Expression of inhibin α in adrenocortical tumours reflects the hormonal status of the neoplasm

Journal of Endocrinology

Volumn 165, Issue 2, 2000, Pages 223-229

  Arola, J ^a   Liu, J ^a   Heikkila P ^a   Ilvesmaki V ^b   Salmenkivi, K ^a   Voutilainen, R ^c   Kahri, A I ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; INHIBIN; MESSENGER RNA;

ADRENAL CORTEX TUMOR; ANDROGEN SYNTHESIS; ARTICLE; CANCER INHIBITION; ENDOCRINE FUNCTION; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHEOCHROMOCYTOMA; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL;

EID: 0034039316     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1650223     Document Type: Article

References (28)

1. Arnheim N 1979 Characterization of mouse ribosomal gene fragments purified by molecular cloning. Gene 7 83-96.
2. Barton DE, Yang-Feng, TL, Mason AJ, Seeburg PH & Francke U 1989 Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. Genomics 5 91-99.
3. Chirgwin JM, Przybyla AE, MacDonald RJ & Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18 5294-5299.
4. Chivite A, Matias-Guiu X, Pons C, Algaba F & Prat J 1998 Inhibin A expression in adrenal neoplasms. Applied Immunohistochemistry 6 42-49.
5. Cibas ES, Medeiros LJ, Weinberg DS, Gelb AB & Weiss LM 1990 Cellular DNA profiles of benign and malignant adrenocortical tumors. American Journal of Surgical Pathology 14 948-955.
6. Crawford RJ, Hammond VE, Evans BA, Coghlan JP, Haralambidis J, Hudson B, Pennschow JD, Richards RI & Tregear GW 1987 α-Inhibin gene expression occurs in the ovine adrenal cortex, and is regulated by adrenocorticotropin. Molecular Endocrinology 1 699-706.
7. Kananen K, Markkula M, Mikola M, Rainio E-M, McNeilly A & Huhtaniemi I 1996 Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin a-subunit gene. Molecular Endocrinology 10 1667-1677.
8. Kjellman M, Roshani L, Teh BT, Kallioniemi O-P, Höög A, Gray S. Farnebo L-O, Holst M, Bäckdahl M & Larsson C 1999 Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. Journal of Clinical Endocrinology and Metabolism 84 730-735.
9. Liu J, Voutilainen R, Kahri AI & Heikkilä P 1995 Expression of the c-myc gene in human adrenals: regulation by adrenocorticotropin in primary cultures. Journal of Endocrinology 148 523-529.
10. Marx C, Wolkersdörfer GW, Brown JW, Scherbaum WA & Bornstein SR 1996 MHC class II expression - a tool to assess malignancy in adrenocortical tumours. Journal of Clinical Endocrinology and Metabolism 81 4488-4491.
11. Mason AJ, Niall HD & Seeburg PH 1986 Structure of two human ovarian inhibins. Biochemical and Biophysical Research Communications 135 957-964.
12. Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW & Bradley A 1992 α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360 313-319.
13. McCluggage WG, Burton J, Maxwell P & Sloan JM 1998 Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against a inhibin. Journal of Clinical Pathology 51 114-116.
14. McNicol AM, Nolan CE, Struthers AJ, Farquharson MA, Hermans J & Haak HR 1997 Expression of p53 in adrenocortical tumours: clinicopathological correlations. Journal of Pathology 181 146-152.
15. Medeiros LJ & Weiss LM 1992 New developments in the pathologic diagnosis of adrenal cortical neoplasms. A review. American Journal of Clinical Pathology 97 73-83.
16. Meunier H, Rivier C, Evans RM & Vale W 1988 Gonadal and extragonadal expression of inhibn α, βA and βB subunits in various tissues predicts diverse functions. Proceedings of the National Academy of Sciences of the USA 85 247-251.
17. Munro LMA, Kennedy A & McNicol AM 1999 The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. Journal of Endocrinology 161 341-347.
18. Nakazumi H, Sasano H, lino K, Ohashi Y & Orikasa S 1998 Expression of cell cycle inhibitor p27 and Ki-67 in human adrenocortical neoplasms. Modern Pathology 11 1165-1170.
19. Nishi Y, Haji M, Takayanagi R, Yanase T, lkuyama S & Nawata H 1995 in vivo and in vitro evidence for the production of inhibin-like immunoreactivity in human adrenocortical adenomas and normal adrenal glands: relatively high secretion from adenomas manifesting Cushing's syndrome. European Journal of Endocrinology 132 292-299.
20. Padberg B-C, Lauritzen I, Achilles E, Holl K, Bressel M, Klöppel G, Dralle H & Schröder S 1991 DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases. Virchows Archiv 419 167-170.
21. Pelkey TJ, Frierson HF, Mills SE & Stoler MH 1998 The alpha subunit of inhibin in adrenal cortical neoplasia. Modern Pathology 11 516-524.
22. Renshaw AA & Granter SR 1998 A comparison of A103 and inhibin reactivity in adrenal cortical tumors: distinction from hepatocellular carcinoma and renal tumors. Modern Pathology 11 1160-1164.
23. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC & Jaffe RB 1992 Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells. Journal of Clinical Investigation 90 142-149.
24. Voutilainen R 1995 What is the function of adrenal inhibins? European Journal of Endocrinology 132 290-291.
25. Voutilainen R, Erämaa M & Ritvos O 1991 Hormonally regulated inhibin gene expression in human fetal and adult adrenals. Journal of Clinical Endocrinology and Metabolism 73 1026-1030.
26. Weiss LM 1984 Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. American Journal of Surgical Pathology 8 163-169.
27. Weiss LM, Medeiros LJ & Vickery AL 1989 Pathologic features of prognostic significance in adrenocortical carcinoma. American Journal of Surgical Pathology 13 202-206.
28. Ying S-Y 1988 Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocrine Reviews 9 267-293.