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Volumn 88, Issue 4, 2000, Pages 1496-1508

Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3

Author keywords

Carotid body; Nitric oxide; Nitric oxide synthase deficiency; Nitric oxide synthase enzyme

Indexed keywords

CYCLIC GMP; NITRIC OXIDE SYNTHASE;

EID: 0034051509     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.4.1496     Document Type: Article
Times cited : (65)

References (60)
  • 1
    • 0033577459 scopus 로고    scopus 로고
    • Modulatory effect of nitric oxide on acetylcholine-induced activation of cat petrosal ganglion neurons in vitro
    • Alcayaga J, Barrios M, Bustos F, Miranda G, Molina MJ, and Iturriaga R. Modulatory effect of nitric oxide on acetylcholine-induced activation of cat petrosal ganglion neurons in vitro. Brain Res 825: 194-198, 1999.
    • (1999) Brain Res , vol.825 , pp. 194-198
    • Alcayaga, J.1    Barrios, M.2    Bustos, F.3    Miranda, G.4    Molina, M.J.5    Iturriaga, R.6
  • 2
    • 0017156070 scopus 로고
    • Interactions between carotid sinus mechanoreceptor and chemoreceptor reflex loops
    • Attinger FM, Attinger EO, Cooperson D, and Gottschalk W. Interactions between carotid sinus mechanoreceptor and chemoreceptor reflex loops. Pflügers Arch 363: 255-261, 1976.
    • (1976) Pflügers Arch , vol.363 , pp. 255-261
    • Attinger, F.M.1    Attinger, E.O.2    Cooperson, D.3    Gottschalk, W.4
  • 3
    • 0028809387 scopus 로고
    • G-nitro-L-arginine methyl ester, on cerebral and myocardial blood flows during hypoxia in the awake dog
    • G-nitro-L-arginine methyl ester, on cerebral and myocardial blood flows during hypoxia in the awake dog. Anesth Analg 81: 945-951, 1995.
    • (1995) Anesth Analg , vol.81 , pp. 945-951
    • Audibert, G.1    Saunier, C.G.2    Siat, J.3    Hartemann, D.4    Lambert, J.5
  • 4
    • 0031713537 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase inhibition on hypercapnia-induced hypothermia and hyperventilation
    • Barros RC and Branco LG. Effect of nitric oxide synthase inhibition on hypercapnia-induced hypothermia and hyperventilation. J Appl Physiol 85: 967-972, 1998.
    • (1998) J Appl Physiol , vol.85 , pp. 967-972
    • Barros, R.C.1    Branco, L.G.2
  • 5
    • 0014867206 scopus 로고
    • Control of breathing in experimental anemia
    • Bartlett D and Tenney SM. Control of breathing in experimental anemia. Respir Physiol 10: 384-395, 1970.
    • (1970) Respir Physiol , vol.10 , pp. 384-395
    • Bartlett, D.1    Tenney, S.M.2
  • 6
    • 0032947296 scopus 로고    scopus 로고
    • Nitric oxide and mitochondrial respiration
    • Brown GC. Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411: 351-369, 1999.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 351-369
    • Brown, G.C.1
  • 7
    • 0018096305 scopus 로고
    • Comparative stability of physiological parameters during sustained anesthesia in rats
    • Buelke-Sam J, Holson JF, Bazare JJ, and Young JF. Comparative stability of physiological parameters during sustained anesthesia in rats. Lab Anim Sci 28: 157-162, 1978.
    • (1978) Lab Anim Sci , vol.28 , pp. 157-162
    • Buelke-Sam, J.1    Holson, J.F.2    Bazare, J.J.3    Young, J.F.4
  • 8
    • 0018627318 scopus 로고
    • Effects of graded reduction of brain blood flow on chemical control of breathing
    • Chapman RW, Santiago TV, and Edelman NH. Effects of graded reduction of brain blood flow on chemical control of breathing. J Appl Physiol 47: 1289-1294, 1979.
    • (1979) J Appl Physiol , vol.47 , pp. 1289-1294
    • Chapman, R.W.1    Santiago, T.V.2    Edelman, N.H.3
  • 10
    • 0032951905 scopus 로고    scopus 로고
    • Nitric oxide and iron proteins
    • Cooper CE. Nitric oxide and iron proteins. Biochim Biophys Acta 1411: 290-309, 1999.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 290-309
    • Cooper, C.E.1
  • 11
    • 0033033738 scopus 로고    scopus 로고
    • Nitric oxide does not modulate whole body oxygen consumption in anesthetized dogs
    • Crystal GJ, Zhou X, Halim AA, Alam S, El Orbany M, and Salem MR. Nitric oxide does not modulate whole body oxygen consumption in anesthetized dogs. J Appl Physiol 86: 1944-1949, 1999.
