Effect of sulfhydryl reagents on the regulatory system of the L-type Ca channel in frog ventricular myocytes

Pflugers Archiv European Journal of Physiology

Volumn 440, Issue 2, 2000, Pages 207-215

  Yamaoka, Kaoru ^a   Yakehiro, Masuhide ^b   Yuki, Tsunetsugu ^a   Fujii, Hideaki ^c   Seyama, Issei ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^c CHUGOKU ROSAI HOSPITAL   (Japan)

Author keywords

Cysteine; Frog ventricle; L type Ca channel; Sulfhydryl reagents

Indexed keywords

2,2' DITHIODIPYRIDINE; CALCIUM; CALCIUM CHANNEL; CYCLIC AMP; DITHIOTHREITOL; GUANINE NUCLEOTIDE BINDING PROTEIN; N ETHYLMALEIMIDE; SULFONIC ACID DERIVATIVE; THIOL REAGENT; TOSYLCHLORAMIDE SODIUM;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; FROG; HEART MUSCLE CELL; HEART VENTRICLE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

2,2'-DIPYRIDYL; ALKYLATING AGENTS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CYCLIC AMP; DISULFIDES; ELECTRIC CONDUCTIVITY; ETHYLMALEIMIDE; GTP-BINDING PROTEINS; HEART VENTRICLES; MYOCARDIUM; OXIDANTS; PYRIDINES; QUATERNARY AMMONIUM COMPOUNDS; RANA CATESBEIANA; SULFHYDRYL REAGENTS; THIOSULFONIC ACIDS; TIME FACTORS;

EID: 0034050028     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240051041     Document Type: Article

References (23)

1. 1. Akabas MH, Kaufmann C, Archdeacon P, Karlin A (1994) Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron 13:919-927
2. 2. Akabas MH, Stauffer DA, Xu M, Karlin A (1992) Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 258:307-310
3. 3. Aktories K, Schultz G, Jakobs KH (1982) Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes. Naunyn Schmiedebergs Arch Pharmacol 321:247-252
4. 4. Campbell DL, Stamler JS, Strauss HC (1996) Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitricoxide and S-nitrosothiols. J Gen Physiol 108:277-293
5. 5. Charnet P, Lory P, Bourinet E, Collin T, Nargeot J (1995) cAMP-dependent phosphorylation of the cardiac L-type Ca channel: a missing link? Biochimie 77:957-962
6. + channels. Circ Res 76: 325-334
7. 2+ channel alpha1C subunits by redox agents and hypoxia. J Physiol (Lond) 514:629-637
8. 2+ channels. Neurosci Lett 146:84-86
9. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 19:185-196
10. 10. Holmgren M, Liu Y, Xu Y, Yellen G (1996) On the use of thiol-modifying agents to determine channel topology. Neuropharmacology 35:797-804
11. 2+ channels by S-nitrosothiol nitric oxide donors. Circ Res 81:742-752
12. 12. Jakobs KH, Lasch P, Minuth M, Aktories K, Schultz G (1982) Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide. J Biol Chem 257:2829-2833
13. + channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis. Biophys J 68:900-905
14. 14. Lacampagne A, Duittoz A, Bolanos P, Peineau N, Argibay JA (1995) Effect of sulfhydryl oxidation on ionic and gating currents associated with L-type calcium channels in isolated guinea-pig ventricular myocytes. Cardiovasc Res 30:799-806
15. 15. Mikami A, Imoto K, Tanabe T, Niidome T, Mori Y, Takeshima H, Narumiya S, Numa S (1989) Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340:230-233
16. 16. Mubagwa K, Pappano AJ (1994) N-Ethylmaleimide increases the L-type calcium current in guinea-pig ventricular myocytes. Arch Int Pharmacodyn Ther 327:125-141
17. 17. Nakajima T, Irisawa H, Giles W (1990) N-Ethylmaleimide uncouples muscarinic receptors from acetylcholine-sensitive potassium channels in bullfrog atrium. J Gen Physiol 96:887-903
18. 18. Scamps F, Rybin V, Puceat M, Tkachuk V, Vassort G (1992) A Gs protein couples P2-purinergic Stimulation to cardiac Ca channels without cyclic AMP production. J Gen Physiol 100:675-701
19. 19. Schoenmakers TJ, Visser GJ, Flik G, Theuvenet AP (1992) CHELATOR: an improved method for computing metal ion concentrations in physiological solutions. Biotechniques 12: 870-879
20. 20. Seyama I, Yamaoka K (1988) A study of the electrical characteristics of sodium currents in single ventricular cells of the frog. J Physiol (Lond) 401:257-275
21. 21. Ukena D, Poeschla E, Huttemann E, Schwabe U (1984) Effects of N-ethylmaleimide on adenosine receptors of rat fat cells and human platelets. Naunyn Schmiedebergs Arch Pharmacol 327:247-253
22. 22. Winslow JW, Bradley JD, Smith JA, Neer EJ (1987) Reactive sulfhydryl groups of alpha 39,a guanine nucleotide-binding protein from brain. Location and function. J Biol Chem 262: 4501-4507
23. 23. Yang N, George AL Jr, Horn R (1997) Probing the outer vestibule of a sodium channel voltage sensor. Biophys J 73: 2260-2268