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The RESPONSIVE TO ANTAGONIST 1 (RAN1) gene from Arabidopsis is cloned. ran1 mutants were identified in a screen for plants that responded to the ethylene antagonist, trans-cyclooctene. Cloning of RAN1 shows that this gene is the Arabidopsis homolog of the yeast CCC2, a gene involved in copper trafficking. The authors propose that RAN1 delivers copper to ethylene receptors in post-Golgi vesicles. They also observe that the ran1 mutation produces a constitutive ethylene response.
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