    • (1999) J Appl Physiol , vol.86 , pp. 1944-1949
    • Crystal, G.J.1    Zhou, X.2    Halim, A.A.3    Alam, S.4    El Orbany, M.5    Salem, M.R.6
  • 12
    • 73049177513 scopus 로고
    • Chemoreceptors in breathing
    • Dejours P. Chemoreceptors in breathing. Physiol Rev 42: 335-358, 1962.
    • (1962) Physiol Rev , vol.42 , pp. 335-358
    • Dejours, P.1
  • 14
    • 0031893415 scopus 로고    scopus 로고
    • Regulation of the cerebral circulation: Role of endothelium and potassium channels
    • Faraci FM and Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 78: 53-97, 1998.
    • (1998) Physiol Rev , vol.78 , pp. 53-97
    • Faraci, F.M.1    Heistad, D.D.2
  • 15
    • 0029750199 scopus 로고    scopus 로고
    • Interactions among metabolic rate, hypoxia, and control of breathing
    • Gautier H. Interactions among metabolic rate, hypoxia, and control of breathing. J Appl Physiol 81: 521-527, 1996.
    • (1996) J Appl Physiol , vol.81 , pp. 521-527
    • Gautier, H.1
  • 16
    • 0029882746 scopus 로고    scopus 로고
    • Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats
    • Gozal D, Gozal E, Gozal YM, and Torres JE. Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats. Neuroreport 7: 1145-1148, 1996.
    • (1996) Neuroreport , vol.7 , pp. 1145-1148
    • Gozal, D.1    Gozal, E.2    Gozal, Y.M.3    Torres, J.E.4
  • 17
    • 0029834761 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat
    • Gozal D, Torres JE, Gozal YM, and Littwin SM. Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat. J Appl Physiol 81: 2068-2077, 1996.
    • (1996) J Appl Physiol , vol.81 , pp. 2068-2077
    • Gozal, D.1    Torres, J.E.2    Gozal, Y.M.3    Littwin, S.M.4
  • 18
    • 0029006245 scopus 로고
    • Nitric oxide synthase in autonomic innervation of the cat carotid body
    • Grimes PA, Mokashi A, Stone RA, and Lahiri S. Nitric oxide synthase in autonomic innervation of the cat carotid body. J Auton Nerv Syst 54: 80-86, 1995.
    • (1995) J Auton Nerv Syst , vol.54 , pp. 80-86
    • Grimes, P.A.1    Mokashi, A.2    Stone, R.A.3    Lahiri, S.4
  • 19
    • 0019850321 scopus 로고
    • The carotid bodies in spontaneously hypertensive (SHR) and normotensive rats - A study concerning size, location and blood supply
    • Habeck JO, Honig A, Pfeiffer C, and Schmidt M. The carotid bodies in spontaneously hypertensive (SHR) and normotensive rats - a study concerning size, location and blood supply. Anat Anz 150: 374-384, 1981.
    • (1981) Anat Anz , vol.150 , pp. 374-384
    • Habeck, J.O.1    Honig, A.2    Pfeiffer, C.3    Schmidt, M.4
  • 21
    • 0016719056 scopus 로고
    • Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation
    • Heistad D, Abboud FM, Mark AL, and Schmid PG. Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J Appl Physiol 39: 411-416, 1975.
    • (1975) J Appl Physiol , vol.39 , pp. 411-416
    • Heistad, D.1    Abboud, F.M.2    Mark, A.L.3    Schmid, P.G.4
  • 24
    • 0027945658 scopus 로고
    • Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    • Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, and Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265: 1883-1885, 1994.
    • (1994) Science , vol.265 , pp. 1883-1885
    • Huang, Z.1    Huang, P.L.2    Panahian, N.3    Dalkara, T.4    Fishman, M.C.5    Moskowitz, M.A.6
  • 25
    • 0002840537 scopus 로고
    • Biology and diseases of mice
    • edited by Fox JG, Cohen BJ. and Loew FM. New York: Academic
    • Jacoby RO and Fox JG. Biology and diseases of mice. In: Laboratory Animal Medicine, edited by Fox JG, Cohen BJ. and Loew FM. New York: Academic, 1984, p. 31-89.
