Molecular genetics of the hair follicle: The state of the art

Proceedings of the Society for Experimental Biology and Medicine

Volumn 223, Issue 1, 2000, Pages 1-7

  Van Steensel, M A M ^a   Happle, R ^b   Steijlen, P M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GENE PRODUCT; HOMEODOMAIN PROTEIN; KERATIN; KERATINOCYTE GROWTH FACTOR;

APOPTOSIS; CELL DIFFERENTIATION; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HOMEOBOX; HUMAN; MOLECULAR GENETICS; MORPHOGENESIS; MOUSE; NONHUMAN; NUDE MOUSE; PILOMATRIXOMA; REVIEW;

MUS MUSCULUS;

EID: 0034031874     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22301.x     Document Type: Review

References (37)

1. Serri F, Cerimele D. Embryologie und Entwicklung des Haarfollikels. In: Orfanos CE, Ed. Haar und Haarkrankheiten. Stuttgart: Gustav Fischer Verlag, pp1-10, 1979.
2. Jones LN, Steinert PM. Hair keratinization in health and disease. Dermatol Clin 14:633-650, 1996.
3. Parry DA. Protein chains in hair and epidermal keratin IF: Structural features and spatial arrangements. EXS 78:177-207, 1997.
4. Kere J, Srivastava AK, Montonen O, Zonana J, Thomas N, Ferguson B, Munoz F, Morgan D, Clarke A, Baybayan P, Chen EY, Ezer S, Saarialho-Kere U, de la Chapelle A, Schlessinger D. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet 13:409-416, 1996.
5. Ferguson BM, Brockdorff N, Formstone E, Ngyuen T, Kronmiller JE, Zonana J. Cloning of Tabby, the murine homolog of the human EDA gene: Evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6:1589-1594, 1997.
6. Monreal AW, Zonana J, Ferguson B. Identification of a new splice form of the EDA1 gene permits detection of nearly all X-linked hypohidrotic ectodermal dysplasia mutations. Am J Hum Genet 63:380-389, 1998.
7. Nusse R. The int genes in mouse mammary tumorigenesis and in normal development. Ciba Found Symp 150:212-226, 1990.
8. Neumann C, Cohen S. Morphogens and pattern formation. Bioessays 19:721-729, 1997.
9. Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P. Induction of a β-catenin-LEF-1 complex by wnt-1 and transforming mutants of β-catenin. Oncogene 15:2833-2839, 1997.
10. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382:225-230, 1996.
11. Van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 8:2691-2703, 1994.
12. Gat U, DasGupta R, Degenstein L, Fuchs E. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin. Cell 95:605-614, 1998.
13. St. Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, McMahon JA, Lewis PM, Paus R, McMahon AP. Sonic hedgehog signaling is essential for hair development. Curr Biol 8:1058-1068, 1998.
14. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253:665-669, 1991.
15. Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J Cell Biol 14:1449-1465, 1998.
16. Huber O, Korn R, McLaughlin J, Ohsugi M, Hermann BG, Kemler R. Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech Dev 59:3-10, 1996.
17. Isaacs K, Brown G, Moore GP. Interactions between epidermal growth factor and the Tabby mutation in skin. Exp Dermatol 7:273-280, 1998.
18. Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam H, Aita VM, Owen J, de Blaquiere M, Frank J, Cserhalmi-Friedman PB, Leask A, McGrath JA, Peacocke M, Ahmad M, Ott J, Christiano AM. Alopecia universalis associated with a mutation in the human hairless gene. Science 279:720-724, 1998.
19. Cichon S, Anker M, Vogt IR, Rohleder H, Putzstuck M, Hillmer A, Farooq SA, Al-Dhafri KS, Ahmad M, Haque S, Rietschel M, Propping P, Kruse R, Nothen MM. Cloning, genomic organization, alternative transcripts, and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. Hum Mol Genet 7:1671-1679, 1998.
20. Sundberg JP, Beamer WG, Shultz LD, Dunstan RW. Inherited mouse mutations as models of human adnexal, cornification, and papulosquamous dermatoses. J Invest Dermatol 95:62S-63S, 1990.
21. Mann SJ. Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 170:485-499, 1971.
22. Panteleyev AA, van der Veen C, Rosenbach T, Muller-Rover S, Sokolov VE, Paus R. Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol 110:902-907, 1998.
23. Soma T, Ogo M, Suzuki J, Takahashi T, Hibino T. Analysis of apoptotic cell death in human hair follicles in vivo and in vitro. J Invest Dermatol 111:948-954, 1998.
24. Wright JT, Kula K, Hall K, Simmons JH, Hart TC. Analysis of the tricho-dento-osseous syndrome genotype and phenotype. Am J Med Genet 72:197-204, 1997.
25. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, Sharpe PT. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development 124:4811-4818, 1997.
26. Price JA, Bowden DW, Wright JT, Pettenati MJ, Hart TC. Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. Hum Mol Genet 7:563-569, 1998.
27. Hebert JM, Rosenquist T, Gotz J, Martin GR. FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations. Cell 78:1017-1025, 1994.
28. Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 12:390-397, 1996.
29. Hajitou A, Calberg-Bacq CM. Fibroblast growth factor 3 is tumorigenic for mouse mammary cells orthotopically implanted in nude mice. Int J Cancer 63:702-709, 1995.
30. Guo L, Degenstein L, Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev 10:165-175, 1996.
31. Falconer DS, Snell GD. Two new hair mutants, rough and frizzy, in the house mouse. J Hered 43:53-57, 1952.
32. Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J. Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. Nat Genet 16:372-374, 1997.
33. Winter H, Rogers MA, Gebhardt M, Wollina U, Boxall L, Chitayat D, Babul-Hirji R, Stevens HP, Zlotogorski A, Schweizer J. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. Hum Genet 101:165-196, 1997.
34. McGrath JA, McMillan JR, Shemanko CS, Runswick SK, Leigh IM, Lane EB, Garrod DR, Eady RA. Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome. Nat Genet 17:240-244, 1997.
35. McGrath JA, Hoeger PH, Christiano AM, McMillan JR, Mellerio JE, Ashton GH, Dopping-Hepenstal PJ, Lake BD, Leigh IM, Harper JI, Eady RA. Skin fragility and hypohidrotic ectodermal dysplasia resulting from ablation of plakophilin 1. Br J Dermatol 140:297-307, 1999.
36. Smith EA, Fuchs E. Defining the interactions between intermediate filaments and desmosome. J Cell Biol 141:1229-1241, 1998.
37. Bonne S, van Hengel J, Nollet F, Kools P, van Roy F. Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosome of epithelial cells. J Cell Sci 112:2265-2276, 1999.