A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students

Psychoneuroendocrinology

Volumn 25, Issue 4, 2000, Pages 339-356

  Lacey, K ^a   Zaharia, M D ^a   Griffiths, J ^b   Ravindran, A V ^b   Merali, Z ^b   Anisman, H ^a  

^a CARLETON UNIVERSITY   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Anticipatory stress; Cortisol; Interleukin 1; Lymphocyte proliferation

Indexed keywords

CORTICOTROPIN; CYTOKINE; INTERLEUKIN 1BETA; PROLACTIN;

ACADEMIC ACHIEVEMENT; ADULT; CONTROLLED STUDY; EDUCATION; EXAMINATION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MALE; NEUROENDOCRINOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; REVIEW; STRESS; STUDENT; WELLBEING;

EID: 0034059955     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(99)00059-1     Document Type: Article

References (60)

1. Anisman, H., Merali, Z., 1999. Defining Stress: caveats and limitations. Alcohol World: Health and Research (in press).
2. Anisman H., Ravindran A.V., Griffiths J., Merali Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol. Psychiat. 4:1999;182-188.
3. Anisman H., Lu Z.W., Song C., Kent P., McIntyre D.C., Merali Z. Influence of psychogenic and neurogenic stressors on endocrine and immune activity: differential effects in fast and slow seizing rat strains. Brain Behav. Immun. 11:1997;63-74.
4. Anisman H., Zalcman S., Zacharko R.M. The impact of stressors on immune and central neurotransmitter activity: bidirectional communication. Rev. Neurosci. 4:1993;147-180.
5. Beckham E.E., Adams R.L. Coping behavior in depression: report on a new scale. Behav. Res. Ther. 22:1984;71-75.
6. Benschop R.J., Nieuwenhuis E.E.S., Tromp E.A.M., Godaert G.L.R., Ballieux R.E., van Doornen L.J.P. Effects of β-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress. Circulation. 89:1994;762-769.
7. Cacioppo J.T., Malarkey W.B., Kiecolt-Glaser J.K., Uchino B.N., Sgoutas-Emch S.A., Sheridan J.F., Berntson G.G., Glaser R. Heterogeneity in neuroendocrine and immune responses to brief psychological stressors as a function of autonomic cardiac activation. Psychosom. Med. 57:1995;154-164.
8. Cohen S., Williamson G.M. Stress and infectious disease in humans. Psychol. Bull. 109:1991;5-24.
9. Cohen S., Kamarck T., Mermelstein R. A global measure of perceived stress. J. Health Soc. Behav. 24:1983;385-396.
10. Covelli V., Massari F., Fallacara C., Munno I., Jirillo E. Interleukin-1β and β-endorphin circadian rhythms are inversely related in normal and stress-altered sleep. Int. J. Neurosci. 63:1992;299-305.
11. De Groote D, Gevaert Y, Lopez M, Gathy R, Fauchet F, Dehart I, Jadoul M, Radoux D, Franchimont P. Novel method for the measurement of cytokine production by a one-stage procedure. J. Immunol. Methods. 163:1993;259-267.
12. Dorian B., Garfinkle P., Brown G., Shore A., Gladman D., Keystone E. Aberrations in lymphocyte subpopulations and function during psychological stress. Clin. Exp. Immunol. 50:1982;132-138.
13. Dugue B., Leppanen E.A., Teppo A.M., Fyhrquist F., Grasbeck R. Effects of psychological stress on plasma interleukins-1β and 6, C-reactive protein, tumor necrosis factor alpha, anti-diuretic hormone and serum cortisol. Scand. J. Clin. Lab. Invest. 53:1993;555-561.
14. Futterman A.D., Kemeny M.E., Shapiro D., Fahey J.L. Immunological and physiological changes associated with induced positive and negative mood. Psychosom. Med. 56:1994;499-511.
15. Glaser R., Kennedy S., Lafuse W.P., Bonneau R.H., Speicher C., Hillhouse J., Kiecolt-Glaser J.K. Psychological stress-induced modulation of interleukin 2 receptor gene expression and interleukin 2 production in peripheral blood leukocytes. Arch. Gen. Psychiat. 47:1990;707-712.
16. Glaser R., Pearl D.K., Kiecolt-Glaser J.K., Malarkey W.B. Plasma cortisol levels and reactivation of latent Epstein-Barr virus in response to examination stress. Psychoneuroendocrinology. 19:1994;765-772.
17. Glaser R., Rice J., Sheridan J., Fertel R., Stout J., Speicher C., Pinsky D., Kotur M., Post A., Beck M., Kiecolt-Glaser J. Stress-related immune suppression: health implications. Brain Behav. Immun. 1:1987;7-20.
