Higher levels of organization in the interphase nucleus of cycling and differentiated cells

Microbiology and Molecular Biology Reviews

Volumn 64, Issue 1, 2000, Pages 138-152

  Leitch, Andrew R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; NUCLEIC ACID; RIBOSOME DNA;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN; CHROMOSOME CONDENSATION; INTERPHASE; NONHUMAN; POLYPLOIDY; REVIEW;

ANIMALIA; FUNGI;

EID: 0034056508     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.64.1.138-152.2000     Document Type: Review

References (160)

1. Abney, J. R., B. Cutler, M. L. Fillbacj, D. Axelrod, and B. A. Scalettar. 1997. Chromatin dynamics in interphase nuclei and its implications for nuclear structure. J. Cell Biol. 137:1459-1468.
2. Abranches, R., A. F. Bevan, L. Aragon-Alcaide, and P. J. Shaw. 1998. Transcription sites are not correlated with chromosome territories in wheat nuclei. J. Cell Biol. 143:5-12.
3. Anamthawat-Jönsson, K., and J. S. Heslop-Harrison. 1990. Centromeres, telomeres and chromatin in the interphase nucleus of cereals. Caryologia 43:205-213.
4. Appels, R., and R. L. Honeycutt. 1986. rDNA: evolution over a billion years, p. 81-135. In S. K. Datta (ed.), DNA systematics, vol. II. Plants. CRC Press Inc., Boca Raton, Fla.
5. Aragon-Alcaide, L., T. Miller, T. Schwarzacher, S. Reader, and G. Moore. 1996. A cereal centromeric sequence. Chromosoma 105:261-268.
6. Aragon-Alcaide, L., S. Reader, A. Bevan, P. Shaw, T. Miller, and G. Moore. Association of homologous chromosomes during floral development. Curr. Biol. 7:905-908.
7. Arnoldus, E. P. J., I. A. Noordermeyer, A. C. B. Peters, A. K. Raap, and M. Van der Ploeg. 1991. Interphase cytogenetics reveals somatic pairing of chromosome 17 centromeres in normal human brain tissue, but no trisomy 7 or sex chromosome loss. Cytogenet. Cell Genet. 56:214-216.
8. Arnoldus, E. P. J., A. C. B. Peters, G. T. A. M. Bots, A. K. Raap, and M. Van der Ploeg. 1989. Somatic pairing of chromosome 1 centromeres in interphase nuclei of human cerebellum. Hum. Genet. 83:231-234.
9. Avivi, L., and M. Feldman. 1980. Arrangement of chromosomes in the interphase nucleus of plants. Hum. Genet. 55:281-295.
10. Baluska, F., K. Bacigalova, J. L. Oud, M. Hauskrecht, and S. Kubica. 1995. Rapid reorganisation of microtubular cytoskeleton accompanies early changes in nuclear ploidy and chromatin structure in post-mitotic cells of barley leaves infected with powdery mildew. Protoplasma 185:140-151.
11. Bajer, A. 1954. Cine-micrographic studies on mitosis in endosperm 1. Acta Soc. Bot. Pol. 23:383-412.
12. Barlow, P. W. 1977. Changes in chromatin structure during the cell cycle. Protoplasma 91:207-211.
13. Barlow, P. W. 1984. The dispersion of chromocentres in plant nuclei and its relation to DNA synthesis. Caryologia 37:167-176.
14. Barlow, P. W. 1985. Nuclear chromatin structure in relation to cell differentiation and cell activation in the cap and quiescent centre of Zea mays L. J. Exp. Bot. 36:1492-1503.
15. Barinaga, M. 1998. Stroke-damaged neurons may commit cellular suicide. Science 281:302-303.
16. Behnke, H. D., and R. D. Sjolund. 1990. Sieve elements. Springer-Verlag KG, Berlin, Germany.
17. Bennett, M. D. 1982. Nucleotypic basis of the spatial ordering of chromosomes in eukaryotes and the implication of order for genome evolution and phenotypic variation, p. 239-261. In G. A. Dover and R. B. Flavell (ed.), Genome evolution. Academic Press, Ltd., London, United Kingdom.
