Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations

Brain Research Bulletin

Volumn 52, Issue 3, 2000, Pages 207-212

  Murphy, Eric J ^a   Zhang, Hui ^b   Sorbi, Sandro ^c   Rapoport, Stanley I ^a   Gibson, Gary E ^b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Alzheimer disease; Cholesterol; Fibroblasts; Phospholipids; Plasmalogen; Presenilin 1

Indexed keywords

CHOLESTEROL; PHOSPHOLIPID; PRESENILIN 1;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL;

ALZHEIMER DISEASE; CELLS, CULTURED; CHOLESTEROL; FAMILY HEALTH; FIBROBLASTS; HUMANS; MEMBRANE PROTEINS; PHOSPHOLIPIDS; PLASMALOGENS; POINT MUTATION; PRESENILIN-1;

EID: 0034014010     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00257-4     Document Type: Article

References (65)

1. Anderson D.K., Saunders R.D., Demediuk P., Dugan L.L., Braughler J.M., Hall E.D., Means E.D., Horrocks L.A. Lipid hydrolysis and peroxidation in injured spinal cord Partial protection with methylprednisolone or vitamin E and selenium . Cent. Nerv. Syst. Trauma. 2:1985;257-267.
2. Blass J.P., Sheu K.F., Piacentini S., Sorbi S. Inherent abnormalities in oxidative metabolism in Alzheimer's disease Interaction with vascular abnormalities . Ann. NY Acad. Sci. 826:1997;382-385.
3. Blusztajn J.K., Gonzalez-Coviella I.L., Logue M., Growdon J.H., Wurtman R.J. Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients. Brain Res. 536:1990;240-244.
4. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
5. Cartier N., Lopez J., Moullier P., Ricchiccioli F., Rolland M.O., Jorge P., Mosser J., Mandel J.L., Bougneres P.F., Danos O., Aubourg P. Retroviral-mediated gene transfer corrects very long chain fatty acid metabolism in adrenoleukodystrophy fibroblasts. Proc. Natl. Acad. Sci. USA. 92:1995;1674-1678.
6. Chandrasekaran K., Giordano T., Brady D.R., Stoll J., Martin L.J., Rapoport S.I. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer's disease. Brain Res. Mol. Brain Res. 24:1994;336-340.
7. Chandrasekaran K., Hatanpaa K., Brady D.R., Rapoport S.I. Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp. Neurol. 142:1996;80-88.
8. Cooper A.L., Sheu K.F., Blass J.P. Normal glutamate metabolism in Alzheimer's disease fibroblasts deficient in alpha-ketoglutarate dehydrogenase complex activity. Dev. Neurosci. 18:1996;499-504.
9. Curti D., Rognoni F., Gasparini L., Cattaneo A., Paolillo M., Racchi M., Zani L., Bianchetti A., Trabucchi M., Bergmaschi S., Govoni S. Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients. Neurosci. Lett. 236:1997;13-16.
10. +-ATPase, and lipid peroxidation . In Vitro Cell. Dev. Biol. 21:1985;569-574.
11. Demediuk P., Saunders R.D., Anderson D.K., Means E.D., Horrocks L.A. Membrane lipid changes in laminectomized and traumatized cat spinal cord. Proc. Natl. Acad. Sci. USA. 82:1985;7071-7075.
12. Doi O., Doi F., Schroeder F., Alberts A.W., Vagelos P.R. Manipulation of fatty acid composition of membrane phospholipid and its effects on cell growth in mouse LM cells. Biochim. Biophys. Acta. 509:1978;239-250.
13. Dugan L.L., Demediuk P., Pendley C.E. II, Horrocks L.A. Separation of phospholipids by high pressure liquid chromatography All major classes including ethanolamine and choline plasmalogens, and most minor classes, including lysophosphatidylethanolamine . J. Chromatogr. 378:1986;317-327.
14. Edlund C., Soderberg M., Kristensson K., Dallner G. Ubiquinone, dolichol, and cholesterol metabolism in aging and Alzheimer's disease. Biochem. Cell Biol. 70:1992;422-428.
15. Farooqui A.A., Rapoport S.I., Horrocks L.A. Membrane phospholipid alterations in Alzheimer's disease Deficiency of ethanolamine plasmalogens . Neurochem. Res. 22:1997;523-527.
16. Favit A., Grimaldi M., Nelson T.J., Alkon D.L. Alzheimer's - Specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. Proc. Natl. Acad. Sci. USA. 95:1998;5562-5567.
17. Foglia T.A., Nungesser E., Marmer W.N. Oxidation of 1-O-(Alk-1-enyl)-2,3-Di-O-Acylglycerols Models for plasmalogen oxidation . Lipids. 23:1988;430-434.
18. Fohr U.G., Gibson G.E., Tofel-Grehl B., Schafer B.W., Heizmann C.W. Expression of intracellular calcium-binding proteins in cultured skin fibroblasts from Alzheimer and normal aged donors. Biochim. Biophys. Acta. 1223:1994;391-397.
