. Steroids 44 (1984) 349-372.
23. 23. Ottow E., Chwalisz K., Klar U. and Michna H.: German patent: DE-A 4216003.
24. 24. Clauberg C.: Der biologische Test für das Corpus-luteum-Hormon. Klin. Wschr. 9 (1930) 2004-2005.
25. 25. McPhail M. K.: The assay of progestin. J. Physiol. (London) 83 (1934) 145-156.
26. 26. Iwamasa J., Shibata S., Tanaka N., Matsuura K. and Okamura H.: The relationship between ovarian progesterone and proteolytic enzyme activity during ovulation in the gonadotropin-treated immature rat. Biol. Reprod. 46 (1992) 309-313.
27. 27. Sanchez-Criado J. E., Bellido C., Galiot F., Lopez F. J. and Gaytan F.: A possible dual mechanism of the antiovulatory action of antiprogesterone RU 486 in the rat. Biol. Reprod. 42 (1990) 877-886.
28. 28. Falck B., Menander K. and Nordanstedt O.: Androgen secretion in the rat ovary. Nature 193 (1962) 593-594.
29. 29. Erickson G. F., Magoffin D. A., Dyer C. A. and Hofeditz C.: The ovarian androgen producing cells. A review of structure/ function relatonships. Endocr. Rev. 6 (1985) 371-399.
30. 30. Sanchez-Criado J. E., Tebar M., Sanchez A. and Gaytan F.: Evidence that androgens are involved in atresia and anovulation induced by antiprogesterone RU 486 in rats. J. Reprod. Fertil. 99 (1993) 173-179.
31. 31. Tanaka N., Iwamasa J., Matsuura K. and Okamura H.: Effects of progesterone and antiprogesterone RU 486 on ovarian 3β-hydroxysteroid-dehydrogenase activity during ovulation in the gonadotrophin-primed immature rat. J. Reprod. Fertil. 97 (1993) 167-172.
32. 32. Beers W. H.: Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall. Cell 6 (1975) 379-386.
33. 33. Downs S. M. and Long F. J.: An ultrastructural study of preovulatory development in mouse ovarian follicles: effects of Indomethacin. Anat. Res. 205 (1983) 159-168.