Kinetic profiles of intraepithelial and invasive prostatic neoplasias: The key role of down-regulated apoptosis in tumor progression

Virchows Archiv

Volumn 436, Issue 5, 2000, Pages 413-420

  Koch, Michael ^a   De Miguel, Manuel ^b   Höfler, Heinz ^c   Diaz Cano, Salvador J ^a,d,e  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^e ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Cell kinetics; DNA ploidy; Intraductal extension; Precancerous lesion; Prostatic intraepithelial neoplasm

Indexed keywords

DNA; MONOCLONAL ANTIBODY KI 67;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INVASION; CELL DENSITY; CLINICAL ARTICLE; DNA DETERMINATION; DOWN REGULATION; EARLY CANCER; HISTOGRAM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KINETICS; MALE; MATHEMATICAL ANALYSIS; METASTASIS; MICROSCOPY; NICK END LABELING; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CARCINOMA; PROSTATIC INTRAEPITHELIAL NEOPLASIA; STATISTICAL ANALYSIS;

AGED; ANTIGENS, NUCLEAR; APOPTOSIS; CELL COUNT; CELL DIVISION; DISEASE PROGRESSION; DNA, NEOPLASM; DOWN-REGULATION; HUMANS; IMAGE CYTOMETRY; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; KI-67 ANTIGEN; KINETICS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PLOIDIES; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS;

EID: 0034025539     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050468     Document Type: Article

References (51)