18. Bennett, M. D. 1984. Nuclear architecture and its manipulation, p. 469-502. In J. P. Gustafson (ed.), Gene manipulation in plant improvement. Plenum Publishing Corp., New York, N.Y.
19. Bennett, M. D. 1996. The nucleotype, the natural karyotype and the ancestral genome, p. 45-52. In J. S. Heslop-Harrison (ed.), Unifying plant genomes. Society for Experimental Biology symposium 50. The Company of Biologists, Cambridge, United Kingdom.
20. Reference deleted.
21. Besansky, N. J., and F. H. Collins. 1992. The mosquito genome: organisation and manipulation. Parasitol. Today 8:186-192.
22. Borden, J., and L. Manuelidis. 1988. Movement of the X chromosome in epilepsy. Science 242:1687-1691.
23. Boveri, T. 1888. Die Befruchtung und Teilung des Eies von Ascaris megalocephala, p. 1-189. In G. Fischer (ed.), Zellen-Studien, H. 2. Jena, Germany.
24. Boveri, T. 1909. Die Blastomerenkerne von Ascaris megalocephala und die Theorie der Chromosomenindividualität. Arch. Zellforsch. 3:181-286.
25. Brandriff, B. F., L. A. Gordon, R. Segraves, and D. Pinkel. 1991. The male-derived genome after sperm-egg fusion: spatial distribution of chromosomal DNA and paternal-maternal genomic association. Chromosoma 100:262-266.
26. Bridger, J. M., H. Hermann, C. Münkel, and P. Lichter. 1998. Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin. J. Cell Sci. 111:1241-1253.
27. Brodsky, V. Y., and I. V. Uryvaeva. 1985. Genome multiplication in growth and development: biology of polyploid and polytene cells. Dev. Cell Biol. Ser. vol. 15. Cambridge University Press, Cambridge, United Kingdom.
28. Burgess, S. M., and N. Kleckner. 1999. Collisions between yeast chromosomal loci in vivo are governed by three layers of organisation. Genes Dev. 15:1871-1973.
29. Burgess, S. M., N. Kleckner, and B. M. Weiner. 1999. Somatic pairing of homologs in budding yeast: existence and modulation. Genes Dev. 15:1627-1642.
30. Caiafa, P., A. Reale, R. Santoro, S. Marenzi, G. Zardo, and R. Strom. 1995. Does hypomethyation of linker DNA play a role in chromatin condensation? Gene 157:247-251.
31. Carmo-Fonseca, M., R. Pepperkok, M. Carvalho, and A. Lamond. 1992. Transcription-dependent colocalisation of the U1, U2, U4, and U5 snRNPs in coiled bodies. J. Cell Biol. 117:1-14.
32. Carmo-Fonseca, M., D. Tollervey, R. Pepperkok, S. M. L. Barzbino, A. Merdes, C. Brunner, P. D. Zamore, M. R. Green, E. Hurt, and A. Lamond. 1991. Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J. 10:195-206.
33. Carter, K. C., D. Bowman, W. Carrington, K. Fogarty, J. A. McNeil, F. S. Fay, and J. B. Lawrence. 1993. A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science 259: 1330-1334.
34. Carter, K. C., K. L. Taneja, and J. B. Lawrence. 1993. Discrete nuclear domains of Poly(A)RNA and their relationship top the functional organisation of the nucleus. J. Cell Biol. 115:1191-1202.
35. Cavalier-Smith, T. 1978. Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth, and the solution of the DNA C-value paradox. J. Cell Sci. 34:247-278.
36. Chandley, A. C., and R. M. Speed. 1995. A reassessment of the Y chromosomal behaviour in germ cells and Sertoli cells of the mouse revealed by in situ hybridisation. Chromosoma 104:282-286.
37. Chandley, A. C., R. M. Speed, and A. R. Leitch. 1996. Different distributions of homologous chromosomes in adult Sertoli cells and in lymphocytes signify nuclear differentiation. J. Cell Sci. 109:773-776.
