Inhibin A expression in adrenal neoplasms: A new immunohistochemical marker for adrenocortical tumors

Applied Immunohistochemistry

Volumn 6, Issue 1, 1998, Pages 42-49

  Chivite, Ana ^a   Matias Guiu, Xavier ^a   Pons, Cristina ^a   Algaba, Ferran ^b   Prat, Jaime ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Adrenal tumors; Adrenocortical tumors; Immunohistochemistry; Inhibin A; Pheochromocytoma

Indexed keywords

INHIBIN A;

ADRENAL TUMOR; ARTICLE; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CLASSIFICATION;

EID: 0031895528     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: 10.1097/00022744-199803000-00008     Document Type: Article

References (17)

1. Chan JKC, Tsang WYW. Endocrine malignancies that may mimic benign lesions. Semin Diagn Pathol 1995;12:45-63.
2. Ramsay J, Asa S, van Nostrand A, Hassaram S, deHarven E. Lipid degeneration in pheochromocytomas mimicking adrenal cortical tumors. Am J Surg Pathol 1987;11:480-6.
3. Komminoth P, Roth J, Schroder S, Saremaslani P, Heitz PU. Overlapping expression of immunohistochemical markers and synaptophysin mRNA in pheochromocytomas and adrenocortical carcinomas. Lab Invest 1995;72:424-31.
4. Chen CLC. Inhibin and activin as paracrine/autocrine factors. Endocrinology 1993;132:4-5.
5. Jaatinen TL, Penttila TL, Kaipia A, Ekfors T, Parvinen M, Toppari J. Expression of inhibin alpha, betaA, and betaB messenger ribonucleic acids in the normal human ovary and in polycystic ovarian syndrome. J Endocrinol 1994;143:127-37.
6. Flemming P, Wellmann A, Maschek H, Lang H, Georgii A. Monoclonal antibodies against inhibin represent key markers of adult granulosa cell tumors of the ovary even in their metastases. Am J Surg Pathol 1995;19:927-930.
7. Lappohn RE, Burger HG, Bouma J, Bangah M, Krans M, Brujin HWA. Inhibin as a marker for granulosa-cell tumors. NEngl J Med 1989;321:790-3.
8. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC, Jaffe RB. Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells. J Clin Invest 1992;90: 142-9.
9. Flemming P, Grothe W, Maschek H, Petry KU, Wellmann A, Georgii A. The site of inhibin production in ovarian neoplasms. Histopathology 1996;29:465-8.
10. Rishi M, Howard LN, Bratthauer GL, Tavassoli FA. Use of mono-clonal antibody against human inhibin as a marker for sex cordstromal tumors of the ovary. Am J Surg Pathol 1997;21:583-9.
11. Weiss L. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 1984; 8:163-9.
12. Hajt M, Nishi Y, Tanaka S, et al. Evidence for the secretion of inhibin-like immunoreactivity from cultured human adrenal cells. J Endocrinol 1991;128:13-16.
13. Brennemann W, Klingmuller D, Eter N, Bidlingmaier F: Immunoreactive inhibin concentrations in human gonads and adrenals during the first years of life. Horm Res 1995;44:115-20.
14. Voutilainen R, Eramaa M, Ritvos O. Hormonally regulated inhibin gene expression in human fetal and adult adrenals. J Clin Endocrinol Metab 1991;73:1026-30.
15. Nishi Y, Haji M, Takayanagi R, Yanase T, Ikuyama S, Nawata H. In vivo and in vitro evidence for the production of inhibin-like immunoreactivity in human adrenocortical adenomas and normal adrenal glands: relatively high secretion from adenomas manifesting Cushing's syndrome. Eur J Endocrinol 1995;132:292-9.
16. Kumar TR, Donehower LA, Bradley A, Matzuk MM. Transgenic mouse models for tumour-suppressor genes. J Intern Med 1995; 238:233-8.
17. Matzuk MM, Kumar TR, Shou W, et al. Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis and development. Recent Prog Horm Res 1996;51:123-54.