Expression of 15 glutamate receptor subunits and various splice variants in tissue slices and single neurons of brainstem nuclei and potential functional implications

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1335-1345

  Paarmann, I ^a   Frermann, D ^a   Keller, B U ^a   Hollmann, M ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; Mouse; NMDA Kainate; Pre Botzinger complex; RT PCR

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BRAIN STEM; CALCIUM TRANSPORT; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RECEPTOR DENSITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; ANIMALS; ANTISENSE ELEMENTS (GENETICS); BRAIN STEM; GENE EXPRESSION; GENETIC HETEROGENEITY; MICE; NEURONS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0034022556     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741335.x     Document Type: Article

References (71)

1. Albus J. S. (1971) A theory of cerebellar function. Math. Biosci. 10, 25-61.
2. Ambalavanar R., Ludlow C. J., Wenthold R. J., Tanaka Y., Damirjian M., and Petralia R. S. (1998) Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the cat. J. Comp. Neurol. 402, 75-92.
3. Bahr B. A., Hoffmann K. B., Kessler M., Hennegriff M., Park G. Y., Yamamoto R. S., Kawasaki B. T., Vanderklish P. W., Hall R. A., and Lynch G. (1996) Distinct distributions of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits and a related 53,000 M(r) antigen (GR53) in brain-tissue. Neuroscience 74, 707-721.
4. ++-permeable AMPA receptors in delayed neurodegeneration. Cold Spring Harb. Symp. Quant. Biol. 61, 373-384.
5. Bettler B., Boulter J., Hermans-Borgmeyer I., O'Shea-Greenfield A., Deneris E. S., Moll C., Borgmeyer U., Hollmann M., and Heinemann S. (1990) Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Neuron 5, 583-595.
6. Blomquist A. J. and Antem A. (1965) Localization of the terminals of the tongue afferents in the nucleus of the solitary tract. J. Comp. Neurol. 124, 127-130.
7. Burnashev N., Monyer H., Seeburg P. H., and Sakmann B. (1992) Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8, 189-198.
8. Choi D. W. and Rothman S. M. (1990) The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13, 171-182.
9. Ciabarra A. M., Sullivan J. M., Gahn L. G., Pecht G., Heinemann S., and Sevarino K. A. (1995) Cloning and characterization of Chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J. Neurosci. 15, 6498-6508.
10. Das S., Sasaki Y. F., Rothe T., Premkumar L. S., Takasu M., Crandall J. E., Dikkes P., Conner D. A., Rayudu P. V., Cheung W., Chen V. H.-S., and Lipton S. (1998) Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 398, 377-381.
11. DePaul R., Abbs J. H., Caligiuri M., Graccco V. L., and Brooks B. R. (1988) Hypoglossal, trigeminal, and facial motoneuron involvement in amyotrophic lateral sclerosis. Neurology 38, 281-283.
12. Dodt H. U. and Zieglgänsberger W. (1994) Infrared videomicroscopy: a new look at neuronal structure and function. Trends Neurosci. 17, 453-458.
13. Egebjerg J., Bettler B., Hermans-Borgmeyer I., and Heinemann S. (1991) Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351, 745-748.
14. Frermann D., Keller B. U., and Richter D. W. (1999) Calcium oscillations in rhythmically active respiratory neurones in the brainstem of the mouse. J. Physiol. (Lond.) 515, 119-131.
15. Funk G. D., Johnson S. M., Smith J. C., Dong X. W., Lai J., and Feldman J. L. (1997) Functional respiratory rhythm generating networks in neonatal mice lacking NMDAR1 gene. J. Neurophysiol. 78, 1414-1420.
16. Greer J. J., Smith J. C., and Feldman J. L. (1992) Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro. J. Neurophysiol. 67, 969-999.
17. Herb A., Burnashev N., Werner P., Sakmann B., Wisden W., and Seeburg P. H. (1992) The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8, 775-785.
18. Hollmann M. (1999) Structure of ionotropic glutamate receptors, in Handbook of Experimental Pharmacology: Ionotropic Glutamate Receptors in the CNS (Jonas P. and Monyer H., eds), pp. 3-98. Springer, Berlin.
19. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