38. Chung, H.-M. M., C. Shea, S. Fields, R. N. Taub, and L.H.T. Van der Ploeg. 1990. Architectural organization in the interphase nucleus of the protozoan Trypanosoma brucei: location of telomeres and mini-chromosomes. EMBO J. 9:2611-2619.
39. Cohen, J. J. 1993. Apoptosis. Immunol. Today 14:126-130.
40. Cook, P. R. 1995. A chromomeric model for nuclear and chromosomal structure. J. Cell Sci. 108:2927-2935.
41. Comings, D. E. 1980. Arrangement of chromatin in the nucleus. Hum. Genet. 53:131-143.
42. Craig, J. M., and W. A. Bickmore. 1993. Chromosome bands - flavours to savour. Bioessays 15:349-354.
43. Cremer, T., C. Cremer, H. Baumann, E.-K. Luedtke, K. Sperling, V. Teuber, and C. Zorn. 1982. Rabl's model of interphase chromosome arrangement tested in chinese hamster cells by premature chromatin condensation and laser UV microbeam analysis. Hum. Genet. 60:46-56.
44. Cremer, T., C. Cremer, T. Schneider, H. Baumann, L. Hens, and M. Kirsch-Volders. 1982. Analysis of chromosome positions in the interphase nucleus of chinese hamster cells by laser-UV-microirradiation experiments. Hum. Genet. 62:201-209.
45. Dietzel, S., A. Jauch, D. Kienle, G. Qu, H. Holtgreve, R. Eils, C. Münkel, M. Bittner, P. S. Meltzer, J. M. Trent, and T. Cremer. 1998. Separate and variable shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei. Chromosome Res. 6:25-33.
46. Duriau-Frankignoul, M. 1972. Evolution interphasique des prochromosomes chez le Bryonia dioica Jacq. Rev. Cytol. Biol. Veg. 35:295-302.
47. Eleftheriou, E. P. 1986. Ultrastructural studies on protophloem sieve elements in Triticum aestivum L. nuclear disintegration. J. Ultrastruct. Mol. Struct. Res. 95:47-60.
48. Eleftheriou, E. P. 1996. Developmental features of protophloem sieve elements in roots of wheat (Triticum aestivum L.). Protoplasma 193:204-212.
49. Eils, R., S. Dietzel, E. Bertin, E. Schröck, M. R. Speicher, T. Reid, M. Robert-Nicoud, C. Cremer, and T. Cremer. 1996. Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X chromosome territories have similar volumes but differ in shape and surface structure. J. Cell Biol. 135:1427-1440.
50. Elves, M. W., J. Gough, J. A. Chapman, and M. C. G. Israels. 1964. Electron microscopic studies of lymphocytes. Transformation under the influence of phytohaemagglutinin. Lancet ii:306-308.
51. Emmerich, P., P. Loos, A. Jauch, A. H. N. Hopman, J. Wiegant, M. J. Higgins, B. N. White, M. van der Ploeg, C. Cremer, and T. Cremer. 1989. Double in situ hybridization in combination with digital image analysis: a new approach to study interphase chromosome tomography. Exp. Cell Res. 181:126-140.
52. Ferguson, M., and D. C. Ward. 1992. Cell cycle dependent chromosomal movement in pre-mitotic human T-lymphocyte nuclei. Chromosoma 101: 557-565.
53. Flavell, R. B. 1986. The structure and control of expression of ribosomal RNA genes. Oxford Surv. Plant Mol. Cell Biol. 3:252-274.
54. Flavell, R. B., M. O'Dell, and W. F. Thompson. 1988. Regulation of cytosine methylation in ribosomal DNA and nucleolus organizer expression in wheat. J. Mol. Biol. 204:523-534.
55. Fulnecek, J., R. Matyášek, A. Kovarík, and M. Bezdek. 1998. Methylation of tobacco 5SrRNA genes determined by genomic sequencing. Mol. Gen. Genet. 259:133-141.
56. Funabiki, H., I. Hagan, S. Uzawa, and M. Yanigida. 1993. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J. Cell Biol. 121:961-976.
