메뉴 건너뛰기




Volumn 278, Issue 2 41-2, 2000, Pages

Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation

Author keywords

1,2 dimethylhydrazine dihydrochloride; Colorectal cancer; Nonsteroidal anti inflammatory drugs

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; SULINDAC; SULINDAC SULFONE; UNCLASSIFIED DRUG;

EID: 0034058848     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.2.g266     Document Type: Article
Times cited : (17)

References (45)
  • 2
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen - Preliminary findings
    • Bird, R. P. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen - preliminary findings. Cancer Lett. 37: 147-151, 1987.
    • (1987) Cancer Lett. , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 4
    • 0031882916 scopus 로고    scopus 로고
    • Mechanisms underlying nonsteroidal antiinflammatory drug mediated apoptosis
    • Chan, T. A., P. J. Morin, B. Vogelstein, and K. W. Kinzler. Mechanisms underlying nonsteroidal antiinflammatory drug mediated apoptosis. Proc. Natl. Acad. Sci. USA 95: 681-686, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 681-686
    • Chan, T.A.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 5
    • 12944270846 scopus 로고
    • Pathogenesis and biological behaviour of 1,2-dimethylhydrazine-induced colonic neoplasms in the mouse
    • edited by D. R. Appleton, J. P. Sunter, and A. J. Watson. Tunbridge Wells, UK: Pitman
    • Chang, W. W. L. Pathogenesis and biological behaviour of 1,2-dimethylhydrazine-induced colonic neoplasms in the mouse. In: Cell Proliferation in the GI Tract, edited by D. R. Appleton, J. P. Sunter, and A. J. Watson. Tunbridge Wells, UK: Pitman, 1980, p. 278-297.
    • (1980) Cell Proliferation in the GI Tract , pp. 278-297
    • Chang, W.W.L.1
  • 6
    • 0029974533 scopus 로고    scopus 로고
    • Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis
    • Charalambous, D., and P. E. O'Brien. Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis. J Gastroenterol. Hepatol. 11: 307-310, 1996.
    • (1996) J Gastroenterol. Hepatol. , vol.11 , pp. 307-310
    • Charalambous, D.1    O'Brien, P.E.2
  • 7
    • 0029883613 scopus 로고    scopus 로고
    • Sulindac and indomethacin inhibit formation of aberrant crypt foci in the colons of dimethyl hydrazine treated rats
    • Charalambous, D., K. C. R. Farmer, and P. E. O'Brien. Sulindac and indomethacin inhibit formation of aberrant crypt foci in the colons of dimethyl hydrazine treated rats. J Gastroenterol. Hepatol. 11: 88-92, 1996.
    • (1996) J Gastroenterol. Hepatol. , vol.11 , pp. 88-92
    • Charalambous, D.1    Farmer, K.C.R.2    O'Brien, P.E.3
  • 8
    • 0032417630 scopus 로고    scopus 로고
    • Sulindac inhibits colorectal tumour growth, but not prostaglandin synthesis in the rat
    • Charalambous, D., S. A. Skinner, and P. E. O'Brien. Sulindac inhibits colorectal tumour growth, but not prostaglandin synthesis in the rat. J Gastroenterol. Hepatol. 13: 1195-1200, 1998.
    • (1998) J Gastroenterol. Hepatol. , vol.13 , pp. 1195-1200
    • Charalambous, D.1    Skinner, S.A.2    O'Brien, P.E.3
  • 9
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R., and B. Vogelstein. A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 11
    • 0030044422 scopus 로고    scopus 로고
    • The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: Alterations in tumour suppressor and cell cycle regulatory proteins
    • Goldberg, Y., I. I. Nassif, A. Pittas, L. L. Tsai, B. D. Dynlacht, B. Rigas, and S. J. Shiff. The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumour suppressor and cell cycle regulatory proteins. Oncogene 12: 893-901, 1996.
    • (1996) Oncogene , vol.12 , pp. 893-901
    • Goldberg, Y.1    Nassif, I.I.2    Pittas, A.3    Tsai, L.L.4    Dynlacht, B.D.5    Rigas, B.6    Shiff, S.J.7
  • 12
    • 0026079628 scopus 로고
    • The biochemistry of ras p21
    • Grand, R. J. A., and D. Owens. The biochemistry of ras p21. Biochem J. 279: 609-631, 1991.
    • (1991) Biochem J. , vol.279 , pp. 609-631
    • Grand, R.J.A.1    Owens, D.2
  • 13
    • 0030602860 scopus 로고
    • Effects of nonsteroidal anti-inflammatory drugs on proliferation, and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway
    • Hanif, R., A. Pittas, Y. Feng, M. I. Koutsos, L. Qiao, L. Staiano-Coico, S. I. Shiff, and B. Rigas. Effects of nonsteroidal anti-inflammatory drugs on proliferation, and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol. 52: 237-245, 1991.
    • (1991) Biochem. Pharmacol. , vol.52 , pp. 237-245
    • Hanif, R.1    Pittas, A.2    Feng, Y.3    Koutsos, M.I.4    Qiao, L.5    Staiano-Coico, L.6    Shiff, S.I.7    Rigas, B.8
  • 15
    • 0026080705 scopus 로고
    • Mutations in the K-ras oncogene induced by 1,2 dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa
    • Jacoby, R. F., X. Llor, B. Teng, N. Davidson, and T. A. Brasitus. Mutations in the K-ras oncogene induced by 1,2 dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa. J. Clin. Invest. 87: 624-630, 1991.
    • (1991) J. Clin. Invest. , vol.87 , pp. 624-630
    • Jacoby, R.F.1    Llor, X.2    Teng, B.3    Davidson, N.4    Brasitus, T.A.5
  • 16
    • 0030911815 scopus 로고    scopus 로고
    • Cyclo-oxygenase isoenzymes: How recent findings affect thinking about nonsteroidal anti-inflammatory drugs
    • Jouzeau, J. Y., B. Terlain, A. Abid, E. Nedelec, and P. Netter. Cyclo-oxygenase isoenzymes: how recent findings affect thinking about nonsteroidal anti-inflammatory drugs. Drugs 53: 563-582, 1997.
    • (1997) Drugs , vol.53 , pp. 563-582
    • Jouzeau, J.Y.1    Terlain, B.2    Abid, A.3    Nedelec, E.4    Netter, P.5
  • 17
    • 0024409196 scopus 로고
    • Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes
    • Kumar, R., and L. L. Dunn. Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes. Oncogene Res. 1: 235-241, 1989.
    • (1989) Oncogene Res. , vol.1 , pp. 235-241
    • Kumar, R.1    Dunn, L.L.2
  • 20
    • 0026048311 scopus 로고
    • K-ras mutations in 1,2 dimethylhydrazine-induced colonic tumours: Effects of supplemental dietary calcium, and vitamin D deficiency
    • Llor, X., R. F. Jacoby, B Teng, N Davidson, M. D. Sitrin, and T. A. Brasitus. K-ras mutations in 1,2 dimethylhydrazine-induced colonic tumours: effects of supplemental dietary calcium, and vitamin D deficiency. Cancer Res. 51: 4305-4309, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4305-4309
    • Llor, X.1    Jacoby, R.F.2    Teng, B.3    Davidson, N.4    Sitrin, M.D.5    Brasitus, T.A.6
  • 21
    • 0027237664 scopus 로고
    • Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: Case-control study of subjects participating in the Nottingham faecal occult blood screening programme
    • Logan, R. F. A, J. Little, and J. D. Hardcastle. Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br. Med. J. 307: 285-289, 1993.
    • (1993) Br. Med. J. , vol.307 , pp. 285-289
    • Logan, R.F.A.1    Little, J.2    Hardcastle, J.D.3
  • 23
  • 24
    • 0024211723 scopus 로고
    • A protective effect of sulindac against chemically induced primary colonic tumours in mice
    • Moorghen, M., P. Ince, K. J. Finny, J. P. Sunter, D. R. Appleton, and A. J. Watson. A protective effect of sulindac against chemically induced primary colonic tumours in mice. J. Pathol. 156: 341-347, 1989.
    • (1989) J. Pathol. , vol.156 , pp. 341-347
    • Moorghen, M.1    Ince, P.2    Finny, K.J.3    Sunter, J.P.4    Appleton, D.R.5    Watson, A.J.6
  • 26
    • 0027141503 scopus 로고
    • Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis
    • Nugent, K. P., K. C. R. Farmer, A. D. Spigelman, C. B. Williams, and R. K. S. Phillips. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br. J. Surg. 80: 1618-1619, 1993.
    • (1993) Br. J. Surg. , vol.80 , pp. 1618-1619
    • Nugent, K.P.1    Farmer, K.C.R.2    Spigelman, A.D.3    Williams, C.B.4    Phillips, R.K.S.5
  • 27
    • 0024418625 scopus 로고
    • Aspirin use and chronic disease: A cohort study of the elderly
    • Paganini-Hill, A., A. Chao, R. K. Ross, and B. E. Henderson. Aspirin use and chronic disease: a cohort study of the elderly. Br. Med. J. 299: 1247-1250, 1989.
    • (1989) Br. Med. J. , vol.299 , pp. 1247-1250
    • Paganini-Hill, A.1    Chao, A.2    Ross, R.K.3    Henderson, B.E.4
  • 30
    • 0030968757 scopus 로고    scopus 로고
    • Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction
    • Piazza, G. A., A. K. Rahm, T. S. Finn, B. H. Fryer, H. Li, A. L. Stoumen, R. Pamukcu, and D. J. Ahnen. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res. 57: 2452-2459, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 2452-2459
