A strong loss-of-function mutation in RAN1 results in constitutive activation of the ethylene response pathway as well as a rosette-lethal phenotype

Plant Cell

Volumn 12, Issue 3, 2000, Pages 443-455

  Woeste, Keith E ^a,b   Kieber, Joseph J ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b USDA Forest Service   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; BIOCHEMICAL PATHWAY; CELL MEMBRANE TRANSPORT; EPISTASIS; ETHYLENE; ETHYLENE RESPONSE PATHWAY; GENE MUTATION; LETHAL MUTANT; MOLECULAR CLONING; PHENOTYPE; RAN1 MUTATION; RAN1 PROTEIN; RECESSIVE MUTATION; ROSETTE LETHAL PHENOTYPE; SIGNAL TRANSDUCTION; WILD RELATIVE;

ARABIDOPSIS; EMBRYOPHYTA;

EID: 0034025925     PISSN: 10404651     EISSN: None     Source Type: Journal    
DOI: 10.1105/tpc.12.3.443     Document Type: Article

References (52)

1. Abeles, F.B., Morgan, P.W., and Saltveit, M.E., Jr. (1992). Ethylene in Plant Biology, 2nd ed. (San Diego, CA: Academic Press).
2. Alonso, J.M., Hirayama, T., Roman, G., Nourizadeh, S., and Ecker, J.R. (1999). EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis. Science 284, 2148-2152.
3. Askwith, C., Eide, D., Van Ho, A., Bernard, P.S., Li, L., Davis-Kaplan, S., Sipe, D.M., and Kaplan, J. (1994). The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76, 403-410.
4. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K., eds (1994). Current Protocols in Molecular Biology. (New York: John Wiley and Sons).
5. Bell, C., and Ecker, J. (1994). Assignment of thirty microsatellite loci to the linkage map of Arabidopsis. Genomics 19, 137-144.
6. Beyer, E.M., Jr. (1976). A potent inhibitor of ethylene action in plants. Plant Physiol. 58, 268-271.
7. Bleecker, A.B., Estelle, M.A., Somerville, C., and Kende, H. (1988). Insensitivity to ethylene conferred by a dominant mutation in Arabidopsis thaliana. Science 241, 1086-1089.
8. Bull, P.C., Thomas, G.R., Rommens, J.M., Forbes, J.R., and Cox, D.W. (1993). The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5, 327-337.
9. Chang, C., Kwok, S.F., Bleecker, A., and Meyerowitz, E. (1993). Arabidopsis ethylene-response gene ETR1: Similarity of product to two-component regulators. Science 262, 539-544.
10. Chao, Q., Rothenberg, M., Solano, R., Roman, G., Terzaghi, W., and Ecker, J.R. (1997). Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins. Cell 89, 1133-1144.
11. Chelly, J., and Monaco, A.P. (1993). Cloning the Wilson disease gene. Nat. Genet. 3, 317-318.
12. Chelly, J., Turner, Z., Tonnesen, T., Petterson, A., Ishikawa Brush, Y., Tommerup, N., Horn, N., and Monaco, A.P. (1993). Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat. Genet. 3, 14-19.
13. Clough, S.J., and Bent, A.F. (1998). Floral dip: A simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 16, 735-743.
14. Dancis, A., Halle, D., Yuan, D.S., and Klausner, R.D. (1994). The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J. Biol. Chem. 269, 25660-25667.
15. 2+-ATPaSe subfamily. Yeast 11, 283-292.
16. Gamble, R.L., Coonfield, M.L., and Schaller, G.E. (1998). Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis. Proc. Natl. Acad. Sci. USA 95, 7825-7829.
17. Hall, A.E., Chen, Q.G., Findell, J.L., Schaller, G.E., and Bleecker, A.B. (1999). The relationship between ethylene binding and dominant insensitivity conferred by mutant forms of the ETR1 ethylene receptor. Plant Physiol. 121, 291-300.
18. Hamza, I., Schaefer, M., Klomp, L.W.J., and Gitlin, J.D. (1999). Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc. Natl. Acad. Sci. USA 96, 13363-13368.
19. Himelblau, E., Mira, H., Lin, S.-J., Culotta, V.C., Peñarrubia, L., and Amasino, P.M. (1998). Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol. 117, 1227-1234.
20. Hirayama, T., Kieber, J.J., Hirayama, N., Kogan, M., Guzman, P., Nourizadeh, S., Alonso, J.M., Dailey, W.P., Dancis, A., and Ecker, J.R. (1999). RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis. Cell 97, 383-393.
21. Hua, J., and Meyerowitz, E.M. (1998). Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. Cell 94, 261-271.
22. Hua, J., Chang, C., Sun, Q., and Meyerowitz, E. (1995). Ethyleneinsensitivity conferred by Arabidopsis EPS gene. Science 269, 1712-1714.
23. Hua, J., Sakai, H., Nourizadeh, S., Chen, Q.G., Bleecker, A.B., Ecker, J.R., and Meyerowitz, E.M. (1998). EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis. Plant Cell 10, 1321-1332.
24. Hung, I.H., Suzuki, M., Yamaguchi, Y., Yuan, D.S., Klausner, R.D., and Gitlin, J.D. (1997). Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 272, 21461-21466.
25. Johnson, P.R., and Ecker, J.R. (1998). The ethylene gas signal transduction pathway: A molecular perspective. Annu. Rev. Genet. 32, 227-254.
26. Kampfenkel, K., Kushnir, S., Babiychuk, E., Inze, D., and Van Montagu, M. (1995). Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue. J. Biol. Chem. 270, 28479-28486.
