Suppressors of cytokine signalling (SOCS): Putative modulators of cytokine bioactivity in health and disease

Journal of Nephrology

Volumn 13, Issue 1, 2000, Pages 9-14

  Diamond, Pauline ^b   Doran, Peter ^b   Brady, Hugh R ^b   McGinty, Ann ^a  

^a Royal College of Dublin   (Ireland)

^b NONE

Author keywords

Cytokine; Host defence; Inflammation; Inhibitor; Janus kinase; Signal transducers and activators of transcription

Indexed keywords

CYTOKINE; ERYTHROPOIETIN RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; SOMATOMEDIN C RECEPTOR; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL MODEL; GENE EXPRESSION; HAMSTER; HYPERLEPTINEMIA; IMMUNE COMPLEX NEPHRITIS; MODEL; MOUSE; MYELOID LEUKEMIA; NEGATIVE FEEDBACK; PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CYTOKINES; DNA-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY DISEASES; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034021701     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Schindler C, Darnell JE. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu Rev Biochem 1995; 64: 621-51.
2. Ihle JN, Kerr IM. JAKS and STATS in signaling by the cytokine receptor superfamily. Trends Genetics 1995; 11: 69-71.
3. Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387: 917-21.
4. 2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J 1995; 14: 2816-26.
5. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997; 387: 924-9.
6. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387: 921-4.
7. Nicholson SE, Hilton DJ. The SOCS proteins: a new family of negative regulators of signal transduction. J Leukocyte Biol 1998; 63: 665-8.
8. Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. J Biol Chem 1997; 272, 43: 27178-2.
9. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A. Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 1997; 239: 439-46.
10. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun 1997; 237: 79-83.
11. Schluter G, Celik A, Obata R, Schliker M, Hofferbert S, Schlung A, Adham IM, Engel W. Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. Mol Reprod Develop 1996; 43: 1-6.
12. Matsumoto A, Masuhara M, Mitsui K, Yokoouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT 5 pathway and modulates STAT 5 activation. Blood 1997; 9: 3148-54.
13. Auernhammer CJ, Bousquet C, Melmed S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci USA 1999; 96: 6964-9.
14. Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A, Yoshimura A. Interleukin-10 (IL-10) selectively enhances CIS-3/SOCS-3 mRNA expression in human neutrophils: evidence for an IL-10 induced pathway that is independent of STAT protein activation. Blood 1999; 94: 2880-9.
15. Dey BR, Spence SL, Nissley P, Furlanetto RW. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-1 receptor.J Biol Chem 1998; 273: 24095-101.
16. Hilton DJ, Richardson RT, Alexander WS, Viney ES, Willson TA, Sprigg NS, Nicholson SE, Metcalf D, Nicola NA. Twenty proteins containing a C-terminal SOCS-box form five structural classes. J Biol Chem 1998; 95: 114-9.
17. Narazaki M, Fujimoto M, Matsumoto T, Monta Y, Saito H, Kajita T, Voshizaki K, Naka T, Kishimoto T. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin-6 signaling. Proc Natl Acad Sci USA 1998; 95: 13130-4.
18. Nicholson SE, Willson TA, Farley A, Starr R, Zhang J-G, Baca M, Alexander WF, Metcalf D, Hilton DJ, Nicola NA. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J 1999; 18: 375-85.
19. Kamura T, Sato S, Hague D, Liu L, Kaelin WG, Conaway RC, Conaway JW. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev 1999; 12: 3872-81.
20. Zhang J-G, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Carey D, Richardson RG, Hausmann BJ Kile, Kent SBH, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 1999; 96: 2071-6.
21. Kaelin WG, Maher ER. The VHL tumour-suppressor gene paradigm. Trends Genet 1998; 14: 423-6.
22. Suzuki R, Sakarnoto H, Yasukawa H, Matsuhara M, Wakioka T, Sasaki A, Yuge K, Komiya S, Inoue A, Yoshimura A. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene 1998; 17: 2271-8.
23. Adams T, Hansen J, Starr Nicola R, Hilton N, Billestrup D N. Growth hormone preferentially induces the rapid transient expression of SOCS-3, a novel inhibitor of cytokine receptor signalling. J Biol Chem 1997; 273: 1285-7.
24. Bjorbaek C, Elmquist J, Frantz J, Shoelson S, Flier J. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998; 1: 619-25.
25. Halaas J, Boozer C, Blair-West J, Fidahusein N, Denton D, Freidman J. Physiological response to long-term peripheral and central leptin resistance in lean and obese mice. Proc Natl Acad Sci USA 1997; 94: 8878-83.
26. Auernhammer CJ, Chesnokova V, Bousquet C, Melmed S. Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Mol Endocrinol 1998; 12: 954-61.
27. Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsuka M, Fujita T, Ohta T, Furukawa Y, Iwase S, Yamada H, Yoshimura A. Ajanus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons. Blood 1998; 5: 1668-76.
28. Mandelli F, Arcese A, Awisati G. The interferons in haematological malignancies. Clin Haematol 1994; 7: 91-113.
29. Starr R, Metcalf D, Elefanty A, Brysha M, Willson T, Nicola N, Hilton D, Alexander W. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signalling-1. Proc Nat Acad Sci USA 1998; 95: 14395-9.
30. Naka T, Matsumoto T, Narazaki M, Fujimoto M, Morita Y, Ohsawa Y, Saito H, Nagasawa T, Uchiyama Y, Kishimoto T. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci USA 1998; 95: 15577-82.
31. Schena FP, Gesualdo L, Grandaliano G, Montinaro V. Progression of renal damage in human glomerulonephritides: is there sleight of hand in winning the game? Kidney Int 1997; 52: 1439-57.
32. McGinty A, King CM, Starr R, Hilton DJ, Brady HR. Suppressors of cytokine signalling (SOCS): expression by mesangial cells and regulation by cytokines and growth factors. JASN 1998; 9: A2459.
33. Ito S, Anasari P, Sakatsume M, Dickensheets H, Vazquez N, Donnelly RP, Lamer AC, Finbloom DS. Interleukin-10 inhibits expression of both interferon-α and interferon-γ-induced genes by suppressing tyrosine phosphorylation of STAT. Blood 1999; 93: 1456-63.
34. Dickensheets HL, Venkataraman C, Schindler U, Donnelly RP. Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc Natl Acad Sci USA 1999; 96: 10800-5.