The acid-labile subunit of the ternary insulin-like growth factor complex in cirrhosis: Relation to liver dysfunction

Journal of Hepatology

Volumn 32, Issue 3, 2000, Pages 441-446

  Møller, Søren ^a,d,e   Juul, Anders ^b   Becker, Ulrik ^c   Henriksen, Jens H ^d  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e Dept Clin Physiol Nucl M   (Denmark)

Author keywords

Binding proteins; Insulin like growth factor I; Portal hypertension

Indexed keywords

ACID; PROTEIN SUBUNIT; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMORAL ARTERY; HEMODYNAMICS; HEPATIC VEIN; HUMAN; LIVER CIRRHOSIS; LIVER DYSFUNCTION; LIVER FAILURE; MALE; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0034052419     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80395-5     Document Type: Article

References (36)

1. Cohick WS, Clemmons DR. The insulin-like growth factors. Annu Rev Physiol. 55:1993;131-153.
2. Langford KS, Miell JP. Review. The insulin-like growth factor-I/binding protein axis - physiology, pathophysiology and therapeutic manipulation. Eur J Clin Invest. 23:1993;503-516.
3. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrine Rev. 16:1995;3-34.
4. Kachra Z, Barash I, Yannopoulos C, Khan MN, Guyda HJ, Posner BI. The differential regulation by glucagon and growth hormone of insulin-like growth factor-1 (IGF-I) and IGF binding proteins in cultured rat hepatocytes. Endocrinology. 128:1991;1723-1730.
5. Guler HP, Zapf J, Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor 1 in healthy adults. N Engl J Med. 317:1987;137-140.
6. Hartmann H, Schmitz F, Christ B, Jungermann K, Creutzfeldt W. Metabolic actions of insulin-like growth factor-1 in cultured hepatocytes from adult rats. Hepatology. 12:1990;1139-1143.
7. Dai J, Scott CD, Baxter RC. Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Endocrinology. 135:1994;1066-1072.
8. Scharf JG, Schmidt-Sandte W, Pahernik SA, Koebe HG, Hartmann H. Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding protein complex in primary cultures of human hepatocytes. J Hepatol. 23:1995;424-430.
9. Phillips LS, Pao CI, Villafuerte BC. Molecular regulation of insulin-like growth factor-I and its principal binding protein, IGFBP-3. Prog Nucl Acid Res Mol Biol. 60:1998;195-265.
10. Arany E, Zabel P, Freeman D, Hill DJ. Elimination of radiolabelled recombinant human insulin-like growth factor binding protein-3 from the circulation, and its distribution amongst organs and tissues in adult male rats. Regul Pept. 48:1993;133-143.
11. Villafuerte BC, Koop BL, Pao C-I, Gu L, Birdsong GG, Phillips LS. Coculture of primary rat hepatocytes and non-parenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro. Endocrinology. 134:1994;2044-2050.
12. Arany E, Zabel P, Hill DJ. Rapid clearance of human insulinlike growth factor binding protein-3 from the rat circulation and cellular localization in liver, kidney and stomach. Growth Regulat. 6:1996;32-41.
13. Sheppard MS, Minuk GY, Bhaumick B, Bala RM. Insulin-like growth factors (IGF) in liver disease: differential changes of IGF-I and IGF-II. Clin Invest Med. 10:1987;49-53.
14. Møller S, Becker U. Insulin-like growth factor 1 and growth hormone in chronic liver disease. Dig Dis. 10:1992;239-248.
15. Møller S, Juul A, Becker U, Flyvbjerg A, Skakkebæk NE, Henriksen JH. Concentrations, release, and disposal of insulin-like growth factor (IGF)-binding proteins (IGFBP), IGF-I, and growth hormone in different vascular beds in patients with cirrhosis. J Clin Endocrinol Metab. 80:1995;1148-1157.
16. Donaghy A, Ross R, Gimson A, Cwyfan Hughes S, Holly J, Williams R. Growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins 1 and 3 in chronic liver disease. Hepatology. 21:1995;680-688.
