Structural organization of the human dihydropyrimidine dehydrogenase gene

Cancer Research

Volumn 57, Issue 9, 1997, Pages 1660-1663

  Johnson, Martin R ^a   Wang, Kangshang ^a   Tillmanns, Silke ^a,b   Albin, Nicolas ^a   Diasio, Robert B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL;

ARTICLE; ENZYME DEFICIENCY; EXON; GENE LIBRARY; GENE MAPPING; GENE STRUCTURE; GENETIC ANALYSIS; HUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

DIHYDROURACIL DEHYDROGENASE (NADP); EXONS; GENES; HUMANS; INTRONS; OXIDOREDUCTASES; RNA, MESSENGER;

EID: 0030981029     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Heidelberger, C. In: A. C. Sartorelli and D. G. John (eds.), Antineoplastic and Immunosuppressive Agents, Part II, pp. 193-231. Berlin: Springer-Verlag, 1975.
2. Grem, J. L. In: B. A. Chabner and D. L. Longo (eds.), Cancer Chemotherapy and Biotherapy, Ed. 2, pp. 149-197. Philadelphia: Lippincott-Raven, 1996.
3. Heggie, G. C., Sommadossi, J. P., Cross, D. S., Huster, W. J., and Diasio. R. B. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res., 47: 2203-2206, 1987.
4. Sommadossi, J. P., Gewirtz, D. A., Diasio, R. B., Aubert, C., Cano, J. P., and Goldman, I. D. Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytcs as analyzed by high performance liquid chromatography. J. Biol. Chem., 257: 8171-8176, 1982.
5. Diasio, R. B., and Lu, Z-H. Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy. J. Clin. Oncol., 12: 2239-2242, 1994.
6. Diasio, R. B., Beavers, T. L., and Carpenter, J. T. Familial deficiency of dihydropyrimidine dehydrogenase. J. Clin. Invest., 81: 47-51, 1988.
7. Lu, Z. Zhang, R., and Diasio, R. B. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients and clinical implication in 5-fluorouracil chemotherapy. Cancer Res., 53: 5433-5438, 1993.
8. Harris, B. E., Carpenter, J. T., and Diasio, R. B. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: a potentially more common pharmacogenetic syndrome. Cancer (Phila.), 68: 499-501, 1991.
9. Etienne, M. C., Lagrange, J. L., Dassonville, O., Fleming, R., Thyss, A., Renee, N., Schneider, M., Demard, F., and Milano, G. Population study of diydropyrimidine dehydrogenase in cancer patients. J. Clin. Oncol., 12: 2248-2253, 1994.
10. Takimoto, C. H., Lu, Z. H., Zhang, R., Liang, M. D., Larson, L. V., Cantilena, L. R., Grem, J. L., Allegra, C. J., Diasio, R. B., and Chu, E. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin. Cancer Res., 2: 477-481, 1996.
11. Milano, G., and Etienne, M. C. Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy. Pharmacogenetics, 4: 301-306, 1994.
12. Yokota, H., Fernandez-Salguero, P., Furuya, H., Lin, K., McBride, O. W., Podschun, B., Schnackerz, K. D., Gonzales, F. J. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uracilurea. J. Biol. Chem., 269: 23192-23196, 1994.
13. Johnson, M. R., Albin, N., Wang, K., and Diasio, R. B. cDNA cloning of dihydropyrimidine dehydrogenase from human lymphocytes. Proc. Am. Assoc. Cancer Res., 36: 503, 1995.
14. Albin, N., Johnson, M. R., Shahinian, H., Wang. K., and Diasio, R. B. Initial characterization of the molecular defect in human diydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer Res., 36: 211, 1995.
15. Meinsma, R., Salguero, P. F., Van Kuilenburg, A. B. P., Van Gennip, A. H., and Gonzalez, F. J. Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea. DNA Cell Biol., 14: 1-6, 1995.
16. Wei, X., McLeod, H. D., McMurrough, J., Gonzalez, F. J., and Salguero, P. F. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin. Invest., 98: 610-615, 1996.
17. Pierce, J. C., Sternber, N., and Sauer, B. A mouse genomic library in the bacteriophage P1 cloning system: organization and characterization. Mamm. Genome, 3: 550-558, 1992.
18. Siebert, P. D., Chenchik, A., Kellogg, D. E., Lukyanov, K. A., and Lukyanov, S. A. An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res., 23: 1087-1088, 1995.
19. Barnes, W. M. PCR amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates. Proc. Natl. Acad. Sci. USA, 91: 2216-2220, 1994.
20. Cheng, S., Fockler, C., Barnes, W. M., and Higuchi, R. Effective amplification of long targets from cloned inserts and human genomic DNA. Proc. Natl. Acad. Sci. USA, 91: 5695-5699, 1994.
21. MacKnight, S. L., and Kingsbury, R. Transcriptional control signals of a eukaryotic protein-coding gene. Science (Washington DC), 217: 316-324, 1982.
22. Borson, N. D., Sato, W. L., and Drewes, L. R. A lock-docking oligo(dT) primer for 5′ and 3′ RACE PCR. PCR Methods Appl., 2: 144-148, 1992.
23. Ogata, H., Fujibuchi, W., and Kanehisa, M. The size differences among mammalian introns are due to the accumulation of small deletions. FEBS Lett., 390: 99-103, 1996.
24. Maiti, S., Doskow, J., Li, S., Nhim, R. P., Lindsey, J. S., and Wilkinson, M. F. The Pem homeobox gene. Androgen-dependent and -independent promoters and tissuespecific alternative RNA splicing. J. Biol. Chem., 271: 17536-17546, 1996.
25. Johansson, M., and Karlsson, A. Cloning and expression of human deoxyguanosine kinase cDNA. Proc. Natl. Acad. Sci. USA, 93: 7258-7262, 1996.
26. Fernandez-Salguero, P., Kimura, S., Gonzalez, F. J., and Yamada, K. Assignment of the human dihydropyrimidine dehydrogenase gene (DPYD) to chromosome region 1p22 by fluorescence in situ hybridization. Genomics, 24: 613-614, 1994.