Hypertonic mannitol loading of NF-κ̄ transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM-1

Stroke

Volumn 31, Issue 5, 2000, Pages 1179-1186

  Hess, David C ^a,b   Howard, Eugene ^b   Cheng, Charles ^b   Carroll, James ^b   Hill, David W ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Department of Neurology ^*  (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Endothelium; Genetic; Intercellular adhesion molecule 1; Nuclear factor kappa B; Transcription

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANNITOL; TRANSCRIPTION FACTOR;

ARTICLE; BRAIN BLOOD VESSEL; BRAIN PROTECTION; CELL ACTIVATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE EXACERBATION; ENDOTHELIUM CELL; GENE ACTIVATION; GENE CONTROL; GENE DISRUPTION; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL;

EID: 0034014992     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.31.5.1179     Document Type: Article

References (34)

1. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999; 19:819-834.
2. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391-387.
3. Barone FC, Schmidt DB, Hillegasss LM, Price WJ, White RF, Feuerstein GZ, Clark RK, Lee EV, Griswold DE, Sarau HM. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat local ischemia. Stroke. 1992;23:1337-1348.
4. Clark RK, Lee EV, White RF, Jonak ZL, Feuerstein GZ, Barone FC. Reperfusion following focal stroke hastens inflammation and resolution of the ischemic injured tissue. Brain Res Bull. 1994;35:387-391.
5. Chopp M, Zhang RL, Chen H, Li Y, Jiang N, Rusche JR. Postischemic administration of an Anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke. 1994;25: 869-876.
6. Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, Anderson DC. Anti-intercellular adhesion molecule- I antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke. 1995;26:1438-1443.
7. Bowes MO, Rothlein R, Fagan SC, Zivin JA. Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy. Neurology. 1995;45: 815-819.
8. Zhang RL, Zhang ZG, Chopp M, Zivin JA. Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke. 1999;30:624-629.
9. Wang X, Feuerstein GZ. Induced expression of adhesion molecules following focal brain ischemia. J Neurotrauma. 1995;12:825-832.
10. Collins T. Endothelial nuclear factor-κB (NF-KB) and the initiation of the atherosclerotic lesion. Lab Invest. 1993;68:499-508.
11. Read M, Whitley MZ, Williams AJ, Collins T. NF-KB and IkBa: an inducible regulatory system in endothelial activation. J Exp Med. 1994; 179:503-512.
12. Karin M. The beginning of the end: IkB kinase (IKK) and NF-kB activation. J Biol Chem. 1999;274:27339-27342.
13. Howard EF, Chen Q, Cheng C, Carroll JE, Hess DC. NF-kB is activated and ICAM-1 gene expression is upregulated during reoxygenation of human brain endothelial cells. Neurosci Lett. 1998;248:199-203.
14. Morishita R, Higaki J, Tomita N, Ogihara T. Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease. Circ Res. 1998;82:1023-1028.
15. Hess DC, Zhao W, Carroll J, McEachin M, Buchanan K. Increased expression of ICAM-1 during reoxygenation in brain endothelial cells. Stroke. 1994;25:1463-1468.
16. Southern PJ, Berg P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet. 1982;1:317-341.
17. Goldring CEP, Narayanan R, Lagadec P, Jeannin JF. Transcriptional inhibition of the inducible nitric oxide synthase gene be competitive binding of NF-kB/rel proteins. Biochem Biophys Res Commun. 1995;209: 73-79.
18. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell. 1986;46:705-716.
19. Okada CY, Rechsteiner M. Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles. Cell. 1982;29: 33-41.
20. Ledebur HC, Parks TP. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. J Biol CHem. 1995;270:933-943.
21. Bielinska A, Shivdasani RA, Zhang L, Nabel GJ. Regulation of gene expression with double-stranded phosphothiorate oligonucleotides. Science. 1990;250:997-999.
22. Eck SL, Perkins ND, Carr DP, Nabel GJ. Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-kB in vivo. Mol Cell Biol. 1993;13:6530-6536.
23. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K, Sawa Y, Kaneda Y, Higaki J, Ogihara T. In vivo transfection of cis element "decoy" against nuclear factor-kb binding site prevents myocardial infarction. Nat Med. 1997;3:894-899.
24. Xu J, Wu Y, He L, Yang Y, Moore SA, Hsu CY, Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells. Biochem Biophys Res Commun. 1997;235: 394-397.
25. Malek AM, Goss GG, Jiang L, Izumo S, Alper SL, Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke. 1998;29:2631-2640.
26. Kroll RA, Neuwelt EA, Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery, 1998;42: 1083-1100.
27. Neuwelt EA, Weissleder R, Nilaver G, Kroll RA, Roman-Goldstein S, Szumowski J, Pagel MA, Jones RS, Remsen LG, McCormick CI, Shannon EM, Muldoon LL, Delivery of virus-sized iron oxide particles to rodent CNS neurons. Neurosurgery 1994,34:777-784.
28. Doran SE, Ren XD, Betz AL, Pagel MA, Neuwelt EA, Roessler BJ, Davidson BL. Gene expression from recombinant viral vectors in the central nervous system after blood-brain harrier disruption, Neurosurgery. 1995;36:965-970.
29. Brightman MW, Hori M, Rapoport SI, Reese TS, Westergaard E. Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol. 1973;152:317-325.
30. Nagy Z, Peters H, Huttner I. Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions. Lab Invest. 1984;50:313-322.
31. Nagashima T, Ikeda K, Wu S, Kondo T, Yamaguchi M, Tamaki N. The mechanism of reversible osmotic opening of the blood-brain barrier: role of intracellular calcium ion in capillary endothelial cells. Acta Neurochir Suppl (Wien). 1997;70:231-233.
32. O'Neill LAJ, Kaltschmidt C. NF-kB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 1997;20:252-258.
33. Schneider A, Martin-Villalba A, Weigh P, Vogel J, Wirth T, Schwaninger M. NF-kB is activated and promotes cell death in focal cerebral ischemia. Nat Med. 1999;5:554-559.
34. Yu Z, Zhao D, Bruce-Kellar AJ, Kindy MS, Mattson MP. Lack of the p50 subunit of nuclear factor-kB increase the vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci. 1999;19:8856-8865.