Glucose uptake increases relative to oxygen consumption during short-term hibernation

Basic Research in Cardiology

Volumn 95, Issue 1, 2000, Pages 39-46

  McFalls, E O ^a   Baldwin, D R ^a   Marx, D ^a   Maxwell, K ^a   Ward, H B ^a  

^a VA MEDICAL CENTER   (United States)

Author keywords

ATP; Creatine phosphate; Glucose; Hibernation; Ischemia; Lactate

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; FATTY ACID; GLUCOSE; GLYCOGEN; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MYOCARDIAL HIBERNATION; NONHUMAN; OXYGEN CONSUMPTION; SWINE;

ANIMALS; ENERGY METABOLISM; FEMALE; GLUCOSE; HIBERNATION; MALE; OXYGEN CONSUMPTION; SWINE; TIME FACTORS;

EID: 0034014459     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050006     Document Type: Article

References (33)

1. Arai A, Pantely G, Anselone C, Bristow J, Bristow J (1991) Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 69: 1458-69
2. Bolukoglu H, Goodwin G, Guthrie P, Carmical S, Chen T, Taegtmeyer H (1996) Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol 270: H817-26
3. Bristow J, Arai A, Anselone C, Pantely G (1991) Response to myocardial ischemia as a regulated process. Circulation 14: 27-51
4. Cross H, Opie L, Radda G, Clarke K (1996) Is a high glycogen content beneficial or detrimental to the ischemic rat heart? Circ Res 78: 482-91
5. Depre C, Vanoverschelde J, Taegtmeyer H (1999) Glucose for the Heart. Circulation 99: 578-88
6. Diaz R, Paolasso E, Piegas L, Tajer C, Moreno M, Corvalan R et al. (1998) Metabolic modulation of acute myocardial infarction: The ECLA glucose-insulin-potassium pilot trial. Circulation 98: 2227-34
7. Fedele F, Gewirtz H, Capone R, Sharaf B, Most A (1988) Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation 78: 729-35
8. King L, Opie L (1998) Glucose delivery is a major determinant of glucose utilization in the ischemic myocardium with a residual coronary flow. Cardiovascular Research 39: 381-92
9. Liedtke A, Brenstrom B, Nellis S, Hall J, Stanley W (1995) Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Coll Cardiol 26: 815-25
10. Liedtke A, Brenstrom B, Nellis S, Subramanian R (1994) Myocardial function and metabolism in pig hearts after relief from chronic partial coronary stenosis. Am J Physiol 267: H1312-9
11. Lopaschuk G, Stanley W (1997) Glucose metabolism in the ischemic heart. Circulation 95: 313-5
12. Manchester J, Kong X, Nerbonne J, Lowry O, Lawrence J (1994) Glucose transport and phosphorylation in single cardiac myocytes: Rate-limiting steps in glucose metabolism. Am J Physiol 266: E326-33
13. Mazer C, Cason B, Stanley W, Shnier C, Wisneski J, Hickey R (1995) Dichloroacetate stimulates carbohydrate metabolism but does not improve systolic function in ischemic pig heart. Am J Physiol 268: H879-85
14. McFalls E, Baldwin D, Palmer B, Marx D, Jaimes D, Ward H (1997) Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomography. Am J Physiol 272: H343-9
15. McNulty P, Luba M (1995) Transient ischemia induces regional myocardial glycogen synthase activation and glycogen sythesiss in vivo. Am J Physiol. 268: H364-70
16. McNulty P, Sinusas A, Shi C, Dione D, Young L, Cline G (1996) Glucose metabolism distal to a critical stenosis in a canine model of low-flow myocardial ischemia. J Clin Invest 98: 62-9
17. McVeigh J, Lopaschuk G (1990) Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol 259: H1079-85
18. Montessuit C, Papageorgiou I, Tardy I, Lerch R (1996) Effect of nutritional state on substrate metabolism and contractile function in postischemic rat myocardium. Am J Physiol 271: H2060-H70
19. Pantely G, Malone S, Rhen W, Anselone C, Arai A, Bristow J et al. (1990) Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res 67: 1481-93
20. Renstrom B, Nellis S, Liedtke A (1989) Metabolic oxidation of glucose during early myocardial reperfusion. Cire Res 65: 1094-101
21. Runnman E, Lamp S, Weiss J (1990) Enhanced utilization of exogenous glucose improves cardiac function in hypoxic rabbit ventricle without increasing total glycolytic flux. J Clin Invest 86: 1222-33
22. Sakai K, Ichihara K, Nasa Y, Kamigaki M, Abiko Y (1990) Dichloroacetate attenuates myocardial acidosis and metabolic changes induced by partial occlusion of the coronary artery in dogs. Arch int Pharmacodyn 307: 92-108
23. Schaefer S, Carr L, Kreutzer U, Jue T (1993) Myocardial adaptation during acute hibernation: mechanisms of phosphocreatine recovery. Cardiovascular Research 27: 2044-51
24. Schulz R, Guth B, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res 70: 1282-95
25. Schulz R, Miyazaki S, Miller M, Thaulow E, Heusch G, Ross Jr J et al. (1989) Consequences of regional inotropic stimulation of ischemic myocardium on regional myocardial blood flow and function in anesthetized swine. Circ Res 64: 1116-26
26. Schulz R, Rose J, Post H, Heusch G (1995) Regional short-term hibernation in swine does not involve endogenous adenosine or KATP channels. Am J Physiol 268: H2294-H3201
27. Stanley W, Hall J, Stone C, Hacker T (1992) Acute myocardial ischemia causes a transmural gradient in glucose extraction but not glucose uptake. Am J Physiol 262: H91-6
28. Sun D, Nguyen N, DeGrado T, Schwaiger M, Brosius III F (1994) Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation 89: 793-8
29. Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M et al. (1986) Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J of Med 314: 884-8
30. Vanoverschelde J, Janier M, Bakke J, Marshall D, Bergmann S (1994) Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion. Am J Physiol 267: H1785-94
31. Vanoverschelde J, Wijns W, Depre C, Essamri B, Heyndrickx G, Borgers M et al. (1993) Mechanisms of chronic regional postischemic dysfunction in humans: new insights from the study of noninfarcted collateral-dependent myocardium. Circulation 87: 1513-23
32. Weiss J, Hiltbrand H (1985) Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. J Clin Invest 75: 436-47
33. Young L, Rengu Y, Russell R, Hu X, Caplan M, Ren J et al. (1997) Low-flow ischemia leads to translocation of canine heart GLUT4 and GLUT1 glucose transporters to the sarcolemma in vivo. Circulation 95: 415-22