    • (1984) Laboratory Animal Medicine , pp. 31-89
    • Jacoby, R.O.1    Fox, J.G.2
  • 28
    • 0032529054 scopus 로고    scopus 로고
    • Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase
    • Kline DD, Yang T, Huang PL, and Prabhakar NR. Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol (Lond) 511: 273-287, 1998.
    • (1998) J Physiol (Lond) , vol.511 , pp. 273-287
    • Kline, D.D.1    Yang, T.2    Huang, P.L.3    Prabhakar, N.R.4
  • 29
    • 0032496759 scopus 로고    scopus 로고
    • Changes in the distribution of nitric oxide synthase immunoreactive nerve fibers in the chronically hypoxic rat carotid body
    • Kusakabe T, Matsuda H, Harada Y, Hayashida Y, Gono Y, Kawakami T, and Takenaka T. Changes in the distribution of nitric oxide synthase immunoreactive nerve fibers in the chronically hypoxic rat carotid body. Brain Res 795: 292-296, 1998.
    • (1998) Brain Res , vol.795 , pp. 292-296
    • Kusakabe, T.1    Matsuda, H.2    Harada, Y.3    Hayashida, Y.4    Gono, Y.5    Kawakami, T.6    Takenaka, T.7
  • 30
    • 0029005799 scopus 로고
    • Effect of chronic hypoxaemia from birth upon chemosensitivity in the adult rat carotid body in vitro
    • Landauer RC, Pepper DR, and Kumar P. Effect of chronic hypoxaemia from birth upon chemosensitivity in the adult rat carotid body in vitro. J Physiol (Lond) 485: 543-550, 1995.
    • (1995) J Physiol (Lond) , vol.485 , pp. 543-550
    • Landauer, R.C.1    Pepper, D.R.2    Kumar, P.3
  • 31
    • 0031021090 scopus 로고    scopus 로고
    • Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate
    • Leonard TO and Lydic R. Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. JNeurosci 17: 774-785, 1997.
    • (1997) JNeurosci , vol.17 , pp. 774-785
    • Leonard, T.O.1    Lydic, R.2
  • 32
    • 0026476287 scopus 로고
    • Endogenous nitric oxide required for an integrative respiratory function in the cat brain
    • Ling L, Karius DR, Fiscus RR, and Speck DF. Endogenous nitric oxide required for an integrative respiratory function in the cat brain. JNeurophysiol 68: 1910-1912, 1992.
    • (1992) JNeurophysiol , vol.68 , pp. 1910-1912
    • Ling, L.1    Karius, D.R.2    Fiscus, R.R.3    Speck, D.F.4
  • 33
    • 0029821693 scopus 로고    scopus 로고
    • Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression
    • Lo EH, Hara H, Rogowska J, Trocha M, Pierce AR, Huang PL, Fishman MC, Wolf GL, and Moskowitz MA. Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke 27: 1381-1385, 1996.
    • (1996) Stroke , vol.27 , pp. 1381-1385
    • Lo, E.H.1    Hara, H.2    Rogowska, J.3    Trocha, M.4    Pierce, A.R.5    Huang, P.L.6    Fishman, M.C.7    Wolf, G.L.8    Moskowitz, M.A.9
  • 34
    • 0021751184 scopus 로고
    • A morphometric study of the carotid body in chronically hypoxic rats
    • McGregor KH, Gil J, and Lahiri S. A morphometric study of the carotid body in chronically hypoxic rats. J Appl Physiol 57: 1430-1438, 1984.
    • (1984) J Appl Physiol , vol.57 , pp. 1430-1438
    • McGregor, K.H.1    Gil, J.2    Lahiri, S.3
  • 35
    • 0027178892 scopus 로고
    • Inhibition of chemoreceptor inputs to nucleus of tractus solitarius neurons during baroreceptor stimulation
    • Mifflin SW. Inhibition of chemoreceptor inputs to nucleus of tractus solitarius neurons during baroreceptor stimulation. Am J Physiol Regulatory Integrative Comp Physiol 265: R14-R20, 1993.
    • (1993) Am J Physiol Regulatory Integrative Comp Physiol , vol.265
    • Mifflin, S.W.1
  • 36
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada S, Palmer RM, and Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-141, 1991.
    • (1991) Pharmacol Rev , vol.43 , pp. 109-141
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 37
    • 0029156908 scopus 로고
    • Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia
    • Ogawa H, Mizusawa A, Kikuchi Y, Hida W, Miki H, and Shirato K. Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia. J Physiol (Lond) 486: 495-504, 1995.
