Effects of antithymocyte globulin on bone marrow CD34+ cells in aplastic anaemia and myelodysplasia

British Journal of Haematology

Volumn 108, Issue 3, 2000, Pages 582-591

  Killick, Sally B ^a,c   Marsh, Judith C W ^a   Gordon Smith, Edward C ^a   Sorlin, Laurent ^b   Gibson, Frances M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b JT)   (France)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aplastic anaemia; Haemopoietic progenitor cell; Myelodysplastic syndrome antithymocyte globulin

Indexed keywords

CD34 ANTIGEN; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; APLASTIC ANEMIA; ARTICLE; BONE MARROW CELL; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; FEMALE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MALE; MYELODYSPLASIA; PRIORITY JOURNAL; STEM CELL;

ADOLESCENT; ADULT; AGED; ANEMIA, APLASTIC; ANTIGENS, CD34; ANTILYMPHOCYTE SERUM; CASE-CONTROL STUDIES; CELL DIVISION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES;

EID: 0034037280     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01853.x     Document Type: Article

References (40)

1. Ayanlar-Batuman, O., Shevitz, J., Traub, U.C., Murphy, S. & Sajewski, D. (1987) Lymphocyte interleukin 2 production and responsiveness are altered in patients with primary myelodysplastic syndrome. Blood, 70, 494-500.
2. Bacigalupo, A., Broccia, G., Corda, G., Arcese, W., Carotenuto, M., Gallamini, A., Locatelli, E., Mori, P.G., Saracco, P. & Todeschini, G. (1995) Antilymphocyte globulin, cyclosporin, and granulocyte colony-stimulating factor in patients with acquired severe aplastic anemia (SAA): a pilot study of the EBMT SAA Working Party. Blood, 85, 1348-1353.
3. Bacigalupo, A., Hows, J., Gluckman, E., Nissen, C., Marsh, J., Van Lint, M.T., Congiu, M., De Planque, M.M., Ernst, P. & McCann, S. (1988) Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. British Journal of Haematology, 70, 177-182.
4. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A., Gralnick, H.R. & Sultan, C. (1982) Proposals for the classification of the myelodysplastic syndromes. British Journal of Haematology 51, 189-199.
5. Bonnefoy-Berard, N., Vincent, C. & Revillard, J.P. (1991) Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins. Transplantation, 51, 669-673.
6. Bourdage, J.S. & Hamlin, D.M. (1995) Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cylometry. Transplantation, 59, 1194-1200.
7. Camitta, B.M., Rappeport, J.M., Parkman, R. & Nathan, D.G. (1975) Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood, 45, 355-363.
8. Champlin. R.E., Ho, W.G. & Figari, O. (1989) Lack of efficacy for intravenous monoclonal antibody (T101) for aplaslic anemia: a randomised controlled trial. Blood, 64, 132a (abstract).
9. Culligan, D.J. & Jacobs, A. (1992) Minimal diagnostic criteria for the myelodysplastic syndrome. Leukemia Research, 16, 4-5.
10. Doney, K., Martin, P., Storb, R., Whitehead, J., Smith, A., Hansen, J.A., Appelbaum, F., Buckner, C.D. & Thomas, E.D. (1985) A randomized trial of antihuman thymocyte globulin versus murine monoclonal antihuman T-cell antibodies as immunosuppressive therapy for aplastic anemia. Experimental Hematology, 13, 520-524.
11. Faille, A., Barrett, A.J., Balitrand, N., Ketels, F., Gluckman, E. & Najean, Y. (1979) Effect of antilymphocyte globulin on granulocyte precursors in aplastic anaemia. British Journal of Haematology, 42, 371-380.
12. Genestier, L., Fournel, S., Flacher, M., Assossou, O., Revillard, J.P. & Bonnefoy-Berard, N. (1998) Induction of Fas (Apo-1, CD95)-mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins. Blood, 91, 2360-2368.
13. Gibson, F.M. & Gordon-Smith, E.C. (1990) Long-term culture of aplaslic anaemia bone marrow. British Journal of Haematology, 75, 421-427.
14. Huang, A.T. & Mold, N.G. (1994) The role of CD45RO in antithymocyte globulin's stimulation of primitive haemopoietic cells. British Journal of Haematology, 88, 643-646.
15. Huang, A.T., Mold, N.G. & Zhang, S.F. (1987) Antithymocyte globulin stimulates human hematopoietic progenitor cells. Proceedings of the National Academy of Sciences of the USA, 84, 5942-5946.
16. Hunter, R.F., Mold, N.G., Mitchell, R.B. & Huang, A.T. (1985) Differentiation of normal marrow and HL60 cells induced by antithymocyte globulin. Proceedings of the National Academy of Sciences of the USA, 82, 4823-4827.
17. Kawano, Y., Nissen, C., Gratwohl, A. & Speck, B. (1988) Immunostimulatory effects of different antilymphocyte globulin preparations: a possible clue to their clinical effect. British Journal of Haematology, 68, 115-119.
18. Kuzmich, P.V., Ecker, G.A. & Karsh, J. (1994) Rheumatic manifestations in patients with myelodysplastic and mycloproliferative diseases. Journal of Rheumatology, 21, 1649-1654.