1. 1. Bibbo M, Bartels PH, Dytch HE, Wied GL (1991) Cell image analysis. In: Bibbo M (ed) Comprehensive cytopathology. Saunders, Philadelphia, pp 965-983
2. 2. Bostwick DG (1996) Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia. Cancer 78:330-336
3. 3. Bostwick DG, Aquilina JW (1996) Prostatic intraepithelial neoplasia (PIN) and other prostatic lesions as risk factors and surrogate endpoints for cancer chemoprevention trials. J Cell Biochem 25 [Suppl]:156-164
4. 4. Bostwick DG, Amin MB, Dundore P, et al (1993) Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum Pathol 24:298-310
5. 5. Brown C, Sauvageot J, Kahane H, Epstein JI (1996) Cell proliferation and apoptosis in prostate cancer - correlation with pathologic stage? Mod Pathol 9:205-209
6. 6. Cheng L, Song SY, Pretlow TG, et al (1998) Evidence of independent origin of multiple tumors from patients with prostate cancer. J Natl Cancer Inst 90:233-237
7. 7. Claus S, Berges R, Senger T, Schulze H (1997) Cell kinetics in epithelial and stroma of benign prostatic hyperplasia. J Urol 158:217-221
8. 8. Diaz-Cano SJ, de Miguel M, Galera Davidson H, Wolfe HJ (1996) Proliferative and apoptotic markers in the malignant diagnosis of adrenal cortical tumors. Pathol Int 46 [Suppl 1]:15
9. 9. Diaz-Cano SJ, de Miguel M, Cummings T, Gagel R, Wolfe HJ (1996) Evidence of cell cycle restriction point misregulation in MEN 2A medullary thyroid carcinoma. Pathol Int 46 [Suppl 1]:233
10. 10. Diaz-Cano SJ, de Miguel M, Galera Davidson H, Wolfe HJ (1996) Are locally invasive pheochromocytomas biologically distinct from benign chromaffin neoplasms? Pathol Int 46 [Suppl 1]:233
11. 11. Diaz-Cano SJ, León MM, de Miguel M, Galera Davidson H, Wolfe HJ (1996) Mitotic index quantification: different approaches and their value in adrenocortical proliferative lesions (abstract). Lab Invest 74:170A
12. 12. Diaz-Cano SJ, Garcia-Moliner M, Carney W, Wolfe HJ (1997) Bcl-2 expression and DNA fragmentation in breast carcinoma. Pathologic and steroid hormone receptor correlates. Diagn Mol Pathol 6:199-208
13. 13. Diaz-Cano SJ, de Miguel M, Tashjian R, Blanes A, Galera H, Wolfe HJ (1997) Clonally heterogeneous proliferations in benign adrenal cortical lesions (abstract). Lab Invest 76:7A
14. 14. Diaz-Cano SJ, Tashjian R, de Miguel M, Blanes A, Galera H, Wolfe HJ (1997) DNA deletions, apoptosis blockage and X-linked clonality analysis in MEN 2a related C-cell lesions (abstract). Lab Invest 76:49A
15. 15. Diaz-Cano SJ, Blanes A, Rubio J, Matilla A, Wolfe HJ (1998) Topographic profiles in muscle invasive transitional cell carcinoma of the urinary bladder: differential genetic and kinetic patterns (abstract). Lab Invest 78:80A
16. 16. Diaz-Cano SJ, Tashjian R, de Miguel M, Blanes A, Galera H, Bender B, Wolfe HJ (1997) Distinctive clonal and histological patterns in locally invasive pheochromocytomas (abstract). Lab Invest 76:153A
17. 17. Diaz-Cano SJ, Blanes A, Rubio J, Matilla A, Wolfe HJ (1998) Is carcinoma in situ of the urinary bladder associated with the precursor lesion or lateral extension of underlying carcinoma? (abstract) Lab Invest 78:163A
18. 18. Drachenberg CB, Ioffe OB, Papadimitriou JC (1997) Progressive increase of apoptosis in prostatic intraepithelial neoplasia and carcinoma: comparison between in situ end labelling of fragmented DNA and detection by routine hematoxylin-eosin staining. Arch Pathol Lab Med 121:54-58
19. 19. Farnsworth WV, DeRose PB, Cohen C (1994) DNA image cytometric analysis of paraffin-embedded sections of small renal cortical neoplasms. Cytometry 18:223-227
20. 20. Habuchi T, Ogawa O, Kakehi Y, Ogura K, Koshiba M, Hamazaki S, Takahashi R, Sugiyama T, Yoshida O (1993) Accumulated allelic losses in the development of invasive urothelial cancer. Int J Cancer 53:579-584
21. 21. Harn HJ, Shen KL, Yueh KC, Ho LI, Yu JC, Chiu SC, Lee WH (1997) Apoptosis occurs more frequently in intraductal carcinoma than in infiltrating duct carcinoma of human breast cancer and correlates with altered p53 expression: detected by terminal-deoxynucleotidyl-transferase-mediated dUTP-FITC nick end labelling (TUNEL). Histopathology 31:534-539
22. 22. Harvey H (1995) A unifying hypothesis that links benign prostatic hyperplasia and prostatic intraepithelial neoplasia with prostata cancer (invited comments). Pathol Res Pract 191: 924-934
23. 23. Helpap B (1995) Cell kinetic studies on prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (AAH) of the prostate. Pathol Res Pract 191:904-907
24. 24. Henson DE, Hutter RVP, Farrow GM (1994) Practice protocol for the examination of specimens removed from patients with carcinoma of the prostate gland. A publication of the Cancer Committee, College of American Pathologists. Arch Pathol Lab Med 118:779-783