    • (1995) J Physiol (Lond) , vol.486 , pp. 495-504
    • Ogawa, H.1    Mizusawa, A.2    Kikuchi, Y.3    Hida, W.4    Miki, H.5    Shirato, K.6
  • 39
    • 0031956738 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibitors alter ventilation in isoflurane anesthetized rats
    • Patel GM, Horstman DJ, Adams JM, and Rich GF. Nitric oxide synthase inhibitors alter ventilation in isoflurane anesthetized rats. Anesthesiology 88: 1240-1248, 1998.
    • (1998) Anesthesiology , vol.88 , pp. 1240-1248
    • Patel, G.M.1    Horstman, D.J.2    Adams, J.M.3    Rich, G.F.4
  • 40
    • 0030443809 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition modulates the ventilatory depressant and antinociceptive actions of fourth ventricular infusions of morphine in the awake dog
    • Pelligrino DA, Laurito CE, and VadeBoncouer TR. Nitric oxide synthase inhibition modulates the ventilatory depressant and antinociceptive actions of fourth ventricular infusions of morphine in the awake dog. Anesthesiology 85: 1367-1377, 1996.
    • (1996) Anesthesiology , vol.85 , pp. 1367-1377
    • Pelligrino, D.A.1    Laurito, C.E.2    VadeBoncouer, T.R.3
  • 41
    • 0032965968 scopus 로고    scopus 로고
    • NO and CO as second messengers in oxygen sensing on the carotid body
    • Prabhakar NR, NO and CO as second messengers in oxygen sensing on the carotid body. Respir Physiol 115: 161-168, 1999.
    • (1999) Respir Physiol , vol.115 , pp. 161-168
    • Prabhakar, N.R.1
  • 43
    • 0022298197 scopus 로고
    • Increased resistance to acute anoxia of the respiratory and cardiac function in spontaneously hypertensive rats
    • Przybylski J, Tafil-Klawe M, Trzebski A, and Klawe J. Increased resistance to acute anoxia of the respiratory and cardiac function in spontaneously hypertensive rats. Acta Physiol Pol 36: 42-50, 1985.
    • (1985) Acta Physiol Pol , vol.36 , pp. 42-50
    • Przybylski, J.1    Tafil-Klawe, M.2    Trzebski, A.3    Klawe, J.4
  • 44
    • 0020285127 scopus 로고
    • Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats
    • Przybylski J, Trzebski A, Czyzewski T, and Jodkowski J. Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats. Bull Eur Physiopath Respir 4: 145-154, 1982.
    • (1982) Bull Eur Physiopath Respir , vol.4 , pp. 145-154
    • Przybylski, J.1    Trzebski, A.2    Czyzewski, T.3    Jodkowski, J.4
  • 45
    • 0019270798 scopus 로고
    • Circulatory responses to acute hypoxia in spontaneously hypertensive and normotensive rats
    • Przybylski J, Trzebski A, and Przybyszewski A. Circulatory responses to acute hypoxia in spontaneously hypertensive and normotensive rats. Acta Physiol Pol 31: 463-468, 1980.
    • (1980) Acta Physiol Pol , vol.31 , pp. 463-468
    • Przybylski, J.1    Trzebski, A.2    Przybyszewski, A.3
  • 46
    • 0028873556 scopus 로고
    • Endogenous opoids modulate ventilation in the obese Zucker rat
    • Schlenker EH and Farkas GA. Endogenous opoids modulate ventilation in the obese Zucker rat. Respir Physiol 99: 97-103, 1995.
    • (1995) Respir Physiol , vol.99 , pp. 97-103
    • Schlenker, E.H.1    Farkas, G.A.2
  • 47
  • 48
    • 0033015343 scopus 로고    scopus 로고
    • 2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism
    • 2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J Neurophysiol 81: 1449-1457, 1999.
    • (1999) J Neurophysiol , vol.81 , pp. 1449-1457
    • Summers, B.A.1    Overholt, J.L.2    Prabhakar, N.R.3
  • 49
    • 0024917703 scopus 로고
    • Attenuation of augmented ventilatory response to hypoxia in essential hypertension in the course of aging
    • Tafil-Klawe M, Raschke F, Kublik A, Stoohs R, and von Wiehert P. Attenuation of augmented ventilatory response to hypoxia in essential hypertension in the course of aging. Respiration 56:154-160, 1989.
