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Volumn 22, Issue 5, 2000, Pages 513-521

Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') are attenuated by the serotonin uptake inhibitor citalopram

Author keywords

3,4 Methylenedioxymethamphetamine; Citalopram; Ecstasy; MDMA; Psychological effects; Selective serotonin reuptake inhibitors; Serotonin

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CITALOPRAM; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

EID: 0034061432     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00148-7     Document Type: Article
Times cited : (209)

References (50)
  • 1
    • 0023914535 scopus 로고
    • Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites
    • Battaglia G., Brooks B.P., Kulsakdinum C., De Souza E.B. Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. Eur J Pharmacol. 149:1988;159-163.
    • (1988) Eur J Pharmacol , vol.149 , pp. 159-163
    • Battaglia, G.1    Brooks, B.P.2    Kulsakdinum, C.3    De Souza, E.B.4
  • 2
    • 0024779523 scopus 로고
    • Pharmacologic profile of amphetamine derivatives at various brain recognition sites: Selective effects on serotonergic systems
    • Battaglia G., De Souza E.B. Pharmacologic profile of amphetamine derivatives at various brain recognition sites. selective effects on serotonergic systems NIDA Res Monograph. 94:1989;240-258.
    • (1989) NIDA Res Monograph , vol.94 , pp. 240-258
    • Battaglia, G.1    De Souza, E.B.2
  • 3
    • 0029826781 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors
    • Baumann P. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 31:1996;444-469.
    • (1996) Clin Pharmacokinet , vol.31 , pp. 444-469
    • Baumann, P.1
  • 5
    • 0026534558 scopus 로고
    • The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine
    • Berger U.V., Gu X.F., Azmitia E.C. The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur J Pharmacol. 215:1992;153-160.
    • (1992) Eur J Pharmacol , vol.215 , pp. 153-160
    • Berger, U.V.1    Gu, X.F.2    Azmitia, E.C.3
  • 6
    • 0027278178 scopus 로고
    • Effect of acute monoamine depletion on 3,4- methylenedioxymethamphetamine-induced neurotoxicity
    • Brodkin J., Malyala A., Nash J.F. Effect of acute monoamine depletion on 3,4- methylenedioxymethamphetamine-induced neurotoxicity. Pharmacol Biochem Behav. 45:1993;647-653.
    • (1993) Pharmacol Biochem Behav , vol.45 , pp. 647-653
    • Brodkin, J.1    Malyala, A.2    Nash, J.F.3
  • 7
    • 0031824265 scopus 로고    scopus 로고
    • The standardized psychometric assessment of altered states of consciousness (ASCs) in humans
    • Dittrich A. The standardized psychometric assessment of altered states of consciousness (ASCs) in humans. Pharmacopsychiat. 31:1998;80-84.
    • (1998) Pharmacopsychiat , vol.31 , pp. 80-84
    • Dittrich, A.1
  • 8
    • 0001288904 scopus 로고
    • International study on altered states of consciousness (ISASC). Summary of the results
    • Dittrich A., von Arx S., Staub S. International study on altered states of consciousness (ISASC). Summary of the results. Germ J Psych. 9:1985;319-339.
    • (1985) Germ J Psych , vol.9 , pp. 319-339
    • Dittrich, A.1    Von Arx, S.2    Staub, S.3
  • 10
    • 0025634097 scopus 로고
    • Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices
    • Fitzgerald J.L., Reid J.J. Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices. Eur J Pharmacol. 191:1990;217-220.
    • (1990) Eur J Pharmacol , vol.191 , pp. 217-220
    • Fitzgerald, J.L.1    Reid, J.J.2
  • 12
    • 0029067178 scopus 로고    scopus 로고
    • Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxydmethamphetamine (MDMA or "ecstasy")
    • Green A.R., Cross A.J., Goodwin G.M. Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxydmethamphetamine (MDMA or "Ecstasy"). Psychopharmacology. 119:1996;247-260.
    • (1996) Psychopharmacology , vol.119 , pp. 247-260
    • Green, A.R.1    Cross, A.J.2    Goodwin, G.M.3
  • 13
    • 0027315361 scopus 로고
    • Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons
    • Gu X.F., Azmitia E.C. Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons. Eur J Pharmacol. 235:1993;51-57.
    • (1993) Eur J Pharmacol , vol.235 , pp. 51-57
