β-adrenoceptor stimulation up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 4, 2000, Pages 410-417

  Ortiz, Jose L ^a   Dasí, Francisco J ^a   Cortijo, Julio ^a   Morcillo, Esteban J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Human peripheral blood neutrophils; Phosphodiesterase 4; Phosphodiesterase isoenzymes; Rolipram; Salbutamol; Up regulation

Indexed keywords

PHOSPHODIESTERASE IV; PROSTAGLANDIN E2; ROLIPRAM; SALBUTAMOL;

ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DESENSITIZATION; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; NEUTROPHIL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADRENERGIC AGONISTS; ADULT; ALBUTEROL; CYCLIC AMP; DINOPROSTONE; ENZYME INHIBITORS; HUMANS; NEUTROPHIL ACTIVATION; NEUTROPHILS; RECEPTORS, ADRENERGIC, BETA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROLIPRAM; SUPEROXIDES; UP-REGULATION; ZYMOSAN;

EID: 0034013447     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000215     Document Type: Article

References (32)

1. Beavo JA, Conti M, Heaslip RJ (1994) Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol 46:399-405
2. Bolger G, Michaeli T, Martins T, St. John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K (1993) A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol 13:6558-6571
3. Busse WW (1977) Decreased granulocyte response to isoproterenol in asthma during upper respiratory tract infections. Am Rev Respir Dis 115:783-789
4. Chan SC, Grewe SR, Stevens SR, Hanifin JM (1982) Functional desensitization due to stimulation of cyclic AMP-phosphodiesterase in human mononuclear leukocytes. J Cyclic Nucleotide Res 8:211-224
5. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
6. Cortijo J, Bou J, Beleta J, Cardelús I, Llenas J, Morcillo E, Gristwood RW (1993) Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br J Pharmacol 108:562-568
7. Cortijo J, Villagrasa V, Navarrete C, Sanz C, Berto L, Michel A, Bonnet PA, Morcillo EJ (1996) Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: Comparison with rolipram, SKF94120 and levcromakalim. Br J Pharmacol 119:99-106
8. Cortijo J, Villagrasa V, Pons R, Berto L, Martí-Cabrera M, Martinez-Losa M, Domenech T, Beleta J, Morcillo EJ (1999) Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. Br J Pharmacol (in press)
9. Engels P, Fichtel K, Lübbert H (1994) Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett 350:291-295
10. Erdogan S, Houslay MD (1997) Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Biochem J 321:165-175
11. 2-adrenoceptor agonists in asthma. Trends Pharmacol Sci 17: 331-336
12. Giembycz MA, Dent G (1992) Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma. Clin Exp Allergy 22:337-344
13. Gillissen A, Jaworska M, Schärling B, Van Zwoll D, Schultze-Werninghaus G (1997) Beta-2-agonists have antioxidant function in vitro. Respiration 64:16-22
14. Gristwood RW, Beleta J, Bou J, Cardelus I, Fernandez AG, Llenas J, Berga P (1992) Studies on the cardiac actions of flosequinan in vitro. Br J Pharmacol 105:985-991
15. Holden CA, Chan SC, Norris S, Hanifin JM (1987) Histamine induced elevation of cyclic AMP phosphodiesterase activity in human monoytes. Agents Actions 22:36-42
16. Kochetkova M, Burns FM, Souness JE (1995) Isoprenaline induction of cAMP-phosphodiesterase in guinea-pig macrophages occurs in the presence, but not in the absence, of the phosphodiesterase type IV inhibitor rolipram. Biochem Pharmacol 50:2033-2038
17. Manning CD, McLaughlin MM, Livi GP, Cieslinski LB, Torphy TJ, Barnette MS (1996) Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B. J Pharmacol Exp Ther 276:810-818
18. Meltzer S, Goldberg B, Lad P, Easton J (1989) Superoxide generation and its modulation by adenosine in the neutrophils of subjects with asthma. J Allergy Clin Immunol 83:960-966
19. Müller T, Engels P, Fozard JR (1996) Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition. Trends Pharmacol Sci 17:294-298
20. i. Naunyn-Schmiedeberg's Arch Pharmacol 344:682-690
21. Sedgwick JB, Vrtis RF, Gourley MF, Busse WW (1988) Stimulus-dependent differences in superoxide anion generation by normal human eosinophils and neutrophils. J Allergy Clin Immunol 81:876-883
22. 2-adrenoceptor desensitization. J Biol Chem 273:20575-20588
23. Synek M, Beasley R, Frew AJ, Goulding D, Holloway L, Lampe FC, Roche WR, Holgate ST (1996) Cellular infiltration of the airways in asthma of varying severity. Am J Respir Crit Care Med 154:224-230
24. Teixeira MM, Gristwood RW, Cooper N, Hellewell PG (1997) Phosphodiesterase (PDE) 4 inhibitors: Anti-inflammatory drugs of the future. Trends Pharmacol Sci 18:164-171
25. Thompson WJ, Strada SJ (1984) Cyclic nucleotide phosphodiesterase (PDE). In: Bergmayer HU (ed) Methods of Enzymatic Analysis, Vol 4, 3rd Edn. Verlag Chemie, Weinheim, pp 127-134
26. Torphy TJ (1998) Phosphodiesterase isozymes. Molecular targets for novel antiasthma agents. Am J Respir Crit Care Med 157: 351-370
27. Torphy TJ, Undem BJ (1991) Phosphodiesterase inhibitors: New opportunities for the treatment of asthma. Thorax 46:512-523
28. Torphy TJ, Zhou HL, Cieslinski LB (1992) Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity. J Pharmacol Exp Ther 263:1195-1205
29. 2. J Biol Chem 270:23598-23604
30. Verghese MW, McConnell RT, Lenhard JM, Hamacher L, Jin S-LC (1995) Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells. Mol Pharmacol 47:1164-1171
31. Wang P, Wu P, Ohleth KM, Egan RW, Billah MM (1999) Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils. Mol Pharmacol 56: 170-174
32. Wright CD, Kuipers PJ, Kobylarz-Singer D, Devall LJ, Klinfekus BA, Weishaar RE (1990) Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase. Biochem Pharmacol 40:699-707