Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 373, Issue 1, 1997, Pages 75-85

  Rossman, Toby G ^a   Goncharova, Ekaterina I ^a   Nádas, Arthur ^a   Dolzhanskaya, Natalia ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antisense; Metallothionein; Spontaneous mutagenesis

Indexed keywords

CADMIUM; COMPLEMENTARY RNA; COPPER; MERCURY; METALLOTHIONEIN; ZINC;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHINESE HAMSTER; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPONTANEOUS MUTATION;

ANIMALS; CADMIUM CHLORIDE; CELL NUCLEUS; CELLS, CULTURED; CHLORIDES; CLONING, MOLECULAR; COPPER; CRICETINAE; CRICETULUS; CYTOPLASM; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GENETIC VECTORS; MERCURIC CHLORIDE; METALLOTHIONEIN; MUTAGENESIS; RIBONUCLEASES; RNA, ANTISENSE; TRANSCRIPTION, GENETIC; TRANSFECTION; VITAMIN K; ZINC COMPOUNDS;

EID: 0031018128     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00192-3     Document Type: Article

References (62)

1. Abel, J. and N. de Ruiter (1989) Inhibition of hydroxyl radical-generated DNA degradation by metallothionein. Toxicol. Lett., 47, 191-119.
2. Ames, B.N. and L.S. Gold (1989) Endogenous mutagens and the causes of aging and cancer. Mutation Res., 214, 3-12.
3. Bakka, A., A.B.S. Johnsen, I. Endersen and U.E. Rugstad (1982) Radioresistance in cells with high content of metallothionein. Experientia, 28, 381-383.
4. Banerjee, D., S. Onosaka and M.G. Cherian (1982) Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney. Toxicol., 24, 95-105.
5. Barrows, L.R. and P.N. Magee (1982) Non-enzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis, 3, 349-351.
6. Basu, A. and J.S. Lazo (1990) A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs. Toxicol. Lett., 50, 123-135.
7. Bauman, J.W., J. Liu, Y.P. Lui and C.D. Klaassen (1991) Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicol. Appl. Pharmacol., 110, 347-354.
8. Bremner, I. (1991) Nutritional and physiologic significance of metallothionein. Methods Enzymol., 205, 25-35.
9. Cai, L., J. Koropatnick and M.G. Cherian (1995) Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro. Chemico-Biol. Interact., 96, 143-155.
10. Cerutti, P.A. and B.F. Trump (1991) Inflammation and oxidative stress in carcinogenesis. Cancer Cells, 3, 1-7.
11. Chen, C. and M.H. Okayama (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
12. 2+ requirement for DNA synthesis by 3T3 cells. Exp. Cell Res., 192, 631-634.
13. Chubatsu, L.S. and R. Meneghini (1993) Metallothionein protects DNA from oxidative damage. Biochem. J., 291, 193-198.
14. Chubatsu, L.S., M. Gennari and R. Menenghini (1992) Glutathione is the antioxidant responsible for resistance to oxidative stress in V79 Chinese hamster fibroblasts rendered resistant to cadmium. Chem. Biol. Interact., 82, 99-110.
15. Dudek, E.J., J.G. Peak, R.M. Roth and M.J. Peak (1993) Isolation of V79 fibroblast cell lines containing elevated metallothionein levels that have increased resistance to the cytotoxic effects of ultraviolet-A radiation. Photochem. Photobiol., 58, 836-840.
16. Eaton, D.L., N.H. Stacey, K.-L. Wong and C.D. Klaasen (1980) Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. Toxicol. Appl. Pharmacol., 55, 393-402.
17. Fraga, C.G., M. Shigenaga, J. Park, P. Degan and B. Ames (1990) Oxidative damage to DNA during aging: 8-hydroxy-2-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA, 87, 4533-4537.
18. Frenkel, K. (1992) Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol. Ther., 53, 127-166.
