Effects of etomidate on free intracellular amino acid concentrations in polymorphonuclear leucocytes in vitro

Acta Anaesthesiologica Scandinavica

Volumn 44, Issue 4, 2000, Pages 429-435

  Muhling J ^a   Weiss, S ^a   Knulle V ^a   Sablotzki, A ^a   Dehne, M G ^a   Hempelmann, G ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Etomidate; High performance liquid chromatography; Intracellular amino acids; Leucocytes

Indexed keywords

AMINO ACID; DRUG ADDITIVE; ETOMIDATE; LIPOFUNDIN; PROPYLENE GLYCOL;

ADULT; AMINO ACID METABOLISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE FUNCTION; LEUKOCYTE METABOLISM; MALE; NEUTROPHIL; PRIORITY JOURNAL;

ADULT; AMINO ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETOMIDATE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; NEUTROPHILS;

EID: 0034015260     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2000.440412.x     Document Type: Article

References (36)

1. 1. Davidson JAH, Boom SJ, Pearsall FJ, Zhang P, Ramsay G. Comparison of the effects of four i.v. anaesthetic agents on polymorphonuclear leucocyte function. Br J Anaesth 1995: 74: 315-318.
2. 2. Gelb AW, Lok P. Etomidate reversibly depresses human neutrophil chemiluminescence. Anesthesiology 1987: 66: 60-63.
3. 3. Krumholz W, Endrass J, Hempelmann G. Inhibition of phagocytosis and killing of bacteria by anaesthetic agents in vitro. Br J Anaesth 1995: 75: 66-70.
4. 4. Devlin EG, Clarke RS, Mirakhur RK, McNeill TA. Effects of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro. Br J Anaesth 1994: 73: 315-317.
5. 5. Al-Sawaf HA, Al-Ghamdi MA, Al-Bekairi AM, Tawfik AM, Abu-Jayyab AR. Changes in free amino acids in peripheral blood (PB), lymphocytes and polymorphonuclear leukocytes after treatment with diazepam. Int J Immunopharmacol 1993: 15: 455-462.
6. 6. Mühling J, Fuchs M, Dehne MG, Sablotzki A, Menges T, Weber B et al. Quantitative determination of free intracellular amino acids in single human polymorphonuclear leucocytes. Recent developments in sample preparation and highperformance liquid chromatography. J Chromatogr B 1999: 728: 157-166.
7. 7. Doenicke A, Loffler B, Kugler J, Suttmann H, Grote B. Plasma concentration and EEG after various regimens of etomidate. Br J Anaesth 1982: 54: 393-400.
8. 8. Mattheussen M, Housmans PR. Mechanism of the direct negative inotropic effect of etomidate in isolated ferret ventricular myocardium. Anesthesiology 1993: 79: 1284-1295.
9. 9. Gelissen HP, Epema AH, Henning RH, Krijnen HJ, Hennis PJ, den Hertog A. Inotropic effects of propofol, thiopenthal, midazolam, etomidate and ketamine on isolated human atrial muscle. Anesthesiology 1996: 84: 397-403.
10. 10. Charleswoth P, Pocock G, Richards CD. Calcium channel currents in bovine adrenal chromaffin cells and their modulation by anesthetic agents. J Physiol Lond 1994: 481: 543-553.
11. 11. Buljubasic N, Marijic J, Berczi V, Supan DF, Kampine JP, Bosnak ZJ. Differential effects of etomidate, propofol and midazolam on calcium and potassium channel currents in canine myocardial cells. Anesthesiology 1996: 85: 1092-1099.
12. 12. Benoit E. Effects of intravenous anaesthetics on nerve axons. Eur J Anaesthesiol 1995: 12: 59-70.
13. 2+, and pH in rat ventricular myocytes. Anesthesiology 1998: 89: 202-214.
14. 14. Segal AW, Geisow M, Garcia R, Harper A, Miller R. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature 1981: 290: 406-412.