18. Griffiths J., Ravindran A.V., Merali Z., Anisman H. Neuroendocrine measures and lymphocyte subsets in depressive illness: Influence of a clinical interview concerning life experiences. Psychoneuroendocrinology. 22:1997;225-236.
19. Harbuz M.S., Lightman S.L. Chronic and immunological activation. J. Endocrinol. 134:1992;327-339.
20. Herbert T.B., Cohen S. Stress and immunity in humans: a meta-analytic review. Psychosom. Med. 55:1993;364-379.
21. Herbert T.B., Cohen S., Marsland A.L., Bachen E.A., Rabin B.S., Muldoon M.F., Manuck S.B. Cardiovascular reactivity and the course of immune response to an acute psychological stressor. Psychosom. Med. 56:1994;337-344.
22. Ironson G., Wynings C., Schneiderman N., Baum A., Rodriguez M., Greenwood D., Benight C., Antoni M., LaPerriere A., Huang H., Klimas N., Fletcher M.A. Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after hurricane Andrew. Psychosom. Med. 59:1997;128-141.
23. Irwin M., Mcclintick J., Costlow C., Fortner M., White J., Gillin J.C. Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB. 10:1996;643-653.
24. Kang D.H., Coe C.L., McCarthy D.O. Academic examinations significantly impact immune responses, but not lung function, in healthy and well-managed asthmatic adolescents. Brain Behav. Immun. 10:1996;164-181.
25. Kiecolt-Glaser J.K., Glaser R. Stress and immune function in humans. Ader R., Felten D.L., Cohen N. Psychoneuroimmunology. 1991;849-867 Academic Press, California.
26. Kiecolt-Glaser J.K., Fisher L.D., Ogrocki P., Stout J.C., Speicher C.E., Glaser R. Marital quality, marital disruption, and immune function. Psychosom. Med. 49:1987;13-34.
27. Kiecolt-Glaser J.K., Garner W., Speicher C., Penn G.M., Holliday J., Glaser R. Psychosocial modifiers of immunocompetence in medical students. Psychosom. Med. 46:1984;7-14.
28. Kiecolt-Glaser J.K, Glaser R., Gravenstein S., Malarkey W.B., Sheridan J. Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc. Natl. Acad. Sci. 93:1996;3043-3047.
29. Kiecolt-Glaser J.K., Glaser R., Strain E.C., Stout J.C., Tarr K.L., Holliday J., Speicher C.E. Modulation of cellular immunity in medical students. J. Behav. Med. 9:1986;5-21.
30. Kirschbaum C., Wust S., Hallhammer D. Consistent sex differences in cortsiol responses to psychological stress. Psychosom. Med. 54:1992;648-657.
31. Kusnecov A.W., Rabin B.S. Stressor-induced alterations of immune function: mechanisms and issues. Int. Arch. Allergy Immunol. 105:1994;107-121.
32. Lazarus R.S. Coping theory and research: past, present, and future. Psychosom. Med. 55:1993;234-247.
33. Lu Z.W., Hayley S., Ravindran A.V., Merali Z., Anisman A. Influence of psychosocial, psychogenic and neurogenic stressors on several aspects of immune functioning in mice. Stress. 3:1999;55-70.
34. Lupien S.J., Gaudreau S., Tchiteya B.M., Maheau F., Sharma S., Nair N.P.V., Hauger R.L., McEwen B.S., Meaney M.J. Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity. J. Clin. Endocrinol. Metab. 82:1997;2070-2075.
35. Lysle D.T., Cunnick J.E., Rabin B.S. Stressor-induced alteration of lymphocyte proliferation in mice: evidence for enhancement of mitogenic responsiveness. Brain Behav. Immun. 4:1990;269-277.
36. Maes M., Hendriks D., Van Gastel A., Demedts P., Wauters A., Neels H., Janca A., Scharpe S. Effects of psychological stress on serum immunoglobulin, complement and acute phase protein concentrations in normal volunteers. Psychoneuroendocrinology. 22:1997;409-414.
37. Maes M., Song C., Lin A., De Jongh R., Van Gastel A., Kenis G., Bosmans E., De Meester I., Benoy I., Neels H., Demedts P., Janca A., Scharpe S., Smith R.S. The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine. 10:1998;313-318.
38. Maes M., Lin A.H., Delmiere L., Van Gastel A., Kenis G., De Jomgh R., Bosmans E. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol. Psychiat. 45:1999;833-839.
39. Maes M., Van Bockstaele D.R., Van Gastel A., Song C., Schotte C., Neels H., DeMeester I, Scharpe S., Janca A. The effects of psychological stress on leukocyte subsert distribution in humans: evidence of immune activation. Biol. Psychiat. 39:1999;1-9.