    • Gu, X.F.1    Azmitia, E.C.2
  • 14
    • 0030070015 scopus 로고    scopus 로고
    • Carrier-mediated release of serotonin by 3,4- methylenedioxymethamphetamine: Implications for serotonin-dopamine interactions
    • Gudelsky G.A., Nash J.F. Carrier-mediated release of serotonin by 3,4- methylenedioxymethamphetamine. implications for serotonin-dopamine interactions J Neurochem. 66:1996;243-249.
    • (1996) J Neurochem , vol.66 , pp. 243-249
    • Gudelsky, G.A.1    Nash, J.F.2
  • 15
    • 0032979515 scopus 로고    scopus 로고
    • 3,4-methylenedioxy analogues of amphetamine: Defining the risks to humans
    • Hegadoren K.M., Baker G.B., Bourin M. 3,4-methylenedioxy analogues of amphetamine. defining the risks to humans Neurosci Biobehav Rev. 23:1999;539-553.
    • (1999) Neurosci Biobehav Rev , vol.23 , pp. 539-553
    • Hegadoren, K.M.1    Baker, G.B.2    Bourin, M.3
  • 16
    • 0025020487 scopus 로고
    • 5-Hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents
    • Hekmatpanah C.R., Peroutka S.J. 5-Hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. Eur J Pharmacol. 177:1990;95-98.
    • (1990) Eur J Pharmacol , vol.177 , pp. 95-98
    • Hekmatpanah, C.R.1    Peroutka, S.J.2
  • 17
    • 0029846521 scopus 로고    scopus 로고
    • Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS
    • Helmlin H.J., Bracher K., Bourquin D., Vonlanthen D., Brenneisen R. Analysis of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. J Anal Toxicol. 20:1996;432-440.
    • (1996) J Anal Toxicol , vol.20 , pp. 432-440
    • Helmlin, H.J.1    Bracher, K.2    Bourquin, D.3    Vonlanthen, D.4    Brenneisen, R.5
  • 19
    • 0024383159 scopus 로고
    • 3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys
    • Insel T.R., Battaglia G., Johannessen J.N., Marra S., De Souza E.B. 3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys. J Pharmacol Exp Ther. 249:1989;713-720.
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 713-720
    • Insel, T.R.1    Battaglia, G.2    Johannessen, J.N.3    Marra, S.4    De Souza, E.B.5
  • 21
    • 0030909052 scopus 로고    scopus 로고
    • MDMA induced dopamine release in vivo: Role of endogenous serotonin
    • Koch S., Galloway M.P. MDMA induced dopamine release in vivo. role of endogenous serotonin J Neural Transm. 104:1997;135-146.
    • (1997) J Neural Transm , vol.104 , pp. 135-146
    • Koch, S.1    Galloway, M.P.2
  • 23
    • 0030603241 scopus 로고    scopus 로고
    • Prolactin response to fenfluramine is independent of serotonin release
    • McCann U.D., Hatzidimitriou G., Ricaurte G.A. Prolactin response to fenfluramine is independent of serotonin release. Eur J Pharmacol. 312:1996;R1-R2.
    • (1996) Eur J Pharmacol , vol.312
    • McCann, U.D.1    Hatzidimitriou, G.2    Ricaurte, G.A.3
  • 24
    • 0027230237 scopus 로고
    • Reinforcing subjective effects of (+/-) 3,4- methylenedioxymethamphetamine ("Ecstasy") may be separable from its neurotoxic actions: Clinical evidence
    • McCann U.D., Ricaurte G.A. Reinforcing subjective effects of (+/-) 3,4- methylenedioxymethamphetamine ("Ecstasy") may be separable from its neurotoxic actions. clinical evidence J Clin Psychopharmacol. 13:1993;214-217.
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 214-217
    • McCann, U.D.1    Ricaurte, G.A.2
  • 25
    • 0032585201 scopus 로고    scopus 로고
    • Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings
    • McCann U.D., Szabo Z., Scheffel U., Dannals R.F., Ricaurte G.A. Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. The Lancet. 352:1998;1433-1437.
    • (1998) The Lancet , vol.352 , pp. 1433-1437
    • McCann, U.D.1    Szabo, Z.2    Scheffel, U.3    Dannals, R.F.4    Ricaurte, G.A.5
  • 26
    • 0025977820 scopus 로고
    • 3,4-Methylendioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine
    • McKenna D.J., Guan X.-M., Shulgin A.T. 3,4-Methylendioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine. Pharmacol Biochem Behav. 38:1991;505-512.
    • (1991) Pharmacol Biochem Behav , vol.38 , pp. 505-512
    • McKenna, D.J.1    Guan, X.-M.2    Shulgin, A.T.3
  • 27
    • 0025976411 scopus 로고
    • Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness
    • Milne R.J., Goa K.L. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 41:1991;450-477.
    • (1991) Drugs , vol.41 , pp. 450-477
    • Milne, R.J.1    Goa, K.L.2
  • 28
    • 0025695028 scopus 로고
    • Ketanserin pretreatment attenuates MDMA induced dopamine release in the striatum as measured by in vivo microdialysis
    • Nash J.F. Ketanserin pretreatment attenuates MDMA induced dopamine release in the striatum as measured by in vivo microdialysis. Life Sciences. 47:1990;2401-2408.
    • (1990) Life Sciences , vol.47 , pp. 2401-2408
    • Nash, J.F.1
  • 29
    • 0026326549 scopus 로고
    • Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: Effect of dopamine uptake inhibitors
    • Nash J.F., Brodkin J. Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release. effect of dopamine uptake inhibitors J Pharmac Exp Ther. 259:1991;820-825.
    • (1991) J Pharmac Exp Ther , vol.259 , pp. 820-825
    • Nash, J.F.1    Brodkin, J.2
  • 31
    • 0022838197 scopus 로고
    • Differences between the mechanism of action of MDMA, MBDB, and the classical hallucinogens. Identification of a new therapeutic class: Entactogens
    • Nichols D.E. Differences between the mechanism of action of MDMA, MBDB, and the classical hallucinogens. Identification of a new therapeutic class. Entactogens J Psychoactive Drugs. 18:1986;305-313.
    • (1986) J Psychoactive Drugs , vol.18 , pp. 305-313
    • Nichols, D.E.1
  • 32
    • 0020326405 scopus 로고
    • Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes
    • Nichols D.E., Lloyd D.H., Hoffman A.J., Nichols M.B., Yim G.K. Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes. J Med Chem. 25:1982;530-535.
    • (1982) J Med Chem , vol.25 , pp. 530-535
    • Nichols, D.E.1    Lloyd, D.H.2    Hoffman, A.J.3    Nichols, M.B.4    Yim, G.K.5
  • 33
    • 0033618638 scopus 로고    scopus 로고
    • Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
    • Ramamoorthy S., Blakely R.D. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science. 285:1999;763-766.
    • (1999) Science , vol.285 , pp. 763-766
    • Ramamoorthy, S.1    Blakely, R.D.2
  • 34
    • 0023797477 scopus 로고
    • 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates
    • Ricaurte G.A., DeLanney L.E., Wiener S.G., Irwin I., Langston J.W. 5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates. Brain Res. 474:1988;359-363.
    • (1988) Brain Res , vol.474 , pp. 359-363
    • Ricaurte, G.A.1    Delanney, L.E.2    Wiener, S.G.3    Irwin, I.4    Langston, J.W.5
  • 35
    • 0026546876 scopus 로고
    • The molecular mechanism of "ecstasy" [3,4-methylenedioxy methamphetamine (MDMA)] serotonin transporters are targets for MDMA-induced serotonin release
    • Rudnick G., Wall S.C. The molecular mechanism of "Ecstasy" [3,4-methylenedioxy methamphetamine (MDMA)] serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci U S A. 89:1992;1817-1821.
    • (1992) Proc Natl Acad Sci U S a , vol.89 , pp. 1817-1821
    • Rudnick, G.1    Wall, S.C.2
  • 36
    • 0038053779 scopus 로고
    • Neurochemistry of serotonin neuronal systems: Consquences of serotonin receptor activation
    • In Meltzer HY (ed), New York, Raven Press
    • Sanders-Bush E, Conn PJ (1987): Neurochemistry of serotonin neuronal systems: consquences of serotonin receptor activation. In Meltzer HY (ed), Psychophar-macology: The Third Generation of Progress, New York, Raven Press, pp 95-103.
    • (1987) Psychophar-macology: The Third Generation of Progress , pp. 95-103
    • Sanders-Bush, E.1    Conn, P.J.2
  • 37
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt C.J. Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J Pharmac Exp Ther. 240:1987;240-247.
    • (1987) J Pharmac Exp Ther , vol.240 , pp. 240-247
    • Schmidt, C.J.1
  • 38
    • 0026613672 scopus 로고
    • 5-HT2 receptors exert a state-dependent regulation of dopaminergic function: Studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymeth-amphetamine
    • Schmidt C.J., Fadayel G.M., Sullivan C.K., Taylor V.L. 5-HT2 receptors exert a state-dependent regulation of dopaminergic function. studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymeth-amphetamine Eur J Pharmacol. 223:1992;65-74.
    • (1992) Eur J Pharmacol , vol.223 , pp. 65-74