27. Kieber, J.J. (1997). The ethylene response pathway in Arabidopsis. Annu. Rev. Plant Physiol. Plant Mol. Biol. 48, 277-296.
28. Kieber, J., and Ecker, J. (1994). Molecular and genetic analysis of the constitutive ethylene response mutant Ctrl. In Plant Molecular Biology: Molecular Genetic Analysis of Plant Development and Metabolism, P. Puigdomenech and G. Coruzzi, eds (Heidelberg, Germany: Springer-Verlag), pp. 193-201.
29. Kleber, J.J., Rothenburg, M., Roman, G., Feldmann, K.A., and Ecker, J.R. (1993). CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the Raf family of protein kinases. Cell 72, 427-441.
30. Konieczny, A., and Ausubel, F.M. (1993). A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers. Plant J. 4, 403-410.
31. Lin, S.-J., Pufahl, R.A., Danois, A., O'Halloran, T.V., and Culotta, V.C. (1997). A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport. J. Biol. Chem. 272, 9215-9220.
32. Linder, M.C. (1991). Biochemistry of Copper. (New York: Plenum Publishing).
33. Lutsenko, S., and Kaplan, J.H. (1995). Organization of P-type ATPases: Significance of structural diversity. Biochemistry 34, 15607-15613.
34. Mercer, J.F., Livingston, J., Hall, B., Paynter, J.A., Begy, C., Chandrasekharappa, S., Lockhart, P., Grimes, A., Bhave, M., Siemieniak, D., and Glover, T.W. (1993). Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat. Genet. 3, 20-25.
35. Petris, M.J., Mercer, J.F.B., Culvenor, J.G., Lockhart, P., Gleeson, P.A., and Camakaris, J. (1996). Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi appa-ratus to the plasma membrane: A novel mechanism of regulated trafficking. EMBO J. 15, 6084-6095.
36. Pufahl, R.A., Singer, C.P., Peariso, K.L., Lin, S.J., Schmidt, P.J., Fahrni, C.J., Culotta, V.C., Penner-Hahn, J.E., and O'Halloran, T.V. (1997). Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science 278, 853-856.
37. Rodriguez, F.I., Esch, J.J., Hall, A.E., Binder, B.M., Schaller, E.G., and Bleecker, A.B. (1999). A copper cofactor for the ethylene receptor ETR1 from Arabidopsis. Science 283, 396-398.
38. Roman, G., Lubarsky, B., Kieber, J.J., Rothenberg, M., and Ecker, J.R. (1995). Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: Five novel mutant loci integrated into a stress response pathway. Genetics 139, 1393-1409.
39. Sakai, H., Hua, J., Chen, Q.G., Chang, C., Medrano, L.J., Bleecker, A.B., and Meyerowitz, E.M. (1998). ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. Proc. Natl. Acad. Sci. USA 95, 5812-5817.
40. Samac, D., Hironaka, C., Yallaly, P., and Shah, D. (1990). Isolation and characterization of the genes encoding basic and acidic chitinase in Arabdopsis thaliana. Plant Physiol. 93, 907-914.
41. Schaller, G., and Bleecker, A. (1995). Ethylene-binding sites generated in yeast expressing the Arabidopsis ETRI gene. Science 270, 1809-1811.
42. Schaller, G., Ladd, A., Lanahan, M., Spanbauer, J., and Bleecker, A. (1995). The ethylene response mediator ETR1 from Arabidopsis forms a disulfide linked dimer. J. Biol. Chem. 270, 12526-12530.
43. Sisler, E.G., Blankenship, S.M., and Guest, M. (1990). Competition of cyclooctenes and cyclooctadienes for ethylene binding and activity in plants. Plant Growth Reg. 9, 157-164.
44. Solioz, M., and Vulpe, C. (1996). CPx-type ATPases: A class of P-type ATPases that pump heavy metals. Trends Biochem. Sci. 21, 237-241.
45. Solioz, M., Odermatt, A., and Krapf, R. (1994). Copper pumping ATPases: Common concepts in bacteria and man. FEBS Lett. 346, 44-47.
46. Stock, J.F., Stock, A.N., and Mottonen, J.M. (1990). Signal transduction in bacteria. Nature 344, 395-400.
47. Tanzi, R.E., et al. (1993). The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat. Genet. 5, 344-350.
48. Vogel, J.P., Schuerman, P., Woeste, K.W., Brandstatter I., and Kieber, J.J. (1998a). Isolation and characterization of Arabidopsis mutants defective in induction of ethylene biosynthesis by cytokinin. Genetics 149, 417-427.
49. Vogel, J.P., Woeste, K.W., Theologis, A., and Kieber, J.J. (1998b). Recessive and dominant mutations in the ethylene biosynthetic gene ACSS of Arabidopsis confer cytokinin insensitivity and ethylene overproduction, respectively. Proc. Natl. Acad. Sci. USA 95, 4766-4771.
50. Vulpe, C., Levinson, B., Whitney, S., Packman, S., and Gitschier, J. (1993). Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat. Genet. 3, 7-13.
51. Yamaguchi, Y., Heiny, M.E., and Gitlin, J.D. (1993). Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease. Biochem. Biophys. Res. Commun. 197, 271-277.
52. Yuan, D.S., Stearman, R., Danois, A., Dunn, T., Beeler, T., and Klausner, R.D. (1995). The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc. Natl. Acad. Sci. USA 92, 2632-2636.