    • Piazza, G.A.1    Rahm, A.K.2    Finn, T.S.3    Fryer, B.H.4    Li, H.5    Stoumen, A.L.6    Pamukcu, R.7    Ahnen, D.J.8
  • 34
    • 0028904461 scopus 로고
    • Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
    • Rao, C. V., A. Rivenson, B. Simi, E. Zang, G. Kelloff, V. Steele, and B. S. Reddy. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res. 55: 1464-1472, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1464-1472
    • Rao, C.V.1    Rivenson, A.2    Simi, B.3    Zang, E.4    Kelloff, G.5    Steele, V.6    Reddy, B.S.7
  • 35
    • 0031000902 scopus 로고    scopus 로고
    • Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: Apoptotic index as a biomarker in colon cancer chemoprevention and promotion
    • Samaha, S. S., G. J. Kelloff, V. Steele, C. V. Rao, and B. S. Reddy. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 57: 1301-1305, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 1301-1305
    • Samaha, S.S.1    Kelloff, G.J.2    Steele, V.3    Rao, C.V.4    Reddy, B.S.5
  • 36
    • 0029115954 scopus 로고
    • Sulindac sulfide, an aspirin like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells
    • Shiff, S. J., L. Qiao, L. L. Tsai, and B. Rigas. Sulindac sulfide, an aspirin like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells. J. Clin. Invest. 96: 491-503, 1995.
    • (1995) J. Clin. Invest. , vol.96 , pp. 491-503
    • Shiff, S.J.1    Qiao, L.2    Tsai, L.L.3    Rigas, B.4
  • 37
    • 0028053788 scopus 로고
    • Molecular markers as intermediate endpoints in chemoprevention of colon cancer: Modulation of ras activation by sulindac and phenylhexylisothiocyanate (PHITC) during colon carcinogenesis
    • Singh, J., C. V. Rao, N. Kulkarni, B. Simi, and B. S. Reddy. Molecular markers as intermediate endpoints in chemoprevention of colon cancer: modulation of ras activation by sulindac and phenylhexylisothiocyanate (PHITC) during colon carcinogenesis. Int. J. Oncol. 5: 1009-1018, 1994.
    • (1994) Int. J. Oncol. , vol.5 , pp. 1009-1018
    • Singh, J.1    Rao, C.V.2    Kulkarni, N.3    Simi, B.4    Reddy, B.S.5
  • 38
    • 0026075136 scopus 로고
    • Sulindac inhibits the rate of growth and appearance of colon tumours in the rat
    • Skinner, S. A., A. G. Penney, and P. E. O'Brien. Sulindac inhibits the rate of growth and appearance of colon tumours in the rat. Arch. Surg. 126: 1094-1096, 1991.
    • (1991) Arch. Surg. , vol.126 , pp. 1094-1096
    • Skinner, S.A.1    Penney, A.G.2    O'Brien, P.E.3
  • 39
    • 0030628655 scopus 로고    scopus 로고
    • Colorectal cancer and nonsteroidal anti-inflammatory drugs
    • Smalley, W. E., and R. N. DuBois. Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv. Pharmacol. 39: 1-20, 1997.
    • (1997) Adv. Pharmacol. , vol.39 , pp. 1-20
    • Smalley, W.E.1    DuBois, R.N.2
  • 40
    • 0026480765 scopus 로고
    • Evidence for a ras gene mutation in AOM-induced colonic aberrant crypts in Sprague-Dawley rats: Earliest recognisable precursor lesions of experimental colon cancer
    • Stopera, S. A., L. C. Murphy, and R. P. Bird. Evidence for a ras gene mutation in AOM-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognisable precursor lesions of experimental colon cancer. Carcinogenesis 13: 2081-2085, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 2081-2085
    • Stopera, S.A.1    Murphy, L.C.2    Bird, R.P.3
  • 43
    • 0027426123 scopus 로고
    • K-ras mutations in aberrant crypt foci, adenomas, and adenocarcinomas during azoxymethane-induced colon carcinogenesis
    • Vivona, A. A., B. Shpitz, A. Medline, W. R. Bruce, K. Hay, M. A. Ward, H. S. Stern, and S. Gallinger. K-ras mutations in aberrant crypt foci, adenomas, and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis 14: 1777-1781, 1993.
    • (1993) Carcinogenesis , vol.14 , pp. 1777-1781
    • Vivona, A.A.1    Shpitz, B.2    Medline, A.3    Bruce, W.R.4    Hay, K.5    Ward, M.A.6    Stern, H.S.7    Gallinger, S.8
  • 45
    • 0030889919 scopus 로고    scopus 로고
    • Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis
    • Ward, R. L., A. V. Todd, F. Santiago, T. O'Connor, and N. J. Hawkins. Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis. Cancer 79: 1106-1113, 1997.
    • (1997) Cancer , vol.79 , pp. 1106-1113
    • Ward, R.L.1    Todd, A.V.2    Santiago, F.3    O'Connor, T.4    Hawkins, N.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.