    • Schmidt, C.J.1    Fadayel, G.M.2    Sullivan, C.K.3    Taylor, V.L.4
  • 39
    • 0023109989 scopus 로고
    • In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
    • Schmidt C.J., Levin J.A., Lovenberg W. In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem Pharmacol. 36:1987;747-755.
    • (1987) Biochem Pharmacol , vol.36 , pp. 747-755
    • Schmidt, C.J.1    Levin, J.A.2    Lovenberg, W.3
  • 40
    • 0028176861 scopus 로고
    • Blockade of striatal 5-hydroxytryptamine2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine
    • Schmidt C.J., Sullivan C.K., Fadayel G.M. Blockade of striatal 5-hydroxytryptamine2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine. J Neurochem. 62:1994;1382-1389.
    • (1994) J Neurochem , vol.62 , pp. 1382-1389
    • Schmidt, C.J.1    Sullivan, C.K.2    Fadayel, G.M.3
  • 41
    • 0031749512 scopus 로고    scopus 로고
    • An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine
    • Sprague J.E., Everman S.L., Nichols D.E. An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology. 19:1998;427-441.
    • (1998) Neurotoxicology , vol.19 , pp. 427-441
    • Sprague, J.E.1    Everman, S.L.2    Nichols, D.E.3
  • 42
    • 0023228746 scopus 로고
    • 3H]monoamines into synaptosomes from different regions of rat brain
    • 3H]monoamines into synaptosomes from different regions of rat brain. Biochem Pharmacol. 36:1987;2297-2303.
    • (1987) Biochem Pharmacol , vol.36 , pp. 2297-2303
    • Steele, T.D.1    Nichols, D.E.2    Yim, G.K.W.3
  • 43
    • 0028178550 scopus 로고
    • The demethylenation of methylenedioxymethamphetamine ("Ecstasy") by debrisoquine hydroxylase (CYP2D6)
    • Tucker G.T., Lennard M.S., Ellis S.W., Woods H.F., Cho A.K., Lin L.Y. The demethylenation of methylenedioxymethamphetamine ("Ecstasy") by debrisoquine hydroxylase (CYP2D6). Biochem Pharmacol. 47:1994;1151-1156.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1151-1156
    • Tucker, G.T.1    Lennard, M.S.2    Ellis, S.W.3    Woods, H.F.4    Cho, A.K.5    Lin, L.Y.6
  • 44
    • 0031783570 scopus 로고    scopus 로고
    • Psychological and cardiovascular effects and short-term sequelae of MDMA ("Ecstasy") in MDMA-naive healthy volunteers
    • a
    • Vollenweider F.X., Gamma A., Liechti M., Huber T. Psychological and cardiovascular effects and short-term sequelae of MDMA ("Ecstasy") in MDMA-naive healthy volunteers. Neuropsychopharmacology. 19:1998;241-251. a.
    • (1998) Neuropsychopharmacology , vol.19 , pp. 241-251
    • Vollenweider, F.X.1    Gamma, A.2    Liechti, M.3    Huber, T.4
  • 46
    • 0032924820 scopus 로고    scopus 로고
    • Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans
    • b
    • Vollenweider F.X., Remensberger S., Hell D., Geyer M.A. Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans. Psychopharmacology. 143:1999;365-372. b.
    • (1999) Psychopharmacology , vol.143 , pp. 365-372
    • Vollenweider, F.X.1    Remensberger, S.2    Hell, D.3    Geyer, M.A.4
  • 48
    • 0030218082 scopus 로고    scopus 로고
    • The effects of methylenedioxymethamphetamine (MDMA, "ecstasy") on monoaminergic neurotransmission in the central nervous system
    • White S.R., Obradovic K.M., Wheaton I., Wheaton M.J. The effects of methylenedioxymethamphetamine (MDMA, "Ecstasy") on monoaminergic neurotransmission in the central nervous system. Prog Neurobiol. 49:1996;455-479.
    • (1996) Prog Neurobiol , vol.49 , pp. 455-479
    • White, S.R.1    Obradovic, K.M.2    Wheaton, I.3    Wheaton, M.J.4
  • 49
    • 0029037007 scopus 로고
    • Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra
    • Yamamoto B.K., Nash J.F., Gudelsky G.A. Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra. J Pharmac Exp Ther. 273:1995;1063-1070.
    • (1995) J Pharmac Exp Ther , vol.273 , pp. 1063-1070
    • Yamamoto, B.K.1    Nash, J.F.2    Gudelsky, G.A.3
  • 50
    • 0023870334 scopus 로고
    • The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat
    • Yamamoto B.K., Spanos L.J. The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat. Eur J Pharmacol. 148:1988;195-203.
    • (1988) Eur J Pharmacol , vol.148 , pp. 195-203
    • Yamamoto, B.K.1    Spanos, L.J.2


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