20. Hume R. I., Dingledine R., and Heinemann S. F. (1991) Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253, 1028-1031.
21. Kalb R. G. and Hockfield S. (1990) Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord. Science 250, 294-296.
22. Katakura N., Jia L., and Nakamura Y. (1995) NMDA-induced rhythmical activity in XII nerve of isolated CNS from newborn rats. Neuroreport 6, 601-604.
23. Korematsu K. and Redies C. (1997) Expression of cadherin-8 mRNA in the developing mouse central nervous system. J. Comp. Neurol. 387, 291-306.
24. Koshiya N. and Guyenet P. G. (1996) Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat. J. Physiol. (Lond.) 491, 859-869.
25. Lamarre Y. (1984) Animal models of physiological, essential and parkinsonian-like tremors, in Movement Disorders: Tremor (Findlay L. Y. and Capiledo R., eds), pp. 183-194. Oxford University Press, New York.
26. Lambolez B., Audinat E., Bochet P., Crepel F., and Rossier J. (1992) AMPA receptor subunits expressed by single Purkinje cells. Neuron 9, 247-258.
27. Laurie D. J., Bartke I., Schoepfer R., Naujoks K., and Seeburg P. H. (1997) Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies. Mol. Brain Res. 51, 23-32.
28. Li Y., Erzurumlu R. S., Chen C., Jhaveri S., and Tonegawa S. (1994) Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76, 427-437.
29. Lips M. and Keller B. U. (1998) Endogenous calcium buffering in motoneurons of the nucleus hypoglossus from mouse. J. Physiol. (Lond.) 511, 105-117.
30. Lomeli H., Wisden W., Köhler M., Keinänen K., Sommer B., and Seeburg P. H. (1992) High-affinity kainate and domoate receptors in rat brain. FEBS Lett. 307, 139-143.
31. Lowe A. A. (1980) The neural regulation of tongue movements. Prog. Neurobiol. 15, 295-344.
32. Marr D. A. (1969) A theory of cerebellar cortex. J. Physiol. (Lond.) 202, 437-470.
33. Molnar E., Baude A., Richmond S. A., Patel P. B., Somogyi P., and McIlhinney R. A. J. (1993) Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: cellular and subcellular distribution in the rat forebrain. Neuroscience 53, 307-326.
34. Monyer H., Seeburg P. H., and Wisden W. (1991) Glutamate-operated channels: developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
35. Monyer H., Burnashev N., Laurie D. J., Sakmann B., and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
36. Morino M., Maeda M., Nakai M., Krieger A. J., and Sapru H. N. (1994) Effects of microinjection of N-methyl-D-aspartic acid into the nucleus tractus solitarii on cerebral blood flow in anesthetized rats. J. Auton. Nerv. Syst. 49, 159-170.
37. Morrison B. M., Hof P. R., and Morrison J. H. (1998) Determinants of neuronal vulnerability in neurodegenerative disease. Ann. Neurol. 44, 32-44.
38. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597-603.
39. Ogawa H., Imoto T., and Hayama T. (1980) Taste relay neurons in the solitary nucleus of rats. Neurosci. Lett. 18, 295-299.
40. Palecek J., Lips M. B., and Keller B. U. (1999) Calcium dynamics and buffering in motoneurones of the mouse spinal cord. J. Physiol. (Lond.) 520, 485-502.
41. Palkovits M. and Zaborsky L. (1977) Neuroanatomy of central cardiovascular control, in Hypertension and Brain Mechanisms (de Jong W., Provoost A., and Shapiro A., eds), pp. 9-34. Elsevier, Amsterdam.
42. Paschen W. and Djuricic B. (1995) Regional differences in the extent of RNA editing of the glutamate receptor subunits GluR2 and GluR6 in rat brain. J. Neurosci. Methods 56, 21-29.
43. Pellegrini-Giampietro D. E., Bennett M. V. L., and Zukin R. S. (1991) Differential expression of three glutamate receptor genes in developing rat brain: an in situ hybridization study. Proc. Natl. Acad. Sci. USA 88, 4157-4161.
44. 2+-permeable AMPA receptors in neurological disorders. Trends Neurosci. 20, 464-470.
45. Petralia R. S. and Wenthold R. J. (1992) Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J. Comp. Neurol. 318, 329-354.
46. Petralia R. S., Wang Y. X., and Wenthold R. J. (1994a) Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies. J. Comp. Neurol. 349, 85-110.
47. Petralia R. S., Yokotani N., and Wenthold R. J. (1994b) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective antipeptide antibody. J. Neurosci. 14, 667-696.
