GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma

Clinical Neuropathology

Volumn 19, Issue 3, 2000, Pages 131-137

  North, P E ^a,b   Mizeracki, A ^b   Mihm Jr , M C ^d   Mrak, R E ^a,b,c  

^a ARKANSAS CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c Central Arkansas Veterans Health System   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brain; GLUT1; Hemangioblastoma; Immunohistochemistry; Renal cell carcinoma

Indexed keywords

EPITHELIAL MEMBRANE ANTIGEN;

ADULT; ANTIBODY LABELING; ARTICLE; BRAIN METASTASIS; CLINICAL ARTICLE; GENE SEQUENCE; GLUCOSE TRANSPORT; HEMANGIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; PRIORITY JOURNAL; PSEUDOGENE; RELIABILITY; VASCULARIZATION; VON HIPPEL LINDAU DISEASE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; CEREBELLAR NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; GLUCOSE TRANSPORTER TYPE 1; HEMANGIOBLASTOMA; HIPPEL-LINDAU DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 0034025449     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ahn YS, Zerban H, Bannasch P 1993 Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions. Virchows Arch B Cell Pathol Mol Pathol 63: 351-357
2. Boado RJ, Wang L, Pardridge WM 1994 Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors. Brain Res Mol Brain Res 22: 259-267
3. Boado RJ 1996 Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene. Neurosci Lett 220: 53-56
4. Boado RJ 1998a Brain-derived peptides increase blood-brain barrier GLUT1 glucose transporter gene expression via mRNA stabilization. Neurosci Lett 255: 147-150
5. Boado RJ 1998b Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors. J Neural Transm Suppl 53: 323-331
6. Bohling T, Maenpaa A, Timonen T, Vantunen L, Paetau A, Haltia M 1996 Different expression of adhesion molecules on stromal cells and endothelial cells of capillary hemangioblastoma. Acta Neuropathol 92: 461-466
7. Brown DF, Gazdar AF, White CL III, Yashima K, Shay JW, Rushing EJ 1997 Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas. J Neuropathol Exp Neurol 56: 1349-1355
8. Cornford EM, Hyman S, Black KL, Cornford, ME, Vinters HV, Pardridge WM 1995 High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium. J Neuropathol Exp Neurol 54: 842-851
9. Flier JS, Mueckler MM, Usher P, Lodish HF 1987 Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235: 1492-1495
10. Gould GW, Holman GD 1993 The glucose transporter family: structure, function and tissue-specific expression. Biochem J 295: 329-341
11. Guerin C, Laterra J, Hruban RH, Brem H, Drewes LR, Goldstein GW 1990 The glucose transporter and blood-brain barrier of human brain tumors. Ann Neurol 28: 758-765
12. Harik SI, Kalaria RN, Andersson L, Lundahl P, Peny G 1990 Immunocytochemical localization of the erythroid glucose transporter: abundance in tissues with barrier functions. J Neurosci 10: 3862-3872
13. Harik SI, Hall AK, Richey P, Andersson L, Lundahl P, Perry G 1993 Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system. Brain Res Dev Brain Res 72: 41-49
14. Harik SI, Roessmann U 1991 The erythrocyte-type glucose transporter in blood vessels of primary and metastatic brain tumors. Ann Neurol 29: 487-491
15. Hatva E, Bohling T, Jaaskelainen J, Persico MG, Haltia M, Alitalo K 1996 Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am J Pathol 148: 763-775
16. Kanno H, Kondo K, Ito S, Yamamoto I, Fujii S, Torigoe S, Sakai N, Hosaka M, Shuin T, Yao M 1994 Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res 54: 4845-4847
17. Lee JY, Dong SM, Park WS, Yoo NJ, Kim CS, Jang JJ, Chi JG, Zbar B, Lubensky IA, Linehan WM, Vortmeyer AO, Zhuang Z 1998 Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas. Cancer Res 58: 504-508
18. Mizuno J, Iwata K, Takei Y 1993 Immunohistochemical study of hemangioblastoma with special reference to its cytogenesis. Neurologia Medico-Chirurgica 33: 420-424
19. Mrak RE 1997 Tumors: Applications of ultrastructural methods. In: Garcia JH (ed) Neuropathology: the Diagnostic Approach. Mosby-Year Book, St Louis, chapter 3
20. North PE, Waner M, Mizeracki A, Mihm MC 2000 GLUT1 is a specific immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31: 11-12
21. Oberstrass J, Reifenberger G, Reifenberger J, Wechsler W, Collins VP 1996 Mutation of the Von Hippel-Lindau tumour suppressor gene in capillary haemangioblastomas of the central nervous system. J Pathol 179: 151-156
22. Omulecka A, Lach B, Alwasiak J, Gregor A 1995 Immunohistochemical and ultrastructural studies of stromal cells in hemangioblastoma. Folia Neuropathol 33: 41-50
23. Richard S, Campello C, Taillandier L, Parker F, Resche F 1998 Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. J Int Med 243: 547-553
24. Stratmann R, Krieg M, Haas R, Plate KH 1997 Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. J Neuropathol Exp Neurol 56: 1242-1252.
25. Taylor CR, Shi SR, Chen C, Young L, Yang C, Cote RJ 1996 Comparative study of antigen retrieval heating methods: microwave, microwave and pressure cooker, autoclave, and steamer. Biotech Histochem 71: 263-270
26. Tsukamoto H, Boado RJ, Pardridge WM 1997 Site-directed deletion of a 10-nucleotide domain of the 3′-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression. J Neurochem 68: 2587-2592
27. Tsukamoto H, Boado RJ, Pardridge WM 1996 Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3′-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. J Clin Invest 97: 2823-2832
28. Vaquero J, Zurita M, Coca S, Salas C, Oya S 1998 Expression of vascular endothelial growth factor in cerebellar hemangioblastomas does not correlate with tumor angiogenesis. Cancer Lett 132: 213-217
29. Vortmeyer AO, Gnarra JR, Emmert-Buck MR, Katz D, Linehan WM, Oldfield EH, Zhuang Z 1997 Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum Pathol 28: 540-543
30. Wheeler TJ, Hinkle PC 1985 The glucose transporter of mammalian cells. Annu Rev Physiol 47: 503-517
31. Wizigmann-Voos S, Breier G, Risau W, Plate KH 1995 Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55: 1358-13564
32. Wizigmann-Voos S, Plate KH 1996 Pathology, genetics and cell biology of hemangioblastomas. Histol Histopathol 11: 1049-1061
33. Younes M, Lechago LV, Lechago J 1996 Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. Clin Cancer Res 2: 1151-1154