Bcl-2 expression and DNA fragmentation in breast carcinoma, pathologic and steroid hormone receptors correlates

Diagnostic Molecular Pathology

Volumn 6, Issue 4, 1997, Pages 199-208

  Diaz Cano, Salvador J ^a   Garcia Moliner, Maria ^a   Carney, Walter ^b   Wolfe E, Hubert J ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b Oncogene Science Inc   (United States)

Author keywords

Apoptosis; Bcl 2 expression; Breast carcinoma; DNA fragmentation; Steroid receptor

Indexed keywords

DNA FRAGMENT; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BREAST BIOPSY; BREAST CARCINOMA; DNA DETERMINATION; DNA STRAND BREAKAGE; DOT HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PARTIAL MASTECTOMY; PRIORITY JOURNAL; PROTEIN DETERMINATION; RECEPTOR DENSITY; SOUTHERN BLOTTING;

APOPTOSIS; BLOTTING, SOUTHERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; DNA FRAGMENTATION; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RECEPTORS, STEROID;

EID: 0031456848     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199708000-00004     Document Type: Article

References (36)

1. Arends MJ, Morris RG, Wyllie AH, Apoptosis. The role of endonuclease. Am J Pathol 1990;136:593-608.
2. Arends MJ, Wyllie AH. Apoptosis: Mechanisms and roles in pathology. Int Rev Exp Pathol 1991;32:223-54.
3. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Current protocols in molecular biology. New York: John Wiley & Sons, 1989.
4. Battifora H, Mehta P, Ahn C, Esteban J. Estrogen receptor immunohistochemical assay in paraffin-embedded tissue, a better gold standard? Applied Immunohistochem 1993;1:39-45.
5. Berges R, Isaacs JT. Programming events in the regulation of cell proliferation and death. Clin Chem 1993;39:356-61.
6. Bhargava V, Kell DL, van de Rijn, Warnke RA. Bcl-2 immunoreactivity in breast carcinoma correlates with hormone receptor positivity. Am J Pathol 1994;145:535-40.
7. Bloom HJG, Richardson WW. Histological grading and prognosis in breast cancer. Br J Cancer 1957;11:359-77.
8. Brada M. Bcl-2 gene current relevance to clinical oncology. Eur J Cancer 1992;28:270-2.
9. Chan WK, Poulsom R, Lu QL, Patel K, Gregory W, Fisher CJ, Hanby AM. Bcl-2 expression in invasive mammary carcinoma: correlation with apoptosis, hormone receptors and p53 expression. J Pathol 1993;169:153A.
10. Colombel M, Symmans F, Gil S, et al. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993;143:390-400.
11. Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539-42.
12. Hockenbery DM, Zutter M. Hickey W, Nahm M, Korsmeyer SJ. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991;88:6961-5.
13. Isola JJ. Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J Pathol 1993;170:31-35.
14. Joensuu H, Pylkkanen L, Toikkanen S. Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 1994;145: 1191-8.
15. Langer M, Kubista E, Schemper M, Spona J. Androgen receptors, serum androgen levels and survival of breast cancer patients. Arch Gynecol Obstet 1990;247:203-9.
16. Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL. Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor positivity, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 1994;69:135-9.
17. Lotem J, Sachs L. Regulation by bcl-2, c-myc, and p53 os susceptibility to induction of apoptosis by heat and shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 1993;4:41-7.
18. Marder BA, Morgan WF. Delayed chromosomal instability induced by DNA damage. Mol Cell Biol 1993;13:6667-77.
19. McDonnell TJ, Troncoso P, Brisbay SM, et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992; 52:6940-4.
20. Meyaard L, Otto SA, Jonker RR, Minjster MJ, Keet RPM, Miedema F. Programmed death of T cells in HIV-1 infection. Science 1992;257:217-9.
21. Murty VV, Ladanyi M, Houldsworth J, Mikraki V, Chaganti RS. Analysis of bcl-2 and myc expression in non-Hodgkin's lymphomas by in situ hybridization: correlation with chromosome translocations. Diagn Mol Pathol 1992;1:221-8.
22. Naber SP, Smith LL, Wolfe HJ. Role of the frozen tissue bank in molecular pathology. Diagn Mol Pathol 1992;1:73-9.
23. Nowel PC. The clonal evolution of tumor cell populations. Science 1976;194:23-8.
24. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994;79:189-92.
25. Pilotti S, Collini P, del Bo R, Cattoretti G, Pierotti MA, Rilke F. A novel panel of antibodies that segregates immunohistochemically poorly differentiates carcinoma from undifferentiated carcinoma of the thyroid gland. Am J Surg Pathol 1994;18:1054-64.
26. Prives C. How loops, β sheets, and α helices help us to understand p53. Cell 1994;78:543-6.
27. Rasbridge SA, Gillet CE, Seymour AM, Patel K, Richards MA, Rubens RD, Millis RR. The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma. Br J Cancer 1994;70:335-41.
28. Reed JC, Meister L, Tanaka S, Cuddy M, Yurn S, Geyer C, Pleasure D. Differential expression of bcl-2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res 1991;51:6529-38.
29. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual, 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989.
30. Silvestrini R, Veroni S, Daidone MG, et al. The bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 1994;86:499-504.
31. Stewart BW. Mechanism of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 1994;86: 1286-96.
32. Tanaka S, Louie DC, Kant JA, Reed JCI. Frequent incidence of somatic mutations in translocated bcl-2 oncogenes of non-Hodgkin's lymphomas. Blood 1992;79:229-37.
33. Vaux DL. Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci USA 1993;90: 786-9.
34. Vaux DL, Hecker G, Strasser A. An evolutionary perspective on apoptosis. Cell 1994;76:777-9.
35. Williams GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell 1993;74:777-9.
36. Zakeri ZF, Quaglino D, Latham T, Lockshin RA. Delayed internucleosomal DNA fragmentation in programmed cell death. FASEB J 1993;7:470-8.