17. Assy N, Hochberg Z, Enat R, Baruch Y. Prognostic value of generation of growth hormone-stimulated insulin-like growth factor-I (IGF-I) and its binding protein-3 in patients with compensated and decompensated liver cirrhosis. Dig Dis Sci. 43:1998;1317-1321.
18. Holt RI, Baker AJ, Jones JS, Miell JP. The insulin-like growth factor and binding protein axis in children with end-stage liver disease before and after orthotopic liver transplantation. Pediatr Transplant. 2:1998;76-84.
19. Gluud C. Serum testosterone concentration in men with alcoholic cirrhosis: background for variation. Metabolism. 36:1987;373-378.
20. Henriksen JH, Ring-Larsen H, Kanstrup I-L, Christensen NJ. Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with cirrhosis. Gut. 25:1984;1034-1043.
21. Khosravi MJ, Diamandi A, Mistry J, Krishna RG, Khare A. Acid-labile subunit of human insulin-like growth factor-binding protein complex: measurement, molecular, and clinical evaluation. J Clin Endocrinol Metab. 82:1997;3944-3951.
22. Juul A, Møller S, Mosfeldt-Laursen E, Rasmussen MH, Scheike T, Pedersen SA, et al. The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency. J Clin Endocrinol Metab. 83:1998;4408-4415.
23. Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jørgensen K, et al. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab. 78:1994;744-752.
24. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. A specific radioimmunoassay for growth hormone (GH)-dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 70:1990;1292-1298.
25. Juul A, Main K, Blum WF, Lindholm J, Ranke MB, Skakkebæk NE. The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. Clin Endocrinol. 41:1994;85-93.
26. Uchijima Y, Takenaka A, Takahashi S, Noguchi T. Production of insulin-like growth factors and their binding proteins in primary cultures of rat liver parenchymal and nonparenchymal cells. Biosci Biotechnol Biochem. 59:1995;1503-1515.
27. Scharf J, Ramadori G, Braulke T, Hartmann H. Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: regulation by insulin, insulin-like growth factor, and growth hormone. Hepatology. 23:1996;818-827.
28. Binoux M. GH, IGFs, IGF-binding protein-3 and acid-labile subunit: what is the pecking order? Eur J Endocrinol. 137:1997;605-609.
29. Shaarawy M, Fikry MA, Massoud BA, Lotfy S. Insulin-like growth factor binding protein-3: a novel biomarker for the assessment of the synthetic capacity of hepatocytes in liver cirrhosis. J Clin Endocrinol Metab. 83:1998;3316-3319.
30. Scharf JG, Ramadori G, Braulke T, Hartmann H. Cellular localization and hormonal regulation of biosynthesis of insulin-like growth factor binding proteins and of the acid-labile subunit within rat liver. Prog Growth Factor Res. 6:1995;175-180.
31. Chin E, Zhou J, Dai J, Baxter RC, Bondy CA. Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex. Endocrinology. 134:1994;2498-2504.
32. Martin JL, Baxter RC. Production of an insulin-like growth factor (IGF)-inducible IGF- binding protein by human skin fibroblasts. Endocrinology. 127:1990;781-788.
33. Labarta JI, Gargosky SE, Simpson DM, Lee PD, Argente J, Guevara-Aguirre J, et al. Immunoblot studies of the acid-labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long-term therapy with GH or IGF-I respectively. Clin Endocrinol. 47:1997;657-666.
34. Møller S, Grønbæk M, Main K, Becker U, Skakkebæk NE. Urinary growth hormone (U-GH) excretion and serum insulin-like growth factor-1 (IGF-1) in patients with alcoholic cirrhosis. J Hepatol. 17:1993;315-320.
35. Møller S, Becker U, Juul A, Skakkebæk NE, Christensen E. Prognostic value of insulinlike growth factor I and its binding protein in patients with alcohol-induced liver disease. Hepatology. 23:1996;1073-1078.
36. Caregaro L, Alberino F, Amodio P, Merkel C, Angeli P, Plebani M, et al. Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis. Nutrition. 13:1997;185-190.