19. Fruen B.R., Lester B.R. Down's syndrome fibroblasts exhibit enhanced inositol uptake. Biochem. J. 270:1990;119-123.
20. Fruen B.R., Lester B.R. Inositol and inositol 1,4,5-triphosphate content in Down syndrome fibroblasts exhibiting enhanced inositol uptake. FEBS Lett. 295:1991;43-47.
21. Gibson G.E., Martins R., Blass J., Gandy S. Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients. Life Sci. 59:1996;477-489.
22. Gibson G.E., Park L.C.H., Zhang H., Sorbi S., Calingasan N.Y. Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. Ann. NY Acad. Sci. 893:1999;79-94.
23. Gibson G.E., Vestling M., Zhang H., Szolosi S., Alkon D., Lannfelt L., Gandy S., Cowburn R.F. Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation. Neurobiol. Aging. 18:1997;573-580.
24. Gibson G.E., Zhang H., Sheu K.F., Bogdanovich N., Lindsay J.G., Lannfelt L., Vestling M., Cowburn R.F. Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. Ann. Neurol. 44:1998;676-681.
25. Gibson G.E., Zhang H., Toral-Barza L., Szolosi S., Tofel-Grehl B. Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease. Biochim. Biophys. Acta. 1316:1996;71-77.
26. Ginsberg L., Atack J.R., Rapoport S.I., Gershfeld N.L. Regional specificity of membrane instability in Alzheimer's disease brain. Brain Res. 615:1993;355-357.
27. Ginsberg L., Rafique S., Xuereb J.H., Rapoport S.I., Gershfeld N.L. Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain. Brain Res. 698:1995;223-226.
28. Ginsberg L., Xuereb J.H., Gershfeld N.L. Membrane instability, plasmalogen content, and Alzheimer's disease. J. Neurochem. 70:1998;2533-2538.
29. Govoni S., Racchi M., Bergamaschi S., Trabucchi M., Battaini F., Bianchetti A., Binetti G. Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts. Ann. N.Y. Acad. Sci. 777:1996;332-337.
30. Hara A., Radin N.S. Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem. 90:1978;420-426.
31. Huang H.-M., Gibson G.E. Altered β-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer's donors. J. Biol. Chem. 268:1993;14616-14621.
32. Huang H.M., Gibson G.E. Phosphatidylinositol metabolism during in vitro hypoxia. J. Neurochem. 52:1989;830-835.
33. Huang H.M., Lin T.-A., Sun G.Y., Gibson G.E. Increased inositol 1,4,5-trisphosphate accumulation correlates with an up-regulation of bradykinin receptors in Alzheimer's disease. J. Neurochem. 64:1995;761-769.
34. Ito E., Oka K., Etcheberrigaray R., Nelson T.J., McPhie D.L., Tofel-Grehl B., Gibson G.E., Alkon D.L. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 91:1994;534-538.
35. Johnston J.A., Cowburn R.F., Norgren S., Wiehager B., Venizelos N., Winblad B., Vigo-Pelfrey C., Schenk D., Lannfelt L., O'Neill C. Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer disease APP670/671 mutation. FEBS Lett. 354:1994;274-278.
36. Karmiol S., Bettger W.J. Accumulation of (n-9)-eicosatrienoic and docosatrienoic acids in human fibroblast phospholipids. Lipids. 23:1988;891-898.
37. Kohlschutter A., Wiesmann U.N., Herschkowitz N.N., Ferber E. Phospholipid composition of cultivated skin fibroblasts in Duchenne's muscular dystrophy. Clin. Chim. Acta. 70:1976;463-465.
38. Lu J.F., Lawler A.M., Watkins P.A., Powers J.M., Moser A.B., Moser H.W., Smith K.D. A mouse model for X-linked adrenoleukodystrophy. Proc. Natl. Acad. Sci. USA. 94:1997;9366-9371.
39. Maltese W.A., DeVivo D.C. Cholesterol and phospholipids in cultured skin fibroblasts from patients with dystonia. Ann. Neurol. 16:1984;250-252.
40. Morand O.H., Zoeller R.A., Raetz C.R.H. Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation. J. Biol. Chem. 263:1988;11597-11606.
41. Murphy E.J., Haun S.E., Rosenberger T.A., Horrocks L.A. Altered lipid metabolism in the presence and absence of extracellular Ca2+ during combined oxygen-glucose deprivation in primary astrocyte cultures. J. Neurosci. Res. 42:1995;109-116.
42. Murphy E.J., Prows D.R., Jefferson J.R., Schroeder F. Liver fatty acid binding protein expression in transfected fibroblasts stimulates fatty acid uptake and metabolism. Biochim. Biophys. Acta. 1301:1996;191-196.
43. Murphy E.J., Rosenberger T.A., Horrocks L.A. Separation of neutral lipids by high performance liquid chromatography Quantification by ultraviolet, light scattering and fluorescent detectors . J. Chromatogr. B. 685:1996;9-14.
