Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3′-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA

Journal of Clinical Investigation

Volumn 97, Issue 12, 1996, Pages 2823-2832

  Tsukamoto, Haruhisa ^a   Boado, Ruben J ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood brain barrier; Brain tumor; Exonuclease; Messenger RNA stability; Ribonuclease

Indexed keywords

CYTOPLASM PROTEIN; GLUCOSE TRANSPORTER; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE; RIBONUCLEASE;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN HEMANGIOMA; CONTROLLED STUDY; GLIOBLASTOMA; GLUCOSE TRANSPORT; HEMANGIOBLASTOMA; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN RNA BINDING; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BRAIN NEOPLASMS; GLIOBLASTOMA; GLUCOSE TRANSPORTER TYPE 1; HEMANGIOBLASTOMA; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MONOSACCHARIDE TRANSPORT PROTEINS; NEOPLASM PROTEINS; RNA, MESSENGER;

EID: 0029993917     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118738     Document Type: Article

References (35)

1. Nishioka, T., Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura, R. Shigemoto, and H. Kikuchi. 1992. Distribution of the glucose transporters in human brain tumors. Cancer Res. 52:3972-3979.
2. Boado, R.J., K.L. Black, and W.M. Pardridge. 1994. Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors. Mol. Brain Res. 27:51-57.
3. Guerin, C., J. Laterra, R.H. Hruban, H. Brem, L.R. Drewes, and G.W. Goldstein. 1990. The glucose transporter and blood-brain barrier of human brain tumors. Ann. Neurol. 28:758-765.
4. Harik, S.I., and U. Roessmann. 1991. The erythrocyte-type glucose transporter in blood vessels of primary and metastatic brain tumors. Ann. Neurol. 29: 487-491.
5. Nagamatsu, S., H. Sawa, A. Wakizaka, and T. Hoshino. 1993. Expression of facilitative glucose transporter isoforms in human brain tumors. J. Neurochem. 61:2048-2053.
6. Cornford, E.M., S. Hyman, K.L. Black, M.E. Cornford, H.V. Vinters, and W.M. Pardridge. 1995. High expression of the GLUT1 glucose transporter in human brain hemangioblastoma endothelium. J. Neuropathol. & Exp. Neurol. 54:842-851.
7. Pardridge, W.M., and R.J. Boado. 1993. Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter. In The Blood-Brain Barrier: Cellular and Molecular Biology. W.M. Pardridge, editor. Raven Press, New York. 395-440.
8. Dwyer, K.J., R.J. Boado, and W.M. Pardridge. 1995. Cis-element/cytoplasmic protein interactions within the 3′-untranslated region of GLUT1 glucose transporter mRNA. J. Neurochem. 66:449-458.
9. Klausner, R.D., and J.B. Harford. 1989. Cis-trans models for post-transcriptional gene regulation. Science (Wash. DC). 246:870-872.
10. Theil, E.C. 1990. Regulation of ferritin and transferrin receptor mRNAs. J. Biol. Chem. 265:4771-4774.
11. Burd, C.G., and G. Dreyfuss. 1994. Conserved structures and diversity of functions of RNA-binding proteins. Science (Wash. DC). 265:615-621.
12. Mansur, N.R., K. Meyer-Siegler, J.C. Wurzer, and M.A. Sirover. 1993. Cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in normal human cells. Nucleic Acids Res. 21:993-998.
13. Mueckler, M., and H.F. Lodish. 1986. The human glucose transporter can insert posttranslationally into microsomes. Cell. 44:629-637.
14. Mueckler, M., C. Caruso, S.A. Baldwin, M. Panico, I. Blench, H.R. Morris, W.J. Allard, G.E. Lienhard, and H.F. Lodish. 1985. Sequence and structure of a human glucose transporter. Science (Wash. DC). 229:941-945.
15. Boado, R.J., H. Tsukamoto, and W.M. Pardridge. 1996. Evidence for translational control elements within the 5′-untranslated region of GLUT1 glucose transporter mRNA. J. Neurochem. In press.
16. Malter, J.S. 1989. Identification of an AUUUA-specific messenger RNA binding protein. Science (Wash. DC). 246:664-666.
17. Krieg, P.A., and D.A. Melton. 1987. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 155:397-415.
18. Boado, R.J., and W.M. Pardridge. 1992. Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin-biotin system. Bioconjugate Chem. 3:519-523.
19. Leibold, E.A., and H.N. Munro. 1988. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. USA. 85:2171-2175.
20. Blackburn, P., G. Wilson, and S. Moore. 1977. Ribonuclease inhibitor from human placenta. J. Biol. Chem. 252:5904-5910.
21. Kwon, Y.K., and H.N. Hecht. 1991. Cytoplasmic protein binding to highly conserved sequence in the 3′-untranslated region of mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells. Proc. Natl. Acad. Sci. USA. 88:3584-3588.
22. Kang, J.H., T.J. Yokoi, and M.J. Holland. 1995. Binding sites for abundant nuclear factors modulate RNA polymerase I-dependent enhancer function in saccharomyces cerevisiae. J. Biol. Chem. 270:28723-28732.
23. Nickelsen, J., and G. Link. 1989. Interaction of 3′ RNA region of the mustard trnK gene with chloroplast proteins. Nucleic Acids Res. 17:9637-9648.
24. Liang, H., and J.P. Jost. 1991. An estrogen-dependent polysomal protein binds to the 5′ untranslated region of the chicken vitellogenin mRNA. Nucleic Acids Res. 19:2289-2294.
25. Birnbaum, M.J., H.C. Haspel, and O.M. Rosen. 1986. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc. Natl. Acad. Sci. USA. 83:5784-5788.
26. +-binding region (Rossman fold). J. Biol. Chem. 270:2755-2763.
27. Cole, M., and S. Mango. 1990. cis-Acting Determinants of c-myc mRNA Stability. Enzymes. 44:167-180.
28. Raue', H. 1994. Metabolic stability of mRNA in yeast - a potential target for modulating productivity? Trends Biotechnol. 12:444-449.
29. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 46:659-667.
30. Vakalopoulou, E., J. Schaack, and T. Shenk. 1991. A 32-kilodalton protein binds to AU-rich domains in the 3′-unlranslated regions of rapidly degraded mRNAs. Mol. Cell. Biol. 11:3355-3364.
31. Bohjanen, P.R., B. Petryniak, C.H. June, C.B. Thompson, and T. Lindsten. 1991. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′-untranslated region of lymphokine mRNA. Mol. Cell. Biol. 11:3288-3295.
32. Gaugitsch, H.W., E.E. Prieschl, F. Kalthoff, N.E. Huber, and T. Baumruker. 1992. A novel transiently expressed, integral membrane protein linked to cell activation. J. Biol Chem. 267:11267-11273.
33. Stephens, J.M., B.Z. Carter, P.H. Pekala, and J.S. Malter. 1992. Tumor necrosis factor α induced glucose transporter (GLUT1) mRNA stabilization in 3T3-L1 preadipocytes. J. Biol. Chem. 267:8336-8341.
34. Wilson, T., and R. Treisman. 1988. Removal of poly (A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences. Nature (Lond.). 336:396-399.
35. Boado, R.J., and W.M. Pardridge. 1990. Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5′-untranslated region. Mol. Cell. Neurosci. 1:224-232.