Endothelium-dependent relaxation followed by contraction mediated by NK1 receptors in precontracted rabbit intrapulmonary arteries

British Journal of Pharmacology

Volumn 129, Issue 5, 2000, Pages 937-942

  Shirahase, Hiroaki ^a   Kanda, Mamoru ^a   Kurahashi, Kazuyoshi ^a   Nakamura, Shohei ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Endothelium dependent contraction; Endothelium dependent relaxation; Intrapulmonary artery; Nitric oxide; Substance P; Substance P methyl ester

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; DOCEBENONE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NEUROKININ 1 RECEPTOR; OZAGREL; PROSTAGLANDIN F2 ALPHA; SAREDUTANT; SUBSTANCE P; SUBSTANCE P METHYL ESTER;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; LUNG ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

EID: 0034010424     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703140     Document Type: Article

References (27)

1. Allen, K.M., Wharton, J., Polak, J.M. & Haworth, S.G. (1989). A study of nerves containing peptides in the pulmonary vasculature of healthy infants and children and of those with pulmonary hypertension. Br. Heart J., 62, 353-360.
2. 2. J. Pharmacol. Exp. Ther., 236, 535-541.
3. Barnes, P.J. & Liu, S.F. (1995). Regulation of pulmonary vascular tone. Pharmacol. Rev., 47, 87-131.
4. 1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa. Am. J. Physiol., 270, L404-L414.
5. Brett, S.J., Simon, J., Gibbs, R., Pepper, J.R. & Evans, T.W. (1996). Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension. Thorax, 51, 89-91.
6. Desai, M.C., Lefkowitz, S.L., Thadeio, P.F., Longo, K.P. & Snider, R.M. (1992). Discovery of a potent substance P antagonist: Recognition of the key molecular determinant. J. Med. Chem. 35, 4911-4913.
7. D'Orleans-Juste, P., Dion, S., Drapeau, G. & Regoli, D. (1986). Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins. Eur. J. Pharmacol., 125, 37-44.
8. 1 receptor antagonist. Eur. J. Pharmacol., 250, 403-413.
9. 2) receptor. Life Sci., 50, 101-106.
10. 2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems. Br. J. Pharmacol., 111, 759-768.
11. Greeno, E.W., Mantyh, P., Vercellotti, G.M. & Moldow, C.F. (1993). Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium. J. Exp. Med., 177, 1269-1276.
12. Iizuka, K., Akahane, K., Momose, D., Nakazawa, M., Tanouchi, T., Kawamura, M., Ohyama, I., Kajiwara, I., Okada, T., Taniguchi, K., Miyamoto, T. & Hayashi, M. (1981). Highly selective inhibitors of thromboxane synthetase. I. Imidazole derivatives. J. Med. Chem., 24, 1139-1148.
13. Kageyama, N., Miura, M., Ichinose, M., Tomaki, M., Ishikawa, J., Ohuchi, Y., Endoh, N. & Shirato, K. (1997). Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. Eur. Respir. J., 10, 13-19.
14. Kurahashi, K., Usui, H., Shirahase, H. & Jino, H. (1994). Endothelium-dependent contraction of cerebral arteries. In: Bevane, R.D. & Bevane, J.A. (eds). The Human Brain Circulation. Humana Press: Totowa pp. 167-178.
15. Milner, P., Ralevic, V., Hopwood, A.M., Feher, E., Lincoln, J., Kirkpatrick, K.A., & Burnstock, G. (1989). Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia. Experientia, 45, 121-125.
16. Ralevic, V., Milner, P., Hudlicka, O., Kristek, F. & Burnstock, G. (1990). Substance P is released from the endothelium of normal and capsaicin-treated rat hind-limb vasculature, in vivo, by increased flow. Circ. Res., 66, 1178-1183.
17. Saria, A., Martling, C.R., Van, Z., Theodorsson-Norheim, E., Gamse, R. & Lundberg, J.M. (1988). Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation. Am. Rev. Respir. Dis., 137, 1330-1335.
18. 2. Br. J. Pharmacol., 115, 1215-1220.
19. Shirahase, H., Kanda, M., Murase, K., Nakamura, S., Jino, H., Usui, H. & Kurahashi, K. (1997). Tachykinin receptor subtypes involved in endothelium-dependent and -independent responses in rabbit intrapulmonary arteries. Folia Pharmacol. Jpn., 110 (Suppl 1): 108P-113P (Abstract in English).
20. 2 in the resting tone and contractile responses to acetylcholine and arachidonic acid in canine cerebral arteries. J. Cardiovasc. Pharmacol., 10, 517-522.
21. + + ionophore in canine basilar artery. J. Pharmacol. Exp. Ther., 247, 701-705.
22. Shirahase, H., Usui, H., Manabe, K., Kurahashi, K & Fujiwara, M. (1988b). Endothelium-dependent contraction and -independent relaxation induced by adenine nucleotides and nucleoside in the canine basilar artery. J. Pharmacol. Exp. Ther., 247, 1152-1157.
23. Shirahase, H., Usui, H., Shimaji, H., Kurahashi, K. & Fujiwara, M. (1991). Endothelium-independent and -dependent contractions induced by endothelin-1 in canine basilar arteries. Life Sci., 49, 273-281.
24. Uren, N.G., Ludman, P.F., Crake, T. & Oakley, C.M. (1992). Response of the pulmonary circulation to acetylcholine, calcitonin gene-related peptide, substance P and oral nicardipine in patients with primary pulmonary hypertension. J. Am. Coll. Cardiol., 19, 835-841.
25. Vane, J.R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol., 231, 232-235.
26. Yoshimoto, T., Yokoyama, C., Ochi, K., Yamamoto, S., Maki, Y., Ashida, Y., Terao, S. & Shiraishi, M. (1982). 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA-861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis. Biochim. Biophys. Acta. 713, 470-473.
27. Zeng, X.-P. & Burcher, E. (1994). Use of selective antagonists for further characterization of tachykinin NK-2, NK-1 and possible 'septide-selective' receptors in guinea pig bronchus. J. Pharmacol. Exp. Ther., 270, 1295-1300.