19. Goncharova, E.I. and T.G. Rossman (1994) A role for metallothionein and zinc in spontaneous mutagenesis. Cancer Res., 54, 5318-5323.
20. Goncharova, E.I. and T.G. Rossman (1995) The antimutagenic effects of metallothionein may involve free radical scavenging, in: B. Sarkar (Ed.), Genetic Response to Metals. Marcel Dekker, New York, pp. 87-100.
21. Goncharova, E.I., A. Nádas and T.G. Rossman (1996) Serum deprivation, but not inhibition of growth per se, induces a hypermutable state in Chinese hamster G12 cells. Cancer Res. (in press).
22. Griffith, B.B., R.A. Walters and M.D. Enger (1983) cDNA cloning and nucleotide sequence comparison of Chinese hamster metallothionein I and II mRNAs. Nucleic Acids Res., 11, 910-910.
23. Hamer, D.H. (1986) Metallothionein. Ann. Rev. Biochem., 55, 913-951.
24. Hart, B.A., G.W. Voss, M.A. Shatos and J. Doherty (1990) Crosss-tolerance to hyperoxia following cadmium aerosol pretreatment. Toxicol. Appl. Pharmacol., 103, 255-270.
25. Iverson, P.L. and M. Ebadi (1992) Antisense oligonucleotides-mediated inhibition of metallothionein protein synthesis in neuroblastoma IM32 and change liver cells in culture. Biol. Signals, 1, 57-64.
26. Joenje, H. (1989) Genetic toxicology of oxygen. Mutation Res., 219, 193-208.
27. Klein, C.B. and T.G. Rossman (1990) Transgenic Chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis. Environ. Mol. Mutagen., 16, 1-12.
28. + V79 cell lines differ in their mutagenic response to clastogens. Mutation Res., 304, 217-228.
29. Koropatnick, J., M. Leibbrand and M.G. Cherian (1989) Organ specific metallothionein induction in mice by X irradiation. Radiat. Res., 119, 356-365.
30. Larramendy, M., A.D. Mello-Filho, E.A. Martins and R. Meneghini (1987) Iron-mediated induction of sister-chromatid exchanges by hydrogen peroxide and superoxide anion. Mutation Res., 178, 57-63.
31. Lazo, J.S., Y. Kondo, D. Dellapiazza, A.E. Michalska, K.H.A. Choo and B.R. Pitt (1995) Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem., 270, 5506-5510.
32. Lee, Y.-W., C.B. Klein, B. Kargacin, K. Salnikow, J. Kitahara, K. Dowjat, A. Zhitkovich, N.T. Christie and M. Costa (1995) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: A new model for epigenetic carcinogens. Mol. Cell Biol., 15, 2547-2557.
33. Leibbrandt, M.E., R. Khokha and J. Koropatnick (1994) Antisense down-regulation of metallothionein in a human monocytic cell line alters adherence, invasion, and the respiratory burst. Cell Growth Differ., 5, 17-25.
34. Loeb, L.A. (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 51, 3075-3079.
35. Maniatis, T., E.F. Fritsch and J. Sambrook (1982) Molecular cloning, A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
36. Mansur, N.R., K. Meyer-Siegler, J.C. Wurzewr and M.A. Sirover (1993) Cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in normal human cells. Nucleic Acids Res., 21, 993-998.
37. Marnett, L.J. and P.C. Burcham (1993) Endogenous DNA adducts: Potential and paradox. Chem. Res. Toxicol., 6, 771-785.
38. Masters, B.A., E.J. Kelly, C.J. Quaife, R.L. Brinster and R.D. Palmiter (1994) Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA, 91, 584-588.
39. Mello-Filho, A.C., M.E. Hoffman and R. Meneghini (1985) Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron. Biochem. J., 218, 273-275.
40. Mello-Filho, A.C., L.S. Chabatsu and R. Meneghini (1988) V79 Chinese-hamster cells rendered resistant to high cadmium concentration also become resistant to oxidative stress. Biochem. J., 256, 475-479.