57. Gall, J. G., E. H. Cohen, and M. L. Polan. 1971. Repetitive DNA sequences in Drosophila. Chromosoma 33:319-344.
58. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
59. Gerlach, W. L., and J. R. Bedbrook. 1979. Cloning and characterisation of ribosomal RNA genes from wheat and barley. Nucleic Acids Res. 7:1869-1885.
60. Glyn, M. C. P., and A. R. Leitch. 1995. The distribution of a spliceosome protein in cereal (Triticeae) interphase nuclei from cells with different metabolic activities and through the cell cycle. Plant J. 8:531-540.
61. Goffeau, A., B. G. Barell, H. Bussey, R. W. Davis, B. Dujon, H. Feldman, F. Gailbert, J. D. Homeisel, C. Jacq, M. Johnston, E. J. Lewis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, and S. G. Oliver. 1996. Life with 6,000 genes. Science 274:546-567.
62. Grant, T. M., M. W. Goldberg, and T. D. Allen. 1998. Nuclear envelope and nuclear pore assembly: analysis of assembly intermediates by electron microscopy. Curr. Opin. Cell Biol. 10:409-415.
63. Gruenbaum, Y., M. Hochstrasser, D. Mathog, H. Saumweber, D. A. Agard, and J. W. Sedat. 1984. Spatial organization of the Drosophila nucleus: A three-dimensional cytogenetic study. J. Cell Sci. Suppl. 1:223-234.
64. Guacci, V., E. Hogan, and D. Koshland. 1997. Centromere position in budding yeast: evidence for anaphase A. Mol. Biol. Cell 8:957-972.
65. Haaf, T., H. Grunenberg, and M. Schmid. 1990. Paired arrangement of non-homologous centromeres during spermatogenesis. Exp. Cell Res. 187: 157-161.
66. Haaf, T., and M. Schmid. 1989. Centromeric association and non-random distribution of centromeres in human tumour cells. Hum. Genet. 81:137-143.
67. Haaf, T., P. Werner, and M. Schmid. 1993. 5-azacytidine distinguishes between active and inactive X-chromosome condensation. Cytogenet. Cell Genet. 63:160-168.
68. Hartman, T. P. V., and D. I. Southern. 1995. Genome re-organization from polytene to polyploid in the nurse cells found in onion fly (Delia antiqua) and cabbage root fly (Delia radicum) ovaries (Diptera, Anthomyiidae). Chromosome Res. 3:271-280.
69. Heitz, E. 1971. Über α-und β-Heterochromatin sowie Konstanz und Bau der Chromomeren bei Drosophila. Biol. Zentbl. 54:588-609.
70. Heslop-Harrison, J. S., J. B. Smith, and M. D. Bennett. 1988. The absence of the somatic association of centromeres of homologous chromosomes in grass mitotic metaphases. Chromosoma 96:119-131.
71. Heslop-Harrison, J. S., M. Huelskamp, S. Wendroth, M. D. Atkinson, A. R. Leitch, and M. D. Bennett. 1988. Chromatin and centromeric structures in interphase nuclei, p. 209-271. In P. E. Brandham (ed.), Kew Chromosome Conference III. Allen & Unwin, London, United Kingdom.
72. Heslop-Harrison, J. S., A. R. Leitch, and T. Schwarzacher. 1993. The physical organisation of interphase nuclei, p. 221-230. In J. S. Heslop-Harrison and R. Flavell (ed.), The chromosome. Bios Scientific Publishers, Oxford, United Kingdom.
73. Heslop-Harrison, J. S., A. R. Leitch, T. Schwarzacher, and K. Anamthawat-Jönsson. 1990. Detection and characterisation of 1B/1R translocations in hexaploid wheat. Heredity 65:385-392.
74. Hochstrasser, M., and J. W. Sedat. 1987. Three-dimensional organisation of Drosophila melanogaster interphase nuclei. I. Tissue-specific aspects of polytene architecture. J. Cell Biol. 104:1455-1470.
75. Hochstrasser, M., and J. W. Sedat. 1987. Three-dimensional organisation of Drosophila melanogaster interphase nuclei. 11. Chromosome spatial organisation and gene regulation. J. Cell Biol. 104:1471-1483.
