Characterization of dopaminergic compounds at hD(2short), hD4.2 and hD4.7 receptors in agonist-stimulated [35S]GTPγS binding assays

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 5, 2000, Pages 498-504

  Gilliland, Sarah L ^a   Alper, Richard H ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Agonist stimulated 35S GTP S binding assays; Atypical antipsychotic drugs; CHO cells; Dopamine receptor subtypes; Dopamine receptors; Functional characterization; Humans; In vitro

Indexed keywords

APOMORPHINE; CLOZAPINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PERGOLIDE; QUETIAPINE; QUINELORANE; QUINPIROLE; RECEPTOR SUBTYPE; RISPERIDONE; SPIPERONE; SULFUR 35; ZIPRASIDONE;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENETIC TRANSFECTION; NONHUMAN; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; APOMORPHINE; BENZODIAZEPINES; BINDING, COMPETITIVE; CHO CELLS; CLOZAPINE; CRICETINAE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; PIRENZEPINE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE; SEROTONIN UPTAKE INHIBITORS; SULFUR RADIOISOTOPES; TRANSFECTION;

EID: 0034018856     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000224     Document Type: Article

References (23)

1. 35S]GTPγS binding in rat hippocampal membranes. Eur J Pharmacol 343:303-312
2. Arnt J, Skarsfeldt T (1998) Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18:63-101
3. Asghari V, Schoots O, Kats S van, Ohara K, Jovanovic V, Guan HC, Bunzow JR, Petronis A, Van Tol HH (1994) Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 46:364-373
4. 3 dopamine receptors to G-proteins. FEBS Eett 315:223-226
5. Cohen BM, Ennulat DJ, Centorrino F, Matthysse S, Konieczna H, Chu H-M, Cherkerzian S (1999) Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs. Psychopharmacology (Berl) 141:6-10
6. 2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs. J Pharmacol Exp Ther 286:85-90
7. 2(long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol 124:978-984
8. 2long dopamine receptors expressed in recombinant cells. Br J Pharmacol 118:1544-1550
9. 3 receptor. J Neural Transm 103:1163-1175
10. 2 dopamine receptors. Br J Pharmacol 121: 731-736
11. 2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol 236: 483-486
12. 4 receptor. J Neurochem 68:804-812
13. Lazareno S, Fairies T, Birdsall NJ (1993) Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4. Life Sci 52:449-456
14. 35S] binding. J Pharmacol Exp Ther 285:119-126
15. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78:189-225
16. 4.4 receptors: actions of antiparkinsonian and antipsychotic agents. J Pharmacol Exp Ther 282:181-191
17. 35S]GTPγS binding study. Eur J Pharmacol 355:245-256
18. 2 receptors? J Neural Transm 92:213-220
19. 4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. Psychopharmacology (Berl) 120:365-368
20. Schotte A, Janssen PFM, Gommeren W, Luyten WHML, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 124:57-73
21. 4 receptors. Neuropsychopharmacology 16:93-110
22. Selley DE, Sim LJ, Xiao R, Liu Q, Childers SR (1997) μ-Opioid receptor-stimulated guanosine-5'-O-(γ-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy. Mol Pharmacol 51: 87-96
23. 4 receptor with high affinity for the antipsychotic clozapine. Nature 350:610-614