    • (1989) Respiration , vol.56 , pp. 154-160
    • Tafil-Klawe, M.1    Raschke, F.2    Kublik, A.3    Stoohs, R.4    Von Wiehert, P.5
  • 50
    • 0025975734 scopus 로고
    • Attenuated carotid body hypoxic sensitivity after prolonged hypoxic exposure
    • Tatsumi K, Pickett CK, and Weil JV. Attenuated carotid body hypoxic sensitivity after prolonged hypoxic exposure. J Appl Physiol 70: 748-755, 1991.
    • (1991) J Appl Physiol , vol.70 , pp. 748-755
    • Tatsumi, K.1    Pickett, C.K.2    Weil, J.V.3
  • 51
    • 0031017145 scopus 로고    scopus 로고
    • ω-nitro-L-arginine on ventilatory response to hypercapnia in anesthetized cats
    • ω-nitro-L-arginine on ventilatory response to hypercapnia in anesthetized cats. J Appl Physiol 82: 292-297, 1997.
    • (1997) J Appl Physiol , vol.82 , pp. 292-297
    • Teppema, L.1    Berkenbosch, A.2    Olievier, C.3
  • 52
    • 0028926977 scopus 로고
    • Inhibition of nitric oxide synthesis potentiates the responsiveness of carotid chemoreceptors to systemic hypoxia in the rat
    • Trzebski A, Sato Y, Suzuki A, and Sato A, Inhibition of nitric oxide synthesis potentiates the responsiveness of carotid chemoreceptors to systemic hypoxia in the rat. Neurosci Lett 190: 29-32, 1995.
    • (1995) Neurosci Lett , vol.190 , pp. 29-32
    • Trzebski, A.1    Sato, Y.2    Suzuki, A.3    Sato, A.4
  • 53
    • 0028935790 scopus 로고
    • Nitric oxide in the regulation of blood flow and arterial pressure
    • Umans JG and Levi R. Nitric oxide in the regulation of blood flow and arterial pressure. Annu Rev Physiol 57: 771-790, 1995.
    • (1995) Annu Rev Physiol , vol.57 , pp. 771-790
    • Umans, J.G.1    Levi, R.2
  • 54
    • 0026531143 scopus 로고
    • Histochemical mapping of nitric oxide synthase in the rat brain
    • Vincent SR and Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46: 755-784, 1992.
    • (1992) Neuroscience , vol.46 , pp. 755-784
    • Vincent, S.R.1    Kimura, H.2
  • 55
  • 56
    • 0027363419 scopus 로고
    • Neurons synthesizing nitric oxide innervate the mammalian carotid body
    • Wang ZZ, Bredt DS, Fidone SJ, and Stensaas LJ. Neurons synthesizing nitric oxide innervate the mammalian carotid body. J Comp Neurol 336: 419-432, 1993.
    • (1993) J Comp Neurol , vol.336 , pp. 419-432
    • Wang, Z.Z.1    Bredt, D.S.2    Fidone, S.J.3    Stensaas, L.J.4
  • 58
    • 0026507762 scopus 로고
    • The co-existence of biogenic amines and neuropeptides in the type I cells of the cat carotid body
    • Wang ZZ, Stensaas LJ, Dinger B, and Fidone SJ. The co-existence of biogenic amines and neuropeptides in the type I cells of the cat carotid body. Neuroscience 47: 473-480, 1992.
    • (1992) Neuroscience , vol.47 , pp. 473-480
    • Wang, Z.Z.1    Stensaas, L.J.2    Dinger, B.3    Fidone, S.J.4
  • 59
    • 0029898108 scopus 로고    scopus 로고
    • Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo
    • Zagvazdin Y, Sancesario G, Wang YX, Share L, Fitzgerald ME, and Reiner A. Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo. Eur J Pharmacol 303: 61-69, 1996.
    • (1996) Eur J Pharmacol , vol.303 , pp. 61-69
    • Zagvazdin, Y.1    Sancesario, G.2    Wang, Y.X.3    Share, L.4    Fitzgerald, M.E.5    Reiner, A.6
  • 60
    • 0030768296 scopus 로고    scopus 로고
    • Species differences in the distribution of nitric oxide synthase in brain stem regions that regulate sympathetic activity
    • Zanzinger J and Seller H. Species differences in the distribution of nitric oxide synthase in brain stem regions that regulate sympathetic activity. Brain Res 764: 265-268, 1997.
    • (1997) Brain Res , vol.764 , pp. 265-268
    • Zanzinger, J.1    Seller, H.2


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