76. Houben, A., N. D. Belyaev, B. M. Turner, and I. Schubert. 1996. Differential immunostaining of plant chromosomes by antibodies, recognising acetylated histone H4 variants. Chromosome Res. 4:191-195.
77. Houben, A., M. Guttenbach, W. Kress, U. Pich, I. Schubert, and M. Schmid. 1995. Immunostaining and interphase arrangement of field bean kinetochores. Chromosome Res. 3:27-31.
78. Hozak, P., O. Zatsepina, I. Vasilyeva, and Y. Chentsov. 1986. An electron microscopic study of the nucleolus-organising regions at some stages of the cell cycle (G0 period, G2 period, mitosis). Biol. Cell 57:197-206.
79. Hozak, P., J. T. Novak, and K. Smetana. 1989. Three-dimensional reconstructions of nucleolus-organizing regions in PHA-stimulated human lymphocytes. Biol. Cell 66:225-233.
80. Ingle, J., J. N. Timmis, and J. Sinclair. 1975. The relationship between satellite deoxyribonucleic acid, ribosomal RNA gene redundancy, and genome size in plants. Plant Physiol. 55:496-501.
81. Inman, D. R., and E. H. Cooper. 1963. Electron microscopy of human lymphocytes stimulated with phytohemagglutinin. J. Cell Biol. 19:441-445.
82. Jacobson, M. D., M. Weil, and M. C. Raff. 1997. Programmed cell death in animal development. Cell 88:347-354.
83. Reference deleted.
84. Jin, Q., E. Trelles-Stricken, H. Scherthan, and J. Loidl. 1998. Yeast nuclei display prominent centromere clustering that is reduced in nondividing cells in meiotic prophase. J. Cell Biol. 141:21-29.
85. Joffe, B. I., I. V. Solovei, and H. C. MacGregor. 1998. Ordered arrangement and rearrangement of chromosomes during spermatogenesis in two species of planarians (Plathelminthes). Chromosoma 107:173-183.
86. Jordan, E. G., G. Martini, M. D. Bennett, and R. B. Flavell. 1982. Nucleolar fusion in wheat. J. Cell Sci. 56:485-495.
87. Jordan, E. G., P. J. Cooper, G. Martini, M. D. Bennett, and R. B. Flavell. 1985. The effects of temperature and ageing on root apical meristems during seedling growth of Triticum aestivum L.: a specific effect on nucleoli. Plant Cell Environ. 8:325-331.
88. Kerr, J. F. R., A. H. Wyllie, and A. R. Currie. 1972. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26:239-257.
89. Keshet, I., J. Yisraeli, and H. Cedar. 1986. DNA methylation affects the formation of active chromatin. Cell 44:535-543.
90. Kleckner, N. 1998. Interactions between and along meiotic chromosomes. Cytogenet. Cell Genet. 81:100.
91. Klechner, N., and B. M. Weiner. 1993. Potential advantages of unstable interactions for pairing of chromosomes in meiotic, somatic, and premeiotic cells. Cold Spring Harbor Symp. Quant. Biol. 58:553-565.
92. Kingham, K. I., J. G. Duckett, M. C. P. Glyn, and A. R. Leitch. 1995. Nuclear differentiation in the filamentous caulonema of the moss Funaria hygrometrica Hedw. New Phytol. 131:543-556.
93. Kovarik, A., R. Matyášek, A. Leitch, B. Gazdová, J. Fulnecek, and M. Bezdek. 1997. Variability in CNG methylation in higher plant genomes. Gene 204:25-33.
94. Kurtz, A., S. Lampel, J. E. Nickolenko, J. Bradl, A. Benner, R. M. Zirbel, T. Cremer, and P. Lichter. 1996. Active and inactive genes localize preferentially in the periphery of chromosome territories. J. Cell Biol. 135:1195-1206.
95. Lamond, A. I., and W. C. Earnshaw. 1998. Structure and function in the nucleus. Science 280:547-553.
96. Lamborot-Mazur, M., P. V. Tishler, and L. Atkins. 1971. Fluorescent drumsticks in male polymorphs. Lancet i:973-974.
97. Leitch, A. R., J. K. M. Brown, W. Mosgöller, T. Schwarzacher, and J. S. Heslop-Harrison. 1994. The spatial localization of homologous chromosomes in human fibroblasts at mitosis. Hum. Genet. 93:275-280.
