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Volumn 276, Issue 2 20-2, 1999, Pages

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

Author keywords

Gene regulation; Platelet derived growth factor

Indexed keywords

ANTIFIBROTIC AGENT; BLEOMYCIN; PIRFENIDONE; PLATELET DERIVED GROWTH FACTOR;

EID: 0032992019     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.2.l311     Document Type: Article
Times cited : (184)

References (33)
  • 2
    • 0028989485 scopus 로고
    • TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression
    • Battegay, E. J., E. W. Raines, T. Colbert, and R. Ross. TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression. J. Immunol. 154: 6040-6047, 1995.
    • (1995) J. Immunol. , vol.154 , pp. 6040-6047
    • Battegay, E.J.1    Raines, E.W.2    Colbert, T.3    Ross, R.4
  • 3
    • 0025114866 scopus 로고
    • TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF-loop
    • Battegay, E. J., E. W. Raines, R. A. Seifert, D. F. Browen-Pope, and R. Ross. TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF-loop. Cell 63: 515-524, 1990.
    • (1990) Cell , vol.63 , pp. 515-524
    • Battegay, E.J.1    Raines, E.W.2    Seifert, R.A.3    Browen-Pope, D.F.4    Ross, R.5
  • 4
    • 0024544456 scopus 로고
    • Differential production of tumor necrosis factor, macrophage colony stimulating factor and interleukin-1 by human alveolar macrophages
    • Becker, S., R. B. Devlin, and J. S. Haskill. Differential production of tumor necrosis factor, macrophage colony stimulating factor and interleukin-1 by human alveolar macrophages. J. Leukoc. BM. 45: 353-361, 1989.
    • (1989) J. Leukoc. BM. , vol.45 , pp. 353-361
    • Becker, S.1    Devlin, R.B.2    Haskill, J.S.3
  • 5
    • 0026308617 scopus 로고
    • Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB and -BB isoforms secreted by rat alveolar macrophages
    • Bonner, J. C., A. R. Osornio-Vargas, A. Badgett, and A. R. Brody. Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB and -BB isoforms secreted by rat alveolar macrophages. Am. J. Respir. Cell Mol. BM. 5: 539-547, 1991.
    • (1991) Am. J. Respir. Cell Mol. BM. , vol.5 , pp. 539-547
    • Bonner, J.C.1    Osornio-Vargas, A.R.2    Badgett, A.3    Brody, A.R.4
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 7
    • 0025408909 scopus 로고
    • Pulmonary response to silica or titanium dioxide: Inflammatory cells, alveolar macrophage-derived cytokines and histopathology
    • Driscoll, K. E., R. C. Lindenschmidt, J. K. Maurer, J. M. Higgins, and G. Ridderm. Pulmonary response to silica or titanium dioxide: inflammatory cells, alveolar macrophage-derived cytokines and histopathology. Am. J. Respir. Cell Mol. Biol. 2: 381-390, 1990.
    • (1990) Am. J. Respir. Cell Mol. Biol. , vol.2 , pp. 381-390
    • Driscoll, K.E.1    Lindenschmidt, R.C.2    Maurer, J.K.3    Higgins, J.M.4    Ridderm, G.5
  • 8
    • 0026709741 scopus 로고
    • Spontaneous production of PDGF-A chain homodimer by rat lung fibroblasts in vitro
    • Lung Cell. Mol. Physiol. 7
    • Fabisiak, J. P., M. Absher, J. A. Evans, and J. Kelley. Spontaneous production of PDGF-A chain homodimer by rat lung fibroblasts in vitro. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L185-L193, 1992.
    • (1992) Am. J. Physiol. , vol.263
    • Fabisiak, J.P.1    Absher, M.2    Evans, J.A.3    Kelley, J.4
  • 9
    • 0022503826 scopus 로고
    • Analysis of bronchoalveolar lavage fluid from bleomycin induced pulmonary fibrosis in hamsters
    • Giri, S. N., D. M. Hyde, and J. M. Nakashima. Analysis of bronchoalveolar lavage fluid from bleomycin induced pulmonary fibrosis in hamsters. Toxicol. Pathol. 14: 149-157, 1986.
    • (1986) Toxicol. Pathol. , vol.14 , pp. 149-157
    • Giri, S.N.1    Hyde, D.M.2    Nakashima, J.M.3
  • 10
    • 0029124143 scopus 로고
    • Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: Downregulation of TGF-β and procollagen I and III gene expression
    • Gurujeyalakshmi, G., and S. N. Giri. Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-β and procollagen I and III gene expression. Exp. Lung Res. 21: 791-808, 1995.
    • (1995) Exp. Lung Res. , vol.21 , pp. 791-808
    • Gurujeyalakshmi, G.1    Giri, S.N.2
  • 11
    • 6544231631 scopus 로고    scopus 로고