40. Malarkey W.B., Pearl D.K., Demers L.M., Kiecolt-Glaser J.K., Glaser R. Influence of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and β-endorphin. Psychoneuroendocrinology. 20:1995;499-508.
41. Malarkey W.B., Hall J.C., Pearl D.K., Kiecolt-Glaser J.K., Glaser R. The influence of academic stress and season on 24-hour concentrations of growth hormone and prolactin. J. Clin. Endocrinol. Metab. 73:1991;1089-1092.
42. Marsland A.L., Manuck S.B., Fazzari T.V., Stewart C.J, . Rabin B.S. Stability of individual differences in cellular immune responses to acute psychological stress. Psychosom. Med. 57:1995;295-298.
43. Merali Z., McIntosh J., Kent P., Michaud D., Anisman H. Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala. J. Neurosci. 18:1998;4758-4766.
44. Moldofsky H. Sleep and the immune system. Int. J. Immunopharmacol. 17:1995;649-654.
45. Pearlin L.I., Lieberman M.A., Menaghan E.G., Mulla J.T. The stress process. J. Health Soc. Behav. 22:1981;337-356.
46. Pruessner J.C., Wolf O.T., Hellhammer D.H., Buske-Kirschbaum A., von Auer K., Jobst S., Kaspers F., Kirschbaum C. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci. 61:1997;2539-2549.
47. Ravindran, A.V., Anisman, H., Merali, Z., et al., 1999. Treatment of primary dysthymia with cognitive therapy and pharmacotherapy: Clinical symptoms and functional Impairments. Am. J. Psychiat. (in press).
48. Ravindran A.V., Griffiths J., Merali Z., Anisman H. Lymphocyte subsets in major depression and dysthymia: modification by antidepressant treatment. Psychosom. Med. 57:1995;555-563.
49. Ravindran A.V., Griffiths J., Merali Z, Anisman H. Primary dysthymia: a study of several psychosocial, endocrine and immune correlates. J. Affect. Disord. 40:1996;73-84.
50. Schedlowski M., Wiecher D., Wagner T.O.F., Tewes U. Acute psychological stress increases plasma levels of cortisol, prolactin and TSH. Life Sci. 50:1992;1201-1205.
51. Schleifer S.J., Keller S.E., Camerino M., Thornton J.C., Stein M. Suppression of lymphocyte stimulation following bereavement. J. Am. Med. Assoc. 250:1983;374-377.
52. Schulkin J., Gold P.W., McEwen B.S. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology. 23:1998;219-243.
53. Schulte H.M., Bamberger C.M., Elsen H., Herrmann G., Bamberger A.M., Barth J. Systemic interleukin-1α and interleukin-2 secretion in response to acute stress and to corticotropin-releasing hormone in humans. Eur. J. Clin. Invest. 24:1994;773-777.
54. Sheehan, D., Lecrubier, Y., Janavs, J., Knapp, E., Weiller, E., Sheehan, M., Lepine, J.P., Teherani, M., 1992. Mini-international Neuropsychiatric Interview, Clinician Rated. Version 2.1.
55. Smythe J., Ockenfels M.C., Porter L., Kirschbaum C., Hellhammer D.H., Stone A.A. Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology. 23:1998;353-370.
56. Song C., Kenis G., van Gestel A., Bosmans E., Lin A., de Jong R., Neels H., Scharpe S., Janca A., Yasukawa K., Mases M. Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti-inflammatory agents and soluble membrane antigens of monocytes and T lympocytes. Psychiat. Res. 22:1999;293-303.
57. Weisse C.S., Pato C.N., McAllister C.G., Littman R., Breier A., Paul S.M., Baum A. Differential effects of controllable and uncontrollable acute stress on lymphocyte proliferation and leukocyte percentages in humans. Brain Behav. Immun. 4:1990;339-351.
58. Workman E.A., La Via M.F. T lymphocyte polyclonal proliferation: effects of stress and stress response style on medical students taking national board examinations. Clin. Immunol. Immunopathol. 43:1987;308-313.
59. Zaharia, M.D., 1998. Stressor effects on immune and endocrine parameters in non-depressed and depressed individuals: Influence of behavioral characteristics. Doctoral dissertation, Carleton University, Ottawa.
60. Zorrilla E.P., Redei E., DeRubeis R.J. Reduced cytokine levels and T-cell function in healthy males: relation to individual differences in subclinical anxiety. Brain Behav. Immun. 8:1994;293-312.