98. Leitch, A. R., M. Glyn, K. Kingham, M. Quinn, L. F. Aragon-Alcaide, A. Somasekaram, and J. G. Duckett. 1995. The dynamic organisation of interphase nuclei during cell differentiation and with changing cell activity, p. 83-95. In P. E. Brandham and M. D. Bennett (ed.), Kew Chromosome Conference IV. Her Majesty's Stationery Office, London, United Kingdom.
99. Leitch, A. R., and J. S. Heslop-Harrison. 1993. Ribosomal RNA gene expression and localization in cereals. Chromosomes Today 11:91-100.
100. Leitch, A. R., W. Mosgöller, M. Shi, and J. S. Heslop-Harrison. 1992. Different patterns of rDNA organisation in nuclei of wheat and rye. J. Cell Sci. 101:751-757.
101. Leitch, A. R., T. Schwarzacher, W. Mosgöller, M. D. Bennett, and J. S. Heslop-Harrison. 1991. Parental genomes are separated throughout the cell cycle in a plant hybrid. Chromosoma 101:206-213.
102. Leitch, I. J., and M. D. Bennett. 1997. Polyploidy in angiosperms. Trends Plant Sci. 12:470-476.
103. Lewis, J. P., H. J. Tanke, A. K. Raap, G. C. Beverstock, and H. C. Kluin-Nelemans. 1993. Somatic pairing of centromeres and short arms of chromosome 15 in the hematopoitic and lymphoid system. Hum. Genet. 92: 577-582.
104. Li, G., G. Sudlow, and A. S. Belmont. 1998. Interphase cell dynamics of a late replicating, heterochromatic homogenously staining region: precise choreography of condensation/decondensation and nuclear positioning. J. Cell Biol. 140:975-989.
105. Lichter, P., T. Cremer, J. Borden, L. Manuelidis, and D. C. Ward. 1988. Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridisation using recombinant DNA libraries. Hum. Genet. 80:224-234.
106. Loidl, J. 1999. General principles of meiosis derived from yeast and other model system. Cytogenet. Cell Genet. 85:113.
107. Lyon, M. F. 1961. Gene action in the X chromosome of mouse (Mus musculus L.). Nature 190:372-373.
108. Reference deleted.
109. Manuelidis, L. 1984. Different central nervous system cell types display distinct and non-random arrangements of satellite DNA sequences. Proc. Natl. Acad. Sci. USA 81:3123-3127.
110. Manuelidis, L. 1997. Interphase chromosome positions and structure during silencing, transcription and replication, p. 145-168. In R. Van Driel and A. P. Otte (ed.), Nuclear organisation, chromatin structure, and gene expression. Oxford University Press, New York, N.Y.
111. Manuelidis, L., and J. Borden. 1988. Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridisation and three-dimensional reconstruction. Chromosoma 96:397-410.
112. Manuelidis, L., and T. L. Chen. 1990. A unified model of eukaryotic chromosomes. Cytometry 11:8-25.
113. Miller, L. J., and J. Marx. 1998. Apoptosis. Science 281:1301.
114. Mittwoch, U. 1964. Frequency of drumsticks in normal women and in patients with chromosomal abnormalities. Nature 201:317-319.
115. Montijn, M. B., R. ten Hoopen, P. F. Fransz, J. L. Oud, and N. Nanninga. 1998. Characterisation of the nucleolar organising regions during the cell cycle in two varieties of Petunia hybrida as visualised by fluorescence in situ hybridisation and silver staining. Chromosoma 107:80-86.
116. Mosgöller, W., E. G. Jordan, and D. Hernandez-Verdun. 1996. News and views on the nucleolus in 1996. Report on the Colloquium on the Nucleolus, a meeting at Paris-Grignon, July 18-20, 1996. Biol. Cell 88:1-4.