25. 25. Hilsenbeck SG, Allred DC (1992) Improve methods of estimating mitotic activity in solid tumors. Hum Pathol 23:601-602
26. 26. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-6965
27. 27. Kerr JF, Winterford CM, Harmon BV (1994) Apoptosis. Its significance in cancer and cancer therapy. Cancer 73:2013-2016
28. 28. Koch M, Aubele M, de Miguel M, Werner M, Hoefler H, Diaz-Cano SJ (1999) Is cancer-associated prostatic intraepithelial neoplasia a precancerous lesion? (abstract) Lab Invest 79:99A
29. 29. Marchevsky AM, Truong H, Tolmachoff T (1997) A rule-based expert system for the automatic classification of DNA "ploidy" histograms measured by the CAS 200 image analysis system. Cytometry 30:39-46
30. 30. McNeal JE, Yemoto CE (1996) Spread of adenocarcinoma within prostatic ducts and acini. Morphologic and clinical correlations. Am J Surg Pathol 20:802-814
31. 31. Montironi R, Magi-Galluzzi C, Scarpelli M, Giannulis I, Diamanti L (1993) Occurrence of cell death (apoptosis) in prostatic intraepithelial neoplasia. Virchows Arch [A] 423: 351-357
32. 32. Montironi R, Magi-Galluzzi C, Muzzonigro G, Prete E, Polito M, Fabris G (1994) Effects of combination endocrine treatment on normal prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. J Clin Pathol 47:906-913
33. 33. Montironi R, Magi-Galluzzi CM, Marina S, Diamanti L (1994) Quantitative characterization of the frequency and location and cell proliferation in prostate pathology. J Cell Biochem 19 [Suppl]:238-245
34. 34. Montironi R, Magi-Galluzzi C, Fabris G (1995) Apoptotic bodies in prostatic intraepithelial neoplasia and prostatic adenocarcinoma following total androgen ablation. Pathol Res Pract 191:873-880
35. 35. Montironi R, Pumante R, Diamanti L, Magi-Galluzzi C (1998) Apoptosis in prostatic carcinoma following complete androgen ablation. Urol Int 60 [Suppl 1]:25-29
36. 36. Mooney II, Ruis Peris JM, O'Neill A, Sweeney EC (1995) Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma. J Clin Pathol 48:242-244
37. 37. Orozco RE, Martin AA, Murphy WM (1994) Carcinoma in situ of the urinary bladder. Clues to host involvement in human carcinogenesis. Cancer 74:115-122
38. 38. Qian J, Bostwick DG (1995) The extent and zonal location of prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia: relationship with carcinoma in radical prostatectomy specimens. Pathol Res Pract 191:860-867
39. 39. Qian J, Jenkins RB, Bostwick DG (1996) Potential markers of aggressiveness in prostatic intraepithelial neoplasia detected by fluorescence in situ hybridization. Eur Urol 30:177-184
40. 40. Qian J, Wollan P, Bostwick DG (1997) The extent and multi-centricity of high-grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma. Hum Pathol 28:143-148
41. 41. Rosin MP, Cairns P, Epstein JI, Schoenberg MP, Sidransky D (1995) Partial allelotype of carcinoma in situ of the human bladder. Cancer Res 55:5213-5216
42. 42. Rubin MA, de La Taille A, Bagiella E, Olsson CA, O'Toole KM (1998) Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implications. Am J Surg Pathol 22:840-848
43. 43. Salomon RN, Diaz-Cano SJ (1995) Introduction to apoptosis. Diagn Mol Pathol 4:235-238
44. 44. Simpson JF, Dutt PL, Page DL (1992) Expression of mitosis per thousand cells and cell density in breast carcinomas. A proposal. Hum Pathol 23:608-611
45. 45. Tamboli P, Amin MB, Schulz D, Linden MD, Kubus J (1996) Comparative analysis of the nuclear proliferative index (Ki-67) in benign prostate, prostatic intraepithelial neoplasia, and prostatic carcinoma. Mod Pathol 9:1015-1019
46. 46. Veltri RW, Partin AW, Epstein JE, Marley GM, Miller CM, Singer DS, Patton KP, Criley SR, Coffey DS (1994) Quantitative nuclear morphometry, Markovian texture descriptors, and DNA content captured on a CAS-200 Image analysis system, combined with PCNA and HER-2/neu immunohistochemistry for prediction of prostate cancer progression. J Cell Biochem 19 [Suppl]:249-258
47. 47. Wheeler TM, Rogers E, Aihara M, Scardino PN, Thompson TC (1994) Apoptotic index as biomarker in prostatic intraepithelial neoplasia (PIN) and prostate cancer. J Cell Biochem 19 [Suppl]:202-207
48. 48. Wijsman JH, Jonker RR, Keijzer R, van de Velde CJ, Cornelisse CJ, van Dierendonck JH (1993) A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA. J Histochem Cytochem 41:7-12
49. 49. Wolf H (1991) Prognostic factors in bladder carcinoma. Scand J Urol Nephrol 138:1531-1560
50. 50. Wolf H, Melsen F, Pedersen SE, Nielsen KT (1994) Natural history of carcinoma in situ of the urinary bladder. Scand J Urol Nephrol 157 [Suppl]:147-151
51. 51. Xu B, Diaz-Cano SJ, Wolfe HJ (1998) Is C-cell hyperplasia in MEN 2A preneoplastic or carcinoma in situ? (abstract) Lab Invest 78:60A