    • Inhibitory effect of interferon gamma, interleukin-1, interleukin-6 and platelet-derived growth factor-A mRNA expression in bleomycin-mouse model of lung fibrosis
    • Gurujeyalakshmi, G., M. A. Hollinger, and S. N. Giri. Inhibitory effect of interferon gamma, interleukin-1, interleukin-6 and platelet-derived growth factor-A mRNA expression in bleomycin-mouse model of lung fibrosis. Res. Commun. Pharmacol. Toxicol. 1: 1-15, 1996.
    • (1996) Res. Commun. Pharmacol. Toxicol. , vol.1 , pp. 1-15
    • Gurujeyalakshmi, G.1    Hollinger, M.A.2    Giri, S.N.3
  • 13
    • 0041605226 scopus 로고    scopus 로고
    • Downregulation of procollagen and TGF-β gene expression by pirfenidone in the bleomycin hamster model of lung fibrosis
    • Iyer, S. N., G. Gurujeyalakshmi, and S. N. Giri. Downregulation of procollagen and TGF-β gene expression by pirfenidone in the bleomycin hamster model of lung fibrosis (Abstract). Am. J. Respir. Crit. Care Med. 155: A741, 1997.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155
    • Iyer, S.N.1    Gurujeyalakshmi, G.2    Giri, S.N.3
  • 14
    • 0031914475 scopus 로고    scopus 로고
    • Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model
    • Iyer, S. N., S. B. Margolin, D. M. Hyde, and S. N. Giri. Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model. Exp. Lung Res. 24: 119-132, 1998.
    • (1998) Exp. Lung Res. , vol.24 , pp. 119-132
    • Iyer, S.N.1    Margolin, S.B.2    Hyde, D.M.3    Giri, S.N.4
  • 15
    • 0029318974 scopus 로고
    • Dietary intake of pirfenidone ameliorates bleomycin induced lung fibrosis in hamsters
    • Iyer, S. N., J. S. Wild, M. J. Schiedt, D. M. Hyde, S. M. Margolin, and S. N. Giri. Dietary intake of pirfenidone ameliorates bleomycin induced lung fibrosis in hamsters. J. Lab. Clin. Med. 125: 779-785, 1995.
    • (1995) J. Lab. Clin. Med. , vol.125 , pp. 779-785
    • Iyer, S.N.1    Wild, J.S.2    Schiedt, M.J.3    Hyde, D.M.4    Margolin, S.M.5    Giri, S.N.6
  • 16
    • 0031557123 scopus 로고    scopus 로고
    • Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice
    • Kehrer, J. P., and S. B. Margolin. Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol. Lett. 90: 125-132, 1997.
    • (1997) Toxicol. Lett. , vol.90 , pp. 125-132
    • Kehrer, J.P.1    Margolin, S.B.2
  • 17
    • 0024730940 scopus 로고
    • Macrophage production of transforming growth factor-β and fibroblast collagen synthesis in chronic pulmonary inflammation
    • Khalil, N., O. Bereznay, M. Sporn, and A. H. Greenberg. Macrophage production of transforming growth factor-β and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 170: 727-737, 1989.
    • (1989) J. Exp. Med. , vol.170 , pp. 727-737
    • Khalil, N.1    Bereznay, O.2    Sporn, M.3    Greenberg, A.H.4
  • 18
    • 0022654646 scopus 로고
    • Intra-alveolar release of competence type growth factor after lung injury
    • Kovacs, E. J., and J. Kelly. Intra-alveolar release of competence type growth factor after lung injury. Am. Rev. Respir. Dis. 133: 68-72, 1986.
    • (1986) Am. Rev. Respir. Dis. , vol.133 , pp. 68-72
    • Kovacs, E.J.1    Kelly, J.2
  • 19
    • 0029246942 scopus 로고
    • Chrysotile asbestos stimulates platelet-derived growth factor-AA production by rat lung fibroblasts in vitro: Evidence for an automne loop
    • Lasky, J. A., P. G. Coin, P. M. Lindroos, L. E. Ostrowski, A. R. Brody, and J. C. Bonner. Chrysotile asbestos stimulates platelet-derived growth factor-AA production by rat lung fibroblasts in vitro: evidence for an automne loop. Am. J. Respir. Cell Mol. Biol. 12: 162-170, 1995.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.12 , pp. 162-170
    • Lasky, J.A.1    Coin, P.G.2    Lindroos, P.M.3    Ostrowski, L.E.4    Brody, A.R.5    Bonner, J.C.6
  • 21
    • 0029870254 scopus 로고    scopus 로고
    • Increased expression of platelet-derived growth factor A and insulin-like growth factor-1 in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice
    • Maeda, A., K. Hiyama, H. Yamakido, S. Ishioka, and M. Yamakido. Increased expression of platelet-derived growth factor A and insulin-like growth factor-1 in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice. Chest 109: 780-786, 1996.
    • (1996) Chest , vol.109 , pp. 780-786
    • Maeda, A.1    Hiyama, K.2    Yamakido, H.3    Ishioka, S.4    Yamakido, M.5
  • 23
    • 0001454995 scopus 로고
    • Pirfenidone: A novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis
    • Margolin, S. B., and S. Lefkowitz. Pirfenidone: a novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis (Abstract). FASEB J. 8: A382, 1994.
    • (1994) FASEB J. , vol.8
    • Margolin, S.B.1    Lefkowitz, S.2
  • 24
    • 0023266217 scopus 로고
    • Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis
    • Martinet, Y., W. N. Rom, G. R. Grotendorst, G. R. Martin, and R. G. Crystal. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 317: 202-209, 1987.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 202-209
    • Martinet, Y.1    Rom, W.N.2    Grotendorst, G.R.3    Martin, G.R.4    Crystal, R.G.5
  • 25
    • 0025314453 scopus 로고
    • Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis
    • Nagaoka, I., B. C. Trapnell, and R. G. Crystal. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J. Clin. Invest. 85: 2023-2027, 1990.
    • (1990) J. Clin. Invest. , vol.85 , pp. 2023-2027
    • Nagaoka, I.1    Trapnell, B.C.2    Crystal, R.G.3
  • 26
    • 0024558848 scopus 로고
    • Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA
    • Raines, E. W., S. K. Dower, and R. Ross. Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 243: 393-395, 1989.
    • (1989) Science , vol.243 , pp. 393-395
    • Raines, E.W.1    Dower, S.K.2    Ross, R.3
  • 27
    • 0026734789 scopus 로고
    • Bleomycin stimulation of cytokine secretion by the human alveolar macrophage
    • Lung Cell. Mol. Physiol. 6
    • Scheule, R. K., R. C. Perkins, R. Hamilton, and A. Holiam. Bleomycin stimulation of cytokine secretion by the human alveolar macrophage. Am. J. Physiol. 262 (Lung Cell. Mol. Physiol. 6): L386-L391, 1992.
    • (1992) Am. J. Physiol. , vol.262
    • Scheule, R.K.1    Perkins, R.C.2    Hamilton, R.3    Holiam, A.4
  • 28
    • 0025967143 scopus 로고
    • Pathogenesis of pulmonary fibrosis in interstitial lung disease: Alveolar macrophage PDGF(B) gene activation and up-regulation by interferon gamma
    • Shaw, R. J., S. H. Benedict, R. A. F. Clark, and T. E. King, Jr. Pathogenesis of pulmonary fibrosis in interstitial lung disease: alveolar macrophage PDGF(B) gene activation and up-regulation by interferon gamma. Am. Rev. Respir. Dis. 143: 167-173, 1991.
    • (1991) Am. Rev. Respir. Dis. , vol.143 , pp. 167-173
    • Shaw, R.J.1    Benedict, S.H.2    Clark, R.A.F.3    King Jr., T.E.4
  • 30
    • 0026279912 scopus 로고
    • Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages, while both interstitial macrophages and alveolar epithelial cells express the c-sis proto-oncogene
    • Vignaud, J. M., M. Allam, N. Martinet, M. Pech, F. Plenat, and Y. Martinet. Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages, while both interstitial macrophages and alveolar epithelial cells express the c-sis proto-oncogene. Am. J. Respir. Cell Mol. Biol. 5: 531-538, 1991.
    • (1991) Am. J. Respir. Cell Mol. Biol. , vol.5 , pp. 531-538
    • Vignaud, J.M.1    Allam, M.2    Martinet, N.3    Pech, M.4    Plenat, F.5    Martinet, Y.6
  • 31
    • 0027728298 scopus 로고
    • Variable expression of platelet-derived growth factor family proteins in acute lung injury
    • Walsh, J., M. Absher, and J. Kelly. Variable expression of platelet-derived growth factor family proteins in acute lung injury. Am. J. Respir. Cell Mol. Biol. 9: 637-644, 1993.
    • (1993) Am. J. Respir. Cell Mol. Biol. , vol.9 , pp. 637-644
    • Walsh, J.1    Absher, M.2    Kelly, J.3
  • 32
    • 0025721842 scopus 로고
    • Regulated expression of PDGF-A chain mRNA in human saphenous vein smooth muscle cells
    • Winkles, J. A., and C. G. Gay. Regulated expression of PDGF-A chain mRNA in human saphenous vein smooth muscle cells. Biochem. Biophys. Res. Commun. 180: 519-524, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.180 , pp. 519-524
    • Winkles, J.A.1    Gay, C.G.2
  • 33
    • 0027212844 scopus 로고
    • Enhanced IL-1β and tumor necrosis factor-α and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure
    • Zhang, Y., T. C. Lee, B. Guillemin, C. Yu, and W. N. Rom. Enhanced IL-1β and tumor necrosis factor-α and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J. Immunol. 150: 4188-4196, 1993.
    • (1993) J. Immunol. , vol.150 , pp. 4188-4196
    • Zhang, Y.1    Lee, T.C.2    Guillemin, B.3    Yu, C.4    Rom, W.N.5


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