117. Mosgöller, W., C. Schofer, J. Wesierska-Gadek, M. Steiner, M. Muller, and F. Wachtler. 1998. Ribosomal gene transcription is organised in foci within nucleolar components. Histochem. Cell Biol. 109:111-118.
118. Mukai, Y., and B. S. Gill. 1991. Detection of barley chromatin added to wheat by genomic in situ hybridisation. Genome 34:448-452.
119. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355-365.
120. Nagele, R., T. Freeman, L. McMorrow, and H.-Y. Lee. 1995. Precise positioning of chromosomes during prometaphase: evidence for chromosomal order. Science 270:1831-1835.
121. Nagele, R. G., T. Freeman, J. Fazekas, K.-M. Lee, Z. Thompson, and H.-Y. Lee. 1998. Chromosome spatial order in human cells: evidence for early origin and faithful propagation. Chromosoma 107:330-338.
122. Nagl, W. 1978. Endopolyploidy and polyteny in differentiation and evolution. North-Holland Publishing Co./Elsevier, Amsterdam, The Netherlands.
123. Nicholson, D. W., and N. A. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22:299-306.
124. Nigg, E. A. 1989. The nuclear envelope. Curr. Opin. Cell Biol. 1:435-440.
125. Oakley, H. A. 1982. Male meiosis in Mesostoma ehrenbergii ehrenbergii. p. 195-199. In P. E. Brandham and M. D. Bennett (ed.), Kew Chromosome Conference II. George Allen & Unwin, London, United Kingdom.
126. Odartchenko, N., and T. Keneklis. 1973. Localization of paternal DNA in interphase nuclei of mouse eggs during early cleavage. Nature 241:528-529.
127. Park, P. C., and U. De Boni. 1991. Dynamics of nucleolar fusion in neuronal interphases nuclei in vitro: association with nuclear rotation. Exp. Cell Res. 197:213-221.
128. Pinkel, D., J. Landegent, C. Collins, J. Fuscoe, R. Segraves, J. Lucas, and J. Gray. 1988. Fluorescence in situ hybridisation with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA 85:9138-9142.
129. Popp, S., H. P. Scholl, P. Loos, A. Jauch, E. Stelzer, C. Cremer, and T. Cremer. 1990. Distribution of chromosome 18 and X centric heterochromatin in the interphase nucleus of cultured human cells. Exp. Cell Res. 189:1-12.
130. Prescott, D. M. 1992. The unusual organization and processing of genomic DNA in hypotrichous ciliates. Trends Genet. 8:439-445.
131. Rabl, C. 1885. Über Zelltheilung. Morphol. Jahrb. 10:214-330.
132. Rae, P. M. M., and W. W. Franke. 1972. The interphase distribution of satellite DNA-containing heterochromatin in mouse nuclei. Chromosoma 39:443-456.
133. Rohlf, F. J., T. C. Rodman, and B. J. Flehinger. 1980. The use of nonmetric multidimensional scaling for the analysis of chromosomal association. Comp. Biomed. Res. 13:19-35.
134. Robinett, C. C., A. Straight, G. Li, C. Willhelm, G. Sudlow, A. Murray, and A. S. Belmont. 1996. In vivo localization of DNA sequences and visualization of large scale chromatin organisation using lac operator/repressor recognition. J. Cell Biol. 135:1685-1700.
135. Rawlins, D. J., and P. J. Shaw. 1990. Three dimensional organization of ribosomal DNA in interphase nuclei of Pisum sativum by in situ hybridization and optical tomography. Chromosoma 99:143-151.
136. Saccone, S., A. De Sario, G. D. Valle, and G. Berbardi. 1992. The highest gene concentrations in the human genome are in the telomeric bands of metaphase chromosomes. Proc. Natl. Acad. Sci. USA 89:4913-4917.
137. Sahlas, D. J., K. Milankov, P. C. Park, and U. De Boni. 1993. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states. J. Cell Sci. 105:347-357.
138. Sanchez, J. A., R. J. Karni, and L. J. Wangh. 1997. Fluorescent in situ hybridisation (FISH) analysis of the relationship between chromosomal location and nuclear morphology in human neutrophils. Chromosoma 106: 168-177.