41. Moriya, M., C. Ou, V. Bodipudi, M. Takeshita and A.A. Grollman (1991) Site specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutation Res., 254, 281-288.
42. Nagel, W.W. and B.L. Vallee (1995) Cell cycle regulation of metallothionein in human colonic cancer cells. Proc. Natl. Acad. Sci. USA, 92, 579-583.
43. Ochi, T., F. Otsuka, K. Takahashi and M. Ohsawa (1988) Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells. Chemico-Biol. Interact., 65, 1-14.
44. Randerath, K., J. Chang and E. Randerath (1985) Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress. in J. Bertram, R. Cutler, A. Mori and L. Packer (Eds.), Oxidative Stress and Aging, Birkhauser Publishing Co., in press.
45. 32P-postlabeling assay and possible significance for spontaneous tumor induction and aging. Carcinogenesis, 7, 1615-1617.
46. 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds. Mutation Res., 250, 135-144.
47. Robson, T., H. Grindley, A. Hall, J. Vormoor and H. Lohrer (1994) Increased DNA-repair capacity and the modulation of 2 proteins in the metallothionein overexpressing Chinese hamster cell line. Mutation Res., 314, 143-157.
48. Rossman, T.G., E.I. Goncharova and A. Nádas (1995) Modeling and measurement of the spontaneous mutation rate in mammalian cells. Mutation Res., 328, 21-30.
49. Sato, M. and I. Bremner (1993) Oxygen free radicals and metallothionein. Free Rad. Biol. Med., 14, 325-337.
50. Schroeder, J.J. and R.J. Cousins (1990) Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc. Natl. Acad. Sci. USA, 87, 3137-3141.
51. Schwarz, M.A., J.S. Lazo, J.C. Yalowich, I. Reynolds, V.E. Kagan, V. Tyurin, Y.-M. Kim, S.C. Watkins and B.R. Pitt (1994) Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem., 269, 15238-15243.
52. Shirname-More, L., T.G. Rossman, W. Troll, G.W. Teebor and K. Frenkel (1987) Genetic effects of 5-hydroxymethyl-2′-deoxyuridine, a product of ionizing radiation. Mutation Res., 178, 177-186.
53. Thomas, J.P., G.J. Bachowski and A.W. Girotti (1986) Inhibition of cell membrane lipid peroxidation by cadmium- and zinc-metallothioneins. Biochim. Biophys. Acta, 884, 448-461.
54. Thornalley, P.T. and M. Vasak (1985) Possible role for metallothionein in protection against radiation induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochem. Biophys. Acta, 827, 36-66.
55. Tsujikawa, K., T. Imai, M. Kakutani, Y. Kayamori, T. Mimura, N. Otaki, M. Kimura, R. Fukuyama and N. Shimizu (1991) Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes. FEBS Lett., 283, 239-242.
56. Udom, A. and F. Brady (1980) Reactivation in vitro of zinc requiring apoenzymes by rat liver thionein. Biochem. J., 187, 329-335.
57. Vallee, B.L. and K.M. Falchuk (1993) The biochemical basis of zinc physiology. Physiol. Rev., 73, 79-118.
58. Waalkes, M.P. and P.L. Goering (1990) Metallothionein and other cadmium-binding proteins: Recent developments. Chem. Res. Toxicol., 3, 281-288.
59. Wood, M.L., M. Dizdaraglu, E. Gajewski and J.M. Essigman (1990) Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine(7-hydro-8 oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry, 29, 7024-7033.
60. Xiao, W. and L. Samson (1993) In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl. Acad. Sci. USA, 90, 2117-2121.
61. Zeng, T., B.L. Valle and H.R. Kagi (1991) Zinc transfer from transcription factor IIIA fingers to thionein clusters. Proc. Natl. Acad. Sci. USA, 88, 9984-9988.
62. Zhitkovich, A., V. Voitkun and M. Costa (1995) Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate. Carcinogenesis, 16, 907-913.