19. Maciejewski, J., Selleri, C., Anderson, S. & Young, N.S. (1995b) Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood, 85, 3183-3190.
20. Maciejewski, J.P., Selleri, C., Sato, T., Anderson, S. & Young, N.S. (1995a) Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia. British Journal of Haematology, 91, 245-252.
21. Marsh, J.C., Chang, J., Testa, N.G., Hows, J.M. & Dexter, T.M. (1990) The hematopoietic defect in aplastic anemia assessed by long-term marrow culture. Blood, 76, 1748-1757.
22. Marsh, J.C., Chang, J., Testa, N.G., Hows, J.M. & Dexter, T.M. (1991) In vitro assessment of marrow 'stem cell' and stromal cell function in aplastic anaemia. British Journal of Haematology, 78, 258-267.
23. Marsh, J.C. & Gordon-Smith, E.C. (1995) Treatment of aplastic anaemia with antilymphocyte globulin and cyclosporin. International Journal of Hematology, 62, 133-144.
24. Molldrem, J., Caples, M., Mavroudis, D., Plante, M., Young, N.S. & Barrett, A.J. (1998a) Antithymocyte globulin for patients with myelodysplastic syndrome. British Journal of Haematology, 99, 699.
25. Molldrem, J.J., Jiang, Y.Z., Stetler-Stevenson, M., Mavroudis, D., Hensel, N. & Barrett, A.J. (1998b) Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles. British Journal of Haematology, 102, 1314-1322.
26. Ogata, K., Tamura, H., Yokose, N., An, E., Dan, K., Hamaguchi, H., Sakamaki, H., Onozawa, Y., Clark, S.C. & Nomura, T. (1995) Effects of interleukin-12 on natural killer cell cytotoxicity and the production of interferon-gamma and tumour necrosis factor-alpha in patients with myelodysplastic syndromes. British Journal of Haematology, 90, 15-21.
27. Peddie, C.M., Wolf, C.R., McLellan, L.I., Collins, A.R. & Bowen, D.T. (1997) Oxidative DNA damage in CDB4+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-alpha concentration. British Journal of Haematology, 99, 625-631.
28. Philpott, N.J., Scopes, J., Marsh, J.C., Gordon-Smith, E.C. & Gibson, F.M. (1995) Increased apoptosis in aplastic anemia bone marrow progenitor cells: possible pathophysiologic significance. Experimental Hematology, 23, 1642-1648.
29. Philpott, N.J., Turner, A.J., Scopes, J., Westby, M., Marsh, J.C., Gordon, S.E.C., Dalgleish, A.G. & Gibson, F.M. (1996) The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood, 87, 2244-2251.
30. Raza, A., Gezer, S., Mundle, S., Gao, X.Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V. & Parcharidou, A. (1995) Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 86, 268-276.
31. Rebellato, L.M., Gross, U., Verbanac, K.M. & Thomas, J.M. (1994) A comprehensive definition of the major antibody specificities in polyclonal rabbit antithymocyte globulin. Transplantation, 57, 685-694.
32. Schmid, I., Uittenbogaart, C.H. & Giorgi, J.V. (1994a) Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry, 15, 12-20.
33. Schmid, I., Uittenbogaart, C.H., Keld, B. & Giorgi, J.V. (1994b) A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. Journal of Immunological Methods, 170, 145-157.
34. Slavin, S., Nagler, A., Naparstek, E., Kapelushnik, Y., Aker, M., Cividalli, G., Varadi, G., Kirschbaum, M., Ackerstein, A., Samuel, S., Amar, A., Brautbar, C., Ben-Tal, O., Elder, A. & Or, R. (1998) Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and non-malignant hematologic diseases. Blood, 91, 756-763.
35. Storb, R., Etzioni, R., Anasetti, C., Appelbaum, F.R., Buckner, C.D., Bensinger, W., Bryant, E., Clift, R., Deeg, H.J. & Doney, K. (1994) Cyclophosphamide combined with antithymocyte globulin in press for allogeneic marrow transplants in patients with aplastic anemia. Blood, 84, 941-949.
36. Symeonidis, A., Kourakli, A., Katevas, P., Perraki, M., Tiniakou, M., Matsouka, P., Georgoulias, V. & Zoumbos, N. (1991) Immune function parameters at diagnosis in patients with myclodysplastic syndromes: correlation with the FAB classification and prognosis. European Journal of Haematology, 47, 277-281.
37. Taniguchi, Y., Frickhofen, N., Raghavachar, A., Digel, W. & Heimpel, H. (1990) Antilymphocyte immunoglobulins stimulate peripheral blood lymphocytes to proliferate and release lymphokines. European Journal of Haematology, 44, 244-251.
38. Tong, J., Bacigalupo, A., Piaggio, G., Figari, O., Sogno, G. & Marmont, A. (1991) In vitro response of T cells from aplastic anemia patients to antilymphocyte globulin and phytohemagglutinin: colony-stimulating activity and lymphokine production. Experimental Hematology, 19, 312-316.
39. Young, N.S. & Barrett, A.J. (1995) The treatment of severe acquired aplastic anemia. Blood, 85, 3367-3377.
40. Zoumbos, N.C., Gascon, P., Djeu, J.Y., Trost, S.R. & Young, N.S. (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. New England Journal of Medicine, 312, 257-265.