48. Petralia R. S., Wang Y. X., and Wenthold R. J. (1994c) The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural-localization patterns similar to those of NR1. J. Neurosci. 14, 6102-6120.
49. Petralia R. S., Wang Y. X., Mayat E., and Wenthold R. J. (1997) Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons. J. Comp. Neurol. 385, 456-476.
50. Pierrefiche O., Foutz A. S., Champagnat J., and Denavit-Saubie M. (1994) NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network. J. Physiol. (Lond.) 474, 509-523.
51. Porter J., Cauli B., Staiger J. F., Rossier J., and Audinat E. (1998) Properties of bipolar VIPergic interneurons and their excitation by pyramidal neurons in the rat neocortex. Eur. J. Neurosci. 10, 3617-3628.
52. Ramirez J. M., Quellmalz U. J. A., and Richter D. W. (1996) Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J. Physiol. (Lond.) 491, 799-812.
53. Ramirez J. M., Quellmalz U. J. A., and Wilken B. (1997) Developmental changes in the hypoxic response of the hypoglossus respiratory motor output in vitro. J. Neurophysiol. 78, 383-392.
54. Reiner A., Medina L., Figueredo-Cardenas G., and Anfinson S. (1995) Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALS. Exp. Neurol. 131, 239-250.
55. Rothstein J. D. and Kuncl R. W. (1995) Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J. Neurochem. 65, 643-651.
56. Ruano D., Lambolez B., Rossier J., Paternain A. V., and Lerma J. (1995) Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing. Neuron 14, 1009-1017.
57. Shatz J. C. (1990) Impulse activity and patterning of connections during CNS development. Neuron 5, 745-756.
58. Shaw P. J. and Ince P. G. (1997) Glutamate, excitotoxicity and amyotrophic lateral sclerosis. J. Neurol. 244, 3-14.
59. Shaw P. J., Williams T. L., Slade J. Y., Eggett C. J., and Ince P. G. (1999) Low expression of GluR2 AMPA receptor subunit protein by human motor neurons. Neuroreport 10, 261-265.
60. Smith J. C., Ellenberger H. H., Ballanyi K., Richter D. W., and Feldmann J. L. (1991) Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254, 726-729.
61. Sommer B., Keinänen K., Verdoorn T. A., Wisden W., Burnashev N., Herb A., Köhler M., Takagi T., Sakmann B., and Seeburg P. H. (1990) Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science 249, 1580-1585.
62. Sucher N. J., Akbarian S., Chi C. L., Leclerc C. L., Awobuluyi M., Deitcher D. L., Wu M. K., Yuan J. P., Jones E. G., and Lipton S. A. (1995) Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J. Neurosci. 15, 6509-6520.
63. Titz S. and Keller B. U. (1997) Rapidly deactivating AMPA receptors determine excitatory synaptic transmission to interneurons in the nucleus tractus solitarius from rat. J. Neurophysiol. 78, 82-91.
64. Tölle T. R., Berthele A., Zieglgänsberger W., Seeburg P. H., and Wisden W. (1995) Flip and flop variants of AMPA receptors in the rat lumbar spinal cord. Eur. J. Neurosci. 7, 1414-1419.
65. Verdoorn T. A., Burnashev N., Monyer H., Seeburg P. H., and Sakmann B. (1991) Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252, 1715-1718.
66. Watanabe M., Inoue Y., Sakimura K., and Mishina M. (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport 3, 1138-1140.
67. Watanabe M., Mishina M., and Inoue Y. (1994) Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem. J. Comp. Neurol. 343, 520-531.
68. Wenzel A., Villa M., Mohler H., and Benke D. (1996) Developmental and regional expression of NMDA receptor subtypes containing the NR2D subunit in rat brain. J. Neurochem. 66, 1240-1248.
69. Williams T. L., Ince P. G., Oakley A. E., and Shaw P. J. (1996) An immunocytochemical study of the distribution of AMPA selective glutamate receptor subunits in the normal human motor system. Neuroscience 74, 185-198.
70. Williams T. L., Day N. C., Ince P. G., Kamboj R. K., and Shaw P. J. (1997) Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann. Neurol. 42, 200-207.
71. Wisden W. and Seeburg P. H. (1993) A complex mosaic of high affinity kainate receptors in rat brain. J. Neurosci. 13, 3582-3598.