139. Schwarzacher, H. G. 1976. Chromosomes in mitosis and interphase. Springer-Verlag KG, Berlin, Germany.
140. Schwarzacher, T., and J. S. Heslop-Harrison. 1991. In situ hybridisation to plant telomeres using synthetic oligomeres. Genome 34:317-324.
141. Shaw, P. J., and E. G. Jordan. 1995. The nucleolus. Annu Rev. Cell Dev. Biol. 11:93-121.
142. Shaw, P., D. Rawlins, and M. Highett. 1993. Nuclear and nucleolar structure, p. 161-171. In J. S. Heslop-Harrison and R. B. Flavell (ed.), The chromosome. Bios Scientific Publishers, Oxford. United Kingdom.
143. Shelby, R. D., K. M. Hahn, and K. F. Sullivan. 1996. Dynamic elastic behavior of α-satellite DNA domains visualised in situ in living human cells. J. Cell Biol. 135:545-557.
144. Silva, M., A. Queiroz, N. Neves, A. Barao, A. Castilho, L. Morais-Cecilio, and W. Viegas. 1995. Reprogramming of rye rDNA in triticale during microsporogenesis. Chromosome Res. 3:492-496.
145. Sigmund, J., H. G. Schwarzacher, and A.-V. Mikelsaar. 1979. Satellite frequency and number of nucleoli depend in cell cycle duration and NOR-activity. Hum. Genet. 50:81-91.
146. Spector, D. L. 1990. Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles. Proc. Natl. Acad. Sci. USA 87:147-151.
147. Sperling, K., and E.-K. Luedeke. 1981. Arrangement of prematurely condensed chromosomes in cultured cells and lymphocytes of the Indian Muntjac. Chromosoma 83:541-553.
148. Tartof, K. D., and S. Henikoff. 1991. Trans-sensing effects from Drosophila to humans. Cell 65:201-203.
149. Therman, E. 1995. Chromosome behavior in cell differentiation: a field ripe for exploration. Genetics 141:799-804.
150. Thornberry, N. A., and Y. Lazebnik. 1998. Caspases: enemies within. Science 281:1312-1316.
151. Vogel, F., and J. Krüger. 1983. Is there a general relationship between estimated chromosome distances in interphase and location of genes with related functions? Hum. Genet. 63:362-368.
152. Weimer, R., T. Haaf, J. Kruger, M. Poot, and M. Schmid. 1992. Characterisation of centromere arrangements and test for random distribution in G0, G1, S, G2, G1 and early S' phase in human lymphocytes. Hum. Genet. 88:673-682.
153. Wergin, W. P., P. J. Gruber, and E. H. Newcomb. 1970. Fine structural investigation of nuclear inclusions in plants. J. Ultrastruct. Res. 30:533-557.
154. Werren, J. H., U. Nur, and E. L. Charnov. 1987. An extrachromosomal factor causing loss of paternal chromosomes. Nature 327:75-76.
155. Wollenberg, C., M. P. Kiefaber, and K. D. Zang. 1982. Quantitative studies on the arrangement of human metaphase chromosomes. IX. Arrangement of chromosomes with and without spindle apparatus. Hum. Genet. 62:310-315.
156. Xing, Y., C. V. Johnson, P. R. Dobner, and J. B. Lawrence. 1993. Higher level organisation of individual gene transcription and RNA splicing. Science 259:1326-1330.
157. Yang, F., P. C. M. O'Brien, J. Weinberg, and M. A. Ferguson-Smith. 1997. A reappraisal of the tandem fusion theory of karyotype evolution in the Indian muntjac using chromosome painting. Chromosome Res. 5:109-117.
158. Reference deleted.
159. Zink, D., T. Cremer, R. Saffrich, R. Fisher, M. F. Trendelenberg, W. Ansorge, and E. H. K. Stelzer. 1998. Structure and dynamics of human interphase chromosome territories in vivo. Hum. Genet. 102:241-251.
160. Zirbel, R. M., U. R. Mathieu, A. Kurtz, T. Cremer, and P. Lichter. 1993. Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chromosome Res. 1:93-106.