15. 15. Lofberg E, Wernerman J, Anderstam B, Bergstrom J. Correction of acidosis in dialysis patients increases branched-chain and total essential amino acid levels in muscle. Clin Nephrol 1997: 48: 230-237.
16. 16. Bailey JL, England BK, Long RC, Mitch WE. Influence of acid loading, extracellular pH and uremia on intracellular pH in muscle. Minor Electrolyte Metab 1996: 22: 66-68.
17. + pump stimulated by serum and a tumor promoter. Biochim Biophys Acta 1986: 86: 187-193.
18. 18. Learn DB, Fried VA, Thomas EL. Taurine and hypotaurine content of human leucocytes. J Leukoc Biol 1990: 48: 174-182.
19. 19. Schousbõe A, Passantes-Morales H. Role of taurine in neural cell volume regulation. Can J Physiol Pharmacol 1992: 70: 356-361.
20. 20. Chen JG, Kempson SA. Osmoregulation of neutral amino acid transport. Proc Soc Exp Biol Med 1995: 210: 1-6.
21. 21. Suleiman MS. New concepts in the cardioprotective action of magnesium and taurine during the calcium paradox and ischemia of the heart. Magnes Res 1994: 7: 295-312.
22. 22. Fugelli K, Kanli H, Terreros DA. Taurine efflux is a cell volume regulatory process in proximal renal tubules from the teleost Carassius auratus. Acta Physiol Scand 1995: 155: 223-232.
23. 23. Olson JE, Putnam RW, Ewers JA, Munoz N. Taurine efflux and intracellular pH during astrocyte volume regulation. Adv Exp Med Biol 1998: 442: 229-235.
24. 24. Rasmusson RL, Davis DG, Lieberman M. Amino acid loss during volume regulatory decrease in chick heart cells. Am J Physiol 1993: 264: C136-C145.
25. 25. Schuller-Levis GB, Sturman JA. "Activation" of alveolar leukocytes isolated from cats fed taurine-free diets. Adv Exp Med Biol 1992: 48: 83-90.
26. 26. Masuda M, Horisaka K, Koeda T. Effects of taurine on neutrophil function in hyperlipidemic rats. Jpn J Pharmacol 1986: 40: 478-480.
27. 27. Naskalski JW. Myeloperoxidase inactivation in the course of catalysis of chlorination of taurine. Biochim Biophys Acta 1997: 485: 291-300.
28. 28. Schuller-Levis G, Mehta PD, Rudelli R, Sturman J. Immunologic consequence of taurine deficiency in cats. J Leukocyte Biol 1990: 47: 321-331.
29. 29. Dinkelborg LM, Kinne RK, Grieshaber MK. Characterization and pH dependence of L-glutamate transport in sarcolemmal vesicles from rat hearts. Am J Physiol 1995: 268: H194-H201.
30. 30. Newsholme EA, Calder PC. The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal. Nutrition 1997: 13: 728-730.
31. 31. Roth E, Spittler A, Oehler R. Glutamine effects on the immune system, protein balance and intestinal functions. Wien Klin Wochenschr 1996: 108: 669-676.
32. 32. Castell LM, Bevan SJ, Calder PC, Newsholme EA. The role of glutamine in the immune system and in intestinal function in catabolic states. Amino Acids 1994: 7: 231-243.
33. 33. Haussinger D, Roth E, Lang F, Gerok W. Cellular hydration state: An important determinant of protein catabolism in health and disease. Lancet 1993: 341: 1330-1332.
34. 34. Vom Dahl S, Haussinger D. Nutritional state and the swelling induced inhibition of proteolysis in perfused rat liver. J Nutr 1996: 126: 395-402.
35. 35. Stringer RE, Edwards SW. Potentiation of the respiratory burst of human neutrophils by cycloheximide: regulation of reactive oxidative oxidant production by a protein(s) with rapid turnover? Inflamm Res 1995: 44: 158-163.
36. 36. Metcoff J. Intracellular amino acid levels as a predictor of protein synthesis. Am J Coll Nutr 1986: 5: 107-120.