The molecular pharmacology of lysophosphatidate signaling

Annals of the New York Academy of Sciences

Volumn 905, Issue , 2000, Pages 232-241

  Santos, Webster L ^a   Rossi, Jason A ^a   Boggs, Sharon D ^a   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID; PHOSPHATE;

CONFERENCE PAPER; LIPOPHILICITY; PHARMACOLOGY; STEREOCHEMISTRY;

EID: 0034060487     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06553.x     Document Type: Conference Paper

References (25)

1. 1. TOKUMURA, A., K. FUKUZAWA, J. ISOBE & H. TSUKATANI. 1981. Lysophosphatidic acid-induced aggregation of human and feline platelets: structure-activity relationship. Biochem. Biophys. Res. Commun. 99: 391-398.
2. 2. WATSON, P.S., R.T. MCCONNELL & E.G. LAPETINA. 1985. Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Biochem. J. 232: 61-66.
3. 3. TOKUMURA, A., N. YUBE, H. FUJIMOTO & H. TSUKATANI. 1991. Lysophosphatidic acids induce contraction of rat isolated colon by two different mechanisms. J. Pharm. Pharmacol. 43: 774-778.
4. 4. TOKOMURA, A., K. FUKUZAWA, S. YAMADA & H. TSUKATANI. 1980. Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregnant rats. Arch. Int. Pharmacodyn. 245: 74-83.
5. 5. SUIDAN, H.S., C.D. NOBES, A. HALL & D. MONARD. 1997. Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase. GLIA 21: 244-252.
6. 2+-mobilizing stimulus for fibroblasts. J. Biol. Chem. 265: 12232-12239.
7. 7. VAN CORVEN, E.J., A. VAN RIJSWIJK, K. JALINK, R.L. VAN DER BEND, W.J. VAN BLITTERSWIJK & W.H. MOOLENAAR. 1992. Mitogenic action of lysophosphatidic acid and phosphatidic acid. Biochem. J. 281: 163-169.
8. 1/ Edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad. Sci. U.S.A. 95: 6151-6156.
9. 9. HECHT, J.H., J.A. WEINER, S.R. POST & J. CHUN. 1996. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135: 1071-1083.
10. 10. AN, S., T. BLEU, W. HUANG, O.G. HALLMARK, S.R. COUGHLIN & E.J. GOETZL. 1997. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. Biochem. J. 317: 279-282.
11. 11. AN, S., M.A. DICKENS, O.G. HALLMARK & E.J. GOETZL. 1997. Molecular cloning of the human Edg protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231: 619-622.
12. 12. LEE, M-J., J.R. VAN BROOKLYN, S. THANGADA, C.H. LIU, A.R. HAND, R. MENZELEEV, S. SPIEGEL & T. HLA. 1998. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor Edg-1. Science 279: 1552-1554.
13. 13. ZONDAG, G.C.M., F.R. POSTMA, I. VAN ETTEN, I. VERLAAN & W.H. MOOLENAAR. 1998. Sphingosine 1-phosphate signaling through the G-protein-coupled receptor Edg-1. Biochem. J. 330: 605-609.
14. 14. MOOLENAAR, W.H., O. KRANENBURG, F.R. POSTMA & C.M. ZONDAG. 1997. Lysophosphatidic acid: G-protein signaling and cellular responses. Curr. Opin. Cell Biol. 9: 168-173.
15. 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem. 273: 4653-4659.
16. 16. HOPPER, D.W., S.P. RAGAN, S.B. HOOKS, K.R. LYNCH & T.L. MACDONALD. 1999. Structure-activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. J. Med. Chem. 42: 963-970.
17. 17. HOOKS, S.B., S.P. RAGAN, D.W. HOPPER, C.W. HONEMANN, M.E. DURIEUX, T.L. MACDONALD & K.R. LYNCH. 1998. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Mol. Pharmacol. 53: 188-194.
18. 2+ mobilization in human A431 cells: structure-activity analysis. Biochem. J. 307: 609-616.
19. 19. HOPPER, D.W., J.G. CATALANO & T.L. MACDONALD. 1996. Facile synthesis of lysophospholipids containing unsaturated fatty acid chains. Tetrahedron Lett. 37: 7871-7874.
20. 20. TOKUMURA, A., K. FUKUZAWA & H. TSUKATANI. 1978. Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species. Lipids 13: 572-574.
21. 21. LYNCH, K., D.W. HOPPER, S.J. CARLISLE, J.G. CATALANO, M. ZHANG & T.L. MACDONALD. 1997. Structure/activity relationships in lysophosphatidic acid: the hydroxyl moiety. Mol. Pharmacol. 52: 75-81.
22. 22. Rossi, J., D.W. HOPPER, S.P. RAGAN, K.E. ROUTENBERG, K.R. LYNCH & T.L. MACDONALD. 1999. Manuscript in preparation.
23. 23. SUGIURA, T., A. TOKUMURA, L. GREGORY, T. NOUCHI, S.T. WEINTRAUB & D.J. HANAHAN. 1994. Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor. Arch. Biochem. Biophys. 311: 358-368.
24. 24. LILIOM, K., R. BITTMAN, B. SWORDS & G. TIGYI. 1996. N-Palmitoyl-serine and N-Palmitoyl-tyrosine phosphoric acids are selective antagonists of the lysophosphatidic acid receptors. Mol. Pharmacol. 50: 616-623.
25. 25. BOGGS, S.D., D. IM, C. HEISE, D.W. HOPPER, K.R. LYNCH & T.L. MACDONALD. 1999. Modifications at the 2-position of the lysophosphatidic acid analog N-palmitoyl serine phosphoric acid. Bioorg. Med. Chem. Lett. Submitted.