44. Murphy E.J., Rosenberger T.A., Horrocks L.A. Effects of maturation on the phospholipid and phospholipid fatty acid compositions in primary rat cortical astrocyte cell cultures. Neurochem. Res. 22:1997;1205-1213.
45. Murphy E.J., Stephens R., Jurkowitz-Alexander M., Horrocks L.A. Acidic hydrolysis of plasmalogens followed by high-performance liquid chromatography. Lipids. 28:1993;565-568.
46. Netik A., Forss-Petter S., Holzinger A., Molzer B., Unterrainer G., Berger J. Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD) Implications for therapy . Hum. Mol. Genet. 8:1999;907-913.
47. Nitsch R.M., Blusztajn J.K., Pittas A.G., Slack B.E., Growdon J.H., Wurtman R.J. Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. USA. 89:1992;1671-1675.
48. Radin N.S. Lipid extraction. Boulton A.A., Baker G.B., Horrocks L.A. Neuromethods, vol. 7. Lipids and related compounds. 1988;1-61 Humana Press, Clifton, NJ.
49. Rouser G., Siakotos A., Fleischer S. Quantitative analysis of phospholipids by thin layer chromatography and phosphorus analysis of spots. Lipids. 1:1969;85-86.
50. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
51. Schroeder F., Frolov A., Schoer J., Gallegos A., Atshaves B.P., Stolwich N.J., Scott A.I., Kier A.B. Intracellular cholesterol binding proteins, cholesterol transport, and membrane domains. Freeman D., Chang T.Y. Intracellular cholesterol trafficking. 1998;231-234 Kluwer Academic Publishers, Boston.
52. Shanahan C., Gibson G.E., Cowburn R.F., Johnston J.A., Wiehager B., Lannfelt L., O'Neill C. G protein subunit levels in fibroblasts from familial Alzheimer's disease patients Lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation . Neurosci. Lett. 232:1997;33-36.
53. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R.J., Wasco W., Dasilva H.A.R., Haines J.L., Pericakvance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M., St. George-Hyslop P.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
54. Singh H., Beckman K., Poulos A. Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver. J. Lipid Res. 34:1993;467-477.
55. Singh I., Lazo O., Dhaunsi G.S., Contreras M. Transport of fatty acids into human and rat peroxisomes. Differential transport of palmitic and lignoceric acids and its implication to X-adrenoleukodystrophy. J. Biol. Chem. 267:1992;13306-13313.
56. Soderberg M., Edlund C., Alafuzoff I., Kristensson K., Dallner G. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. J. Neurochem. 59:1992;1646-1653.
57. Soderberg M., Edlund C., Kristensson K., Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids. 26:1991;421-425.
58. Spector A.A., Mathur S.N., Kaduce T.L., Hyman B.T. Lipid nutrition and metabolism of cultured mammalian cells. Proc. Lipid Res. 19:1981;155-186.
59. Svennerholm L., Gottfries C.G. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (Type I) and demyelination in late-onset form (Type II). J. Neurochem. 62:1994;1039-1047.
60. Tesco G., Latorraca S., Piersanti P., Piacentini S., Amaducci L., Sorbi S. Alzheimer skin fibroblasts show increased susceptibility to free radicals. Mech. Aging Dev. 66:1992;117-120.
61. Vestling M., Cowburn R.F., Venizelos N., Lannfelt L., Winblad B., Adem A. Characterization of muscarinic acetylcholine receptors in cultured adult skin fibroblasts Effects of the Swedish Alzheimer's disease APP670/671 mutation on binding levels . J. Neural. Transm. Park. Dis. Dement. Sect. 10:1995;1-10.
62. Wallin A., Gottfries C.G., Karlsson I., Svennerholm L. Decreased myelin lipids in Alzheimer's disease and vascular dementia. Acta Neurol. Scand. 80:1989;319-323.
63. Wells K., Farooqui A.A., Liss L., Horrocks L.A. Neural membrane phospholipids in Alzheimer disease. Neurochem. Res. 20:1995;1329-1333.
64. Wood W.G., Schroeder F., Avdulov N.A., Chochina S.V., Igbauboa U. Recent advances in brain cholesterol dynamics Transport, domains, and Alzheimer's disease . Lipids. 34:1999;225-234.
65. Zoeller R.A., Morand O.H., Raetz C.R.H. A possible role for plasmalogens in protecting animal cells against photosensitized killing. J. Biol. Chem. 263:1988;11590-11596.